Methods of Capsule Preparation

1. NASRIN AKTER MUKTA
Faculty of Veterinary Science
Bangladesh Agricultural University

2.  Introduction
 Hard gelatin capsule
 Soft gelatin capsule
 Evaluation of capsule

3. Capsules are solid dosage forms in which drug
substance is enclosed within hard or soft
soluble shell . The shells are generally formed
from gelatin.
Capsules are of two types
1.Hard gelatin capsules
2.Soft gelatin capsules

4. Gelatin is a heterogeneous product derived by
hydrolytic extraction of animal’s collagen.
The source of gelatin including animal bones ,
hide portions and frozen pork skin

5. Methods of preparation of hard gelatin
capsule shells
 Dipping
 Spinning
 Drying
 Stripping
 Trimming
 Joining

6. Methods of preparation of capsule shell
.

7. Developing and
preparing formulation
Filling the capsule
shell
Capsule sealing
Cleaning and polishing
the filled capsules

9. .

10. Is manufactured by four methods
1.Plate process
2.Rotary die process
3.Reciprocating die
4.Accogel machine

11.  Liquid mixture is placed in one hopper and
the liquid medicament in other hopper
 The two rotating dies rotate in opposite
directions when the fluid gelatin mixture
enters the machine from the hopper it
produces two continuous ribbons

12.  These half shell of the capsule is formed
 At this stage medicament is filled into it
with the stroke of a pump with subsequent
movement of the dies the other half capsule
is formed
 The two halves of the capsules are sealed
together by the heat and pressure of the
rotating dies
 As the die rolls rotate , the matching die
pocket seals and cuts out the filled
capsules.

13. .

15.  Weight variation test
 Content uniformity test
 Dissolution test
 Disintegration test