Nanotechnology deals regulating matter at dimension of 1-100 nanometers. its use in fundamental physics, biology, chemistry, technology of nanometer scale objects. It also includes how such objects can be used in the areas of computation, sensors, nanostructure materials, biolabeling, biomedical, agricultural, biolabeling , cancer, biotechnology. There are 3 methods for preparation of nanoparticles Physical, chemical &biological. Cancer is as an abnormal growth of cells. It is due to lack of proper regulation in cell cycle. Cancer develops through an accumulation of genetic changes or mutations which could emerge due to different factors like physical, chemical, biological. Currently available cancer chemotherapeutic agents insidiously affect the host cells especially bone marrow, epithelial tissues, reticule-endothelial system and gonads Because of high death rate associated with cancer and the serious side effects of chemotherapy & radiation therapy. Silver NanoParticles as an anticancer agent and they have all turned up positive. Many plant-derived products have been reported to exhibit potent antitumour activity against several rodent and human cancer cell lines. Plants history about use in the treatment of cancer. It is significant that over 60% of currently used anticancer agents are derived, in one way or another, from natural sources (plants, marine organism, and microorganisms)

1. Nanoparticle of plant extract: A Novel approach for cancer therapy
1 | P a g e NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
NATIONAL CONFERENCE:
A Phytomedicine: A Novel Approach For Cancer Treatment
Sponsered By
Indian Councial of Medical Research, Delhi.
Organised By
Kamla Nehru College of Pharmacy, Butibori, Nagpur 441108, Maharastra, India.
ON 25 & 26 March 2017
Conference Paper
Nanoparticle of plant extract: A Novel approach for cancer therapy
Roshan Telrandhe*
Kamla Nehru College of Pharmacy, Butibori, Nagpur 441108, Maharashtra, India
Presented on 26 March 2017
Abstract
Nanotechnology deals regulating matter at dimension of 1-100 nanometers. its use in
fundamental physics, biology, chemistry, technology of nanometer scale objects. It also includes
how such objects can be used in the areas of computation, sensors, nanostructure materials,
biolabeling, biomedical, agricultural, biolabeling , cancer, biotechnology. There are 3 methods
for preparation of nanoparticles Physical, chemical &biological. Cancer is as an abnormal
growth of cells. It is due to lack of proper regulation in cell cycle. Cancer develops through an
accumulation of genetic changes or mutations which could emerge due to different factors like
physical, chemical, biological. Currently available cancer chemotherapeutic agents insidiously
affect the host cells especially bone marrow, epithelial tissues, reticule-endothelial system and
gonads Because of high death rate associated with cancer and the serious side effects of
chemotherapy & radiation therapy. Silver NanoParticles as an anticancer agent and they have all
turned up positive. Many plant-derived products have been reported to exhibit potent antitumour
activity against several rodent and human cancer cell lines. Plants history about use in the
treatment of cancer. It is significant that over 60% of currently used anticancer agents are
derived, in one way or another, from natural sources (plants, marine organism, and
microorganisms).

