0
Author(s):
 University of Michigan Medical School, Department of Cell andDevelopmental Biology
License:
Unless otherwise n...
Citation
Key
                           for
more
information
see:
http://open.umich.edu/wiki/CitationPolicy

Use
+
Share
+...
Cells
and
Tissues
Sequence
                       
       Medical
Histology   Integumentary
System,                       ...
The
Integument                                    
1.

Skin:         
Epidermis
and
Dermis






















Hypodermi...
The
skin
consists
of
                                               epidermis
and
dermis
                                 ...
Functions
of
skin
1.

Protection
(from
abrasion,
friction,
infection,
UV
rays)
       Keratin,
melanin
2.

Permeability
Ba...



















Skin
                                                       Epidermis:
                                ...
Cells
of
the
Epidermis                                       
                                                       Kerat...
Cellular
Layers
of
the
Epidermis                                                 
Epidermis
 Epidermis DermisDermis
      ...
St.
Spinosum
                            Cells
of
the
Stratum
Basale
                                           St.
Basale...




                         


















Stratum
spinosum 
 
   
 

                                            
So...
Blistering
Skin
Disorders                                  
Pemphigus:

Separation
    of
epidermal
cells
from
    each
ot...
Stratum
Granulosum
Keratohyalin
Granules
(KG)
 
 
Histidine-rich
protein


(filaggrin:
filament
aggregating














...
Keratohyalin
Granules
Weiss,
L.,
Cell
and
Tissue
Biology
6th
ed.
P.
549

Membrane
Coating
Granules
                                               Primary
                                         ...
Stratum
corneum
                                 15-20
layers
of
non-                                 nucleated
flattened
...
Thick
and
thin
skin
Source Undetermined      Blue
arrows:
Cells
of
the
stratum
granulosum

Melanocytes                        
                   
                  Skin
color                           
Red
blood
...
Melanocytes            
                                                           
                                      ...
Melanocytes
produce
Melanin
Melanin:       
Eumelanin 

 
 
           
Pheomelanin
    
   

    
   



Tyrosinase
(defi...
Epidermal-
                      melanin
unit
                      Cytocrine
secretion
Source Undetermined
Ross/Romrell,
Histology
2nd
ed.
P.
356

Pigment
distribution
in
light
(left)
and
dark
(right)

skin
     Michigan
Medical
School
Histology
Slide
Collection
   Mic...



Merkel s
cell
                 
   
Langerhans
cell
                                                 Bone
marrow
derive...

Proliferation
and
Maturation
of
Epithelial
Cells Source Undetermined
Psoriasis                              
Source Undetermined
Dermis
                       
                   Papillary
Dermis
                  Reticular
Dermis 
Contains
blood
and
...
Epithelial
Pegs
and
Dermal
Papillae
Source Undetermined       Source Undetermined
Papillary
(PL)
and
Reticular
(RL)
Dermis                                        
          Type
III
Collagen
             ...
Papillary
Dermis                                                      
                                                   ...
Dermis
and
skin
circulation   
Wheater
Fig.
9.18
 Wheater 9.18
Michigan
Medical
School
Histology
Slide
Collection
                         Sebaceous
                         gland
     ...
Hair
follicle:
hair
bulb
and
hair
shaft
    
(B,C)
    (A)
                                                     Young/
Hea...
Growth
Cycle
of
the
Hair
Follicle
                          testosterone
                          
                      ...
Pilo-sebaceous
Apparatus
Source Undetermined
Holocrine
Secretion
Source Undetermined
Mode
of
Secretion
Merocrine
(Exocytosis)
  Almost
all
exocrine
glands,
including
eccrine
    and
apocrine
sweat
glands.
Ap...

Hair
follicle
                           and
it s
                           associated
                           struct...
Eccrine
Sweat
Glands
Michigan
Medical
School
Histology
Slide
Collection

Secretory
portion
   Eccrine
                                                                           Sweat
            ...
Myoepithelial
Cells                                        
Source Undetermined
Apocrine
Sweat
Glands                                
Michigan
Medical
School
Histology
Slide
Collection

Apocrine
Sweat
Glands                                          
                     Myoepithelial
cells
Michigan
Medical
...
Secretory
Portions
of
                                    
                                        
        Eccrine
and
Ap...
Source Undetermined
Glandular
Lobules
and
Lobes                                
                            Many
Lobules
form
a
Lobe.         ...
Gray s Anatomy, Wikimedia Commons                                    US Federal Government
Change
in
Mammary
Gland
Alveoli
and
Ducts                                        
                         Inactive:
No
al...
Inactive
and
active
mammary
glands                                             
                                          ...

