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Evolution of
Assessment
Karen Lillywhite
Mitchell Fitzgerald
Cyndie McCarley
Introduction
2012: Flinders adopted
Moodle institution wide; -
staff required to learn new
LMS (Flinders Learning
Online – FLO)
2013: Teachers
looking to
extend usage
2014: Topics across the
faculty using quizzes in
creative ways, particularly
the “embedded answers
(cloze)” question type
Paramedics – ECG Interpretation
http://youtu.be/TEC_XMx97as
Paramedics – ECG Interpretation
• Difficult yet critical skill for paramedic students to learn
• Requires a systematic approach
• 20 identically formatted questions for 20 different ECG
strips.
– reinforce systematic approach taught in lecture
– Important ECG traces in clinical practice – interpretation essential
for optimal pre-hospital care
Draw conclusion
Paramedics – ECG Interpretation
lecture slide quiz question
Speech Pathology
http://youtu.be/VfEz5-I8MRU
Speech Pathology
Auditory Perceptual Voice Analysis
• Method to assess voices
• Requires specific training to develop these skills
• Quizzes (formative & summative)
– Modelled on a paper-based perceptual profile used in a clinical setting
– Listen to range of voice types, make judgments about quality of the voice, and complete the profile.
– Check answers for feedback on their assessment of the voice
– Staff can review data on student performance & usage
Note: loudness too hard to rate
with recorded material
•2 Separate Tables
•When window is wide
enough, they sit
alongside each other
(maximal representation
of paper form)
•When window isn’t large
enough, the tables stack
Speech Pathology
Students get partial marks when 1 severity
rating different from expert opinion
Nursing Drug Calculations
• Essential skill that student nurses need to develop and
demonstrate competence in
• Questions are presented in a ‘real-life’ format to
contextualise otherwise basic mathematics
• Cloze question is best suited as we are testing both what
dose to administer and the volume/quantity of the dose
Nutrition: AGHE Diet Analysis
• Simulated clinical task providing an introduction to patient
dietary assessment
• Assessment of dietary adequacy involves:
1. Dietary interview to collect food intake information from patients
2. Rationalise interview notes to construct a food intake list
3. Determine the number of AGHE serves & food group for each item
4. Determine overall AGHE serves of each food group
5. Make assessment about the nutritional adequacy
* AGHE: Australian Guidelines to Healthy Eating
Nutrition
AGHE diet analysis quiz
• Provided with compiled food
intake list
• Student determines
– Serve sizes
– Food group
– Overall intake per food group
* AGHE: Australian Guidelines to Healthy Eating
Steps 1 & 2
Step 3
Step 4
• Acts as an introduction to common
Australian foods for international
students who are unfamiliar with
western foods.
44 “questions” in one
Optometry
• 3 different uses of multipart embedded (cloze) questions
1. Diagnostic Photograph interpretation – Fundography
2. Test result interpretation – Visual field plots
3. Instrument interpretation - Corneal Topography
• Banks ~50 of each type
– Healthy eyes and eyes with a range of conditions
– Formative and summative uses
Optometry 1: Fundography Interpretation
“Normal can look very different”
Optometry 2:
Visual Field Plot
Test result interpretation
Optometry 3: Corneal Topography
Very complex, information dense results display – considerable practice/exposure required
Optometry 3: Corneal Topography Interpretation
Feedback
available by
hovering
over
ticks/crosses
Neuroscience
Bachelor of Medical Science
• Student numbers have doubled in last 5 years with continuing
growth
• Needed to find efficiencies in marking
• Re-structured “paper assignment” so that all questions were multiple
choice
• Students work on assignment over a few weeks, transpose answers
into quiz
• All assignments are automatically marked
Neuroscience
Automate assignment marking
INSTRUCTIONS: This assignment should be printed out. Please submit all answers in the answer
sheet in FLO. The assignment is worth 17% of your final mark. Don’t leave it to the last minute
– it may only involve multiple choice questions, but it isn’t easy.
