Nanoparticle for cancer treatment. Induction and formulation and evaluation

1. PRACTICE SCHOOL REVIWE-2
A REVIEW ON NANO particle FOR CANCER TREATMENT
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY,ANATAPUR
BACHLER’S OF
PHARMACY
Submitted By
SK Ameer
HT.NO:-20DM1R0074
B pharmacy IV year
Under Guided by
Mr. P Venkata Anudeep
Assistant professor
Department of pharmaceutics
RATNAM INSTITUE OF PHARMACY ,NELLORE

2. CONTENTS
 INTRODUCTION TO NANOPARTICLES
 REVIEW OF LITERATURE
 AIM & OJECTIVE
 PREPARATION OF NANOPARTICLES
 EVALUATION OF NANOPARTICLES
 FDA APPROVED NANOPARTICLES
 APPLICATIONS
 CONCLUSION
 REFERENCES

3. INTRODUCTION TO NANO
PARTICLES
 Nanoparticles are small particles typically ranging from 1 to
100 nanometers (nm)
 Nanoparticles often exhibit unique properties.
 Nanoparticles 100 times smaller than a cell.

4.  The doctors and researchers are trying to kill the
cancer cells in the human body .
 The drugs and radiations are administration to kill the
cancer cells and also adversely impact healthy cells.
 Researches are find solution to this problem by using
of the nanoparticles , they are few nanometers in size

5. PROPERTIES OF NANOPARTICLES
• Stable in blood
• Non-toxic
• Bio-degradable
• Non-inflammatory

6. MERITS
1. Increased Solubility of highly lipophilic drugs
2. Good bio-availability, bio-Compatability
3. Decreased the toxicity or side effects of the drug
4. Nanoparticles can also used for controlled delivery
of drugs
DE MERITS
1. More expensive
2. Handling nanoparticle is difficult in liquid and dry
form

7. FORMULATION OF NANOPARTICLES
 Polymers utilized in preparation of nanoparticles
should be biocompatible and biodegradable
 Natural Polymers
1. Proteins
Examples:- * Gelatin
* Albumin
* Lectin
* Legumin

8.  Polysaccharides
Examples:- * Alginate
* Dextran
* Agarose
 Synthetic Polymers
Examples:- * Poly lactide
* Poly acrylate
* Poly methacrylate

9. LITERATURE REIEW
S.NO AUTHOR TITTLE PUBLISHED CONCLUSION
1 DR.Dang*et.al Nanoparticles
based drug
delivery system
cancer thraphy
2022 Author concluded in
this article author
mainly focusing on
nanoparticles
preparation methods
2 TaimourHassan*,et
.al
A review on
nano particle for
cancer
treatment
2021 Author mainly focusing
nanoparticles used in
treatment of cancer
cells .
3 Ms. Adelina-Gabriela
et.al
Novel Tumor-
Targeting
Nanoparticles for
Cancer
Treatment—A
Review
2021 In this article author
mainly f focusing on the
novel developments in
the field.

10. 4 Nandish Pathak et.al Nanoparticles and
targeted drug delivery
2020 The review aim to
present the conventual
cancer treatment to
over come the side
effect
5 Taimoor Hassan et.al A review on nanoparticles
for cancer treatment
2020 The author mainly
focusing the
applications of
nanoparticles
6 Somnath Dey, .et.al A review on gold nano
particles
2019 The author mainly
focusing of gold nano
particles for cancer
treatment
7 William H et.al Nanotechnology for
cancer treatment
2019 The author focusing
the nanotechnology for
cancer treatment
Targeted drug delivery
8 Jaya Baranwal et.al Nanoparticles in cancer
diagnosis and treatment
2019 The review aimed to
present the most
commonly used
nanoparticles for
cancer application

11. AIM & OBJECTIVES OF NANOPARTICLES
 The current study is Nanoparticles for cancer
treatment
 The objective is to study the new techniques to
minimizing the side effects with out adversely impact on
normal cell

12. PREPARATION OF NANOPARTICLES
 Solvent Evaporation Method
 Solvent Diffusion Method
 Nanoprecipitation Method
 Emulsion Polymerization
 Double Emulsification Method
 Ionic Gelation Technique.
 Dialysis Method

13.  Solvent Evaporation Method
 Polymer is dissolved in organic solvents
 The mixture is emulsified in aqueous phase containing surfactant
 The organic solvents are
evaporated by increasing
the temperature
 Recovery of nanoparticles

