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Introduction of parathyroid gland and hormone secreted by gland, its function and disease caused by decrease level of hormone production
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<PARATHYROID HORMONES (The Calcium Regulating Gland)> first recognized in 1850 by Richard Owen. <INTRODUCTION>Parathyroid glands are small glands of the endocrine system which are located in the neck behind the thyroid.><Called parathyroid due to proximity to the thyroid gland.><Yellowish brown, small ovoid bodies about 6 mm long, 3mm wide and 2mm thick.><Human being have 4 tiny parathyroid glands.><Each weighting around 30-50mg, but may weight as much as 70 mg, and in diameter is 3-4 or till 8 millimeters> <Each parathyroid gland is made up of chief cells and oxyphil cells.><Chief cells more numerous, smaller, with a slightly eosinophilic cytoplasm.><secrete Parathyroid hormone (PTH). Also known as parathormone or parathyrin.> <PARATHORMONE>Protein in nature (84 amino acids)><Molecular weight= 9,500.>< Half- life = 10 minutes><Normal plasma level of PTH = 1.5 to 5.5 ng/dL> <SYNTHESIS OF AND SECRETION OF PARATHORMONE>PTH is encoded by a gene in chromosome 11><After translation, it become pre-pro-parathyroid hormone (pre-pro-PTH) contains 115 amino acids><In endoplasmic reticulum 29 amino acids removed, so it called pro-parathyroid hormone (pro-PTH) contains 89 amino acids><In the Golgi, removed more amino acids by peptidase to become mature hormone (PTH).><It is stored in secretory vesicles within the cells, and released when required> <METABOLISM OF PTH>Half-life= 4 minute><60- 70 % of PTH is degraded by kupffer cells of liver, by means of proteolysis><Degradation of about 20-30% PTH occurs in kidneys and to a lesser extent in other organs> <Half life – 4 min. How does PTH produce its effect on biological system?> <REGULATION OF PARATHORMONE SECRETION>Regulators of secretion of PTH include calcium, vit D and phosphorus.> <MECHANISM OF SECRETION OF PARATHORMONE> <CALCIUM-SENSING RECEPTORS (CaSR)><CaSR is a plasma membrane or a cell surface receptor, structured as G protein-coupled that is expressed in the parathyroid hormone-producing chief cells of the parathyroid gland and the cells lining the kidney tubule. (Hendy & et al., 2000)><PTH RECEPTORS>PTHR1 is physiologically more important than others two.><PTHR = 60-80 kDa membrane glycoprotein.> <ACTION OF PTH>Important role in maintaining blood calcium level.>< Also controls blood phosphate level> <DISORDERS OF PARATHORMONE.><increased pth secretion leads to an increase in serum levels by increasing bone resorption and enhancing renal calcium reabsorption. > <3 TYPES>Primary hyperparathyroidism, Secondary hyperparathyroidism, Tertiary hyperparathyroidism.><The most common cause of hypercalcaemia is primary hyperparathyroidism>
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Parathyroid hormone Calcium salts in bone provide structural integrity of the skeleton Calcium ions in extracellular and cellular fluids is essential to normal function of a host of biochemical processes Neuoromuscular excitability Blood coagulation Hormonal secretion Enzymatic regulation The important role that calcium plays in so many processes dictates that its concentration, both extracellulary and intracellulary, be maintained within a very narrow range. Normal level of calcium is about 9.4 mg/dl. 0.1 % extracellular fluid 1 % stored in cells (mitochondria and ER) 99% stored in bones in hydroxyapatite crystals. Very little Ca2+ can be released from the bone– though it is the major reservoir of Ca2+ in the body. Calcium in Plasma is present in three forms: 1. Ionized and diffusible calcium 50% 2. Protein-bound calcium 41% non diffusible form 90% bound to albumin Remainder bound to globulins 3. Calcium complexed to serum constituents 9% Citrate and phosphate
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Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor (high levels in bone and kidney) and the parathyroid hormone 2 receptor (high levels in the central nervous system, pancreas, testis, and placenta).PTH half-life is approximately 4 minutes. It has a molecular mass of 9.4 kDa.
