This is lecture on NSAIDS. DO SEND YOUR FEEDBACKS.

1. NSAIDS Dr.B.M.PUROHIT Assistant Professor (Pharmacology) P.D.U.MEDICAL COLLEGE, Rajkot (GUJARAT). 360001 [email_address]

4. So both phenomenon are beneficial

8. PGG2 MEMBRANE PHOSPHOLIPID ARACHIDONIC ACID 12-HPETE PHOSPHOLIPASE CHEMICAL AND MECHANICAL STIMULIE 5-HPETE PGH2 ISOMERASE THROMBOXANE SYNTHEASE PROSTACYCLINE SYNTHEASE CYCLOXYGENASE PATHWAY LIPOXYGENASE PATHWAY 15-HPETE PGD2 PGE2 PGF2 α TXA2 TXB2 PGI2 LTB4 LTA4 LTC4 LTD4 LTE4 LTF4

10. PGG2 MEMBRANE PHOSPHOLIPID ARACHIDONIC ACID 12-HPETE PHOSPHOLIPASE CHEMICAL AND MECHANICAL STIMULIE 5-HPETE PGH2 ISOMERASE THROMBOXANE SYNTHEASE PROSTACYCLINE SYNTHEASE CYCLOXYGENASE PATHWAY LIPOXYGENASE PATHWAY 15-HPETE PGD2 PGE2 PGF2 α TXA2 TXB2 PGI2 LTB4 LTA4 LTC4 LTD4 LTE4 LTF4

13. They are Opposite !!! Store it in your mind !!!

14. It is not possible to remember everything !! Don’t worry !!

20. SOMATIC SENSORY CORTEX ` Amygdala Hypothalamus Midbrain periaqueductal gray matter Parabrachial nucleus Medullary Reticular formation Locus cerulous Raphe nuclei Dorsal horn of the spinal cord Anterolateral System

22. Pharmacological/Physiological Effects I. Cardiovascular System

23. II. PLATELETS

24. NORMALLY IN GIT… NSAIDS blocks this So PGS have PROTECTIVE effect on GIT

25. RESPIRATORY SYSTEM

26. GI TRACT

27. V. Reproductive Organs

29. PGS produce PAIN… how ?

32. PGs PRODUCES INFLAMMATION … HOW ? INFLAMMATION

33. Mechanism Of Action : NSAIDS MOST IMPORTANT MECHANISM Efficacy of these mechanisms is doubtful.. So you are not required to remember everything!! Just keep in mind that such mechanisms exist !!

37. SALICYLATES

39. NSAIDS blocks.. REDUCES THE INTENSITY OF PAIN

50. GIT

51. KIDNEY

52. REYE’S SYNDROME

53. Aspirin Toxicity - Salicylism

57. ANTIRHEUMATIC Antirheumatic action

65. NAC SUPPLIES GLUTATHIONES so detoxifies toxic metabolites !! NAC “MAY”directly conjugates with quinones/epoxide. MAY BE… NAC has additional antioxidant and antiinflammatory activity

78. Selection of NSAID