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FORMULATION AND EVALUATION OF MULTIPURPOSE HERBAL CREAM
USING ALOE VERA AND TURMERIC
PRESENTED BY
Shrutika Satish Dasture Supriya Pralhad Khartude
Renuka Vasant Misal Ruchita Tukaram Pise
Rohit Rameshwar Raut Ritesh Sanjay Ubarhande
Vaishnavi Gopal Tupkar
( B Pharm 8th Semester )
GUIDED BY
Prof. S. L. KHEDEKAR
Parmahansa Ramkrishna Maunibaba Shikshan Sanstha’s
ANURADHA COLLEGE OF PHARMACY
Contents:
1) Introduction
2) Material and Equipment
3) Experimental
4) Evaluation
5) Observation Table
6) Result and Conclusion
7) References
INTRODUCTION
• In today’s era, the use of herbal medicines become popular
worldwide. An herbal cosmetic have growing demand in the
world market .
• Herbal formulations always have attracted considerable
attention because of their good activity and comparatively
lesser or nil side effects.
• “Creams are defines as a semisolid dosage form containing
one or more drug substance dissolve or dispersed in a suitable
base”
• A Cream is a Topical Preparation usually for application to the
skin, these are either (o/w) or (w/o) type .
What is herbal cream?
Herbal cosmetics are defined as the beauty products which
posses desirable physiological activity such as healing,
smoothing appearance, enhancing and conditioning properties
because of herbal ingredient.
 A herbal cream that can give effective protection to skin and
free from any toxicity or toxic residue or any irritation when
regularly used and should also be cosmetically acceptable
AIM
To develop a herbal cream which can give
multipurpose effect, like moisturizer, reduce acne and
skin irritation, reduce skin diseases like eczema,
psoriasis, wrinkles, rashes etc. and also adding glow to
the face.
• To set a formula for herbal cream by using different
herbs.
• To evaluate formulated product by using different
tests.
OBJECTIVES
MAIN HERBAL CONSTITUENTS :
1) Aloe Vera:
 Synonyms: Musabar, Ghrit-Kumari
 Family: liliaceae
 Chemical constituents: Aloin, barbaloin, Isobarbaloin & Resine.
 Parts used: Leaf gel
 Synonyms: Turmeric, Kurkum, haldi.
 Chemical constituents: Curcumin
 Parts used: Rhizome paste, powder
 Family: Zingiberaceae
2) Curcuma longa:
MATERIALS AND METHODS :
Ingredients Quantities Roles
Aloe Vera gel 0.8ml Anti-ageing, anti-inflammatory,
moisturizer, reduce acne and
pimples.
Bees wax 1.5gm Give thickness and increase the
water holding capacity of the cream
Liquid paraffin 5ml Lubricating agent
Borax 0.5gm Emulsifier, buffering agent and
preservative
Turmeric extract 1ml anti-inflammatory ,Cures acne,
Reduce dark circles
,Could help psoriasis, eczema
wound healing
Ethanol (15ml) Solvent
Rose oil q.s. Fragrance
Total: 10gm
FORMULATION OF HERBAL MULTIPURPOSE CREAM:
1) PREPARATION OF HERBAL EXTRACT :
Turmeric extract:
Aloe-vera extract:
• Collect mature and fresh aloe-vera
leaf from plant and washed it with
distilled water. Dried it properly
• The semi-solid aloe-vera is collected.
Remove fibers and impurities form it.
Aloe-vera extract is obtained
• Take 1 g turmeric powder in
10 ml distilled water
• Heated in water bath at
80°C to 100°C for 5 to 10 min
Then filtered it
2) PREPARATION OF CREAM :
1) Heat liquid paraffin and beeswax in a beaker and maintain
that heating temperature.
2) In another beaker, dissolve borax in distilled water and heat
this beaker to 75 ℃ .
3) Then slowly add this aqueous phase to heated oily phase .
4)Then add a measured amount of aloe Vera gel, Turmeric
extract and stir vigorously until it forms a smooth cream.
