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Alpha fold 2

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Vishwas N

Alpha fold 2

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Alpha Fold 2 By : Vishwas Narayan
Lot of new things Proteomics,Genomics,Computer Architecture and other aspects of science just started to emerge in 2015 as soon as tensorflow was open source thus its a new journey from then to everybody.
Lot of new things Proteomics,Genomics,Computer Architecture and other aspects of science just started to emerge in 2015 as soon as tensorflow was open source thus its a new journey from then to everybody, but it changed now.
HOW??
Let's just focus on proteomics
What is a protein?
CASP Challenge https://predictioncenter.org/
Isoforms of the Protein
There is a lot of Complexity in studying these structures ● Money ● Time ● Efforts ● Infrastructure
https://predictioncenter.org/casp14/index.cgi?page=format#RR
They still love their world.
Potential of this project is phenomenal
Reference 1. https://deepmind.com/blog/article/AlphaFold-Using-AI-for-scientific-discovery 2. https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology 3. https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13 4. https://github.com/dellacortelab/prospr 5. https://www.nature.com/articles/s41586-019-1923-7 6. https://www.nature.com/articles/s41586-019-1923- 7.epdf?author_access_token=Z_KaZKDqtKzbE7Wd5HtwI9RgN0jAjWel9jnR3ZoTv0MCcgAwHMgRx9mvLj NQdB2TlQQaa7l420UCtGo8vYQ39gg8lFWR9mAZtvsN_1PrccXfIbc6e- tGSgazNL_XdtQzn1PHfy21qdcxV7Pw-k3htw%3D%3D 7. https://onlinelibrary.wiley.com/doi/full/10.1002/prot.25834 8. https://deepmind.com/research/case-studies/alphafold

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Alpha fold 2

Editor's Notes

  1. https://www.ebi.ac.uk/training/online/course/proteomics-introduction-ebi-resources/proteomics-resources-ebi
  2. http://rosalind.info/glossary/protein-isoform/
  3. https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance
  4. https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy
  5. https://en.wikipedia.org/wiki/X-ray_crystallography
  6. https://www.nobelprize.org/uploads/2018/06/anfinsen-lecture.pdf
  7. https://en.wikipedia.org/wiki/Protein_primary_structure https://web.archive.org/web/20110523080407/http://www-miller.ch.cam.ac.uk/levinthal/levinthal.html
  8. TWO EXAMPLES OF PROTEIN TARGETS IN THE FREE MODELLING CATEGORY. ALPHAFOLD PREDICTS HIGHLY ACCURATE STRUCTURES MEASURED AGAINST EXPERIMENTAL RESULT.
  9. https://predictioncenter.org/caspcommons/index.cgi
  10. https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13