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M. Siddique
Definition:
 Contrast:- defined as the degree of blackness to
whiteness of target.
 Contrast threshold:-is the smallest amount of contrast
required to be able to see the target.
 Contrast sensitivity:- is the reciprocal of the contrast
threshold.
 the ability to perceive slight changes in
luminance between regions which are not
separated by definite borders and is just as
important as the ability to perceive sharp
outlines of relatively small objects.
 Snellen’s charts test VA at a very high contrast
thus many patients have a good snellens VA but
they may be visually handicapped in real life
situations.
 The VA drops in the situations with low contrast
and the quality of vision is not good.
 It provides the information that cannot be
obtained from visual acuity, and it is often a
better predictor of visual performance then VA.
 C .S is presented as
curve which plots
the lowest contrast
level a patient can
detect for specific
size target.
 The x-axis curve is
for spatial
frequency, y-axis is
for contrast
sensitivity.
 The contrast sensitivity function proposed by
Manos and Sakrison.
 A plot of CS over a range of spatial frequencies
gives the contrast sensitivity function(CSF).
 Contrast sensitivity depends on spatial frequency.
 Spatial frequency of visual stimuli is given in
cycles per degree.
 
 Contrast sensitivity function (CSF) is a
subjective measurement of a person's ability
to detect a low contrast pattern stimuli,
usually vertical stripes of decreasing shades
of black to grey. The resulting measurement is
said to give a more accurate representation of
the eyes' visual performance.
 CSF has a peak value
of approximately 1 to 8
cycles/ degree.
 Distinction of high
frequencies not
possible because of
limited number of
photoreceptors.
 Neural and optical
attenuation limits
the high spatial
frequency CS.
 Point where the
CSF cuts the x axis
is called cut off
frequency.
MICHELSON FORMULA:
 L max- Lmin/Lmax+Lmin
 Lmax = Luminance on the lighter surface
 Lmin = Luminance on the darker surface
WEBERS FORMULA:
Defined as ( Lb – Lt ) / Lb
 Lb & Lt are the luminance of the background and
target respectively.
 Weber contrast used in calculating the contrast of
letters.
low medium high
object:
100%
contrast
image
spatial frequency
contrast
1
0
• The modulation transfer function (MTF) indicates the ability of an optical
system to reproduce (transfer) various levels of detail (spatial
frequencies) from the object to the image.
• Its units are the ratio of image contrast over the object contrast as a
function of spatial frequency.
• It is the optical contribution to the contrast sensitivity function (CSF).
MTF: Cutoff FrequencyMTF: Cutoff Frequency
0
0.5
1
0 50 100 150 200 250 300
1 mm
2 mm
4 mm
6 mm
8 mm
modulationtransfer
spatial frequency (c/deg)
cut-off frequency
57.3
cutoff
a
f
λ
=
⋅
Rule of thumb: cutoff
frequency increases by
~30 c/d for each mm
increase in pupil size
 One adjacent pair of light and dark bars
makes up one cycle.
 The thickness of the grating is described by
their spatial frequency in cycles per degree of
the visual angle at the eye..
 Large number of grating can fit with in a
degree of visual angle
 Gratings are broader and are of low spatial
frequency.
 Spatial phase defines its position.
 Change in spatial phase by 180 degrees
indicates that the grating is displaced by half
a cycle.
 These gratings are
lacking in sharp
borders.
 Sinusoidal gratings are
used because they
are not subject to
defocus,
aberration,diffraction,
light scatter.
 Only the contrast and
spatial position are
affected.
 square-wave
gratings have
characteristics like
a square such as
sharp edges.
 1. Spatial contrast sensitivity
 2. temporal contrast sensitivity
 Detection of striped pattern at various levels of
contrast and spatial frequency.
 Sine wave gratings of parallel light and dark
bands.
 Measured with stationary gratings
 width of the bar is defined as spatial frequency
 High spatial frequency- narrow bars.
 low spatial frequency- wide bars.
 The spatial frequency
increases
exponentially from left
to right. The contrast
also varies
logarithmically from
100% at the bottom to
about 0.5% at the top
 Temporal contrast sensitivity is measured with
gratings that reverse contrast at various rates over
time.
 here contrast sensitivity function is generated
for the time related processing in the visual
system by presenting a uniform target field
modulated sinusoidal in time.
 Both the system provides more complete and
systemic data on the status of visual
performance.
The shape of the contrast sensitivity function
varies with factors:
 Luminance
 Target size
 Grating motion
 Grating shape
 Have problems with night
driving, including inability to
see traffic lights
 May require extra light to read
 Their eyes may become tired
when they read or watch
television
 Not being able to see spots
on clothes, counters, or dishes
 Missing facial gestures
 There are three variables in measurement of
contrast sensitivity:
1. Average amount of light reflected depends on
illumination of paper and darkness of ink.