5) Then add few drops of rose oil as a fragrance. Put this
cream in mortor and pestle to give a smooth texture to the
cream and to mix all the ingredients properly.
6) Cream is ready for Evaluation tests
Evaluation of Formulated Herbal cream:
(a) Physical examination :
Figure 1: Physical Examination of cream
• Formulated cream was evaluated for its colour, odour, taste,
smoothness, relative density.
• Results showed that the cream and both gels had a cosmetically
appealing appearance and smooth texture, and they were all
homogenous with no signs of phase separation
(b) pH determination:
Figure 2: The pH Meter
pH of formulated herbal cream was determined by
using pH meter. 0.5 g cream was taken and dispersed in
50 ml distilled water and then PH was measured by
using digital PH meter
(c) Spreadability:
Figure 3: Spreadability Test
 The spreadability was expressed in terms of time in seconds taken by
two slides to slip off from the cream, placed in between the slides,
under certain load.
 Lesser the time taken for separation of the two slides better the
spreadability.
 Then a weight or certain load was placed on the upper slide so that the
cream between the two slides was pressed uniformly to form a thin
layer.
Spread ability= m × l/t
Where,
m= Standard weight which is tied to or placed over the upper slide (10g)
l= length of a glass slide (7.5cm)
t= time taken in seconds(7sec)
d) Phase separation:
• Prepared cream was kept in a closed container at a
temperature of 25-100 ℃ .
• Then phase separation was checked for 24 h for 30 d.
Any change in the phase separation was
observed/checked.
• According to the results no phase separation was
observed in formulations.
e) Wash ability:
Wash ability test was carried out by applying a
small amount of cream on the hand and then washing it
with help of tap water. formulation were easily
washable.
LABLE :
OBSERVATION TABLE
(a) Physical Evolution:
Table : Physical Properties
Parameters Observation
Colour Yellow
Odour Aromatic
State Semisolid
Texture Smooth
(b) Evaluation Test:
Table 6: Evaluation of Herbal Cream
Parameters Observ0ation
Parameters Standard Value Observation
pH 4.5-6 5.8
Spreadability 8.50-11.50 10.71
Viscosity 1000-7000lcp 119lcP
Washability Good Easily Washable
Phase Separation - No Phase Separation
CONCLUSION
• From above project we can conclude By using Aloe
Vera gel and Turmeric the cream showed a
multipurpose effect and all these herbal ingredients
showed significant different activities. Based on results
and discussion, the formulation were stable at room
temperature and can be safely used on the skin.
• It has best properties and having nutritional values
using less chemical which protects the skin from the
various skin problem. Since the cream was prepared by
using simple ingredients and simple method so the
cream is also economical.
• Natural remedies are more acceptable in the belief
that they are safer with fewer side effects than the
synthetic ones.
REFERENCE
1. Manisha Yogesh Sonalkar, Sachin Annasaheb Nitave. Formulation and evaluation of
polyherbal cosmetic cream. World J Pharm Pharm Sci 2016;5:772-9.
2. T Reynolds, AC Dweck. Aloe vera leaf gel: a review update. J Ethno Pharmacol 1999;68:3-37.
3. Priyanka Sharma, Amit C Kharkwal, Harsha Kharkwal, MZ Abdin, Ajit Varma. A review on the
pharmacological properties of Aloe Vera. Int J Pharm Sci Rev Res 2014;29:31-7.
4. Sharma Pankaj, Tomar Lokeshwar, Bachwani Mukesh, Bansal Vishnu. Review on neem
(Azadirachta indica): thousand problems one solution. Int Res J Pharm 2011;2:97-102.
5. KP Sampath Kumar, Debjit Bhowmik, Biswajit, Chiranjib, Pankaj, KK Tripathi Margret Chandira.
Traditional Indian herbal plants Tulsi and its medical importance: a review. Res Rev: J
Pharmacogn Phytochem 2010;2:103-8.