Page 3 of 11
PART A: LIST OF NEURAL CHARACTERISTICS
(a) equilibrium potential (EK) for potassium ions
(b) space constant of membrane
(c) a moment where delayed rectifier channels dominate membrane potential
(d) calcium activated Mg++
current
(e) amplitude of inhibitory post synaptic potential
(f) conduction delay along a cholinergic neuron’s axon
(g) full duration of an excitatory post synaptic potential
(h) moment where an EPSP summates with an IPSP
(i) threshold for action potential
(j) amplitude of after-hyperpolarisation
(k) duration of inhibitory post synaptic potential
(l) where an afterhyperpolarisations summates with an EPSP
(m)action potential overshoot
(n) measure reflecting cell input resistance
(o) moment where large inward, voltage-dependent Na+ current is near its maximum
(p) sodium equilibrium potential
(q) resting potential of GABA-ergic neuron
(r) synaptic latency for inhibitory synaptic potential
(s) threshold of a GABAergic neuron
(t) resting membrane potential of a cholinergic neuron
(u) synaptic latency for excitatory post synaptic potential
(v) time constant for nerve cell membrane
(w) half duration of action potential of glutamatergic neuron
(x) where voltage sensitive Na channels are largely inactivated
(y) action potentials at a frequency of about 80Hz
(z) point where two EPSPs summate
Record Part A answers here –5 marks out of 17
Fill in your answers here to Part A. Don't open the online answer
sheet until you have completed the whole assignment, because
once it opens you only have 60 minutes to complete it!!!
Feature #
from Fig 2
Characteristic #
(A-Z)
Feature #
from Fig 2
Characteristic #
(A-Z)
1 10
2 11
3 12
4 13
5 14
6 15
7 16
8 17
9 18
Page 5 of 11
What would happen if the following drugs/toxins/ion substitutions/pulses were made:
i. a drug such as hexamethonium, which specifically blocks nicotinic cholinergic
receptors, is given in a moderate concentration, sufficient for only partial block
ii. extra K+ ions are added to the bathing fluid to raise the extracellular concentration
from about 5mM to 7mM
iii. a benzodiazepine drug which acts as an “allosteric modulator” of the GABAA
receptor, potentiating the effects of GABA
iv. physostigmine is added in a concentration that potently blocks the action of
acetylcholinesterase on all cells in the bath
v. all Ca++
ions in the bathing fluid are substituted with Mg++
which does not pass
through voltage-operated Ca++
channels
vi. An antagonist at NMDA receptors (ligand gated ion channels) in glutamatergic
synapses is added in a blocking concentration
vii. Tetrodotoxin, a blocker of voltage-sensitive ion channels is added to the bath at a
dose that blocks all such channels
viii. a larger amplitude of hyperpolarizing and depolarising current pulses (0.7nA) is
applied to Cell α through the grey electrode
Fill in the answers in the marksheet in FLO, with question 16 corresponding to the recording for
Cell α for drug (i) ie: hexamethonium, Question 17 is trace B for drug (i) etc. Note that no single
answer is to be used twice although some answers are identical (eg: traces for Cell α - A, D, E, F
and H are all identical – any of these is correct in the appropriate place).
HINTS:
· You may find it easier to use the table below to work out and exclude possibilities – work
from the easiest cases to the more difficult ones…
· you may want to measure the latency of some events after the presynaptic action potential
that causes them….use a ruler…. and include conduction delays in your calculations….
· Also, look for inflections where synaptic potentials summate….