                   The
stroma
of
the
mammary
gland                                                              Lactifero...
The
antibodies
resist
enteric
infections.                                                
                                ...
Nipple
-
Lactiferous
ducts                         
                                  
                                   ...
#265
(nipple)
Lactiferous
ducts                                       
                                                   ...
Learning
Objectives                                                  
•    Be
able
to
identify
principal
layers
of
the
ski...
Additional
Source
Information
                            for
more
information
see:
http://open.umich.edu/wiki/CitationPol...
Slide 36: Source UndeterminedSlide 37: Source UndeterminedSlide 38: Tsaitgaist, Wikipeda, http://en.wikipedia.org/wiki/Fil...
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09.24.08: Skin and Glands

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Transcript of "09.24.08: Skin and Glands "

  1. 1. Author(s):
 University of Michigan Medical School, Department of Cell andDevelopmental Biology
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  3. 3. Cells
and
Tissues
Sequence
 
 Medical
Histology Integumentary
System, 
 Glands/mammary
gland
 
 
 Fall,
2008 
 
 Cell
and
Developmental
Biology
  4. 4. The
Integument 
1.

Skin: 
Epidermis
and
Dermis






















Hypodermis
(a.k.a.
superficial
fascia)
2.

Appendages:

Specialization
of
epidermis
 
 A.




Pilosebaceous
apparatus
 
Hair
 
Sebaceous
glands
 
Arrecto
pili
muscle
 B.




Sweat
glands
 
 
Eccrine
sweat
glands
 
Apocrine
(odoriferous)
sweat
glands
 C.  Nail
 
 Mammary
gland 

  5. 5. The
skin
consists
of
 epidermis
and
dermis
 
and
is
the
largest
 organ
in
the
body,

 accounting
for
about
 16%
of

the
body
 weight.
UM
Medical
School
Anatomy
Laboratory
Manual

  6. 6. Functions
of
skin
1.

Protection
(from
abrasion,
friction,
infection,
UV
rays)
 Keratin,
melanin
2.

Permeability
Barrier

(prevention
of
extreme
water
loss)
 Keratin,
lipid,
sebum
3.

Thermoregulation
 Sweat
glands,
blood
vessels,
fat
4.

Sensory
Perception
 Free
and
encapsulated
nerve
endings
5.

Immunologic
Defense
 Keratinocytes,
Langerhans
cells
6.

Dermatoglyphics
(fingerprints)

  7. 7. 


















Skin
 Epidermis:
 
Keratinized,
strat.
sq.
 epithelium
 
 
 Dermis:
 
Dense
irregular
ct.
 



Type
III
and
 



Type
I
collagen
 



Elastic
fibers
 
 
Sweat
Glands:
 


Eccrine
and

 


Apocrine
glands
 
 
 Hypodermis
(superficial
fascia):
 
Fatty
conn.
Tissue
Michigan
Medical
School
Histology
Slide
Collection


  8. 8. Cells
of
the
Epidermis 
 Keratinocytes
(80%)
 
 Melanocytes
(5-10%)
 
 Langerhans
cells
(5%)
 
 Merkel
cells
(<1%)
 
Michigan
Medical
School
Histology
Slide
Collection


  9. 9. Cellular
Layers
of
the
Epidermis 
Epidermis
 Epidermis DermisDermis
 Michigan
Medical
School
Histology
Slide
Collection

 Weiss,
L.,
Cell
and
Tissue
Biology
6th
ed.
P.
543

  10. 10. St.
Spinosum
 Cells
of
the
Stratum
Basale
 St.
Basale
 Dermis
 Source Undetermined
  11. 11. 



 


















Stratum
spinosum 
 
 
 

 
Source Undetermined
  12. 12. Blistering
Skin
Disorders 
Pemphigus:

Separation
 of
epidermal
cells
from
 each
other
(acantholysis)
 caused
by
loss
of
 desmosome
functions.

Bullous
pemphigoid:

 Separation
of
epidermis
 from
the
dermis
due
to
 blistering
in
the
basement
 membrane
caused
by
 loss
of
anchoring
 filaments
and
 hemidesmosomes.
 Source Undetermined

  13. 13. Stratum
Granulosum
Keratohyalin
Granules
(KG)
 
 
Histidine-rich
protein


(filaggrin:
filament
aggregating





















protein
that
cross
-links
keratin)
 
 
Polysaccharides
and
lipids

Membrane-coating
granules
(MCG)


 
 
(a.k.a.
lamellar
granules,
Odland
bodies)
 
 
Primary
intercellular
lipid
barrier
to
water

-
ceramide










cross-links
cell
membranes.

