A comprehensive collection of our autoimmunity research done in an effort to help bridge the gap for the large and growing needs of the autoimmune community. This bibliography is a sneak peak at an upcoming white paper for the lonely voices of autoimmune disease.
Topics Include:
Prevalence & Incidence
Immunology
Polyautoimmunity
Current Treatments & Therapies
The Microbiome
Data and Digital Tools
Causes of Autoimmune Disease
Prevention & Lifestyle Modification
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Bridging the Autoimmune Abyss through New Discoveries
1. Š 2015 - All rights reserved.
Bonnie Feldman DDS MBA
Priya Sahdev
Tiffany Simms
Bridging the Autoimmune Abyss
through New Discoveries
2. Š 2015 - All rights reserved.
Bridging the Autoimmune Abyss through
New Discoveries
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/YourAutoimmunityConnection
Bonnie Feldman, DDS, MBA
Business Development for Digital Health
Priya Sahdev, BS
UCLA Class of 2016
Microbiology, Immunology,
& Molecular Genetics
Tiffany Simms, BS
UCLA Class of 2015
Anthropology
3. Š 2015 - All rights reserved.
The Invisible Epidemic: Incidence & Prevalence
⢠Feldman, Bonnie. âWhy is Autoimmune Disease Under-served.â Slideshare (2015).
http://bit.ly/1B57pNb
⢠Groza, Tudor et al. âThe Human Phenotype Ontology: Semantic Unification of Common and
Rare Disease.â The American Journal of Human Genetics (2015). http://www.irdirc.org/the-
human-phenotype-ontology-semantic-unification-of-common-and-rare-disease/
⢠Nakazawa Jackson, Donna. The Autoimmune Epidemic. New York: A Touchstone Book, 2008.
Print
⢠âMore than 450 Medicines in Development for Rare Diseases.â Medicines in Development
(2013). http://phrma.org/Medicines-Development-Rare-Diseases
4. Š 2015 - All rights reserved.
Basic Science Foundation for Discovery
5. Š 2015 - All rights reserved.
New Discovery Fuels Collaboration: Immunology
& Repertoire Sequencing
⢠Burton, Bronwen et al. âSequential transcriptional changes dictate safe and effective
antigen-specific immunotherapy.â Nature Communications (2014).
http://scholar.qsensei.com/content/1yq4qh
⢠Norman, Jason et al. âDisease-Specific Alterations in the Enteric Virome in Inflammatory
Bowel Disease.â Cell (2015). http://f1000.com/prime/725326230
⢠Poletaev et al. âImmunophysiology versus immunopathology: Natural autoimmunity in
human health and disease.â Pathophysiology 19.3 (2012): 221-
231.<http://www.researchgate.net/publication/230655913_Immunophysiology_versus_im
munopathology_Natural_autoimmunity_in_human_health_and_disease
6. Š 2015 - All rights reserved.
New Discovery Fuels Collaboration: Immunology
& Repertoire Sequencing
⢠Ramesh, Manish et al. âClonal and Constricted T cell repertoire in Common Variable
Immune Deficiency.â Clinical immunology (Orlando, Fla.) (2015).
http://www.bioportfolio.com/resources/pmarticle/1148910/Clonal-and-Constricted-T-cell-
repertoire-in-Common-Variable-Immune-Deficiency.html
⢠Robins, Harlan. âImmunosequencing: applications of immune repertoire deep sequencing.â
Current Opinion in Immunology 25.5 (2013): 646â52.
http://www.researchgate.net/publication/258059445_Immunosequencing_applications_of
_immune_repertoire_deep_sequencing
7. Š 2015 - All rights reserved.