2. Nanoparticle of plant extract: A Novel approach for cancer therapy
2 | P a g e NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
Objective of study
This focuses on the synthesis of Ag
nanoparticles using various plant sources.
Generally surgery, chemotherapy and
radiation treatment are the most prevalent
therapeutic option for cancer. Its side effects
due to lack of targeted delivery and cancer
specificity. To overcome these limitations,
nanoparticle could ensure targeted drug
therapy. The active herbal compounds of
plants induce cytoprotective enzymes by the
modulation of molecular targets of cancer
while acting in co-ordination to detoxify and
remove reactive substances formed by
carcinogenic agents. The cell line
proliferation were significantly inhibited by
AgNP isolated from various species studied.
it is cost effective, eco-friendly, stable and
safe in cancer treatment.
Material and Method
Instrumentation: Characterization of silver
nanoparticle are carried out by this
instrument
#UV visible spectrophotometer
#Fourier transforms infra- red spectroscopy
#Scanning electron microscope
#Transmission electron microscope
Synthesis of Silver Nanoparticles
1]freshly prepared 1mM silver nitrate and
stored under dark conditions with the plant
extract. solution are prepared in ratio of
9:1(AgNO3:Plant Extract).
Nanoparticle of plant extract: A Novel approach for cancer therapy
NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
This focuses on the synthesis of Ag
nanoparticles using various plant sources.
Generally surgery, chemotherapy and
radiation treatment are the most prevalent
therapeutic option for cancer. Its side effects
due to lack of targeted delivery and cancer
icity. To overcome these limitations,
nanoparticle could ensure targeted drug
therapy. The active herbal compounds of
plants induce cytoprotective enzymes by the
modulation of molecular targets of cancer
ordination to detoxify and
reactive substances formed by
carcinogenic agents. The cell line
proliferation were significantly inhibited by
AgNP isolated from various species studied.
friendly, stable and
: Characterization of silver
nanoparticle are carried out by this
red spectroscopy
#Transmission electron microscope
es
1]freshly prepared 1mM silver nitrate and
stored under dark conditions with the plant
extract. solution are prepared in ratio of
2]1 mM solution of AgNO3
Erlenmeyer flask. Then 1, 2, 3, 4 and 5 mL
of plant extract was added separately to 10
mL of silver nitrate solution keeping its
concentration at 1 mM.
3]AgNO3 (1mM-5mM) keeping extract
concentration constant (1 mL)
This setup was incubated in a dark chamber
to minimize photo-activation of silver nitrate
at room temperature.
Result and Discussion
The cell line proliferation were significantly
inhibited by AgNPs isolated from Jatropha
species with Jatropha curcus and Jatropha
gossypifolia. The in vitro screening of the
AgNPs showed potential cytotoxic activity
against the lung cancer cell lines A549.
Nanoparticle of plant extract: A Novel approach for cancer therapy
NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
prepared in an
flask. Then 1, 2, 3, 4 and 5 mL
ract was added separately to 10
mL of silver nitrate solution keeping its
5mM) keeping extract
concentration constant (1 mL)
This setup was incubated in a dark chamber
activation of silver nitrate
The cell line proliferation were significantly
inhibited by AgNPs isolated from Jatropha
species with Jatropha curcus and Jatropha
gossypifolia. The in vitro screening of the
AgNPs showed potential cytotoxic activity
against the lung cancer cell lines A549.

3. Nanoparticle of plant extract: A Novel approach for cancer therapy
3 | P a g e NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
Nanoparticle of plant extract: A Novel approach for cancer therapy
NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
Conclusion
Silver nanoparticles in nano
area has increased its importance to create
ecofriendly; cost effective, stable
nanoparticles and their applications in
medicines, agriculture and electronics are
wider. silver nanoparticles it is found that it
is safer and better by using natural plants
Phytochemical chemopreventive agents are
believed to play significant roles in
controlling, inhibiting, and blocking signals
which can cause translation of normal cells
to cancer cells.
.
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Nanoparticle of plant extract: A Novel approach for cancer therapy
NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
Silver nanoparticles in nano-biotechnology
area has increased its importance to create
ecofriendly; cost effective, stable
nanoparticles and their applications in
electronics are
wider. silver nanoparticles it is found that it
is safer and better by using natural plants
Phytochemical chemopreventive agents are
believed to play significant roles in
controlling, inhibiting, and blocking signals
ation of normal cells
Telrandhe R. Nanotechnology for
cancer therapy: Recent
developments. Eur J Pharm Med
Res. 2016;3(11): 284-294.
Telrandhe R, Mahapatra D K,
Kamble M A. Bombax ceiba thorn
extract mediated synthesis of silver
nanoparticles: Evaluation of anti-
Staphylococcus aures activity. Int J

4. Nanoparticle of plant extract: A Novel approach for cancer therapy
4 | P a g e NATIONAL CONFERENCE: A Phytomedicine: A Novel Approach For Cancer Treatment
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