Sterilization refers to any process that eliminates, removes, kills, or deactivates all forms of life and other biological agents from pharma products. So this study plays a vital role to get sterilized Products.

1. Presentation On:
Sterilization

2. Name: Reg. No.:
Md. Kamrul Hasan 15103088
Md. Abdur Rauf 15103089
Smaranika Rahman 15103092
Md. Sadikur Rahman 15103093
Zobaida Mostarin Nishi 15103094

3. It is defined as any process that effectively kills or
eliminates transmissible agents ( i.e. fungi, viruses,
bacteria or prions) from a surface, equipment, foods,
medications or biological culture media.

4. Terminal Sterilization:
Low temperature sterilization
process (115°C).
Moist Heat
Sterilization:
• Done by spraying hot water on the product units in the
sterilizer.
• NOT use steam.
• E.g.: large volume parenteral (LVP), small volume
parenteral (SVP), ophthalmic products etc.
Irradiation &
Sterilization by
ethylene
oxide:
• Useful for the products those are highly heat sensitive.
• E.g.: Pre-filled syringe and other medical devices.

5. Drug
product
Container
/closure
Excipients
Sterilization
Process
Sterile Product

6. It is defined as the processing of
drug components (e.g. drug
product, container, closure,
excipient) in a manner that
precludes microbial
contamination of the final sealed
products.

7. Facility
Equipment
Process
Personnel
Control &
Verification
Finish
Product
testing
Document
ation
Aseptic
Processing

8. Sterilization
Process
Sterile
Drug
Product
Sterile
Container
/closure
Sterile
Excipient
Aseptic
Processing
Sterile Final
Product