New Discovery Fuels Collaboration: Immunology
& Repertoire Sequencing
⢠Robinson, William. âSequencing the functional antibody repertoireâdiagnostic and
therapeutic discovery.â Nature Reviews Rheumatology 11.3 (2015): 171â182.
http://www.pubfacts.com/detail/25536486/Sequencing-the-functional-antibody-
repertoire-diagnostic-and-therapeutic-discovery
⢠Spreafico, Roberto et al. âA circulating reservoir of pathogenic-like CD4+ T cells shares a
genetic and phenotypic signature with the inflamed synovial micro-environment.â Annals of
the Rheumatic Diseases (2014): annrheumdisâ2014â206-226.
http://www.researchgate.net/publication/269719321_A_circulating_reservoir_of_pathoge
nic-
like_CD4_T_cells_shares_a_genetic_and_phenotypic_signature_with_the_inflamed_synovi
al_micro-environment
8. Š 2015 - All rights reserved.
Polyautoimmunity: No Longer Organ Specific
⢠Castiblanco, John, Mauricio Arcos-Burgos, and Juan-Manuel Anaya. âWhat is next after the
genes for autoimmunity?â BMC Medicine 11 (2013): 197.
http://www.biomedcentral.com/1741-7015/11/197
⢠Franco, -S, and -M Anaya. âThe autoimmune tautology with a focus on antiphospholipid
syndrome.â Lupus 23.12 (2014): 1273-1275.
http://www.researchgate.net/publication/265733380_The_autoimmune_tautology_with_a
_focus_on_antiphospholipid_syndrome
⢠Groza, Tudor et al. âThe Human Phenotype Ontology: Semantic Unification of Common and
Rare Disease.â The American Journal of Human Genetics (2015). http://www.irdirc.org/the-
human-phenotype-ontology-semantic-unification-of-common-and-rare-disease/
9. Š 2015 - All rights reserved.
Polyautoimmunity: No Longer Organ Specific
⢠Greenwood, Veronique. âDisease Networks Show Molecular Connections." Quanta
Magazineâ (2015). https://www.quantamagazine.org/20150129-networks-reveal-the-
connections-of-disease/
⢠Zippi, Maddalena. âExtraintestinal manifestations in a large series of Italian inflammatory
bowel disease patients.â World Journal of Gastroenterology 20.46 (2014): 17463-
17467.http://docrchive.com/document/extraintestinal-manifestations-in-a-large-series-of-
italian-inflammatory-bowel-disease-patients-7348008145211277/
10. Š 2015 - All rights reserved.
Personal Trial and Error: Treatments & Therapies
⢠Bot, Adrian et al. âTarget discovery for T cell therapy: next steps to advance
Immunotherapies.â Journal for Immunotherapy of Cancer (2015).
http://www.immunotherapyofcancer.org/content/pdf/s40425-015-0061-5.pdf
⢠Burton, Bronwen et al. âSequential transcriptional changes dictate safe and effective
antigen-specific immunotherapy.â Nature Communications (2014). http://research-
information.bristol.ac.uk/en/publications/sequential-transcriptional-changes-dictate-safe-
and-effective-antigenspecific-immunotherapy(8e1716fd-8874-45eb-84a9-
0dc5540e26a8)/export.html
⢠Chang, Christopher. âUnmet needs in the treatment of autoimmunity: From aspirin to stem
cells.â Autoimmunity Reviews 13 (2014).
http://www.researchgate.net/publication/259917083_Unmet_Needs_in_the_Treatment_o
f_Autoimmunity_From_Aspirin_to_Stem_Cells
11. Š 2015 - All rights reserved.
Personal Trial and Error: Treatments & Therapies
⢠Curatola, Gerard. âOral Microbiome Homeostasis: The New Frontier in Oral Care Therapies.â
Symbiosis (2013):1-3. http://www.symbiosisonlinepublishing.com/dentistry-oraldisorders-
therapy/dentistry-oraldisorders-therapy05.php
⢠Gertner, Jon. âWhatâs Lurking In Your Microbiome? Possibly, a Cure for Disease.â Fast
Company (2015). http://www.fastcompany.com/3039891/gut-check
⢠Nakazawa Jackson, Donna. The Autoimmune Epidemic. New York: A Touchstone Book, 2008.
Print.
⢠Olle, Bernat. âMedicines from microbiota.â Nature Biotechnology 31.4 (2013): 309-315.
http://www.researchgate.net/publication/236128149_Medicines_from_microbiota
12. Š 2015 - All rights reserved.
