3Brain’s pioneering work on CMOS technology has allowed researchers to visualize signal propagations occurring at a sub-millisecond scale between thousands of cells. See how a partnership with 3Brain can advance your research. Visit our website at https://www.3brain.com for more information.

1. Forge a partnership
3Brain is the leading company in developing and producing breakthrough CMOS-based
high-density multi electrode array (CMOS-MEA) technology. In addition to the opportunity
to refine 3Brain’s systems for high-throughput in vitro screening, partners will have access to:
Electrophysiological imaging for advanced preclinical drug screening
Generating statistically robust data is
made possible through 3Brain’s single-
well and multi-well systems that offer
thousands of electrodes per well, more
electrodes than any system currently on
the market.
Main Specifications
System form factor Single-well and multi-well
Recording sites Up to 4,096
Electrode size 21µm2
Recording area 7mm2 up to 25mm2
Full-array sampling rate 18kHz / electrode
Noise 11 µVrms (0.1Hz - 20 kHz)
Temperature control Heating and cooling 34° - 40°C
cutting edge technology
tailor-made solutions
free evaluation period
Tech in a nutshell
3Brain’s core CMOS-MEA technology
allows uninterrupted, simultaneous
high-fidelity and high-density electro-
physiological recording of network
activity at single-cell resolution.

2. Contact
Mauro Gandolfo (CEO)
Alessandro Maccione (CSO)
Applications
Boost your research activities with 3Brain’s high spatio-temporal resolution technology,
ideal for a wide array of in vitro experimental contexts and biological models.
Results
Analyze high content data with 3Brain’s
advanced software and detect activity
spikes in human- and animal- derived cell
cultures and brain tissue.
Collaborative framework
3Brain aims to establish partnerships
with pharmaceutical companies and CROs
for projects featuring its multi-well high-
density MEA technology in experimental
contexts. We ask for a data sharing
agreement with suitably anonymized data
when necessary.
Our offer
• Acquisition systems
• Consumables
• Training
• Data analysis
Your opportunity
• Exclusive relationship with a maximum
of 4 strategic partners
• Priority access to downstream and
next generation technology
• Valued input in steering future
developments (e.g. analysis tools)
Biological models
Dissociated neuronal cultures
Cardiomyocyte cultures
Human stem cell-derived neurons
Acute brain tissue
Explanted retina
Organoids and spheroids
alessandro.maccione@3brain.com
mauro.gandolfo@3brain.com
In vitro experimental contexts
Disease modeling
Drug discovery
Safety studies, acute and long-term toxicology
LTP and LTD protocols
Plasticity and homeostatic studies
Spontaneous and evoked activities
Optogenetics-combined studies