  14. 14. Keratohyalin
Granules
Weiss,
L.,
Cell
and
Tissue
Biology
6th
ed.
P.
549

  15. 15. Membrane
Coating
Granules
 Primary
 intercellular
 barrier
to
water
Weiss,
Cell
and
Tissue
Bilogy6th
ed.
P.
547

  16. 16. Stratum
corneum
 15-20
layers
of
non- nucleated
flattened
cells
 filled
with
keratain
filaments.
 Keratin
filaments
are
cross- linked
with
filaggrin.
 The
keratin-filaggrin
 deposited
on
the
inside
of
 the
plasma
membrane
form
 a
thickened
cell
envelope.
 

Source Undetermined
  17. 17. Thick
and
thin
skin
Source Undetermined Blue
arrows:
Cells
of
the
stratum
granulosum

  18. 18. Melanocytes 
 
 Skin
color 
Red
blood
cells
in
the
dermal
vascular
beds.
Carotenes
from
exogenous
foods
stored
in
fatty
 tissues.
Hemoglobin
and
bilirubin
(endogenous
degradation
 products).
Melanin
(pigment
produced
by
melanocytes)

  19. 19. Melanocytes 
 
 (neural
crest
origin)Michigan
Medical
School
Histology
Slide
Collection
 Rhodin,
Histology,
pp.
485

  20. 20. Melanocytes
produce
Melanin
Melanin: 
Eumelanin 

 
 
 
Pheomelanin
 
 

 
 



Tyrosinase
(deficiency:
albinism)


Tyrosine 









3,4-dihydroxyphenyalanine
(dopa) 


 
 
dopaquinone 
 











Melanin

  21. 21. Epidermal-
 melanin
unit
 Cytocrine
secretion
Source Undetermined
  22. 22. Ross/Romrell,
Histology
2nd
ed.
P.
356

  23. 23. Pigment
distribution
in
light
(left)
and
dark
(right)

skin
 Michigan
Medical
School
Histology
Slide
Collection
 Michigan
Medical
School
Histology
Slide
Collection

  24. 24. 


Merkel s
cell
 
 
Langerhans
cell
 Bone
marrow
derived
 Bind,
process
and
 present
antigen
to
T- lymphocytes
 Role
in
immunologic
 skin
reactions.
 Fawcett,
Histology,
pp.
536

  25. 25. 
Proliferation
and
Maturation
of
Epithelial
Cells Source Undetermined
  26. 26. Psoriasis 
Source Undetermined
  27. 27. Dermis
 
 Papillary
Dermis
 Reticular
Dermis 
Contains
blood
and
lymphatic
vessels,
nerves,
 hair
follicles,
sebaceous
glands,
arrecto
pili
 muscle,
and
sweat
(eccrine
and
apocrine)
 glands

 Hypodermis 
 (superficial
fascia
with
fat
cells) 

  28. 28. Epithelial
Pegs
and
Dermal
Papillae
Source Undetermined Source Undetermined
  29. 29. Papillary
(PL)
and
Reticular
(RL)
Dermis 
 Type
III
Collagen
 Elastic
fibers
(EF)
 Type
I
Collagen
Source Undetermined
  30. 30. Papillary
Dermis 
 
 houses
blood
vessels,
nerve
endings,
etc. Epidermis
 Papillary
dermis
 Reticular
dermis
Michigan
Medical
School
Histology
Slide
Collection
 Source
Undetermined
  31. 31. Dermis
and
skin
circulation 
Wheater
Fig.
9.18
 Wheater 9.18
  32. 32. Michigan
Medical
School
Histology
Slide
Collection
 Sebaceous
 gland
 Arrecto
 Pilosebaceous
 
 pile
 muscle
 apparatus 
 hair,
sebaceous
gland

 
 and
arrecto
pile
muscle hair
 Swaet
 gland
Michigan
Medical
School
Histology
Slide
Collection

  33. 33. Hair
follicle:
hair
bulb
and
hair
shaft
 
(B,C)
 (A)
 Young/
Heath
Wheater’s
Histology
4th
ed.
P.
167
 (D)
 Ross/Romrell,
Histology
2nd
ed.
P.
361
 Source
Undetermined
  34. 34. Growth
Cycle
of
the
Hair
Follicle
 testosterone
 
 
 5α-reductase
(?)
 