·
RECORD YOUR ANSWERS (A-H) HERE FOR QUESTIONS 19-50 (9 marks/17)
Drug: hexameth 7mM K+ benzodi Physostig
0mM
Ca++
NMDA
block TTX
0.7nA
pulses
Trace (i) (ii) (iii) (iv) (v) (vi) (vii) (viii)
Cell α-
mV/Cell
α-nA Q19 Q23 Q27 Q31 Q35 Q39 Q43 Q47
Cell β
Q20 Q24 Q28 Q32 Q36 Q40 Q44 Q48
Cell γ
Q21 Q25 Q29 Q33 Q37 Q41 Q45 Q49
Cell δ
Q22 Q26 Q30 Q34 Q38 Q42 Q46 Q 50
Page 6 of 11 Page 8 of 11
PART C – multiple choice questions (3 MARKS/17)
Please write answers in the following table for questions 1-28 below:
51 56 61 66
52 57 62 67
53 58 63 68
54 59 64 69
55 60 65 70
51. The four major components of the cell membrane are:
a. cholesterol, phospholipids, glycolipids and proteins
b. triglycerides, proteins, phospholipids and glycolipids
c. phospholipids, cholesterol, triglycerides and proteins
d. phospholipids, cholesterol, triglycerides and saccharides
e. cholesterol, glycolipids, proteins and saccharides
52. Ion channels always have one of the following features – which?
a. a charged region that detects transmembrane voltage (membrane potential)
b. sugar groups coupled to the region that faces the inside of the cell
c. a transmembrane pore that allows ions to pass through under some conditions
d. binding sites for transmitter substances
e. intracellular binding sites for cell metabolites
53. The equilibrium potential for an ion is defined as the potential at which:
a. the number of positively charged ions leaving the cell exactly equals the number of
negatively charged ions entering the cell
b. Na+, K+ and Cl- ions are in equilibrium across the membrane
c. the tendency for the ion to move down its concentration gradient is exactly counterbalanced
by its tendency to move down its electrical gradient
d. there are equal numbers of ions inside and outside the membrane
e. the Na+/K+ co-transporter exactly counterbalances the movement of ions through ion
channels in the membrane
54. Calcium ions contribute little to the resting membrane potential in most cells despite the fact
that they have a large transmembrane concentration gradient and hence a very positive equilibrium
potential. Why?
a. because Ca++ ions are too insoluble to contribute to resting potential
b. because Ca++ ions are too large to pass through proteinaceous ion channels
c. because there are no Ca ion channels in normal cells
d. because Ca++ ions are so toxic to the cell
e. because Ca ion channels are rarely open at resting membrane potential
55. Three important elements involved in nerve cell electrical signaling are potassium, sodium and
calcium. Which of the following shows these 3 ions, in descending order of concentration, as they
occur in the cytoplasm of a healthy neuron?
a. K+
, Na+
, Ca++
b. K+
, Ca++,
Na+
c. Na+
, Ca++
, K+
Page 9 of 11
d. Na+
, K+
, Ca++
e. Ca++
, K+
, Na+
,
56. The resistance of a nerve cell soma membrane is inversely proportional to:
a. The total number of open K channels
b. The total number of ion channels
c. The total number of Na channels
d. The surface area of the membrane irrespective of ion channels
e. The total number of open ion channels
57. The time constant (tau) for most neurons falls in the range of:
a. 1-5ms
b. 2-20ms
c. 10 – 100ms
d. 100-1000ms
e. >1000ms
58. The rising phase of an action potential is mostly due to:
a. inward flux of Na+
b. inward flux of K+
c. inward flux of Na+ and K+
d. outward flux of Na+
e. the Na/K ATPase
59. Voltage activated sodium channels are inactivated when the Vm remains depolarised above
threshold for more than about half a millisecond. How do they recover their voltage sensitivity
again?
a. they are phosphorylated by cellular kinases activated by depolarisation
b. they reactivate when membrane potential falls below threshold
c. they reactivate when K+ ions bind to them
d. they are recycled via the Golgi apparatus
e. they are reactivated by neurotransmitters
60. Which of the following would be expected to alter the voltage threshold for an action potential
in a nerve?
a. the number/density of chloride channels
b. the number/density of calcium channels
c. the number/density of voltage-activated sodium channels
d. the number/density of potassium channels
e. the number of dendrites
61. Squid giant axons are about 350-500µm in diameter, yet they conduct at only about 25m/s.
Why do such large axons conduct relatively slowly?