2.Degree of blackness in relation to white
background that is contrast.
3. The distance between the grating periods of
cycles per degree of visual angle.
 The various methods available to measure CS
include
 Pelli Robson test
 Bailey Lovie chart
 Vision contrast test system (VCTS) by Vistech
 Cambridge low contrast grating
 Regan charts
 FACT charts
 letters of the same
size but with
reducing contrast
 two charts and two
scoring pads.
 Each chart has 6
letters in each row
organized into two
triplets of varying
contrast.
 illumination of the
chart is 85 cd/mm2
 1 meter distance
 The score of the test
is recorded by the
faintest triplet out of
which at least 2
letters are correctly
identified.
 The log CS value for
this triplet is given
by the number on
the scoring pad.
 It is a rapid and simple screening test for
contrast sensitivity.
 Performed at a distance of 6m.
 It comprises of 12 pair of plates consisting of
stripes of varying contrast.
 First one is for demonstration and rest are for
the proper testing and are numbered from 1-10.
 The plates are changed sequentially starting
from plate 1 till the patient fails to respond.
 Then a new series is begun starting 4 plates
prior to where the patient failed to respond.
 Four such series are completed and the score
of each series is noted (numbered as per the
number of plate read) and added.
 The final total value is converted into contrast
sensitivity from the provided table.
 Low contrast acuity testing & acuity testing in
presence of glare.
 Each row has same no. of symbols & constant
spacing is used between rows & letters.
 Chart is logarithmic based & visual acuity is based on
log of minimum angle of resolution or logMAR.
 Berkely Glare Test provides 10% of contrast & is
provided with glare source
 FACT charts were developed by Dr. Arthur Ginsburg.
 FACT comprises of a chart with sine-wave gratings of
varying frequencies.
 The chart tests five spatial frequencies (sizes) and
nine levels of contrast
 The Contrast varies in a row, decrease from left to
right
 And the spatial frequencies increase as one
move down the various columns from top to
bottom.
 This test is performed at a distance of 10 feet.
 The patient determines the last grating seen for
each row (A, B, C, D and E) and reports the
orientation of the grating: right, up or left.
 The last correct grating seen for each spatial
frequency is plotted on a contrast sensitivity
curve.
 Introduced in 1978.
 Consists of a booklet
containing several sine
wave gratings patterns
 Each grating is oriented
vertically
 The contrast varies from the
top to the bottom of the
grating, lowest at the top
and highest at the bottom.
 These charts consist of sine wave gratings.
Each chart contains five rows and nine
columns of circular photographic plates (disc)
on gray background.
 Each row has different spatial frequency (1.5 to
18 c.p.d. at three meters) and contrast within
the row reduces from left to right.
 The gratings are presented in three
orientations: vertical 90 degrees, 15 degrees
clockwise or anticlockwise.
 Two separate Vistech charts are available: the
VCTS-6500 for distance testing and the VCTS-
6000 for near testing.
 A projector slide the VCTS-500S is also
available.
 A luminance of between 103 and 240cd/m2 is
recommended.
 It can be used to document the performance of
low vision patients.
 Consists of three letter charts, printed on white
cardboard having contrast of 97%, 7% and 4%
 3 meter with eight letters in each line
 Patients are instructed to start at the top and to
continue reading until they can correctly identify no
letters on a line.
 For one chart letter size goes on reducing and
contrast remains constant
 Regan in 1988 suggested there chief role in
detecting early visual loss in diabetes and
glaucoma.
1. refractive errors.
2. age
3.cataract
4.contact lenses
5.refractive surgery.
6.glaucoma.
7.diabetic retinopathy.
8.optic neruopathies
9.pituitary adenoma.
10.drugs.
11.toxic chemicals
Refractive errors:
 Uncorrected refractive disorders manifest
themselves as a decline in contrast sensitivity
first at smaller grating sizes or higher spatial
frequencies for mild refractive disorders.
 As the degree of refractive disorder increases,
contrast sensitivity declines at the middle and
then larger grating sizes (middle to lower
spatial frequencies).
 Measurements were made at distance (with Vistech
charts), at near (with Arden gratings), and with a
pinhole to control pupil size.
 Under all conditions, when visual acuity was
reduced by spherical lenses, there was a loss of
contrast sensitivity over a broad range of spatial
frequencies.
Ophthalmology 1988 Jan;95(1):139-43.
