PERTUSSIS (whooping cough) Chiara Rose M. Salalima AAPD2A Dr. Balacanao
PERTUSSIS <ul><li>an acute respiratory tract infection that was described by Sydenham as  pertussis,  meaning intense coug...
ETIOLOGY <ul><li>Bordetella pertussis  is the cause of epidemic pertussis and the usual cause of sporadic pertussis.  </li...
EPIDEMIOLOGY <ul><li>Spread occurs by direct contact or droplet infections during cough.  </li></ul><ul><li>Infants less t...
WHAT ARE THE SYMPTOMS OF PERTUSSIS? <ul><li>The &quot;whoop&quot; sound occurs with the forceful inspiration after a cough...
<ul><li>A complete blood count may show a high lymphocyte count.  If the neutrophil count is high and/or fever is present,...
CLINICAL MANIFESTATIONS: <ul><li>The incubation period of pertussis has a mean of 7 and a range of 6-20 days. </li></ul><u...
CATARRHAL STAGE <ul><li>The term  &quot;catarrh&quot;  is derived from historic Middle English, meaning  &quot;to flow.&qu...
  PAROXYSMAL STAGE (2-4WK) <ul><li>The term  &quot;paroxysm&quot;  means a  sudden, violent burst .  The paroxysms or &quo...
CONVALESCENT STAGE ( ≥2 WK ) <ul><li>The coughing fits become less frequent and less intense.  Young infants may develop l...
WHAT ARE THE POSSIBLE COMPLICATIONS OF PERTUSSIS? <ul><li>Infants less than 6 months of age are at the highest risk for co...
TREATMENT <ul><li>Goals of therapy are to </li></ul><ul><li>limit the number of paroxysms,  </li></ul><ul><li>to observe t...
HOW IS PERTUSSIS TREATED? <ul><li>Hospitalization is common, especially for infants less than 6 months.  Respiratory suppo...
ANTIBIOTICS <ul><li>An antimicrobial agent is always given when pertussis is suspected or confirmed  primarily  to limit t...
<ul><li>Erythromycin [50mg/kg/day] for 14 days may eliminate pertussis organisms from the nasopharynx within 3-4 days, the...
SHOULD EXPOSED FAMILY MEMBERS BE TREATED? <ul><li>Yes.  Family members and close contacts of an infected child should be t...
ISOLATION <ul><li>Patients with suspected pertussis are placed in respiratory isolation with use of masks by all health ca...
CAN PERTUSSIS BE PREVENTED? <ul><li>The pertussive vaccine is effective for at least 5 years.  This helps prevent infectio...
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Pertussis/Whooping cough

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Pertussis/Whooping cough

  1. 1. PERTUSSIS (whooping cough) Chiara Rose M. Salalima AAPD2A Dr. Balacanao
  2. 2. PERTUSSIS <ul><li>an acute respiratory tract infection that was described by Sydenham as pertussis, meaning intense cough, it is preferable to whooping cough because most infected individuals do not “whoop.” </li></ul>
  3. 3. ETIOLOGY <ul><li>Bordetella pertussis is the cause of epidemic pertussis and the usual cause of sporadic pertussis. </li></ul><ul><li>Bordetella parapertussis is an occasional cause of sporadic pertussis that contributes significantly to 5% of the total cases of pertussis. </li></ul><ul><li>All are gram-negative coccobacilli that are recovered best on Bordet- Gengou media. </li></ul>
  4. 4. EPIDEMIOLOGY <ul><li>Spread occurs by direct contact or droplet infections during cough. </li></ul><ul><li>Infants less than one year of age constitute 50-70% of diagnosed cases. </li></ul><ul><li>The disease occurs 3-12 days after exposure to an infected individual </li></ul><ul><li>The coughing stage lasts for approximately six weeks before subsiding. In some countries, this disease is called the 100 days' cough or cough of 100 days because of its length. </li></ul>Period of communicability
  5. 5. WHAT ARE THE SYMPTOMS OF PERTUSSIS? <ul><li>The &quot;whoop&quot; sound occurs with the forceful inspiration after a coughing fit.  This sound is uncommon in young infants and adults, but may be more common in children. </li></ul><ul><li>The entire illness may last as long as 6 weeks. </li></ul><ul><li>The illness occurs in 3 major stages (the catarrhal, paroxysmal , and convalescent stages) </li></ul><ul><li>Infants and adults may not show the normal progression of stages </li></ul><ul><li>Children (especially infants) may appear perfectly well in between episodes of coughing. </li></ul>
  6. 6. <ul><li>A complete blood count may show a high lymphocyte count.  If the neutrophil count is high and/or fever is present, then other types of infection should be considered. </li></ul><ul><li>A chest x-ray may be normal or show mild abnormalities. </li></ul><ul><li>Bacterial culture of respiratory secretions is the best test. </li></ul>
  7. 7. CLINICAL MANIFESTATIONS: <ul><li>The incubation period of pertussis has a mean of 7 and a range of 6-20 days. </li></ul><ul><li>Classically, divided into: </li></ul><ul><li>1- Catarrhal, </li></ul><ul><li>2- Paroxysmal, and </li></ul><ul><li>3- Convalescent stages. </li></ul>
