3. Importance of pathology
• Understanding cause of disease
• Progression of disease
• Early and effective diagnosis
• Prevention of diseases
• Management of disease conditions
4. • pathos = suffering, logos = study
• foundation of modern pathology is
understanding the cellular and molecular
abnormalities that give rise to disease
5.
6. Cellular adaptation
• cellular adaptation refers to changes made by
a cell in response to adverse or varying
environmental changes
• physiologic (normal) or pathologic (abnormal).
7. Cellular Adaptation
• Atrophy – decrease in the size of the cells-thymus
• Hypertrophy – increase in the size of the cells-
skeletal muscle
• Hyperplasia-increase in the number of cells-
endometrium
• Metaplasia –change of one cell type to another-
esophagus
• Dysplasia-abnormal changes in cell size, shape or
organisation
21. NECROSIS
• is a form of cell death in which cellular
membranes fall apart, and cellular enzymes
leak out and ultimately digest the cell
• Always abnormal
• Always accompanied by Inflammation
29. APOPTOSIS
• Programmed cell death.
• Distinctive pattern of cell death to eliminate
unwanted cells
• Physiological or pathological (abnormal)
• No inflammation
31. • Physiological – embryogenesis, endometrial
shedding during menstruation
• Pathological – viral infection, destruction of
cells by cancer drugs
32. Steps of apoptosis
• Initiation – trigger of FAS or lack of hormones
or heat or radiation
• Execution – activation of enzymes
33.
34. • Caspases – cleave cytoskeletal proteins
• Nucleases – hromatin condensation
• Flipping out of phosphatidyl serine for
phagocytosis
• Appearance of thrombospondin bodies
35.
36. Pathological calcification
• Dystrophic calcification – calcium depositd in
dead tissues
• Post TB lesion with calcification
• Metastatic calcification – deposition of
calcium in living tissue
• Hyperparathyroidism and hypervitaminosis D
37. INFLAMMATION
• Inflammation is a response of vascularized
tissues
• to infections and tissue damage that brings
cells and molecules of host defense
• from the circulation to the sites where they
are needed,
• to eliminate the offending agents.
42. Changes in acute inflammation
• Vascular – dilation of blood vessel, increase in
microvasculature permeability
• Cellular – extravasation of neutrophils
43. Mediators of inflammation
• Cell derived – histamine, serotinin
• Plasma derived – kinin system, complement
system
44. Effects of acute inflammation
• Beneficial - Dilution of toxins, entry of
antibodies, drugs and nutrients
• Harmful – digestion of normal tissue, swelling,
allergic response
45. What does it look like
• Ulcer
• Abscess
• cellulitis
46.
47. Result of acute inflammation
• Resolution
• Fibrosis
• Abscess
• Chronic inflammation
48. Chronic inflammation
• Slow onset and progressive
• Lymphocytes and monocytes/macrophges
• Severe tissue destruction
• Less local signs and synptoms
53. PHAGOCYTOSIS
• Process of engulfment of solid material by
cells
• Phagocytes - Neutrophils and macrophages
• Steps – recognition and attachment,
engulfment, killing or degradation
56. Wound healing
• Orderly and timely reparative process that
results in durable restoration of the anatomy
and functionality of the organ
• Healing by primary intention
• Healing by secondary intention