 5α
dihydrotestosterone,
 which
binds
the
 intracellular
receptors
and
 Inhibits
the
metabolism
of
 condemned
follicles.
 
 
 
 
 







Weiss, pg. 562
  35. 35. Pilo-sebaceous
Apparatus
Source Undetermined
  36. 36. Holocrine
Secretion
Source Undetermined
  37. 37. Mode
of
Secretion
Merocrine
(Exocytosis)
 Almost
all
exocrine
glands,
including
eccrine
 and
apocrine
sweat
glands.
Apocrine
(some
parts
of
cells
are
secreted)
 Mammary
glands
(lipid
secretion)
Holocrine
(whole
cells
are
secreted)
 
Sebaceous
glands
 Source Undetermined
  38. 38. 
Hair
follicle
 and
it s
 associated
 structures
Tsaitgaist,,
Wikipedia
  39. 39. Eccrine
Sweat
Glands
Michigan
Medical
School
Histology
Slide
Collection

  40. 40. Secretory
portion
 Eccrine
 Sweat
 Gland
Myoepithelial
cells
 Ducts
 Secretory
portion
Michigan
Medical
School
Histology
Slide
Collection

  41. 41. Myoepithelial
Cells 
Source Undetermined
  42. 42. Apocrine
Sweat
Glands 
Michigan
Medical
School
Histology
Slide
Collection

  43. 43. Apocrine
Sweat
Glands 
 Myoepithelial
cells
Michigan
Medical
School
Histology
Slide
Collection

  44. 44. Secretory
Portions
of
 
 
 Eccrine
and
Apocrine
Sweat
GlandsMichigan
Medical
School
Histology
Slide
Collection

  45. 45. Source Undetermined
  46. 46. Glandular
Lobules
and
Lobes 
 Many
Lobules
form
a
Lobe. 
 Source UndeterminedAdapted and modified from Leson TS, Leson CR, Paparo AA:Text/Atlas of Histology. Philadelphia, WB Saunders, 1988
  47. 47. Gray s Anatomy, Wikimedia Commons US Federal Government
  48. 48. Change
in
Mammary
Gland
Alveoli
and
Ducts 
 Inactive:
No
alveoli
and
 undifferentiated
terminal
 ducts.
 
 Active
(during
pregnancy):
 

Proliferation
and
 differentiation
of
alveoli.
 
 
 Active
(lactating):
Secretion
 of
milk
and
accumulation
in
 alveolar
lumen.
 Source Undetermined
  49. 49. Inactive
and
active
mammary
glands 
 Inactive
gland
(left):



 Lobules
are
arranged
 sparsely
and
each
lobule
 consists
of
mainly
bluntly
 ending
ducts
with
no
 secretory
alveoli.
 
 Active
gland
(right):

 Lobules
are
well
developed
 and
pack
the
gland.

In
each
 lobule,
secretory
alveoli
have
 formed
and
their
lumens
are

 highly
dilated.
Michigan
Medical
School
Histology
Slide
Collection
(all
images)

  50. 50. 
 The
stroma
of
the
mammary
gland Lactiferous







 
 duct
 Intralobular
CT
 Lobule
 Source Undetermined The
loose,
more
cellular
and
less
fibrous,
intralobular
 connective
tissue
makes
the
stroma
distensible
for
the
 hypertrophy
of
the
epithelial
elements
and
differentiation
of
the
 alveoli.

Numerous
plasma
cells
(arrows
above),
which
appear
 in
the
intralobular
connective
tissue
during
pregnancy
and
Interlobular
CT
 lactation,
produce
immunoglobulin
IgA.

IgA
is
taken
up
by
the
 epithelial
cells,
secreted
in
the
milk,
and
transported
to
the
 infant s
intestine
where
the
antibodies
resist
bacterial
 Michigan
Medical
School
Histology
Slide
Collection
 infection.

  51. 51. The
antibodies
resist
enteric
infections. 
 Image of mother breastfeeding infant antibodies removedSource Undetermined
  52. 52. Nipple
-
Lactiferous
ducts 
 
 
15-20
independent
lactiferous
ducts,
 each
draining
one
of
the
lobes
of
the
 gland,
open
at
the
tip
of
the
nipple.