Eeffectof visual blur on contrast sensitivity. Clinical implication
Marmor MF, Gawande A
Age:
 There occurs a definite decrease in contrast
sensitivity with increasing age.
 The pathogenesis of this decline in vision is
likely involves changes in the spherical
aberration of the crystalline lens
 As the aperture of lens increases the average
focal point move towards the lens so that a
larger pupil produces greater spherical
aberration
 Spherical aberration of cornea changes little
with the age of the people.
 Total wavefront aberration of the eye increases
more than threefold, between 20 to 70 years of
age.
 the aging lens loses its balance with the
cornea, because both the magnitude and sign
of its spherical aberration change significantly.
 A loss of balance between corneal and
lenticular spherical aberration causes the
degradation of optical quality in the aging eye.
 Monocular and binocular contrast sensitivity function
for a range of spatial frequencies was measured in two
groups of subjects with normal vision.
 In the age range 50-87 years there was a linear decline
in contrast sensitivity with age for medium and high
spatial frequencies, but sensitivity for low spatial
frequencies was independent of age.
Effect of age on contrast sensitivity function: uniocular and binocular findings
 J E Ross D D Clarke and A J Bron.

Cataract:
 Early cataracts generally cause contrast
sensitivity losses similar to refractive disorders
at higher spatial frequencies.
 The addition of glare source will exacerbate the
results for patients with cataract, producing
lower contrast sensitivity at some or all grating
sizes
 significant loss of contrast sensitivity at all spatial
frequencies with increasing cataract severity.
Contrast sensitivity was significantly reduced at
high spatial frequency (18 cpd) in cortical cataracts
in the presence of glare in day light and at low
spatial frequency (3 cpd) in night light.
 Contrast sensitivity scores may offer additional
information over standard VA tests in patients with
early age-related cataracts.

 Ophthalmic Vis Res. 2011 January; 6(1): 26–31.
 Effect of Cataract Type and Severity on Visual Acuity and Contrast
Sensitivity
Javad Heravian Shandiz MSc, PhD,1
Akbar Derakhshan MD,2
Contact lenses:
 to ensure proper contact lens fit as well as
determining when replacement is necessary.
 Uncorrected residual astigmatism from soft
contact lens can result in decrease contrast
sensitivity at the middle and higher spatial
frequencies when compared to hard contact
lenses.
 study concluded that those female professional
and collegiate tennis players wearing no
corrective lenses were significantly higher in
CS at intermittent and high spatial frequencies
than those who wore daily-wear soft contact
lenses in competition.
Kluka, D.A. and Love, P.A. “Effects of Daily – Wear Contact Lenses Upon Contrast
Sensitivity in Selected Professional and Collegiate Female Tennis Players,” UBA
at Birmingham
 Glaucoma: Glaucoma can reduce contrast sensitivity for
all grating sizes, a number of studies shown reduce
contrast sensitivity mostly at the middle spatial
frequencies.
 study was carried out to explore the effects of glaucoma
on low-spatial-frequency contrast sensitivity by using
tests designed to assess performance of either the
magnocellular (M) or parvocellular (P) visual pathways.
Sensitivity was reduced foveally and in the midperiphery
across the spatial frequency range. In the area of early
visual field loss, the glaucoma group demonstrated further
sensitivity reduction across the spatial frequency range.
 The low-spatial-frequency-sensitive channels of
both pathways, which are presumably mediated
by cells with larger receptive fields, are
approximately equivalently impaired in
glaucoma.
 Contrast sensitivity changes due to glaucoma and normal aging: low-spatial-
frequency losses in both magnocellular and parvocellular pathways.
 McKendrick AM Sampson GP, Walland MJ, Badcock DR
 Invest Ophthalmol Vis Sci.2007 May;48(5):2115-22
 IOLs
 A study was carried out to evaluate the contrast
sensitivity at near and distance after MFIOL
implantation in 21 patients. A control group with
monofocal iol was also studied. CS measured
after 1,3,6,12,and 18 months after IOL.
 multifocal In patients with unilateral cataract,
monofocal, accommodating and partially diffractive
multifocal IOL provided higher CS scores when
compared with refractive IOL.
Clinical and experimental ophthalmology
Differences in contrast sensitivity between monofocal,
multifocal and
accommodatingintraocular lenses: long-term results
Cem Mesci MD, Hasan H Erbil MD, Ali Olgun MD, Nihat Aydin MD,
Article first published online: 3 NOV 2010 DOI: 10.1111/j.1442-
9071.2010.02357.
Diabetic retinopathy:
 In diabetic retinopathy patients, contrast sensitivity
loss may occur for all grating sizes.
 a study was carried out to evaluate contrast
sensitivity (CS) and visual acuity (VA) in detecting
functional losses in participants with type 2
diabetes.