Personal Trial and Error: Treatments & Therapies
⢠Petrof et al. âMicrobial ecosystems therapeutics: a new paradigm in medicine?â Beneficial
microbes 4.1 (2013): 53-65.
http://www.researchgate.net/publication/233963283_Microbial_ecosystems_therapeutics
_A_new_paradigm_in_medicine
⢠Sabatos-Peyton, Catherine A, Johan Verhagen, and David C Wraith. âAntigen-specific
immunotherapy of autoimmune and allergic diseases.â Current opinion in immunology 22.5
(2010): 609â15. http://www.researchgate.net/publication/46305185_Antigen-
specific_immunotherapy_of_autoimmune_and_allergic_diseases
⢠Velasquez-Manoff, Moises. An Epidemic of Absence. New York: Scribner, 2012. Print.
13. Š 2015 - All rights reserved.
Treatments & Therapies: Fecal Microbiota
Transplants
⢠Borody, Thomas, and Alexander Khoruts. âFecal microbiota transplantation and emerging
applications.â Nature Reviews Gastroenterology and Hepatology 9.2 (2011): 88â96.
http://www.researchgate.net/publication/51901488_Borody_TJ_Khoruts_A.._Fecal_microb
iota_transplantation_and_emerging_applications._Nat_Rev_Gastroenterol_Hepatol_9_88-
96
⢠BrĂźssow, Harald. âMicrobiota and the human nature: know thyself.â Environmental
Microbiology 17.1 (2015): 10â15.
http://www.researchgate.net/publication/269727325_Microbiota_and_the_human_nature
_know_thyself
14. Š 2015 - All rights reserved.
Treatments & Therapies: Fecal Microbiota
Transplants
⢠Petrof, Elaine, and Alexander Khoruts. âFrom stool transplants to next-generation
microbiota therapeutics.â Gastroenterology 146.6 (2014): 1573-1582.
http://www.researchgate.net/publication/259698247_From_Stool_Transplants_to_Next-
generation_Microbiota_Therapeutics
⢠Scher, Jose et al. âDecreased Bacterial Diversity Characterizes the Altered Gut Microbiota in
Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease.â
Arthritis & Rheumatology 67.1 (2015): 128â139.
http://www.researchgate.net/publication/266974816_Decreased_Bacterial_Diversity_Char
acterizes_the_Altered_Gut_Microbiota_in_Patients_With_Psoriatic_Arthritis_Resembling_
Dysbiosis_in_Inflammatory_Bowel_Disease
15. Š 2015 - All rights reserved.
Treatments & Therapies: Prebiotics and Probiotics
⢠Bindels, Laure et al. âTowards a more comprehensive concept for prebiotics.â Nature
Reviews Gastroenterology & Hepatology (2015).
http://www.researchgate.net/publication/274319084_Towards_a_more_comprehensive_c
oncept_for_prebiotics
⢠Derrien, Muriel, and Johan Vlieg. âFate, activity, and impact of ingested bacteria within the
human gut microbiota.â Trends in Microbiology (2015).
http://www.researchgate.net/publication/274405159_Fate_activity_and_impact_of_ingest
ed_bacteria_within_the_human_gut_microbiota
⢠Vieira, AngĂŠlica, Mauro Teixeira, and Flaviano Martins. âThe Role of Probiotics and
Prebiotics in Inducing Gut Immunity.â Frontiers in Immunology 4 (2013): 445.
http://www.researchgate.net/publication/259492313_The_Role_of_Probiotics_and_Prebio
tics_in_Inducing_Gut_Immunity
16. Š 2015 - All rights reserved.
The Microbiome Lifeline
⢠Ackerman, Jennifer. âThe Ultimate Social Network.â Scientific American 306.6 (2012): 36â43.
http://www.researchgate.net/publication/225084801_The_ultimate_social_network
⢠Brusca, Samuel, Steven Abramson, and Jose Scher. âMicrobiome and mucosal inflammation as
extra-articular triggers for rheumatoid arthritis and autoimmunity.â Current Opinion in
Rheumatology (2014).
http://www.researchgate.net/publication/258700816_Brusca_S.B._Abramson_S.B.__Scher_J.U.
