Pharmaceutical Analysis may be defined as the application of analytical procedures used to determine the purity, safety and quality of drugs and chemicals

2. Introduction
Pharmaceutical Analysis
Pharmaceutical Analysis may be defined as the application of analytical procedures
used to determine the purity, safety and quality of drugs and chemicals
This course has access to the full range of
 Titration Methods
Spectroscopic technique
Chromatographic method
Spectrophotometry etc.

3.  Pharmaceutical analysis involves
 Identification
 Determination
 Quantification
 Purification of a substance
 Separation of components of a solution or mixture
 Determination of structure of chemical compounds

4. Types of Pharmaceutical Analysis
1. Qualitative Analysis
2. Quantitative analysis
 Qualitative – Identification
 Detection of evolved gas
 Formation of precipitates
 Limit tests
 Color change reactions
 Melting point
 Boiling point test etc.,

5. 2. Quantitative – Estimation
 Chemical reactions
 Instrumental reactions
 Electrical measurements
 Spectroscopy methods
 Absorption
 Emission
 Chromatography
 Bio assays and microbiological assays

6. Chemical reactions
 Titrations Methods
 Acid base titrations
 Complexometric titrations
 Redox titrations
 Non aqueous titrations
 Precipitation titrations
 Nitrimetic titrations
 Gravimetric methods
 Gasometric analysis

7. Electrical measurements
 Potentiometry
 Conductometry
 Polarography
 Voltametry
 Amperometry

8. Spectroscopy methods
Absorption Spectroscopy
UV-Visible
Infra red
Atomic absorption spectroscopy
NMR
Emission spectroscopy
Flame emission spectroscopy
Fluorimetry

9.  Chromatography methods
 Gas chromatography
 HPLC
 TLC
 HPTLC
 Paper chromatography
 Others
 Mass
 Refractive index
 Specific rotation etc.,

10. Bio assays and microbiological assays
 Potency of a substance is estimated using micro
organisms, animal tissues or intact animals

11. Applications of Pharmaceutical Analysis
 In Pharma industry
 Quality control
 Quality assurance
 Analytical Research and development etc.,
 In geographical surveys
 To analyze soil samples
 In pollution control
 To analyze air samples, water, soil etc.,