. 6. Renisheya Joy Jeba Malar T, Johnson M, Nancy Beaulah S, Laju RS, Anupriya G, Renola Joy
Jeba Ethal T. Anti-bacterial and anti-fungal activity of aloe Vera gel extract. Int J Biomed Adv Res
2012;3:184-7.
7. Kalpesh Chhotalal Ashara. Importance of trituration technique on preparation and evaluation
of cold cream. Inventi Rapid Pharm Tech 2013;1-2:2012.
8. Sk Uddandu Saheb, Aduri Prakash Reddy, K Rajitha, B Sravani, B Vanitha. Formulation and
evaluation of cream from naturally containing plant extracts. World J Pharm Pharm Sci
2018;7:851-62.
9. Bhakti Mali, Sumedh N Moharil, Vaibhav Mhasal, Mahesh B Narkhede. Drug-excipient
interaction study of Tramadol HCL with polymers. World J Pharm Res 2017;6:848-61.
10. Donald L Pavia, Gary M Lampman, George S kriz, James R Vyvyan. Introduction to
spectroscopy. 5th edition. Patparganj-Delhi; Cengage learning India pvt. ltd. Chapter 2: Infrared
spectroscopy; 2015. p. 14-106.
11. Mali AS, Karekar P, Yadav AV. Formulation and evaluation of multipurpose herbal cream. Int J
Sci Res. 2015; 4(11): 1495-1497
12. Christaki EV, Florou-Paneri PC. Aloe vera: A plant for many uses. J Food Agric Environ. 2010;
8(2): 245-249.
13. Rignall A. ICHQ1A (R2) stability testing of new drug substance and product and ICHQ1C
stability testing of new dosage forms. ICH quality guidelines: An implementation guide. 2017.
14. Gupta N, Dubey A, Prasad P, Roy A. Formulation and evaluation of herbal fairness cream
comprising hydroalcoholic extracts of Pleurotus ostreatus, Glycyrrhiza glabra and Camellia
sinensis. Pharma Bio Sci J. 2015: 40-45
FORMULATION AND EVALUATION OF MULTIPURPOSE  HERBAL CREAM USING aloevera 111.pptx

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FORMULATION AND EVALUATION OF MULTIPURPOSE HERBAL CREAM USING aloevera 111.pptx

  • 1. FORMULATION AND EVALUATION OF MULTIPURPOSE HERBAL CREAM USING ALOE VERA AND TURMERIC PRESENTED BY Shrutika Satish Dasture Supriya Pralhad Khartude Renuka Vasant Misal Ruchita Tukaram Pise Rohit Rameshwar Raut Ritesh Sanjay Ubarhande Vaishnavi Gopal Tupkar ( B Pharm 8th Semester ) GUIDED BY Prof. S. L. KHEDEKAR Parmahansa Ramkrishna Maunibaba Shikshan Sanstha’s ANURADHA COLLEGE OF PHARMACY
  • 2. Contents: 1) Introduction 2) Material and Equipment 3) Experimental 4) Evaluation 5) Observation Table 6) Result and Conclusion 7) References
  • 3. INTRODUCTION • In today’s era, the use of herbal medicines become popular worldwide. An herbal cosmetic have growing demand in the world market . • Herbal formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects. • “Creams are defines as a semisolid dosage form containing one or more drug substance dissolve or dispersed in a suitable base” • A Cream is a Topical Preparation usually for application to the skin, these are either (o/w) or (w/o) type .