_Microbiome_and_mucosal_inflammation_as_extra-
articular_triggers_for_rheumatoid_arthritis_and_autoimmunity._Curr._Opin._Rheumatol._26_1
01-107
⢠BrĂźssow, Harald. âMicrobiota and the human nature: know thyself.â Environmental Microbiology
17.1 (2015): 10â15.
http://www.researchgate.net/publication/269727325_Microbiota_and_the_human_nature_kn
ow_thyself
17. Š 2015 - All rights reserved.
The Microbiome Lifeline
⢠Garrett, Wendy. âFrom cell biology to the microbiome: An intentional infinite loop.â The
Journal of Cell Biology (2015).
http://www.researchgate.net/publication/279862421_From_cell_biology_to_the_microbio
me_An_intentional_infinite_loop
⢠Hevia, Arancha et al. âIntestinal Dysbiosis Associated with Systemic Lupus Erythematosus.â
mBio (2014).
http://www.academia.edu/13411926/Intestinal_dysbiosis_associated_with_systemic_lupus
_erythematosus
⢠Kamada, Nobuhiko et al. âRole of the gut microbiota in immunity and inflammatory
disease.â Nature Reviews Immunology 13.5 (2013): 321â335.
http://www.researchgate.net/publication/236337970_Role_of_gut_microbiota_in_immuni
ty_and_inflammatory_disease
18. Š 2015 - All rights reserved.
The Microbiome Lifeline
⢠Proal, Amy, Paul Albert, and Trevor Marshall. âInflammatory disease and the human
microbiome.â Discovery medicine 17.95 (2014): 257â65.
http://www.researchgate.net/publication/262782132_Inflammatory_disease_and_the_hu
man_microbiome
⢠âModern Medicine: Microbes Maketh Man." The Economist, (2012).
http://www.economist.com/node/21560559
⢠Waldor, Matthew et al. âWhere next for microbiome research?â PLoS biology 13.1 (2015).
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050
⢠Yurkovetskiy, Leonid, Joseph Pickard, and Alexander Chervonsky. âMicrobiota and
Autoimmunity: Exploring New Avenues.â Cell Host & Microbe (2015).
http://scifeeds.com/journal-article/microbiota-and-autoimmunity-exploring-new-avenues/
19. Š 2015 - All rights reserved.
The Microbiome Lifeline: Gut As An Organ of
Immunity
⢠Campbell, Andrew. âAutoimmunity and the Gut.â Autoimmune Diseases 2014 (2014): 152-428.
http://www.researchgate.net/publication/262886119_Autoimmunity_and_the_Gut
⢠Goldszmid, Romina, and Giorgio Trinchieri. âThe price of immunity.â Nature Immunology 13.10
(2012): 932â8. http://www.researchgate.net/publication/230879962_The_price_of_immunity
⢠Kamada, Nobuhiko et al. âRole of the gut microbiota in immunity and inflammatory disease.â
Nature Reviews Immunology 13.5 (2013): 321â335.
http://www.researchgate.net/publication/236337970_Role_of_gut_microbiota_in_immunity_a
nd_inflammatory_disease
⢠Kohn, David. âJoint Pain, From the Gut.â The Atlantic (2015).
http://www.theatlantic.com/health/archive/2015/01/joint-pain-from-the-gut/383772/
20. Š 2015 - All rights reserved.
The Microbiome Lifeline: Gut As An Organ of
Immunity
⢠Mowat, Allan, and William Agace. âRegional specialization within the intestinal immune
system.â Nature Reviews Immunology 14.10 (2014): 667â85.
http://www.researchgate.net/publication/265862048_Regional_specialization_within_the_
intestinal_immune_system
⢠Sorini, Chiara, and Marika Falcone. âShaping the (auto)immune response in the gut: the role
of intestinal immune regulation in the prevention of type 1 diabetes.â American journal of
clinical and experimental immunology 2.2 (2013): 156â71.
http://www.researchgate.net/publication/251876845_Shaping_the_(auto)immune_respon
se_in_the_gut_the_role_of_intestinal_immune_regulation_in_the_prevention_of_type_1_
diabetes
21. Š 2015 - All rights reserved.
