1. CycleCloud: Utility supercomputing
for everyone
Jason A. Stowe
CEO, @jasonastowe

2. Change in capability for
science / math / analysis workloads

3. Helps do what we’re capable of

4. Utility Supercomputing

5. On-demand creation of
small to massive HPC,
as a metered, pay-for-use service.

6. Software that creates Cloud HPC
from 50 to 50,000 cores

7. Hartford, JPMorgan,…
Lockheed Martin,
Purdue DiaGrid, Duke, U.Wisc

8. Cycle’s Utility Supercomputing in
WSJ, NY Times, Wired, Bio-IT World
BusinessWeek

10. Today
50,000-core CycleCloud
Utility Supercomputer
on AWS

11. With Nimbus Discovery,
looking at a cancer drug target

12. How big is 50,000 cores?
Why does this matter?

13. (W.H.O./Globocan 2008)

14. Every day is
crucial and costly

15. Let’s look at drug designers
trying to treat these diseases

16. Develops leading computational
chemistry algorithms

17. Drug Design involves identifying
protein targets

18. Flickr: AMagill
Which are like locks

19. Then finding molecules that may fit

20. Find the matches in millions of molecules

21. But, internal HPC clusters are too small
when you need them most…
and too large every other time.

22. Challenge: To run a virtual screen with a
higher accuracy algorithm & 21 million compounds

23. 50,000-core CycleCloud
on AWS

24. Scales to 50 - 50,000+ cores
- Automation & Error Handling
- Encryption & Key Mgmt
- Elastic, Massive CPU/FS
Cloud HPC Software - Data scheduling, migration
- Security, Security, Security…
Deploying, Auto-scaling
Internal HPC HPC clusters
Hardware Audit & Reporting Applications
Traditional Scheduler
Security Automation,
Monitoring
Encryption/Key Mgmt
Chef (SW config)
Shared FS Storage/Data Scheduling
OS / File System
Scale Certification
Instances
Job/Cluster APIs
EBS
User Application Templates
S3 EBS

25. Now I could bore you with
infrastructure details

26. Details: http://blog.cyclecomputing.com

27. Details: http://blog.cyclecomputing.com

28. Details: http://blog.cyclecomputing.com

29. Resource Count
Total Instances 6,742 ($20+ million datacenter spend)
- c1.xlarge instances 5,435
- c1.medium instances 779
- cc1.4xlarge instances 297
- cc2.8xlarge instance 231
cores 51,132
RAM 58.78-TB
AWS Regions All (7: us-east, us-west1, us-west2, eu-west, sa-east,
ap-northeast, ap-southeast )

30. Metric Count
Compute Hours of Work 109,927 hours
Compute Days of Work 4,580 days
Compute Years of Work 12.55 years
Ligand Count ~21 million ligands
Using CycleCloud & AWS
The impossible run finished in…

31. 3 Hours…
For $4828.85/hr

32. Today
For < $1,000/hr

33. Instead of $20+ Million in infrastructure:
At Peak Cost: <$1,000/hr to run

34. With Nimbus Discovery,
already acquiring the “new leads”

35. Every day is
crucial and costly...

36. Not just in cancer research
And not just for big jobs.

37. With analysis,
humans can be the bottleneck

38. We only have so much
time on the planet

39. Big 10 Pharma with peak loads:
<1,000 core use case

40. Researcher/
CycleServer SubmitOnce™
Engineer Big 10 Pharma
Jobs
HPC / Workload Analytics CycleCloud clusters look exactly like
internal environments
- SubmitOnce™ routes workloads
- Computational Fluid Dynamics
- Agile Workload placement,
Application-aware scheduling™ - Clinical Trial Simulation
File
File File
File
System
System System
System

41. Lab-generated Image Analysis Workload
(very similar to satellite imagery)
CycleCloud HPC Cluster
- Linux and Windows workload
Processing - Cluster spun up only during analysis
- Similar to any imagery, document,
or audio analysis
Imagery File
Analyst Data
File
System
System

42. Engineering, Modeling
40 – 800 cores

43. EDA/Engineering company
running 100s of cores,
once a month

44. CycleCloud clusters look exactly like
internal environments
Compute Jobs -Periodic Usage, far 10,000% cheaper
-Costs < $100/month
Data File
Researcher File
System
System

45. Financial Modeling,
Analogous to
Tax revenue modeling
80 – 1,600 cores

46. Researcher/
CycleServer SubmitOnce™
Quant Fortune 500 FinSer/Insurance
Jobs
HPC / Workload Analytics CycleCloud clusters look exactly like
internal environments
- SubmitOnce™ routes workloads
- Windows Cluster for Hedging analysis
- Data scheduling seamless to user
- Data migrated seamlessly
File
File File
File
System
System System
System

47. Tax Revenue modeling
Imagery/document/audio Analysis
Infectious disease analysis
Time is of the essence…

48. Tax Revenue modeling
Satellite Imagery Analysis
Infectious disease analysis
Time is of the essence…

49. Lastly
Cell identification

50. Cycle
BigScience
Challenge

51. Victor Ruotti,
Morgridge Institute for
Research

52. Big Data, meet
Big Compute
(1 million hours,
78 TBs Genome data)

53. Our software aided a
ComputeCentury™
In a week
For ~$19,555

57. Will hopefully help with
infectious/other disease
treatment

58. Every day is
crucial and costly...

59. Utility Supercomputing
can help

60. To that end, Cycle wants
to help you

61. Will help 3
FED/SLED projects
get started this month

62. Talk to me afterwards:
jstowe@cyclecomputing.com

63. Utility Supercomputing,
Cycle & AWS

64. Make IT a force for good,
a force for the public good

65. Make impossible BigScience, possible.

66. Thank you, Thanks AWS!
Questions? Follow us at: @cyclecomputing
http://www.cyclecomputing.com
We’re hiring!
jobs@cyclecomputing.com