SlideShare a Scribd company logo
Cerebrospinal Fluid
Dr Faiza
Assistant Professor of Physiology
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology,
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
By the end of this session, you should be able to;
• Describe the secretion, flow, absorption and functions of
Cerebrospinal fluid
• Correlate the abnormal CSF pressure signs and symptoms with its
pathophysiology.
PROTECTION OF BRAIN
AND SPINAL CORD
Cerebrospinal Fluid (CSF)
a) Definition, normal volume & pressure
b) Production (site and mechanism)
c) Composition of CSF
d) Flow of CSF
e) Absorption of CSF
f) Regulation of CSF Pressure
g) Functions of CSF
h) Abnormalities of CSF Pressure (Hydrocephalus)
Cerebrospinal Fluid
• About 150 milliliters of CSF present in:
a) Ventricles of the brain
b) Subarachnoid space around both the brain and the spinal cord
c) In the cisterns around the outside of the brain
d) Central canal of spinal cord
FORMATION OF CSF
• Cerebrospinal fluid is formed at a rate of about 500 milliliters/day
by;
1. Choroid plexuses in the four ventricles (2/3rd of CSF, mainly in two
lateral ventricles)
2. Ependymal surfaces of all the ventricles
3. Arachnoidal membranes
4. Brain itself through the perivascular spaces that surround the blood
vessels
Choroid plexus
Cauliflower like growth of blood vessels covered by a thin layer of
epithelial cells that project into ventricles
SECRETION OF CSF:
• First plasma is passively filtered across the choroidal capillary
endothelium
• Next, active control of CSF composition and quantity by
a) Active transport of sodium ions through the epithelial cells
(Which pulls Chloride and water along with it)
a) Small amounts of glucose moves into the cerebrospinal fluid
b) Both potassium and bicarbonate ions move out of the cerebrospinal fluid into
the capillaries
c) Aquaporins provide for water movement to balance osmotic gradients.
COMPOSITION OF CSF:
• Same as that of brain extracellular fluid (ECF)
ABSORPTION OF CSF:
CSF in
subarachnoid
spaces
surrounding the
cerebrum
2
Absorbed through
multiple arachnoidal
villi
Into large sagittal
venous sinus and
other venous
sinuses of the
cerebrum.
• Arachnoidal villi allow relatively free flow of
(1) cerebrospinal fluid
(2) dissolved protein molecules
(3) even particles as large as red and white blood cells into the venous
blood
• Bulk flow
• Unidirectional (arachnoidal villi function like “valves” )
• Which of the followinganatomical structures serves as the primary
route for CSF drainagefrom the subarachnoid space back into the
bloodstream?
A) Arachnoid villi
B) Dural sinuses
C) Foramen of Magendie
D) Cerebral aqueduct
Cerebrospinal Fluid Pressure
• 130 millimeters of water (10 mm Hg)
• Normal range: 65 millimeters of water -195 millimeters of water
Regulation of Cerebrospinal Fluid Pressure
• Valve action of the villi allows CSF to begin to flow into the blood
when CSF pressure is about 1.5 mm Hg greater than the pressure of
the blood in the venous sinuses
• While rate of cerebrospinal fluid formation remains nearly constant
FUNCTIONS OF CSF
• cushion the brain within cranial vault
• Acts as shock absorber
• Acts as mechanical buffer
• Acts as reservoir and regulates the contents of cranium
• Serves as medium for nutritional exchange in CNS
• Removes metabolic waste products through absorption
• Brain simply floats in CSF
• When a blow to the head is extremely severe, it may not damage the
brain on the side of the head where the blow is struck but on the
opposite side. This phenomenon is known as “contrecoup”
• Poles and the inferior surfaces of the frontal and temporal lobes, are
more at risk of contusions
• If the contusion occurs on the same side as the impact injury, it is a
coup injury
Cerebrospinal Fluid (CSF)
a) Definition, normal volume & pressure
b) Production (site and mechanism)
c) Composition of CSF
d) Flow of CSF
e) Absorption of CSF
f) Regulation of CSF Pressure
g) Functions of CSF
h) Abnormalities of CSF Pressure (Hydrocephalus)
HIGH CSF PRESSURE
• Blockage of the absorption through the Arachnoidal villi
1. Brain tumor
2. Hemorrhage
3. Infection
4. Congenital hydrocephalus (Some babies are born with high CSF pressure, due
high resistance to fluid reabsorption through the arachnoidal villi)
• Increased production of CSF
HIGH CSF PRESSURE SIGNS AND SYMPTOMS
• Headache
• Lethargy
• Loss of coordination or balance
• Papilledema
• Poor appetite
• Seizures
• Urinary incontinence
• Vomitting
Thank You