a. because squids lead such boring lives that they don’t need fast information
b. because they have large gaps between their Nodes of Ranvier
c. because they live in cold water
d. because they do not have a myelin sheath
e. because they have a high axoplasmic resistance
62. Gap junctions consist of:
a. 12 connexins arranged into two connexons which bridge between cells
b. 24 connexons arranged in two rows connecting two cells
Page 10 of 11
c. gaps in the phospholipid bilayer with cytoplasmic continuity between cells
d. fused membranes from two cells that touch
e. voltage-activated ion channels aligned serially across the gap between two cells
63. Glutamate is the most abundant excitatory transmitter in the brain. What class of
neurotransmitter does it belong to?
a. amino acids
b. amines
c. peptides
d. a class of its own
e. reactive gases
64. Which is true about gap junctions? They are permeable to:
a. only CO2 and O2
b. ions and water
c. ions water and molecules with molecular weight <100
d. ions water and molecues with molecular weight <1000
e. ions water and all intracellular molecules
65. The least common mechanism for the removal of transmitter from the synaptic cleft is:
a. diffusion
b. degradative enzymes
c. uptake by surrounding cells or nerve terminals
d. oxidation by mitochondria in the synaptic cleft
e. spontaneous breakdown of the transmitter molecule
66. If a synaptic potential was mediated by closure of leak K+ channels, which of the following
would be true during the course of the potential:
a. the cell would depolarise and Rm would increase
b. the cell would hyperpolarise and Rm would increase
c. the cell would depolarise and Rm would decrease
d. the cell would hyperpolarise and Rm would decrease
e. the cell would depolarise, but there would be no change in Rm
67. Which transmitter has ionotropic receptors that can be distinguished by their sensitivities to
NMDA, kainate and AMPA?
a. acetylcholine
b. glutamate
c. dopamine
d. 5-hydroxytryptamine
e. adenosine triphosphate
68. Which of the following ligand-gated ion channels generally have inhibitory effects on nerve
cell excitability, when opened by their endogenous transmitters?
a. GABAA and glycine
b. glutamate and glycine
c. 5-Hydroxytryptamine3 and glycine
d. P2x and GABA
e. P2X and glutamate
69. Which of the following is true about ligand gated ion channels (“ionotropic receptors”)?
a. they are made up of several protein subunits
“
”
Cloze question layout mimics
assignment layout – facilitates
answer transcription by students
that causes them….use a ruler…. and include conduction delays in your calculations….
· Also, look for inflections where synaptic potentials summate….
·
RECORD YOUR ANSWERS (A-H) HERE FOR QUESTIONS 19-50 (9 marks/17)
Drug: hexameth 7mM K+ benzodi Physostig
0mM
Ca++
NMDA
block TTX
0.7nA
pulses
Trace (i) (ii) (iii) (iv) (v) (vi) (vii) (viii)
Cell α-
mV/Cell
α-nA Q19 Q23 Q27 Q31 Q35 Q39 Q43 Q47
Cell β
Q20 Q24 Q28 Q32 Q36 Q40 Q44 Q48
Cell γ
Q21 Q25 Q29 Q33 Q37 Q41 Q45 Q49
Cell δ
Q22 Q26 Q30 Q34 Q38 Q42 Q46 Q 50
Benefits
• Scope be creative, simulate authentic tasks, more complex
questions.
• Can allow ranges (for numeric questions), partial marks
• Check, check and test again. Get a colleague to have a “fresh look”.
• Have a go
Advice/Lessons learnt
Images in feedback
Images as Answer Options
Considerations
• Syntax/Code – scary at first
• Layout/Screen real-estate
• Thinking of all possibilities for short answer type question parts
• Each question part is independent
• Multichoice (dropdown) options always shuffle
• No “checkbox” option
• “Specific feedback” display inconsistent
• Answer box length for short answer type
• Including images within the cloze code possible but tricky
Sudoku (because I could!)