  8. 8. CATARRHAL STAGE <ul><li>The term &quot;catarrh&quot; is derived from historic Middle English, meaning &quot;to flow.&quot;   That is, secretions from the nose and mucous membranes flow, causing nasal congestion and runny nose. </li></ul><ul><li>Nasal congestion </li></ul><ul><li>Runny nose </li></ul><ul><li>Mild fever </li></ul><ul><li>Eye redness and excess eye watering </li></ul>
  9. 9. PAROXYSMAL STAGE (2-4WK) <ul><li>The term &quot;paroxysm&quot; means a sudden, violent burst .  The paroxysms or &quot;fits&quot; of coughing may... </li></ul><ul><li>start as a dry, intermittent, annoying cough that increases in intensity and frequency </li></ul><ul><li>occur at least once an hour </li></ul><ul><li>cause the child to turn red, blue, or purple </li></ul><ul><li>cause the eyes to bulge and water excessively </li></ul><ul><li>cause significant distress in the child </li></ul><ul><li>have a &quot;machine-gun&quot; pattern </li></ul><ul><li>vomiting after coughing </li></ul><ul><li>Young infants may have small bursts of cough or no cough before developing... </li></ul><ul><li>Gasping </li></ul><ul><li>Choking </li></ul><ul><li>Turning red, blue or purple </li></ul><ul><li>Apnea (episodes of not breathing) </li></ul>
  10. 10. CONVALESCENT STAGE ( ≥2 WK ) <ul><li>The coughing fits become less frequent and less intense.  Young infants may develop louder coughing but typically the breathing difficulty improves. </li></ul>
  11. 11. WHAT ARE THE POSSIBLE COMPLICATIONS OF PERTUSSIS? <ul><li>Infants less than 6 months of age are at the highest risk for complications.  These include: </li></ul><ul><li>Apnea </li></ul><ul><li>Ear infections </li></ul><ul><li>Pneumonia </li></ul><ul><li>Seizures </li></ul><ul><li>Encephalopathy (brain damage) </li></ul><ul><li>Death (approximately 1% of infants less than 2 months of age) </li></ul>
  12. 12. TREATMENT <ul><li>Goals of therapy are to </li></ul><ul><li>limit the number of paroxysms, </li></ul><ul><li>to observe the severity of the cough, </li></ul><ul><li>to provide assistance when necessary, </li></ul><ul><li>to maximize nutrition, rest, and recovery without sequelae </li></ul>
  13. 13. HOW IS PERTUSSIS TREATED? <ul><li>Hospitalization is common, especially for infants less than 6 months.  Respiratory support such as supplemental oxygen or even mechanical venitlation may be necessary for severe disease.  </li></ul><ul><li>All individuals with confirmed (or highly suspected) pertussis should be treated with antibiotics such as erythromycin, azithromycin or clarithromycin.  Note - erythromycin increases the risk of hypertrophic pyloric stenosis in young infants.  Antibiotics reduce the severity of illness and also reduce the spread of the illness. </li></ul>
  14. 14. ANTIBIOTICS <ul><li>An antimicrobial agent is always given when pertussis is suspected or confirmed primarily to limit the spread of infection and secondarily for possible clinical benefit. </li></ul><ul><li>Macrolides are preferred agents. </li></ul><ul><li>Resistance has been reported rarely. </li></ul>
  15. 15. <ul><li>Erythromycin [50mg/kg/day] for 14 days may eliminate pertussis organisms from the nasopharynx within 3-4 days, thereby reducing communicability and may abort or eliminate pertussis if given within 14 days, of onset of the disease. </li></ul><ul><li>Supportive care : avoidance of factors that provoke attacks of coughing, maintenance of the hydration and nutrition, oxygen if there is distress, gentle suction for viscid secretions. </li></ul>
  16. 16. SHOULD EXPOSED FAMILY MEMBERS BE TREATED? <ul><li>Yes.  Family members and close contacts of an infected child should be treated with antibiotics to prevent spread of the illness.  This is true even for vaccinated individuals.  Typically 14 days of an antibiotic such as erythromycin is prescribed.  Azithromycin and clarithromycin may be acceptable alternatives. </li></ul>
  17. 17. ISOLATION <ul><li>Patients with suspected pertussis are placed in respiratory isolation with use of masks by all health care personnel entering the room. Screening for cough should be performed and isolation until 5 days after initiation of macrolide therapy. </li></ul><ul><li>Children and staff with pertussis in child-care facilities or schools should be excluded until macrolide prophylaxis has been taken for 5 days. </li></ul>
  18. 18. CAN PERTUSSIS BE PREVENTED? <ul><li>The pertussive vaccine is effective for at least 5 years.  This helps prevent infection in the age group where pertussis infection is most severe.  The pertussis vaccine is part of the DTaP vaccine (along with tetanus and diphtheria).  The DTaP vaccine should be given in five doses at ages 2 months, 4 months, 6 months, 15 to 18 months, and 4 to 6 years.  A booster dose is recommended at 11 to 12 years of age. </li></ul>
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