 Within
the
nipple,
each
duct
is
slightly
 Lactiferous
ducts
 dilated
to
form
a
lactiferous
sinus
(inset).
 Gray s Anatomy, Wikimedia CommonsMichigan
Medical
School
Histology
Slide
Collection

  53. 53. #265
(nipple)
Lactiferous
ducts 
 The
lactiferous
duct
is
lined
 by
a
superficial
layer
of
 cuboidal
epithelial
cells
and
 a
basal
layer
of
 myoepithelial
cells
(arrows).
 
Michigan
Medical
School
Histology
Slide
Collection

  54. 54. Learning
Objectives 
•  Be
able
to
identify
principal
layers
of
the
skin
(epidermis,
dermis
and
 hypodermis)
at
the
light
microscope
level
and
know
the
major
functions
of
each
 layer.
•  Be
able
to
identify
the
strata
of
the
epidermis
in
thick
and
thin
skin
and
know
the
 major
cellular
events
that
take
place
in
each
layer
in
the
process
of
 keratinization.
•  Be
able
to
identify
the
cells
in
different
layer
of
the
epidermis
at
the
electron
 microscope
level
by
recognizing
characteristic
organelles
and
structures
present
 in
each
layer.
•  Be
able
to
recognize
melanocytes
and
know
the
process
of
pigment
formation
in
 the
skin.
•  Be
able
to
identify
eccrine
and
apocrine
sweat
glands
at
the
light
microscope
 level
and
distinguish
ductal
and
secretory
portions.
•  Be
able
to
identify
the
components
of
the
pilosebacous
apparatus
and
know
the
 structural
relationship
between
each
component
and
the
epidermis.
•  Be
able
to
identify
the
mammary
gland,
by
recognizing
its
structural
components
 (lactiferous
ducts,
alveoli,
lobules,
the
stromal
connective
tissue),
and
know
the
 histological
differences
in
active
and
inactive
glands.

  55. 55. Additional
Source
Information
 for
more
information
see:
http://open.umich.edu/wiki/CitationPolicy

Slide 5: UM Medical School Anatomy Laboratory ManualSlide 7: Michigan Medical School Histology Slide CollectionSlide 8: Michigan Medical School Histology Slide CollectionSlide 9: Michigan Medical School Histology Slide Collection ; Source UndeterminedSlide 10: Source UndeterminedSlide 11: Source UndeterminedSlide 12: Source UndeterminedSlide 14: Source UndeterminedSlide 15: Source UndeterminedSlide 16: Source UndeterminedSlide 17: Source UndeterminedSlide 19: Michigan Medical School Histology Slide Collection ; Source Undetermined;Slide 21: Source UndeterminedSlide 22: Source Undetermined;Slide 23: Michigan Medical School Histology Slide Collection ; Source UndeterminedSlide 24: Source UndeterminedSlide 25: Source UndeterminedSlide 26: Source UndeterminedSlide 28: Source UndeterminedSlide 29: Source UndeterminedSlide 30: Michigan Medical School Histology Slide Collection ; Source UndeterminedSlide 31: Wheater 9.18Slide 32: Michigan Medical School Histology Slide CollectionSlide 33: Sources UndeterminedSlide 34: Weiss, pg. 562Slide 35: Source Undetermined
  56. 56. Slide 36: Source UndeterminedSlide 37: Source UndeterminedSlide 38: Tsaitgaist, Wikipeda, http://en.wikipedia.org/wiki/File:Hair_follicle-en.svgSlide 39: Michigan Medical School Histology Slide CollectionSlide 40: Michigan Medical School Histology Slide CollectionSlide 41: Source UndeterminedSlide 42: Michigan Medical School Histology Slide CollectionSlide 43: Michigan Medical School Histology Slide CollectionSlide 44: Michigan Medical School Histology Slide Collection ; Source UndeterminedSlide 45: Source UndeterminedSlide 46: Adapted and modified from Leson TS, Leson CR, Paparo AA: Text/Atlas of Histology. Philadelphia, WB Saunders, 1988; Source UndeterminedSlide 47: Gray s Anatomy, Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Dissected_lactating_breast_gray1172.png; U.S. Federal GovernmentSlide 48: Source UndeterminedSlide 49: Michigan Medical School Histology Slide CollectionSlide 50: Michigan Medical School Histology Slide Collection ; Source UndeterminedSlide 51: Source Undetermined;Slide 52: Gray s Anatomy, Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Dissected_lactating_breast_gray1172.png; Michigan Medical School Histology Slide CollectionSlide 53: Michigan Medical School Histology Slide Collection
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