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Study by Amarjit Mishra – Metabolic
Adaptations and Type-2 Low Asthma
As a result, Dr. Amarjit Mishra
Auburn University was one of the
forerunners in discovering this
connection and has been working
on studies to further substantiate
the relationships between the
various metabolic adaptations and
type-2 mild asthma.
The importance of CD4+ T cell subsets such
as Th1, Th2, and Th17 cells in the
pathogenesis of autoimmune, allergy, and
chronic inflammatory disorders is well-
known. The metabolic profile and
signatures for each T cell subset are
primarily established during antigen
presentation and differentiation of naive
CD4+ T cells in secondary lymphoid organs,
despite the fact that activated effector T
cells undergo rapid metabolic switch to
support increased energy demand and
anabolic functions.
In order to reverse severe
asthma’s unresponsive steroid
profile, Dr. Mishra noted that
FAO inhibition presents an
intriguing target for treatment.
Dr. Amarjit Mishra who was an
Ex-Assistant Professor of Auburn
University has also established
the diverse roles of mTORC
supramolecules in regulating T-
cell polarisation through a variety
of assays.
It has long been recognized
that the severe asthma
phenotype is characterised
by the presence of Th17 cells
that secrete IL-17. The
transcription factor
mediating this effector
function is RORt.
Dr. Amarjit Mishra has also done
extensive research on the
function of arginine metabolism
in the Th17 pathway. PI3-AKT
and mTORC signalling-dependent
production of inducible nitric
oxide synthase and nitric oxide,
whose levels correlate with the
severity of asthma and are
frequently used as a biomarker to
predict response to therapy,
Source:- https://yourgoogledoc.com/auburn-university-ex-professor-dr-amarjit-mishra-explained-allergic-asthma-a-research-perspective/

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Study by Amarjit Mishra – Metabolic Adaptations and Type-2 Low Asthma

  • 1. Study by Amarjit Mishra – Metabolic Adaptations and Type-2 Low Asthma As a result, Dr. Amarjit Mishra Auburn University was one of the forerunners in discovering this connection and has been working on studies to further substantiate the relationships between the various metabolic adaptations and type-2 mild asthma.
  • 2. The importance of CD4+ T cell subsets such as Th1, Th2, and Th17 cells in the pathogenesis of autoimmune, allergy, and chronic inflammatory disorders is well- known. The metabolic profile and signatures for each T cell subset are primarily established during antigen presentation and differentiation of naive CD4+ T cells in secondary lymphoid organs, despite the fact that activated effector T cells undergo rapid metabolic switch to support increased energy demand and anabolic functions.
  • 3. In order to reverse severe asthma’s unresponsive steroid profile, Dr. Mishra noted that FAO inhibition presents an intriguing target for treatment. Dr. Amarjit Mishra who was an Ex-Assistant Professor of Auburn University has also established the diverse roles of mTORC supramolecules in regulating T- cell polarisation through a variety of assays.
  • 4. It has long been recognized that the severe asthma phenotype is characterised by the presence of Th17 cells that secrete IL-17. The transcription factor mediating this effector function is RORt.
  • 5. Dr. Amarjit Mishra has also done extensive research on the function of arginine metabolism in the Th17 pathway. PI3-AKT and mTORC signalling-dependent production of inducible nitric oxide synthase and nitric oxide, whose levels correlate with the severity of asthma and are frequently used as a biomarker to predict response to therapy, Source:- https://yourgoogledoc.com/auburn-university-ex-professor-dr-amarjit-mishra-explained-allergic-asthma-a-research-perspective/