2. A multi component reaction (MCR) between a ketone
or aldehyde, an amine, an isocyanide and a
carboxylic acid to form a bis-amide (α-aminoacyl
amide derivatives).
Reported first by Prof. Ivar Karl Ugi in the year 1959.
4. Exothermic Reaction.
Usually completes in minutes after isocyanide addition.
This is an uncatalyzed reaction.
Has high atom economy as only a molecule of water is
lost.
High chemical yield.
Changing substituents, R1, R2, R3, R4 and R5 a huge
chemical Libraries can be built.
5.
6.
7. Exploited explicitly to develop chemical
libraries.
Using the principles of combinatorial
chemistry it is used to synthesize a great
number of different compounds in one
reaction.
Using the Ugi reaction in combination with
other reactions enlarges the chemical
diversity of possible products
8. Crixivan can be prepared using the Ugi
reaction.
Many of the caine-type anesthetics are
synthesized using this reaction. Examples
include lidocaine and bupivacaine.
9. Boukis A. C., et al., “Multicomponent
Reactions Provide Key Molecules for Secret
Communication”, Nature Communications,
2018, 9:1439.
https://www.organic-
chemistry.org/namedreactions/ugi-
reaction.shtm
https://www.organic-reaction.com/organic-
reaction/multi-component-reactions/ugi-
reaction/