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<PARATHYROID HORMONES (The Calcium Regulating Gland)> first recognized in 1850 by Richard Owen. <INTRODUCTION>Parathyroid glands are small glands of the endocrine system which are located in the neck behind the thyroid.><Called parathyroid due to proximity to the thyroid gland.><Yellowish brown, small ovoid bodies about 6 mm long, 3mm wide and 2mm thick.><Human being have 4 tiny parathyroid glands.><Each weighting around 30-50mg, but may weight as much as 70 mg, and in diameter is 3-4 or till 8 millimeters> <Each parathyroid gland is made up of chief cells and oxyphil cells.><Chief cells more numerous, smaller, with a slightly eosinophilic cytoplasm.><secrete Parathyroid hormone (PTH). Also known as parathormone or parathyrin.> <PARATHORMONE>Protein in nature (84 amino acids)><Molecular weight= 9,500.>< Half- life = 10 minutes><Normal plasma level of PTH = 1.5 to 5.5 ng/dL> <SYNTHESIS OF AND SECRETION OF PARATHORMONE>PTH is encoded by a gene in chromosome 11><After translation, it become pre-pro-parathyroid hormone (pre-pro-PTH) contains 115 amino acids><In endoplasmic reticulum 29 amino acids removed, so it called pro-parathyroid hormone (pro-PTH) contains 89 amino acids><In the Golgi, removed more amino acids by peptidase to become mature hormone (PTH).><It is stored in secretory vesicles within the cells, and released when required> <METABOLISM OF PTH>Half-life= 4 minute><60- 70 % of PTH is degraded by kupffer cells of liver, by means of proteolysis><Degradation of about 20-30% PTH occurs in kidneys and to a lesser extent in other organs> <Half life – 4 min. How does PTH produce its effect on biological system?> <REGULATION OF PARATHORMONE SECRETION>Regulators of secretion of PTH include calcium, vit D and phosphorus.> <MECHANISM OF SECRETION OF PARATHORMONE> <CALCIUM-SENSING RECEPTORS (CaSR)><CaSR is a plasma membrane or a cell surface receptor, structured as G protein-coupled that is expressed in the parathyroid hormone-producing chief cells of the parathyroid gland and the cells lining the kidney tubule. (Hendy & et al., 2000)><PTH RECEPTORS>PTHR1 is physiologically more important than others two.><PTHR = 60-80 kDa membrane glycoprotein.> <ACTION OF PTH>Important role in maintaining blood calcium level.>< Also controls blood phosphate level> <DISORDERS OF PARATHORMONE.><increased pth secretion leads to an increase in serum levels by increasing bone resorption and enhancing renal calcium reabsorption. > <3 TYPES>Primary hyperparathyroidism, Secondary hyperparathyroidism, Tertiary hyperparathyroidism.><The most common cause of hypercalcaemia is primary hyperparathyroidism>
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Klinik_ Apotek Onlin 085657271886 Solusi Menggugurkan Masalah Kehamilan Anda Jual Obat Aborsi Asli KLINIK ABORSI TERPEECAYA _ Jual Obat Aborsi Cytotec Misoprostol Asli 100% Ampuh Hanya 3 Jam Langsung Gugur || OBAT PENGGUGUR KANDUNGAN AMPUH MANJUR OBAT ABORSI OLINE" APOTIK Jual Obat Cytotec, Gastrul, Gynecoside Asli Ampuh. JUAL ” Obat Aborsi Tuntas | Obat Aborsi Manjur | Obat Aborsi Ampuh | Obat Penggugur Janin | Obat Pencegah Kehamilan | Obat Pelancar Haid | Obat terlambat Bulan | Ciri Obat Aborsi Asli | Obat Telat Bulan | Pil Aborsi Asli | Cara Menggugurkan Konten | Cara Aborsi Tuntas | Harga Obat Aborsi Asli | Pil Aborsi | Jual Obat Aborsi Cytotec | Cara Aborsi Sendiri | Cara Aborsi Usia 1 Bulan | Cara Aborsi Usia 2 Tahun | Cara Aborsi Usia 3 Bulan | Obat Aborsi Usia 4 Bulan | Cara Abrasi Usia 5 Bulan | Cara Menggugurkan Konten | Kandungan Obat Penggugur | Cara Menghitung Usia Konten | Cara Mengatasi Terlambat Bulan | Penjual Obat Aborsi Asli | Obat Aborsi Garansi | Kandungan Obat Peluntur | Obat Telat Datang Bulan | Obat Telat Haid | Obat Aborsi Paling Murah | Klinik Jual Obat Aborsi | Jual Pil Cytotec | Apotik Jual Obat Aborsi | Kandungan Dokter Abrasi | Cara Aborsi Cepat | Jual Obat Aborsi Bergaransi | Jual Obat Cytotec Asli | Obat Aborsi Aman Manjur | Obat Misoprostol Cytotec Asli. "APA ITU ABORSI" “Aborsi Adalah dengan membendung hormon yang di perlukan untuk mempertahankan kehamilan yaitu hormon progesteron, karena hormon ini dibendung, maka jalur kehamilan mulai membuka dan leher rahim menjadi melunak,sehingga mengeluarkan darah yang merupakan tanda bahwa obat telah bekerja || maksimal 1 jam obat diminum || PENJELASAN OBAT ABORSI USIA 1 _7 BULAN Pada usia kandungan ini, pasien akan merasakan sakit yang sedikit tidak berlebihan || sekitar 1 jam ||. namun hanya akan terjadi pada saatdarah keluar merupakan pertanda menstruasi. Hal ini dikarenakan pada usiakandungan 3 bulan,janin