Answer box size is
determined by longest
answer +/- random
amount
Multichoice dropdown:
options always shuffle –
not always desireable
Alternate setup for “Select all that are present”
Evolution of
Assessment
Karen.Lillywhite@flinders.edu.au
Mitchell.Fitzgerald@flinders.edu.au
Cyndie.McCarley@flinders.edu.au

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Evolution of Assessment - Karen Lillywhite, Mitchell Fitzgerald and Cyndie McCarley

  • 2. Introduction 2012: Flinders adopted Moodle institution wide; - staff required to learn new LMS (Flinders Learning Online – FLO) 2013: Teachers looking to extend usage 2014: Topics across the faculty using quizzes in creative ways, particularly the “embedded answers (cloze)” question type
  • 3. Paramedics – ECG Interpretation http://youtu.be/TEC_XMx97as
  • 4. Paramedics – ECG Interpretation • Difficult yet critical skill for paramedic students to learn • Requires a systematic approach • 20 identically formatted questions for 20 different ECG strips. – reinforce systematic approach taught in lecture – Important ECG traces in clinical practice – interpretation essential for optimal pre-hospital care
  • 5. Draw conclusion Paramedics – ECG Interpretation lecture slide quiz question
  • 7. Speech Pathology Auditory Perceptual Voice Analysis • Method to assess voices • Requires specific training to develop these skills • Quizzes (formative & summative) – Modelled on a paper-based perceptual profile used in a clinical setting – Listen to range of voice types, make judgments about quality of the voice, and complete the profile. – Check answers for feedback on their assessment of the voice – Staff can review data on student performance & usage
  • 8. Note: loudness too hard to rate with recorded material •2 Separate Tables •When window is wide enough, they sit alongside each other (maximal representation of paper form) •When window isn’t large enough, the tables stack
  • 9. Speech Pathology Students get partial marks when 1 severity rating different from expert opinion
  • 10. Nursing Drug Calculations • Essential skill that student nurses need to develop and demonstrate competence in • Questions are presented in a ‘real-life’ format to contextualise otherwise basic mathematics • Cloze question is best suited as we are testing both what dose to administer and the volume/quantity of the dose
  • 11.
  • 12. Nutrition: AGHE Diet Analysis • Simulated clinical task providing an introduction to patient dietary assessment • Assessment of dietary adequacy involves: 1. Dietary interview to collect food intake information from patients 2. Rationalise interview notes to construct a food intake list 3. Determine the number of AGHE serves & food group for each item 4. Determine overall AGHE serves of each food group 5. Make assessment about the nutritional adequacy * AGHE: Australian Guidelines to Healthy Eating
  • 13. Nutrition AGHE diet analysis quiz • Provided with compiled food intake list • Student determines – Serve sizes – Food group – Overall intake per food group * AGHE: Australian Guidelines to Healthy Eating Steps 1 & 2 Step 3 Step 4
  • 14. • Acts as an introduction to common Australian foods for international students who are unfamiliar with western foods. 44 “questions” in one
  • 15. Optometry • 3 different uses of multipart embedded (cloze) questions 1. Diagnostic Photograph interpretation – Fundography 2. Test result interpretation – Visual field plots 3. Instrument interpretation - Corneal Topography • Banks ~50 of each type – Healthy eyes and eyes with a range of conditions – Formative and summative uses
  • 16. Optometry 1: Fundography Interpretation “Normal can look very different”
  • 17. Optometry 2: Visual Field Plot Test result interpretation
  • 18. Optometry 3: Corneal Topography Very complex, information dense results display – considerable practice/exposure required
  • 19. Optometry 3: Corneal Topography Interpretation Feedback available by hovering over ticks/crosses