The Microbiome Lifeline: Gut As An Organ of
Immunity
⢠Strober, Warren. âImpact of the gut microbiome on mucosal inflammation.â Trends in
Immunology (2013).
http://www.researchgate.net/publication/255984931_Impact_of_the_gut_microbiome_on
_mucosal_inflammation
⢠Yurkovetskiy, Leonid, Joseph Pickard, and Alexander Chervonsky. âMicrobiota and
Autoimmunity: Exploring New Avenues.â Cell Host & Microbe (2015).
http://www.researchgate.net/publication/276358904_Microbiota_and_Autoimmunity_Expl
oring_New_Avenues
22. Š 2015 - All rights reserved.
The Microbiome Lifeline: Gut-Brain Axis
⢠Alcock, Joe, Carlo Maley, and Athena Aktipis. âIs eating behavior manipulated by the
gastrointestinal microbiota? Evolutionary pressures and potential mechanisms.â BioEssays
(2014). https://ucsf.box.com/shared/static/pdz2z4b5fdvwlpr9hfdh.pdf
⢠Brod, Samuel et al. ââAs above, so belowâ examining the interplay between emotion and the
immune system.â Immunology 143.3 (2014): 311â8.
http://www.researchgate.net/publication/263291162_As_above_so_below_Examining_the
_interplay_between_emotion_and_the_Immune_System
⢠Forsythe, Paul et al. âMood and gut feelings.â Brain, Behavior, and Immunity (2010).
http://www.journals.elsevier.com/brain-behavior-and-immunity/
23. Š 2015 - All rights reserved.
The Microbiome Lifeline: Gut-Brain Axis
⢠Foster, Jane, and Karen-Anne Neufeld. âGutâbrain axis: how the microbiome influences
anxiety and depression.â Trends in Neurosciences (2013).
http://www.researchgate.net/publication/235404335_Gut-
brain_axis_How_the_microbiome_influences_anxiety_and_depression
⢠Hadhazy, Adam. âThink Twice: How the Gutâs âSecond Brainâ Influences Mood and Well-
Being." Scientific American (2010). http://www.scientificamerican.com/article/gut-second-
brain/
⢠Mayer, Emeran et al. âGut Microbes and the Brain: Paradigm Shift in Neuroscience.â The
Journal of Neuroscience (2014).
http://www.researchgate.net/publication/268233441_Gut_Microbes_and_the_Brain_Para
digm_Shift_in_Neuroscience
24. Š 2015 - All rights reserved.
The Microbiome Lifeline: Gut-Brain Axis
⢠OâMahony et al. âSerotonin, tryptophan metabolism and the brain-gut-microbiome axis.â
Behavioural Brain Research 277 (2015): 3248.
http://www.researchgate.net/publication/264389028_Serotonin_Tryptophan_Metabolism_
and_the_Brain-Gut-_Microbiome_Axis
⢠Steenbergen, Laura et al. âA randomized controlled trial to test the effect of multispecies
probiotics on cognitive reactivity to sad mood.â Brain, Behavior, and Immunity (2015).
http://www.researchgate.net/publication/274781872_A_randomized_controlled_trial_to_t
est_the_effect_of_multispecies_probiotics_on_cognitive_reactivity_to_sad_mood
25. Š 2015 - All rights reserved.