More Related Content

Similar to Cerebrospinal Fluid & Hydrocephalus.pdf

Special circulation
Special circulationSpecial circulation
Special circulation
DanielWaweru5
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
“Karishma R.Pandey”
 
PHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGY
PHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGYPHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGY
PHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGY
Unnikrishnan Prathapadas
 
Hydrocephalus
Hydrocephalus   Hydrocephalus
Hydrocephalus
sruthysunny86
 
Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...
Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...
Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...
Ayub Abdi
 
Lec 23 csf &amp
Lec 23 csf &ampLec 23 csf &amp
Lec 23 csf &amp
muntazirkhan2
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
SKYFALL
 
Csf and blood brain barrier
Csf and blood brain barrierCsf and blood brain barrier
Csf and blood brain barrier
Raghu Veer
 
Cns 11
Cns 11Cns 11
Cns 11
MBBS IMS MSU
 
Cerebral blood flow
Cerebral blood flowCerebral blood flow
Cerebral blood flow
bigboss716
 
Cerebrospinal fluid and intracranial pressure
Cerebrospinal fluid and intracranial pressureCerebrospinal fluid and intracranial pressure
Cerebrospinal fluid and intracranial pressure
Muhammad Saim
 
CSF imaging
CSF imaging CSF imaging
CSF imaging
MiadAlsulami
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
Shaimaa Sayed
 
Brain vascular supply
Brain vascular supplyBrain vascular supply
Brain vascular supply
Mukhtar Khan
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
Herman Franklin Ndjamen
 
44 cer vascul (1)
44 cer vascul (1)44 cer vascul (1)
44 cer vascul (1)
Abigail Brinkman
 
CSF examination
CSF examinationCSF examination
CSF SEMINAR.pptx
CSF SEMINAR.pptxCSF SEMINAR.pptx
CSF SEMINAR.pptx
SunilMulgund1
 
Csf circulation
Csf circulationCsf circulation
Csf circulation
Dr Himanshu Soni
 
Cerebral circulation & csf formation
Cerebral circulation & csf formationCerebral circulation & csf formation
Cerebral circulation & csf formation
farhan_aq91
 

Similar to Cerebrospinal Fluid & Hydrocephalus.pdf (20)

Special circulation
Special circulationSpecial circulation
Special circulation
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
 
PHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGY
PHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGYPHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGY
PHYSIOLOGY OF CSF PRODUCTION AND CIRCULATION, ALTERATIONS IN VARIOUS PATHOLOGY
 
Hydrocephalus
Hydrocephalus   Hydrocephalus
Hydrocephalus
 
Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...
Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...
Lect 15 electroencephalogram (eeg), cerebrospinal fluid (csf), blod brain bar...
 
Lec 23 csf &amp
Lec 23 csf &ampLec 23 csf &amp
Lec 23 csf &amp
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
 
Csf and blood brain barrier
Csf and blood brain barrierCsf and blood brain barrier
Csf and blood brain barrier
 
Cns 11
Cns 11Cns 11
Cns 11
 
Cerebral blood flow
Cerebral blood flowCerebral blood flow
Cerebral blood flow
 
Cerebrospinal fluid and intracranial pressure
Cerebrospinal fluid and intracranial pressureCerebrospinal fluid and intracranial pressure
Cerebrospinal fluid and intracranial pressure
 
CSF imaging
CSF imaging CSF imaging
CSF imaging
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
 
Brain vascular supply
Brain vascular supplyBrain vascular supply
Brain vascular supply
 