  • 20. Neuroscience Bachelor of Medical Science • Student numbers have doubled in last 5 years with continuing growth • Needed to find efficiencies in marking • Re-structured “paper assignment” so that all questions were multiple choice • Students work on assignment over a few weeks, transpose answers into quiz • All assignments are automatically marked
  • 21. Neuroscience Automate assignment marking INSTRUCTIONS: This assignment should be printed out. Please submit all answers in the answer sheet in FLO. The assignment is worth 17% of your final mark. Don’t leave it to the last minute – it may only involve multiple choice questions, but it isn’t easy. Page 3 of 11 PART A: LIST OF NEURAL CHARACTERISTICS (a) equilibrium potential (EK) for potassium ions (b) space constant of membrane (c) a moment where delayed rectifier channels dominate membrane potential (d) calcium activated Mg++ current (e) amplitude of inhibitory post synaptic potential (f) conduction delay along a cholinergic neuron’s axon (g) full duration of an excitatory post synaptic potential (h) moment where an EPSP summates with an IPSP (i) threshold for action potential (j) amplitude of after-hyperpolarisation (k) duration of inhibitory post synaptic potential (l) where an afterhyperpolarisations summates with an EPSP (m)action potential overshoot (n) measure reflecting cell input resistance (o) moment where large inward, voltage-dependent Na+ current is near its maximum (p) sodium equilibrium potential (q) resting potential of GABA-ergic neuron (r) synaptic latency for inhibitory synaptic potential (s) threshold of a GABAergic neuron (t) resting membrane potential of a cholinergic neuron (u) synaptic latency for excitatory post synaptic potential (v) time constant for nerve cell membrane (w) half duration of action potential of glutamatergic neuron (x) where voltage sensitive Na channels are largely inactivated (y) action potentials at a frequency of about 80Hz (z) point where two EPSPs summate Record Part A answers here –5 marks out of 17 Fill in your answers here to Part A. Don't open the online answer sheet until you have completed the whole assignment, because once it opens you only have 60 minutes to complete it!!! Feature # from Fig 2 Characteristic # (A-Z) Feature # from Fig 2 Characteristic # (A-Z) 1 10 2 11 3 12 4 13 5 14 6 15 7 16 8 17 9 18 Page 5 of 11 What would happen if the following drugs/toxins/ion substitutions/pulses were made: i. a drug such as hexamethonium, which specifically blocks nicotinic cholinergic receptors, is given in a moderate concentration, sufficient for only partial block ii. extra K+ ions are added to the bathing fluid to raise the extracellular concentration from about 5mM to 7mM iii. a benzodiazepine drug which acts as an “allosteric modulator” of the GABAA receptor, potentiating the effects of GABA iv. physostigmine is added in a concentration that potently blocks the action of acetylcholinesterase on all cells in the bath v. all Ca++ ions in the bathing fluid are substituted with Mg++ which does not pass through voltage-operated Ca++ channels vi. An antagonist at NMDA receptors (ligand gated ion channels) in glutamatergic synapses is added in a blocking concentration vii. Tetrodotoxin, a blocker of voltage-sensitive ion channels is added to the bath at a dose that blocks all such channels viii. a larger amplitude of hyperpolarizing and depolarising current pulses (0.7nA) is applied to Cell α through the grey electrode Fill in the answers in the marksheet in FLO, with question 16 corresponding to the recording for Cell α for drug (i) ie: hexamethonium, Question 17 is trace B for drug (i) etc. Note that no single answer is to be used twice although some answers are identical (eg: traces for Cell α - A, D, E, F and H are all identical – any of these is correct in the appropriate place). HINTS: · You may find it easier to use the table below to work out and exclude possibilities – work from the easiest cases to the more difficult ones… · you may want to measure the latency of some events after the presynaptic action potential that causes them….use a ruler…. and include conduction delays in your calculations…. · Also, look for inflections where synaptic potentials summate…. · RECORD YOUR ANSWERS (A-H) HERE FOR