The Microbiome Lifeline: Fixing Your Leaky Gut is Key
⢠Derrien, Muriel, and Johan Vlieg. âFate, activity, and impact of ingested bacteria within the
human gut microbiota.â Trends in Microbiology (2015).
http://www.researchgate.net/publication/274405159_Fate_activity_and_impact_of_ingested_
bacteria_within_the_human_gut_microbiota
⢠Fasano, Alessio. âLeaky gut and autoimmune diseases.â Clinical reviews in allergy & immunology
42.1 (2012): 71â8.
http://www.researchgate.net/publication/51823457_Leaky_gut_and_autoimmune_diseases
⢠Ghosh, Subrata et al. âNew tools and approaches for improved management of inflammatory
bowel diseases.â Journal of Crohnâs and Colitis 8.10 (2014): 1246â53.
http://www.researchgate.net/publication/261756210_New_tools_and_approaches_for_improv
ed_management_of_inflammatory_bowel_diseases
26. Š 2015 - All rights reserved.
The Microbiome Lifeline: Fixing Your Leaky Gut is Key
⢠Kostic, Aleksandar, Ramnik Xavier, and Dirk Gevers. âThe Microbiome in Inflammatory Bowel
Disease: Current Status and the Future Ahead.â Gastroenterology 146.6 (2014): 1489â99.
http://www.researchgate.net/publication/260374207_The_Microbiome_in_Inflammatory_Bow
el_Diseases_Current_Status_and_the_Future_Ahead
⢠Strober, Warren. âImpact of the gut microbiome on mucosal inflammation.â Trends in
Immunology (2013).
http://www.researchgate.net/publication/255984931_Impact_of_the_gut_microbiome_on_mu
cosal_inflammation
⢠Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. âAn Integrative View of Microbiome-
Host Interactions in Inflammatory Bowel Diseases.â Cell Host & Microbe (2015).
http://www.researchgate.net/publication/276359033_An_Integrative_View_of_Microbiome-
Host_Interactions_in_Inflammatory_Bowel_Diseases
27. Š 2015 - All rights reserved.
The Microbiome Lifeline: Fixing Your Leaky Gut is Key
⢠Zippi, Maddalena. âExtraintestinal manifestations in a large series of Italian inflammatory
bowel disease patients.â World Journal of Gastroenterology 20.46 (2014): 17463-17467.
http://docrchive.com/document/extraintestinal-manifestations-in-a-large-series-of-italian-
inflammatory-bowel-disease-patients-7348008145211277/
28. Š 2015 - All rights reserved.
The Microbiome Lifeline: Health Starts in the Mouth
⢠Atanasova, Kalina, and Ăzlem Yilmaz. âPrelude to oral microbes and chronic diseases: past,
present and future.â Microbes and Infection (2015).
http://www.researchgate.net/publication/274258034_Prelude_to_Oral_Microbes_and_Chronic
_Diseases_Past_Present_and_Future
⢠Costalonga, Massimo, and Mark Herzberg. âThe oral microbiome and the immunobiology of
periodontal disease and caries.â Immunology Letters (2014).
http://www.researchgate.net/publication/268079979_The_oral_microbiome_and_the_immun
obiology_of_periodontal_disease_and_caries
⢠He, Jinzhi et al. âThe oral microbiome diversity and its relation to human diseases.â Folia
Microbiologica (2014).
http://www.researchgate.net/publication/264987867_The_oral_microbiome_diversity_and_its
_relation_to_human_diseases
29. Š 2015 - All rights reserved.
The Microbiome Lifeline: Health Starts in the Mouth
⢠Marsh, P, and D Bradshaw. âDental plaque as a biofilm.â Journal of Industrial Microbiology
15.3 (1995): 169â175.
http://www.researchgate.net/publication/14678794_Dental_plaque_as_a_biofilm._J_Ind_
Microbiol
⢠Schwarzberg, Karen et al. âThe Personal Human Oral Microbiome Obscures the Effects of
Treatment on Periodontal Disease.â PLoS ONE 9.1 (2014).
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086708
⢠Steinberg, Doron. âDental Chatter: Bacterial CrossâTalk in the Biofilm of the Oral Cavity.â
Israel Journal of Chemistry (2015).
http://onlinelibrary.wiley.com/doi/10.1002/ijch.201400143/abstract
30. Š 2015 - All rights reserved.