14.  Solvent Diffusion Method
 It consists of a conventional o/w emulsion between a partially water
Miscible solvent containing Drug
and polymer
 The aqueous solution contain
Surfactant
 Recovery of nanoparticles

15.  Nanoprecipitation Method
 Also called as solvent desperation method.
 Useful for slightly water soluble drugs.
 Drug+ polymer in organic solvent
 Polymer precipitation takes place and
Solvent diffusion also occur

16. EVALUATIONS OF NANOPARTICLES
 Particle size
 In-vitro study
 Yield of nanoparticles
 Stability of nanoparticles

17.  Particle Size
 Particle size and its distribution is important characterization.
 Particle size determined by using
1. Scanning electronic microscope
2. Photon-correlation Spectroscopy

18. IN VITRO STUDY
 It is performed in USP Type II dissolution apparatus at a
rotation speed of 50 rpm.
 It is immersed in 900ml of phosphate buffer solution in a
vessel, and temperature should be maintained at 37±0.20°
 The withdrawal 5ml of samples are analyzed using uv-
spectrophotometer

19. STABILITY OF NANOPARTICLES
 Accelerating stability testing
 Stored the formulation temperature at 4°C ±1°C and 30°C ± 2°
in the stability chamber for 90 days.
 The samples were analyzed after some time like at 0, 1, 2, and
3 months to check any changes in their physical appearance
or for their drug content, drug release rate

20. FDA APPROVED NANOPARTICLES
_______________________________________________________________________________________________
TRADENAME MATERIAL DRUG COMPANY INDICATION YEAR APPROVED
____________________________________________________________________________________________________________________________________
DROXIL Liposome-PEG Doxorubicin Janssen MBC, metastatic ovarian cancer 1995
Eligard® PLGA Leuprolide acetate Tolma Prostate Cancer 2002
Abraxane® Albumin Paclitaxel Celgene Metastatic breast cancer 2005
Onivyde® Liposome Irinotecan Merrimack Pancreatic cancer 2015
___________________________________________________________________________________________________________________________________________

21. APPLICATIONS OF NANOPARTICLES
 Medicine and Healthcare:
 Drug Delivery: Nanoparticles can be designed to carry and deliver
drugs to specific target cells or tissues in the body, enhancing the
efficacy and reducing side effects.
 Cancer Treatment: Gold nanoparticles, for example, can be used for
targeted photothermal therapy in cancer treatment.
 Imaging: Quantum dots and other nanoparticles are used as contrast
agents for imaging techniques like MRI, CT, and fluorescence
microscopy

22. CONCLUSION
 They are different treatments are available for cancer
treatment but here so many draw back .
 By using this nanoparticles to recache the targeted site
and kill the cancer tumour cell without effect on
normal cell.

23. REFERENCES
 DR Danang et.al: Nanoparticle based drug delivery systemin cancer thraphy: Biomedical
journals of scientific research: 2022; 7(4):39-45.
 Taimoor Hassan, Xiaojia Huang et.al. Nanoparticles in cancer treatment A review : Pakistan
academy and sciences: 2021; 58(3): 33-50.
 Ms. Adelina et.al: Novel Tumours targeting nanoparticles for cancer treatment: International
journals regulatory affairs:2022;7(1):53-58.
 Nandish Pathak et.al: Nanoparticles and targeted delivery for cancer treatment:
International journals of regulatory affairs: 2019; 7(1): 53-58.
 Somant Dey et .al: Gold nanoparticles in cancer treatment : Biomedical journals of scientific
research: 2022; 43(3): 34592-34565
 Taimoor Hassan, Xiaojia Huang et.al. Nanoparticles in cancer treatment A review :
International journal's of advanced research: 2021; 58(3): 33-50.
 Patel J, Amrutiya J, et al. Nanoparticles for cancer treatment: Journals of
microencapsulation:2019;35(2)420-438.

24.  Shree Laxmi Guavas et al. Nanoparticles for cancer thraphy : Springers
journals: 2022; 4(6):16-123.
 K Sztandera, et al. Gold nanoparticles for cancer treatment: molecular
pharmaceutics 2018;1(23): 505-22.
 Aegle RL, et al. nanoparticles for the treatment of cancer : A cancer journals
of clinicians: 2018; 67(3):177-93.
 Sinha R, et al. Nanotechnology in cancer therapeutics : official journals of
controlled release society:2018;5(8):120-132

25. THANK YOU