QUESTIONS 19-50 (9 marks/17) Drug: hexameth 7mM K+ benzodi Physostig 0mM Ca++ NMDA block TTX 0.7nA pulses Trace (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) Cell α- mV/Cell α-nA Q19 Q23 Q27 Q31 Q35 Q39 Q43 Q47 Cell β Q20 Q24 Q28 Q32 Q36 Q40 Q44 Q48 Cell γ Q21 Q25 Q29 Q33 Q37 Q41 Q45 Q49 Cell δ Q22 Q26 Q30 Q34 Q38 Q42 Q46 Q 50 Page 6 of 11 Page 8 of 11 PART C – multiple choice questions (3 MARKS/17) Please write answers in the following table for questions 1-28 below: 51 56 61 66 52 57 62 67 53 58 63 68 54 59 64 69 55 60 65 70 51. The four major components of the cell membrane are: a. cholesterol, phospholipids, glycolipids and proteins b. triglycerides, proteins, phospholipids and glycolipids c. phospholipids, cholesterol, triglycerides and proteins d. phospholipids, cholesterol, triglycerides and saccharides e. cholesterol, glycolipids, proteins and saccharides 52. Ion channels always have one of the following features – which? a. a charged region that detects transmembrane voltage (membrane potential) b. sugar groups coupled to the region that faces the inside of the cell c. a transmembrane pore that allows ions to pass through under some conditions d. binding sites for transmitter substances e. intracellular binding sites for cell metabolites 53. The equilibrium potential for an ion is defined as the potential at which: a. the number of positively charged ions leaving the cell exactly equals the number of negatively charged ions entering the cell b. Na+, K+ and Cl- ions are in equilibrium across the membrane c. the tendency for the ion to move down its concentration gradient is exactly counterbalanced by its tendency to move down its electrical gradient d. there are equal numbers of ions inside and outside the membrane e. the Na+/K+ co-transporter exactly counterbalances the movement of ions through ion channels in the membrane 54. Calcium ions contribute little to the resting membrane potential in most cells despite the fact that they have a large transmembrane concentration gradient and hence a very positive equilibrium potential. Why? a. because Ca++ ions are too insoluble to contribute to resting potential b. because Ca++ ions are too large to pass through proteinaceous ion channels c. because there are no Ca ion channels in normal cells d. because Ca++ ions are so toxic to the cell e. because Ca ion channels are rarely open at resting membrane potential 55. Three important elements involved in nerve cell electrical signaling are potassium, sodium and calcium. Which of the following shows these 3 ions, in descending order of concentration, as they occur in the cytoplasm of a healthy neuron? a. K+ , Na+ , Ca++ b. K+ , Ca++, Na+ c. Na+ , Ca++ , K+ Page 9 of 11 d. Na+ , K+ , Ca++ e. Ca++ , K+ , Na+ , 56. The resistance of a nerve cell soma membrane is inversely proportional to: a. The total number of open K channels b. The total number of ion channels c. The total number of Na channels d. The surface area of the membrane irrespective of ion channels e. The total number of open ion channels 57. The time constant (tau) for most neurons falls in the range of: a. 1-5ms b. 2-20ms c. 10 – 100ms d. 100-1000ms e. >1000ms 58. The rising phase of an action potential is mostly due to: a. inward flux of Na+ b. inward flux of K+ c. inward flux of Na+ and K+ d. outward flux of Na+ e. the Na/K ATPase 59. Voltage activated sodium channels are inactivated when the Vm remains depolarised above threshold for more than about half a millisecond. How do they recover their voltage sensitivity again? a. they are phosphorylated by cellular kinases activated by depolarisation b. they reactivate when membrane potential falls below threshold c. they reactivate when K+ ions bind to them d. they are recycled via the Golgi apparatus e. they are reactivated by neurotransmitters 60. Which of the following would be expected to alter the voltage threshold for an action potential in a nerve? a. the number/density of chloride channels b. the number/density of calcium channels c. the number/density of voltage-activated sodium channels d. the number/density of potassium channels e. the number