Cerebrospinal fluid
Cerebrospinal fluidCerebrospinal fluid
Cerebrospinal fluid
 
44 cer vascul (1)
44 cer vascul (1)44 cer vascul (1)
44 cer vascul (1)
 
CSF examination
CSF examinationCSF examination
CSF examination
 
CSF SEMINAR.pptx
CSF SEMINAR.pptxCSF SEMINAR.pptx
CSF SEMINAR.pptx
 
Csf circulation
Csf circulationCsf circulation
Csf circulation
 
Cerebral circulation & csf formation
Cerebral circulation & csf formationCerebral circulation & csf formation
Cerebral circulation & csf formation
 

More from MedicoseAcademics

The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
MedicoseAcademics
 
The Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic PrinciplesThe Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic Principles
MedicoseAcademics
 
Physiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of TastePhysiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of Taste
MedicoseAcademics
 
Physiology of Chemical Sensation of smell.pdf
Physiology of Chemical Sensation of smell.pdfPhysiology of Chemical Sensation of smell.pdf
Physiology of Chemical Sensation of smell.pdf
MedicoseAcademics
 
Non-respiratory Functions of the Lungs.pdf
Non-respiratory Functions of the Lungs.pdfNon-respiratory Functions of the Lungs.pdf
Non-respiratory Functions of the Lungs.pdf
MedicoseAcademics
 
Circulation through Special Regions -characteristics and regulation
Circulation through Special Regions -characteristics and regulationCirculation through Special Regions -characteristics and regulation
Circulation through Special Regions -characteristics and regulation
MedicoseAcademics
 
Cardiac Impulse: Rhythmical Excitation and Conduction in the Heart
Cardiac Impulse: Rhythmical Excitation and Conduction in the HeartCardiac Impulse: Rhythmical Excitation and Conduction in the Heart
Cardiac Impulse: Rhythmical Excitation and Conduction in the Heart
MedicoseAcademics
 
Cardiovascular Physiology - Regulation of Cardiac Pumping
Cardiovascular Physiology - Regulation of Cardiac PumpingCardiovascular Physiology - Regulation of Cardiac Pumping
Cardiovascular Physiology - Regulation of Cardiac Pumping
MedicoseAcademics
 
Connective Tissue II - Dr Muhammad Ali Rabbani - Medicose Academics
Connective Tissue II - Dr Muhammad Ali Rabbani - Medicose AcademicsConnective Tissue II - Dr Muhammad Ali Rabbani - Medicose Academics
Connective Tissue II - Dr Muhammad Ali Rabbani - Medicose Academics
MedicoseAcademics
 
Histology of Epithelium - Dr Muhammad Ali Rabbani - Medicose Academics
Histology of Epithelium - Dr Muhammad Ali Rabbani - Medicose AcademicsHistology of Epithelium - Dr Muhammad Ali Rabbani - Medicose Academics
Histology of Epithelium - Dr Muhammad Ali Rabbani - Medicose Academics
MedicoseAcademics
 
Cytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose Academics
Cytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose AcademicsCytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose Academics
Cytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose Academics
MedicoseAcademics
 
The Events of Cardiac Cycle - Wigger's Diagram
The Events of Cardiac Cycle - Wigger's DiagramThe Events of Cardiac Cycle - Wigger's Diagram
The Events of Cardiac Cycle - Wigger's Diagram
MedicoseAcademics
 
Physiologic Anatomy of Heart_AntiCopy.pdf
Physiologic Anatomy of Heart_AntiCopy.pdfPhysiologic Anatomy of Heart_AntiCopy.pdf
Physiologic Anatomy of Heart_AntiCopy.pdf
MedicoseAcademics
 
Difference Between Skeletal Smooth and Cardiac Muscles
Difference Between Skeletal Smooth and Cardiac MusclesDifference Between Skeletal Smooth and Cardiac Muscles
Difference Between Skeletal Smooth and Cardiac Muscles
MedicoseAcademics
 
Cardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their RegulationCardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their Regulation
MedicoseAcademics
 