sudah terbentuk sebesar kepalan tangan orang dewasa. Cara kerja obat aborsi : JUAL OBAT ABORSI AMPUH dosis 3 bulan secara umum sama dengan cara kerja || DOSIS OBAT ABORSI 2 bulan”, hanya berbedanya selain mengisolasijanin juga menghancurkan janin dengan formula methotrexate dikandungdidalamnya. Formula methotrexate ini sangat ampuh untuk menghancurkan janinmenjadi serpihan-serpihan kecil akan sangat berguna pada saat dikeluarkan nanti. APA ALASAN WANITA MELAKUKAN ABORSI? Aborsi di lakukan wanita hamil baik yang sudah menikah maupun belum menikah dengan berbagai alasan , akan tetapi alasan yang utama adalah alasan-alasan non medis (termasuk aborsi sendiri / di sengaja/ buatan] MELAYANI PEMESANAN OBAT ABORSI SETIAP HARI, SIAP KIRIM KESELURUH KOTA BESAR DI INDONESIA DAN LUAR NEGERI. HUBUNGI PEMESANAN LEBIH NYAMAN VIA WA/: 085657271886
Jual Obat Aborsi Hongkong ( Asli No.1 ) 085657271886 Obat Penggugur Kandungan...
Jual Obat Aborsi Hongkong ( Asli No.1 ) 085657271886 Obat Penggugur Kandungan...
ZurliaSoop
Python notes for Unit 1 Avanthi PG College
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People are more triggered by positive news than negative news. Audience does not want to hear, read or receive any kind of bad news. So these slides show how to convey negative news to someone without affecting their emotions.
COMMUNICATING NEGATIVE NEWS - APPROACHES .pptx
COMMUNICATING NEGATIVE NEWS - APPROACHES .pptx
annathomasp01
Wednesday 20 March 2024, 09:30-15:30.
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This will help people alote.
Salient Features of India constitution especially power and functions
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https://app.box.com/s/7hlvjxjalkrik7fb082xx3jk7xd7liz3
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latest AZ-104 Exam Questions and Answers
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dalebeck957
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Basic Civil Engineering notes first year Notes Building notes Selection of site for Building Layout of a Building What is Burjis, Mutam Building Bye laws Basic Concept of sunlight ventilation in building National Building Code of India Set back or building line Types of Buildings Floor Space Index (F.S.I) Institutional Vs Educational Building Components & function Sills, Lintels, Cantilever Doors, Windows and Ventilators Types of Foundation AND THEIR USES Plinth Area Shallow and Deep Foundation Super Built-up & carpet area Floor Area Ratio (F.A.R) RCC Reinforced Cement Concrete RCC VS PCC
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The pricing and discounting feature is very essential for Odoo POS. Global discount is actually a discount that will apply to the entire order. And it indicates that the discount is applied to every item in the order, regardless of how much each item costs separately. This slide will show how to manage global discounts in odoo 17 POS.
How to Manage Global Discount in Odoo 17 POS
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Celine George
Wizards are very useful for creating a good user experience. In all businesses, interactive sessions are most beneficial. To improve the user experience, wizards in Odoo provide an interactive session. For creating wizards, we can use transient models or abstract models. This gives features of a model class except the data storing. Transient and abstract models have permanent database persistence. For them, database tables are made, and the records in such tables are kept until they are specifically erased.
How to Create and Manage Wizard in Odoo 17
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This Presentation is about the Unit 5 Mathematical Reasoning of UGC NET Paper 1 General Studies where we have included Types of Reasoning, Mathematical reasoning like number series, letter series etc. and mathematical aptitude like Fraction, Time and Distance, Average etc. with their solved questions and answers.
UGC NET Paper 1 Mathematical Reasoning & Aptitude.pdf
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Graduate Outcomes Presentation Slides - English
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kelenjar partiroid-endokrinologi
1.
THE PARATHYROID GLAND
2.
3.
Anatomy & Location
of Parathyroid Gland
4.
PARATHYROID HORMONE
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7.
Physiologic Anatomy of
the Parathyroid Gland
8.
Effect of Parathyroid
Hormone on Calcium and Phosphate Concentrations in the ECF
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12.
Control of Parathyroid
Hormone Secretion
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