of dendrites 61. Squid giant axons are about 350-500µm in diameter, yet they conduct at only about 25m/s. Why do such large axons conduct relatively slowly? a. because squids lead such boring lives that they don’t need fast information b. because they have large gaps between their Nodes of Ranvier c. because they live in cold water d. because they do not have a myelin sheath e. because they have a high axoplasmic resistance 62. Gap junctions consist of: a. 12 connexins arranged into two connexons which bridge between cells b. 24 connexons arranged in two rows connecting two cells Page 10 of 11 c. gaps in the phospholipid bilayer with cytoplasmic continuity between cells d. fused membranes from two cells that touch e. voltage-activated ion channels aligned serially across the gap between two cells 63. Glutamate is the most abundant excitatory transmitter in the brain. What class of neurotransmitter does it belong to? a. amino acids b. amines c. peptides d. a class of its own e. reactive gases 64. Which is true about gap junctions? They are permeable to: a. only CO2 and O2 b. ions and water c. ions water and molecules with molecular weight <100 d. ions water and molecues with molecular weight <1000 e. ions water and all intracellular molecules 65. The least common mechanism for the removal of transmitter from the synaptic cleft is: a. diffusion b. degradative enzymes c. uptake by surrounding cells or nerve terminals d. oxidation by mitochondria in the synaptic cleft e. spontaneous breakdown of the transmitter molecule 66. If a synaptic potential was mediated by closure of leak K+ channels, which of the following would be true during the course of the potential: a. the cell would depolarise and Rm would increase b. the cell would hyperpolarise and Rm would increase c. the cell would depolarise and Rm would decrease d. the cell would hyperpolarise and Rm would decrease e. the cell would depolarise, but there would be no change in Rm 67. Which transmitter has ionotropic receptors that can be distinguished by their sensitivities to NMDA, kainate and AMPA? a. acetylcholine b. glutamate c. dopamine d. 5-hydroxytryptamine e. adenosine triphosphate 68. Which of the following ligand-gated ion channels generally have inhibitory effects on nerve cell excitability, when opened by their endogenous transmitters? a. GABAA and glycine b. glutamate and glycine c. 5-Hydroxytryptamine3 and glycine d. P2x and GABA e. P2X and glutamate 69. Which of the following is true about ligand gated ion channels (“ionotropic receptors”)? a. they are made up of several protein subunits “ ”
  • 22. Cloze question layout mimics assignment layout – facilitates answer transcription by students
  • 23. that causes them….use a ruler…. and include conduction delays in your calculations…. · Also, look for inflections where synaptic potentials summate…. · RECORD YOUR ANSWERS (A-H) HERE FOR QUESTIONS 19-50 (9 marks/17) Drug: hexameth 7mM K+ benzodi Physostig 0mM Ca++ NMDA block TTX 0.7nA pulses Trace (i) (ii) (iii) (iv) (v) (vi) (vii) (viii) Cell α- mV/Cell α-nA Q19 Q23 Q27 Q31 Q35 Q39 Q43 Q47 Cell β Q20 Q24 Q28 Q32 Q36 Q40 Q44 Q48 Cell γ Q21 Q25 Q29 Q33 Q37 Q41 Q45 Q49 Cell δ Q22 Q26 Q30 Q34 Q38 Q42 Q46 Q 50
  • 24. Benefits • Scope be creative, simulate authentic tasks, more complex questions. • Can allow ranges (for numeric questions), partial marks • Check, check and test again. Get a colleague to have a “fresh look”. • Have a go Advice/Lessons learnt
  • 26. Images as Answer Options
  • 27. Considerations • Syntax/Code – scary at first • Layout/Screen real-estate • Thinking of all possibilities for short answer type question parts • Each question part is independent • Multichoice (dropdown) options always shuffle • No “checkbox” option • “Specific feedback” display inconsistent • Answer box length for short answer type • Including images within the cloze code possible but tricky
  • 28. Sudoku (because I could!)
  • 29. Answer box size is determined by longest answer +/- random amount
  • 30. Multichoice dropdown: options always shuffle – not always desireable Alternate setup for “Select all that are present”