The Microbiome Lifeline: Health Starts in the Mouth
⢠Struzycka, Izabela. âThe oral microbiome in dental caries.â Polish journal of microbiology /
Polskie Towarzystwo MikrobiologĂłw = The Polish Society of Microbiologists 63.2 (2014):
127â35. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086708
⢠Warinner, Christina, Camilla Speller, and Matthew Collins. âA new era in
palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the
human oral microbiome.â Philosophical Transactions of the Royal Society of London B:
Biological Sciences 370.1660 (2015). http://www.pubfacts.com/detail/25487328/A-new-
era-in-palaeomicrobiology:-prospects-for-ancient-dental-calculus-as-a-long-term-record-of-
the-
31. Š 2015 - All rights reserved.
The Microbiome Lifeline: Health Starts in the Mouth
⢠Zarco, Vess, and Ginsburg. âThe oral microbiome in health and disease and the potential
impact on personalized dental medicine.â Oral Diseases 18.2 (2012): 109â120.
http://www.researchgate.net/publication/51628583_The_oral_microbiome_in_health_and
_disease_and_the_potential_impact_on_personalized_dental_medicine
⢠Zhang, Xuan et al. âThe oral and gut microbiomes are perturbed in rheumatoid arthritis and
partly normalized after treatment.â Nature Medicine (2015).
http://www.researchgate.net/publication/280036160_The_oral_and_gut_microbiomes_ar
e_perturbed_in_rheumatoid_arthritis_and_partly_normalized_after_treatment
32. Š 2015 - All rights reserved.
Data as an Enabling Tool:
Getting Closer to Precision Medicine
33. Š 2015 - All rights reserved.
Big Data: Top-Down Bottom-Up Convergence
⢠Dove, Edward, Vural Ăzdemir, and Yann Joly. âHarnessing Omics Sciences, Population Databases, and
Open Innovation Models for TheranosticsâGuided Drug Discovery and Development.â Drug
Development Research (2012).
http://www.researchgate.net/publication/263060822_Harnessing_Omics_Sciences_Population_Dat
abases_and_Open_Innovation_Models_for_TheranosticsGuided_Drug_Discovery_and_Developmen
t
⢠Farh, Kyle et al. âGenetic and epigenetic fine mapping of causal autoimmune disease variants.â
Nature 518.7539 (2015): 337â43.
http://www.researchgate.net/publication/267753091_Genetic_and_epigenetic_fine_mapping_of_c
ausal_autoimmune_disease_variants
⢠Greene, Casey et al. âUnderstanding multicellular function and disease with human tissue-specific
networks.â Nature Genetics (2015).
http://www.researchgate.net/publication/275525447_Understanding_multicellular_function_and_d
isease_with_human_tissue-specific_networks
34. Š 2015 - All rights reserved.
Big Data: Top-Down Bottom-Up Convergence
⢠Groza, Tudor et al. âThe Human Phenotype Ontology: Semantic Unification of Common and
Rare Disease.â The American Journal of Human Genetics (2015).
http://www.researchgate.net/publication/279631558_The_Human_Phenotype_Ontology_Sem
antic_Unification_of_Common_and_Rare_Disease
⢠Ramos-Casals, Manuel et al. âGoogle-driven search for big data in autoimmune
geoepidemiology: Analysis of 394,827 patients with systemic autoimmune diseases.â
Autoimmunity Reviews (2015). http://www.researchgate.net/publication/274513423_Google-
driven_search_for_big_data_in_autoimmune_geoepidemiology_Analysis_of_394827_patients_
with_systemic_autoimmune_diseases
35. Š 2015 - All rights reserved.
Big Data: Top-Down Bottom-Up Convergence
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Bridging the Autoimmune Abyss
through New Discoveries
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/YourAutoimmunityCon
nection
Bonnie Feldman, DDS, MBA
Business Development for Digital Health
Editor's Notes
In rehearsing my coach, we think there should be one more slide.It is a picture of the same patient as the one at the end, but surrounded by a continuous feedback loop of personalized data.
In rehearsing my coach, we think there should be one more slide.It is a picture of the same patient as the one at the end, but surrounded by a continuous feedback loop of personalized data.