done by Inspiration group,Rawda Bint Jassim School.Nano Scale Drug Delivery module,Nanoparticle we learn how can Nanotechnology improve the way diseases are treated.
1. Inspiration Group
-Ghufran Mohamed -Athba Alkurbi -Ahlam Moneer -Fatma Abdulaziz
Al-Bairaq
I am Discovering Materials
“Nanoscale Drug Delivery Module”
Rawda Bint Jassim School
2. (Activity 1): Designing Nanomedicine.
(Activity 2): Hunting for Nanoparticle Drug Delivery Systems.
(Activity 3): Making Biodegradable Alginate Beads.
(Activity4): Determining the Rate of “Drug” Release.
Outline:
Introduction
Design project : Design a time-release nanomedicine
Product Idea: Nanotechnology in Surgery
3. Introduction
It is a part of a thousandth of a
micrometer any part of a millionth of
a millimeter. Usually deal with
nanotechnology measurements
between 0.1 to 100 nm. This
identification and measurement
offset by expansion in the nature of
the materials used Valtqana
nanoparticles are dealing with any
phenomena or structures on the
nanoscale level.
5. ACTIVITY(1): DESIGNING NANOMEDICINE
*Affinity: affects how much the nanoparticals is
attracted to a certain type of cell.e.g : canser cell
*Absorption: affects how likely the nanoparticle will
be absorbed by a certain type of cancer cell.
*Potency: affects how much damage the nanoparticle
does to a certain type of cancer cell.
6. ACTIVITY(2): HUNTING FOR NANOPARTICLE
DRUG DELIVERY SYSTEM.
Laser beams emit particles of gold, resulting micro-
bubbles see microscopically, and the size can be
controlled by changing the strength of the rays help
in identifying diseased cells. Shows according to
the study published recently in the journal
Nanotechnology that control laser assists in
determining the size of the nano-bubbles, the
bubbles characterized by small ones followed by
the possibility of a microscope, and the great ability
to blow up the target cell.
7. ACTIVITY(3) MAKING BIODEGRDABLE ALGINATE
BEADS.
we add sodium alginate into calsium chlorid
solution in different size of beads *S,M,L*
Na sodium alginate +CaCl2
8. we added 2ml
Red food dye
into S,M,L
beads.
ACTIVITY(4): DETERMINING THE RATE OF
“DRUG”RELEASE.
9. We add sodium
citrate solution to
dissolve the beads
and comparing every
2 mins
ACTIVITY(4): DETERMINING THE RATE OF
“DRUG”RELEASE.
10. ACTIVITY(4):DETERMINING THE RATE OF
“DRUG”RELEASE.
SmallmediumLargeTime
2
4
6
8
10
12
14
0
0.02
0.04
0.06
01020
concentratio
n(mg/mL)
time (min)
Rate of Drug Release
Concentrati
on (mg/mL)
- Small
Beads
11. 1. O.1 % W/V sodium alginate solution: using a magnetic
stirrer dissolve 0.08 g of sodium alginate in 80 ml distilled water
2. While stirring at the maximum speed add 5 ml of
0.0359 M CaCl2 solution(drop-wise)using a pipette, stir 10
minutes.
3. Add 0.35 g of red dye, stir for 15 minutes.
4. Prepare 2 pipettes, one with 5 ml of 0.1 M
NaOH prepared in step 1 and the other with 5 ml
of Eudragit solution prepared in step 2 and add
them at same time after dye has dissolved and stir
at maximum speed for 30 minutes.
12. 5. Pour solution into two 50-ml
centrifuge tubes at equal amount and
centrifuge at 2000 rpm for 20
minutes.
6. Pour off the liquid leaving the
nanoparticle pellet and spread it on
microscope slide and observe the
particles using a light microscope.
13. product idea : Nanotechnology in Surgery
At Rice University, a flesh welder is used to fuse two pieces of
chicken meat into a single piece. The two pieces of chicken are
placed together touching. A greenish liquid containing gold-
coated nanoshells is dribbled along the seam. An infrared laser
is traced along the seam, causing the two sides to weld
together. This could solve the difficulties and blood leaks
caused when the surgeon tries to restitch the arteries that have
been cut during a kidney or heart transplant. The flesh welder
could weld the artery perfectly
We dream that this technique will apply widely.
14. Acknowledgment
*We thank all people, teachers, friends, and
school that supported our during our journey
in Al-bairaq .
Also we don’t forget to thank Al-Bairaq team
and the sponsors who gave as the opportunity to
participate in Al-Bairaq project, create and
innovate.