  • 4. What is herbal cream? Herbal cosmetics are defined as the beauty products which posses desirable physiological activity such as healing, smoothing appearance, enhancing and conditioning properties because of herbal ingredient.  A herbal cream that can give effective protection to skin and free from any toxicity or toxic residue or any irritation when regularly used and should also be cosmetically acceptable
  • 5. AIM To develop a herbal cream which can give multipurpose effect, like moisturizer, reduce acne and skin irritation, reduce skin diseases like eczema, psoriasis, wrinkles, rashes etc. and also adding glow to the face. • To set a formula for herbal cream by using different herbs. • To evaluate formulated product by using different tests. OBJECTIVES
  • 6. MAIN HERBAL CONSTITUENTS : 1) Aloe Vera:  Synonyms: Musabar, Ghrit-Kumari  Family: liliaceae  Chemical constituents: Aloin, barbaloin, Isobarbaloin & Resine.  Parts used: Leaf gel
  • 7.  Synonyms: Turmeric, Kurkum, haldi.  Chemical constituents: Curcumin  Parts used: Rhizome paste, powder  Family: Zingiberaceae 2) Curcuma longa:
  • 8. MATERIALS AND METHODS : Ingredients Quantities Roles Aloe Vera gel 0.8ml Anti-ageing, anti-inflammatory, moisturizer, reduce acne and pimples. Bees wax 1.5gm Give thickness and increase the water holding capacity of the cream Liquid paraffin 5ml Lubricating agent Borax 0.5gm Emulsifier, buffering agent and preservative Turmeric extract 1ml anti-inflammatory ,Cures acne, Reduce dark circles ,Could help psoriasis, eczema wound healing Ethanol (15ml) Solvent Rose oil q.s. Fragrance Total: 10gm
  • 9. FORMULATION OF HERBAL MULTIPURPOSE CREAM: 1) PREPARATION OF HERBAL EXTRACT : Turmeric extract: Aloe-vera extract: • Collect mature and fresh aloe-vera leaf from plant and washed it with distilled water. Dried it properly • The semi-solid aloe-vera is collected. Remove fibers and impurities form it. Aloe-vera extract is obtained • Take 1 g turmeric powder in 10 ml distilled water • Heated in water bath at 80°C to 100°C for 5 to 10 min Then filtered it
  • 10. 2) PREPARATION OF CREAM : 1) Heat liquid paraffin and beeswax in a beaker and maintain that heating temperature. 2) In another beaker, dissolve borax in distilled water and heat this beaker to 75 ℃ . 3) Then slowly add this aqueous phase to heated oily phase . 4)Then add a measured amount of aloe Vera gel, Turmeric extract and stir vigorously until it forms a smooth cream. 5) Then add few drops of rose oil as a fragrance. Put this cream in mortor and pestle to give a smooth texture to the cream and to mix all the ingredients properly. 6) Cream is ready for Evaluation tests
  • 11. Evaluation of Formulated Herbal cream: (a) Physical examination : Figure 1: Physical Examination of cream • Formulated cream was evaluated for its colour, odour, taste, smoothness, relative density. • Results showed that the cream and both gels had a cosmetically appealing appearance and smooth texture, and they were all homogenous with no signs of phase separation
  • 12. (b) pH determination: Figure 2: The pH Meter pH of formulated herbal cream was determined by using pH meter. 0.5 g cream was taken and dispersed in 50 ml distilled water and then PH was measured by using digital PH meter
  • 13. (c) Spreadability: Figure 3: Spreadability Test  The spreadability was expressed in terms of time in seconds taken by two slides to slip off from the cream, placed in between the slides, under certain load.  Lesser the time taken for separation of the two slides better the spreadability.  Then a weight or certain load was placed on the upper slide so that the cream between the two slides was pressed uniformly to form a thin layer. Spread ability= m × l/t Where, m= Standard weight which is tied to or placed over the upper slide (10g) l= length of a glass slide (7.5cm) t= time taken in seconds(7sec)
  • 14. d) Phase separation: • Prepared cream was kept in a closed container at a temperature of 25-100 ℃ . • Then phase separation was checked for 24 h for 30 d. Any change in the phase separation was observed/checked. • According to the results no phase separation was observed in formulations. e) Wash ability: Wash ability test was carried out by applying a small amount of cream on the hand and then washing it with help of tap water. formulation were easily washable.
