In this comprehensive lecture on Red Blood Cells (RBCs) delivered by Dr. Faiza, Assistant Professor of Physiology at CIMS Multan, a detailed exploration of various aspects related to RBC physiology and related disorders is provided. Beginning with an overview of hemopoiesis, the lecture delves into the intricate processes of erythropoiesis, elucidating the factors influencing RBC production and maturation. The composition and functions of blood, including the role of plasma proteins, are thoroughly discussed, offering insights into the physiological mechanisms underlying hematopoiesis. Furthermore, the lecture encompasses an extensive examination of different types of anemias, covering their etiology, pathophysiology, clinical presentations, and laboratory findings. The morphology and physiology of hemoglobin are elucidated, alongside an exploration of iron metabolism and its crucial role in RBC synthesis. The lecture also sheds light on polycythemia, providing an understanding of both secondary erythrocytosis and primary polycythemia (Polycythemia Vera). Throughout the lecture, Dr. Faiza employs a structured approach to elucidate complex physiological concepts, making the material accessible and engaging for learners. By integrating theoretical knowledge with clinical correlations, the lecture equips students with a comprehensive understanding of RBC physiology and related disorders, thereby fostering a deeper appreciation for the intricacies of hematopoiesis and its clinical implications