Circulatory Shock, types and stages, compensatory mechanisms
Circulatory Shock, types and stages, compensatory mechanismsCirculatory Shock, types and stages, compensatory mechanisms
Circulatory Shock, types and stages, compensatory mechanisms
MedicoseAcademics
 
Cerebral circulation with its regulation & Brain metabolism
Cerebral circulation with its regulation & Brain metabolismCerebral circulation with its regulation & Brain metabolism
Cerebral circulation with its regulation & Brain metabolism
MedicoseAcademics
 
Cerebral Circulation, cerebrovascular accident and Brain Metabolism
Cerebral Circulation, cerebrovascular accident and Brain MetabolismCerebral Circulation, cerebrovascular accident and Brain Metabolism
Cerebral Circulation, cerebrovascular accident and Brain Metabolism
MedicoseAcademics
 
Epilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdf
Epilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdfEpilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdf
Epilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdf
MedicoseAcademics
 
Electrocardiogram (ECG) physiological basis .pdf
Electrocardiogram (ECG) physiological basis .pdfElectrocardiogram (ECG) physiological basis .pdf
Electrocardiogram (ECG) physiological basis .pdf
MedicoseAcademics
 

More from MedicoseAcademics (20)

The Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of RespirationThe Nervous and Chemical Regulation of Respiration
The Nervous and Chemical Regulation of Respiration
 
The Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic PrinciplesThe Electrocardiogram - Physiologic Principles
The Electrocardiogram - Physiologic Principles
 
Physiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of TastePhysiology of Special Chemical Sensation of Taste
Physiology of Special Chemical Sensation of Taste
 
Physiology of Chemical Sensation of smell.pdf
Physiology of Chemical Sensation of smell.pdfPhysiology of Chemical Sensation of smell.pdf
Physiology of Chemical Sensation of smell.pdf
 
Non-respiratory Functions of the Lungs.pdf
Non-respiratory Functions of the Lungs.pdfNon-respiratory Functions of the Lungs.pdf
Non-respiratory Functions of the Lungs.pdf
 
Circulation through Special Regions -characteristics and regulation
Circulation through Special Regions -characteristics and regulationCirculation through Special Regions -characteristics and regulation
Circulation through Special Regions -characteristics and regulation
 
Cardiac Impulse: Rhythmical Excitation and Conduction in the Heart
Cardiac Impulse: Rhythmical Excitation and Conduction in the HeartCardiac Impulse: Rhythmical Excitation and Conduction in the Heart
Cardiac Impulse: Rhythmical Excitation and Conduction in the Heart
 
Cardiovascular Physiology - Regulation of Cardiac Pumping
Cardiovascular Physiology - Regulation of Cardiac PumpingCardiovascular Physiology - Regulation of Cardiac Pumping
Cardiovascular Physiology - Regulation of Cardiac Pumping
 
Connective Tissue II - Dr Muhammad Ali Rabbani - Medicose Academics
Connective Tissue II - Dr Muhammad Ali Rabbani - Medicose AcademicsConnective Tissue II - Dr Muhammad Ali Rabbani - Medicose Academics
Connective Tissue II - Dr Muhammad Ali Rabbani - Medicose Academics
 
Histology of Epithelium - Dr Muhammad Ali Rabbani - Medicose Academics
Histology of Epithelium - Dr Muhammad Ali Rabbani - Medicose AcademicsHistology of Epithelium - Dr Muhammad Ali Rabbani - Medicose Academics
Histology of Epithelium - Dr Muhammad Ali Rabbani - Medicose Academics
 
Cytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose Academics
Cytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose AcademicsCytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose Academics
Cytoskeleton and Cell Inclusions - Dr Muhammad Ali Rabbani - Medicose Academics
 
The Events of Cardiac Cycle - Wigger's Diagram
The Events of Cardiac Cycle - Wigger's DiagramThe Events of Cardiac Cycle - Wigger's Diagram
The Events of Cardiac Cycle - Wigger's Diagram
 
Physiologic Anatomy of Heart_AntiCopy.pdf
Physiologic Anatomy of Heart_AntiCopy.pdfPhysiologic Anatomy of Heart_AntiCopy.pdf
Physiologic Anatomy of Heart_AntiCopy.pdf
 
