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LIPID PROFILE: VARIATIONS PREDISPOSING TO COMMON CLINICAL DISORDER
- 1. LIPID PROFILE VARIATIONS PREDISPOSING TO COMMON CLINICAL DISORDER PBL WRAP-UP SESSION 3rd Group : E AUG,2017th batch. 5/31/2018 1
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- 3. INTRODUCTION • Lipids are group of organic substance of fatty nature which are insoluble in water, soluble in fat solvents and which are related to fatty acids. 5/31/20183
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- 6. Plasma lipid profile Analyte Reference value • Total plasma lipids 400–600 mg/dL • Total cholesterol 140–200 mg/dL • HDL cholesterol, male 30– 60 mg/dL • HDL cholesterol, female 35– 75 mg/dL • LDL cholesterol, 30-39 years 80–130 mg/dL • Triglycerides, male 50–150 mg/dL • Triglycerides, female 40–150 mg/dL • Phospholipids 150–200 mg/dL • Free fatty acids 10– 20 mg/dL 5/31/2018 6
- 7. SIGNIFICANCE OF LIPID PROFILE TEST • Screening for primary and secondary hyperlipidemias • Monitoring for risk of atherosclerosis • Monitoring treatment of hyperlipidemias 5/31/2018 7
- 8. SERUM CHOLESTEROL LEVEL INCREASED • Secondary hyper lipoproteinemia • Diabetes mellitus • Hypothyroidism • Nephrotic syndrome • Liver disease • Chronic alcoholism DECREASED • Severe liver damage • Hyperthyroidism • Malnutrition • Hypobetalipoproteinemia • Tangier’s disease • Chronic anemia 5/31/2018 8
- 9. TRIGLYCERIDE LEVEL INCREASED • Familiar hypertriglyceridemia • Von gierke disease • Diabetes mellitus • Hypothyroidism • Nephrosis DECREASED • Malnutrition • Recent weight loss • Vigorous exercise • Drugs 5/31/2018 9
- 10. HDL CHOLESTEROL LEVEL INCREASED • Moderate consumption of alcohol, insulin and estrogen • Hyper alpha lipoproteinemia • Hypo beta lipoproteinemia DECREASED • Stress • Acute MI • Stroke • Hypothyroidism • Starvation 5/31/2018 10
- 11. LDL CHOLESTEROL INCREASED • Familiar hypocholestrolemia • Familiar combined hyperlipidemia • Diabetes mellitus • Hypothyroidism • Nephrosis • Chronic renal failure DECREASED • Severe illness • Certain drugs • A beta lipoproteinemia 5/31/2018 11
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