  • 16. OBSERVATION TABLE (a) Physical Evolution: Table : Physical Properties Parameters Observation Colour Yellow Odour Aromatic State Semisolid Texture Smooth
  • 17. (b) Evaluation Test: Table 6: Evaluation of Herbal Cream Parameters Observ0ation Parameters Standard Value Observation pH 4.5-6 5.8 Spreadability 8.50-11.50 10.71 Viscosity 1000-7000lcp 119lcP Washability Good Easily Washable Phase Separation - No Phase Separation
  • 18. CONCLUSION • From above project we can conclude By using Aloe Vera gel and Turmeric the cream showed a multipurpose effect and all these herbal ingredients showed significant different activities. Based on results and discussion, the formulation were stable at room temperature and can be safely used on the skin. • It has best properties and having nutritional values using less chemical which protects the skin from the various skin problem. Since the cream was prepared by using simple ingredients and simple method so the cream is also economical. • Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones.
  • 19. REFERENCE 1. Manisha Yogesh Sonalkar, Sachin Annasaheb Nitave. Formulation and evaluation of polyherbal cosmetic cream. World J Pharm Pharm Sci 2016;5:772-9. 2. T Reynolds, AC Dweck. Aloe vera leaf gel: a review update. J Ethno Pharmacol 1999;68:3-37. 3. Priyanka Sharma, Amit C Kharkwal, Harsha Kharkwal, MZ Abdin, Ajit Varma. A review on the pharmacological properties of Aloe Vera. Int J Pharm Sci Rev Res 2014;29:31-7. 4. Sharma Pankaj, Tomar Lokeshwar, Bachwani Mukesh, Bansal Vishnu. Review on neem (Azadirachta indica): thousand problems one solution. Int Res J Pharm 2011;2:97-102. 5. KP Sampath Kumar, Debjit Bhowmik, Biswajit, Chiranjib, Pankaj, KK Tripathi Margret Chandira. Traditional Indian herbal plants Tulsi and its medical importance: a review. Res Rev: J Pharmacogn Phytochem 2010;2:103-8. . 6. Renisheya Joy Jeba Malar T, Johnson M, Nancy Beaulah S, Laju RS, Anupriya G, Renola Joy Jeba Ethal T. Anti-bacterial and anti-fungal activity of aloe Vera gel extract. Int J Biomed Adv Res 2012;3:184-7. 7. Kalpesh Chhotalal Ashara. Importance of trituration technique on preparation and evaluation of cold cream. Inventi Rapid Pharm Tech 2013;1-2:2012.
  • 20. 8. Sk Uddandu Saheb, Aduri Prakash Reddy, K Rajitha, B Sravani, B Vanitha. Formulation and evaluation of cream from naturally containing plant extracts. World J Pharm Pharm Sci 2018;7:851-62. 9. Bhakti Mali, Sumedh N Moharil, Vaibhav Mhasal, Mahesh B Narkhede. Drug-excipient interaction study of Tramadol HCL with polymers. World J Pharm Res 2017;6:848-61. 10. Donald L Pavia, Gary M Lampman, George S kriz, James R Vyvyan. Introduction to spectroscopy. 5th edition. Patparganj-Delhi; Cengage learning India pvt. ltd. Chapter 2: Infrared spectroscopy; 2015. p. 14-106. 11. Mali AS, Karekar P, Yadav AV. Formulation and evaluation of multipurpose herbal cream. Int J Sci Res. 2015; 4(11): 1495-1497 12. Christaki EV, Florou-Paneri PC. Aloe vera: A plant for many uses. J Food Agric Environ. 2010; 8(2): 245-249. 13. Rignall A. ICHQ1A (R2) stability testing of new drug substance and product and ICHQ1C stability testing of new dosage forms. ICH quality guidelines: An implementation guide. 2017. 14. Gupta N, Dubey A, Prasad P, Roy A. Formulation and evaluation of herbal fairness cream comprising hydroalcoholic extracts of Pleurotus ostreatus, Glycyrrhiza glabra and Camellia sinensis. Pharma Bio Sci J. 2015: 40-45