Difference Between Skeletal Smooth and Cardiac Muscles
Difference Between Skeletal Smooth and Cardiac MusclesDifference Between Skeletal Smooth and Cardiac Muscles
Difference Between Skeletal Smooth and Cardiac Muscles
 
Cardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their RegulationCardiac Output, Venous Return, and Their Regulation
Cardiac Output, Venous Return, and Their Regulation
 
Circulatory Shock, types and stages, compensatory mechanisms
Circulatory Shock, types and stages, compensatory mechanismsCirculatory Shock, types and stages, compensatory mechanisms
Circulatory Shock, types and stages, compensatory mechanisms
 
Cerebral circulation with its regulation & Brain metabolism
Cerebral circulation with its regulation & Brain metabolismCerebral circulation with its regulation & Brain metabolism
Cerebral circulation with its regulation & Brain metabolism
 
Cerebral Circulation, cerebrovascular accident and Brain Metabolism
Cerebral Circulation, cerebrovascular accident and Brain MetabolismCerebral Circulation, cerebrovascular accident and Brain Metabolism
Cerebral Circulation, cerebrovascular accident and Brain Metabolism
 
Epilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdf
Epilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdfEpilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdf
Epilepsy, Alzheimer, Schizophrenia, Bipolar disorder_AntiCopy.pdf
 
Electrocardiogram (ECG) physiological basis .pdf
Electrocardiogram (ECG) physiological basis .pdfElectrocardiogram (ECG) physiological basis .pdf
Electrocardiogram (ECG) physiological basis .pdf
 

Recently uploaded

Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptxMuscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
rishi2789
 
Cardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdfCardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdf
shivalingatalekar1
 
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Oleg Kshivets
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
HongBiThi1
 
Abortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentationAbortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentation
AksshayaRajanbabu
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
LaniyaNasrink
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
rishi2789
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
suvadeepdas911
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
Earlene McNair
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Tina Purnat
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Ayurveda ForAll
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
Donc Test
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
rishi2789
 
Histopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treatHistopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treat
DIVYANSHU740006
 
Top-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India ListTop-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India List
SwisschemDerma
 
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptxVestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
Health Advances
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
rishi2789
 

Recently uploaded (20)

Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptxMuscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
 
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdfCHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
 
Cardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdfCardiac Assessment for B.sc Nursing Student.pdf
Cardiac Assessment for B.sc Nursing Student.pdf
 
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
 
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấuK CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
K CỔ TỬ CUNG.pdf tự ghi chép, chữ hơi xấu
 
Abortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentationAbortion PG Seminar Power point presentation
Abortion PG Seminar Power point presentation
 
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptxREGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
 
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
CHEMOTHERAPY_RDP_CHAPTER 2 _LEPROSY.pdf1
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
 
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptxshare - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
 
Histopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treatHistopathology of Rheumatoid Arthritis: Visual treat
Histopathology of Rheumatoid Arthritis: Visual treat
 
Top-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India ListTop-Vitamin-Supplement-Brands-in-India List
Top-Vitamin-Supplement-Brands-in-India List
 
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptxVestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
 
