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MEDICAL ENGLISH                  TEAM N° 02

       LATEST RESEARCHES ON
            PSIQUIATRY

 INTEGRANTS : CARRIÓN ARCELA FIORELLA
            CHIQUINTA SALINAS CRISTIAN
            CUSTODIO BALLENA SPENCER
            FERNANDEZ MEZA MERCY
            FERNANDEZ PEÑA DAYTON
            REYES CARRASCO WILLIAM
potential advances in
       the treatment                 prematur
          of                          e death
                      is one of
                      the leading
                      causes          disabilit
                                         y

AVAILABLE
                              Effective -----
 DRUGS                       have substantial
                               limitations
Recent              new antidepressant
 advances            treatment strategies


melatonin-receptor
     agonist




                           EFFECTS
gastrointesti
            treated with                  nal

                              not side
                               effects               sexua
                                                     l
                                         metabolic
improves the quality
     of sleep
                       reduced waking after sleep on
                                   set
Chromatin modifications, especially
         histone-tail acetylation, have been
          implicated in memory formation
                                    inhibitors of histone
                                  deacetylases (HDACis)
Increased histone-tail
     acetylation



  facilitates learning and
           memory
for harnessing the therapeutic potential of
                  HDACis



   requires
knowledge of                                to cognitive
 the specific            linked            enhancement
HDAC family
 member(s)
in increased synapse
                 number


        memory facilitation


synapse number


  learning impairment of HDAC2-
        overexpressing mice
NEUROIMAGING AND
NEUROPSYCHOLOGY OF
OBSESSIVE-COMPULSIVE
  DISORDER: RECENT
      ADVANCES
Neuroimaging and Neuropsychology of obsessive-
   compulsive disorder: RECENT ADVANCES




   This has contributed significantly to our
   understanding of the neural basis of this
                   disorder
RESULTS

    Structural                           Functional
  imaging studies                      Imaging studies

                                        hyperactivity of
                                    cortico-striatal circuit-
Volumetric abnormalities                   thalamic
 in the striatum nucleus
                                              specific
   and other structures
                           orbitofrontal cortex and caudate nucleus
New paradigms of neuroactivation

    METABOLIC
ABNORMALITIES IN OCD


                              Dysfunctional
          origin              striate nucleus


    to other cortical
                                      that
  regions to "take his
                                   "forcing"
         place"
The most recent neuropsychological studies

 using more refined designs




 provided new dates
                         can integrate the
                           above results

                   therefore

                  Cognitive deficits in OCD are
                secondary to system malfunctions
                          EXECUTIVE
Disorder by attention deficit and
                hyperactivity
                    The lack of treatment

problems of school performance     reduced quality of life in the
                                  short, medium and long term

                    increases

the possibility of using drugs   having a personality disorder
Disorder by attention deficit and
             hyperactivity

                     neurodevelopmental disorder
 CAUSED BY
                     brain maturation

causality genetic    alteration in the neurotransmission

psychopathological
expression                  dopaminergic and
                             noradrenergic system
 not dependent on
the environment,
Disorder by attention deficit and
            hyperactivity
The hyperactive need to move more

maintain the required level of alertness
                       while

performing tasks that challenge their working memory

Children who suffer from DADH

 more likely than other children
to commit crimes when they grow up.
DADH share genetic risk with cigarette
 smoking

Early DADH treatment can prevent consume of drug




 DADH share genetic risk with asma
that SSRIs are no more effective
  in the treatment of depression
 than other kinds of older drugs,
such as tricyclic antidepressants


                         PLACEBO




                    initial treatment

                   patients with mild or
                   moderate depression
OTHERS




The cutaneous pathology may mask a psychiatric
disorder




diagnosis of autism using tomography
2   psychiatric research

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2 psychiatric research

  • 1. MEDICAL ENGLISH TEAM N° 02 LATEST RESEARCHES ON PSIQUIATRY INTEGRANTS : CARRIÓN ARCELA FIORELLA CHIQUINTA SALINAS CRISTIAN CUSTODIO BALLENA SPENCER FERNANDEZ MEZA MERCY FERNANDEZ PEÑA DAYTON REYES CARRASCO WILLIAM
  • 2. potential advances in the treatment prematur of e death is one of the leading causes disabilit y AVAILABLE Effective ----- DRUGS have substantial limitations
  • 3. Recent new antidepressant advances treatment strategies melatonin-receptor agonist EFFECTS
  • 4. gastrointesti treated with nal not side effects sexua l metabolic improves the quality of sleep reduced waking after sleep on set
  • 5. Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation inhibitors of histone deacetylases (HDACis) Increased histone-tail acetylation facilitates learning and memory
  • 6. for harnessing the therapeutic potential of HDACis requires knowledge of to cognitive the specific linked enhancement HDAC family member(s)
  • 7. in increased synapse number memory facilitation synapse number learning impairment of HDAC2- overexpressing mice
  • 9. Neuroimaging and Neuropsychology of obsessive- compulsive disorder: RECENT ADVANCES This has contributed significantly to our understanding of the neural basis of this disorder
  • 10. RESULTS Structural Functional imaging studies Imaging studies hyperactivity of cortico-striatal circuit- Volumetric abnormalities thalamic in the striatum nucleus specific and other structures orbitofrontal cortex and caudate nucleus
  • 11. New paradigms of neuroactivation METABOLIC ABNORMALITIES IN OCD Dysfunctional origin striate nucleus to other cortical that regions to "take his "forcing" place"
  • 12. The most recent neuropsychological studies using more refined designs provided new dates can integrate the above results therefore Cognitive deficits in OCD are secondary to system malfunctions EXECUTIVE
  • 13. Disorder by attention deficit and hyperactivity The lack of treatment problems of school performance reduced quality of life in the short, medium and long term increases the possibility of using drugs having a personality disorder
  • 14. Disorder by attention deficit and hyperactivity neurodevelopmental disorder CAUSED BY brain maturation causality genetic alteration in the neurotransmission psychopathological expression dopaminergic and noradrenergic system not dependent on the environment,
  • 15. Disorder by attention deficit and hyperactivity The hyperactive need to move more maintain the required level of alertness while performing tasks that challenge their working memory Children who suffer from DADH more likely than other children to commit crimes when they grow up.
  • 16. DADH share genetic risk with cigarette smoking Early DADH treatment can prevent consume of drug DADH share genetic risk with asma
  • 17. that SSRIs are no more effective in the treatment of depression than other kinds of older drugs, such as tricyclic antidepressants PLACEBO initial treatment patients with mild or moderate depression
  • 18. OTHERS The cutaneous pathology may mask a psychiatric disorder diagnosis of autism using tomography