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
 

Cerebrospinal Fluid & Hydrocephalus.pdf

  • 1. Cerebrospinal Fluid Dr Faiza Assistant Professor of Physiology MBBS (Best Graduate, AIMC Lahore) FCPS Physiology, ICMT, CHPE, DHPE (STMU) MPH (GC University, Faisalabad) MBA (Virtual University of Pakistan)
  • 2. Learning Objectives: By the end of this session, you should be able to; • Describe the secretion, flow, absorption and functions of Cerebrospinal fluid • Correlate the abnormal CSF pressure signs and symptoms with its pathophysiology.
  • 4. Cerebrospinal Fluid (CSF) a) Definition, normal volume & pressure b) Production (site and mechanism) c) Composition of CSF d) Flow of CSF e) Absorption of CSF f) Regulation of CSF Pressure g) Functions of CSF h) Abnormalities of CSF Pressure (Hydrocephalus)
  • 5. Cerebrospinal Fluid • About 150 milliliters of CSF present in: a) Ventricles of the brain b) Subarachnoid space around both the brain and the spinal cord c) In the cisterns around the outside of the brain d) Central canal of spinal cord
  • 6.
  • 7. FORMATION OF CSF • Cerebrospinal fluid is formed at a rate of about 500 milliliters/day by; 1. Choroid plexuses in the four ventricles (2/3rd of CSF, mainly in two lateral ventricles) 2. Ependymal surfaces of all the ventricles 3. Arachnoidal membranes 4. Brain itself through the perivascular spaces that surround the blood vessels
  • 8. Choroid plexus Cauliflower like growth of blood vessels covered by a thin layer of epithelial cells that project into ventricles
  • 9. SECRETION OF CSF: • First plasma is passively filtered across the choroidal capillary endothelium • Next, active control of CSF composition and quantity by a) Active transport of sodium ions through the epithelial cells (Which pulls Chloride and water along with it) a) Small amounts of glucose moves into the cerebrospinal fluid b) Both potassium and bicarbonate ions move out of the cerebrospinal fluid into the capillaries c) Aquaporins provide for water movement to balance osmotic gradients.
  • 10. COMPOSITION OF CSF: • Same as that of brain extracellular fluid (ECF)
  • 11.
  • 12.
  • 13.
  • 14. ABSORPTION OF CSF: CSF in subarachnoid spaces surrounding the cerebrum 2 Absorbed through multiple arachnoidal villi Into large sagittal venous sinus and other venous sinuses of the cerebrum.
  • 15.
  • 16. • Arachnoidal villi allow relatively free flow of (1) cerebrospinal fluid (2) dissolved protein molecules (3) even particles as large as red and white blood cells into the venous blood • Bulk flow • Unidirectional (arachnoidal villi function like “valves” )
  • 17. • Which of the followinganatomical structures serves as the primary route for CSF drainagefrom the subarachnoid space back into the bloodstream? A) Arachnoid villi B) Dural sinuses C) Foramen of Magendie D) Cerebral aqueduct
  • 18. Cerebrospinal Fluid Pressure • 130 millimeters of water (10 mm Hg) • Normal range: 65 millimeters of water -195 millimeters of water
  • 19.
  • 20. Regulation of Cerebrospinal Fluid Pressure • Valve action of the villi allows CSF to begin to flow into the blood when CSF pressure is about 1.5 mm Hg greater than the pressure of the blood in the venous sinuses • While rate of cerebrospinal fluid formation remains nearly constant
  • 21. FUNCTIONS OF CSF • cushion the brain within cranial vault • Acts as shock absorber • Acts as mechanical buffer • Acts as reservoir and regulates the contents of cranium • Serves as medium for nutritional exchange in CNS • Removes metabolic waste products through absorption
  • 22.
  • 23. • Brain simply floats in CSF • When a blow to the head is extremely severe, it may not damage the brain on the side of the head where the blow is struck but on the opposite side. This phenomenon is known as “contrecoup” • Poles and the inferior surfaces of the frontal and temporal lobes, are more at risk of contusions • If the contusion occurs on the same side as the impact injury, it is a coup injury
  • 24. Cerebrospinal Fluid (CSF) a) Definition, normal volume & pressure b) Production (site and mechanism) c) Composition of CSF d) Flow of CSF e) Absorption of CSF f) Regulation of CSF Pressure g) Functions of CSF h) Abnormalities of CSF Pressure (Hydrocephalus)
  • 25.
  • 26. HIGH CSF PRESSURE • Blockage of the absorption through the Arachnoidal villi 1. Brain tumor 2. Hemorrhage 3. Infection 4. Congenital hydrocephalus (Some babies are born with high CSF pressure, due high resistance to fluid reabsorption through the arachnoidal villi) • Increased production of CSF
  • 27. HIGH CSF PRESSURE SIGNS AND SYMPTOMS • Headache • Lethargy • Loss of coordination or balance • Papilledema • Poor appetite • Seizures • Urinary incontinence • Vomitting
  • 28.