 LogMAR VA and letter CS were measured on 20 type
2 diabetic and 24 age-matched control participants.
The diabetic participants were sub-grouped
according to the level of retinopathy present.
RESULTS:
 Letter CS was able to distinguish those participants
with and without macular oedema and those with no
or minimal diabetic retinopathy from the control
group, whereas VA was not.
Clinical optom 2003 May;86(3):152-6
Letter contrast sensitivity changes in early diabetic retinopathy
Stavrou EP, Wood JM
Optic neuropathies:
 A variety of optic neuropathies including
afferent pupillary defect, optic neuritis, and
multiple sclerosis will affect contrast sensitivity
losses over some or all grating sizes.
 Multiple sclerosis can sometimes affect only
middle sizes.
Pituitary adenoma:
 Pituitary adenoma has been shown to cause
contrast sensitivity loss at the middle grating
sizes.
 Cases report was made by
neuroophthalmological examination in two
patients with parasellar pituitary adenoma
before and after surgery.
 The twelve months follow-up of visual
dysfunction includes standard Snellen visual
acuity and low contrast number visual acuity.
 The presented cases indicate that the low contrast
acuity tests in patients with parasellar pituitary
adenoma are sensitive indicators.
 The loss of low contrast visual acuity improved after
surgery as did other visual measures, except in
cases with significant low contrast deficit at 1.5%
contrast.
Kruzer, A.R. (1986) “ Contrast Sensitivity Signals Pitutary Adenoma,” Rev. Of.Opt. 123(4), 119
Toxic Chemicals:
 Several occupational studies have indicated that
chronic, airborne exposure adversely affects
neurobehavioral functions in workers, particularly
visual color discrimination and tasks dependent on
rapid visual-information processing
Frenette, B.,Mergler, D. And Bowler, R.(1991) “Contrast Sensitivity Loss in Group of
Former
Microelectronics Workers with Normal Visual Acuity,” Opt. and Sci.,68(7),.
 Why refractive surgery can affect the quality of
vision.
there are other factors in the eye, which affect
vision quality, that are unrelated to eye focus.
These factors can cause the quality of vision to
vary greatly, even when a patient has 20/20 or
better acuity. Contrast sensitivity is the best
method for quantifying the quality of vision
Contrast sensitivity

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Contrast sensitivity

  • 2. Definition:  Contrast:- defined as the degree of blackness to whiteness of target.  Contrast threshold:-is the smallest amount of contrast required to be able to see the target.  Contrast sensitivity:- is the reciprocal of the contrast threshold.
  • 3.  the ability to perceive slight changes in luminance between regions which are not separated by definite borders and is just as important as the ability to perceive sharp outlines of relatively small objects.
  • 4.  Snellen’s charts test VA at a very high contrast thus many patients have a good snellens VA but they may be visually handicapped in real life situations.  The VA drops in the situations with low contrast and the quality of vision is not good.  It provides the information that cannot be obtained from visual acuity, and it is often a better predictor of visual performance then VA.
  • 5.  C .S is presented as curve which plots the lowest contrast level a patient can detect for specific size target.  The x-axis curve is for spatial frequency, y-axis is for contrast sensitivity.
  • 6.  The contrast sensitivity function proposed by Manos and Sakrison.  A plot of CS over a range of spatial frequencies gives the contrast sensitivity function(CSF).  Contrast sensitivity depends on spatial frequency.  Spatial frequency of visual stimuli is given in cycles per degree.  
  • 7.  Contrast sensitivity function (CSF) is a subjective measurement of a person's ability to detect a low contrast pattern stimuli, usually vertical stripes of decreasing shades of black to grey. The resulting measurement is said to give a more accurate representation of the eyes' visual performance.
  • 8.  CSF has a peak value of approximately 1 to 8 cycles/ degree.  Distinction of high frequencies not possible because of limited number of photoreceptors.
  • 9.  Neural and optical attenuation limits the high spatial frequency CS.  Point where the CSF cuts the x axis is called cut off frequency.
  • 10. MICHELSON FORMULA:  L max- Lmin/Lmax+Lmin  Lmax = Luminance on the lighter surface  Lmin = Luminance on the darker surface WEBERS FORMULA: Defined as ( Lb – Lt ) / Lb  Lb & Lt are the luminance of the background and target respectively.  Weber contrast used in calculating the contrast of letters.
  • 12. • The modulation transfer function (MTF) indicates the ability of an optical system to reproduce (transfer) various levels of detail (spatial frequencies) from the object to the image. • Its units are the ratio of image contrast over the object contrast as a function of spatial frequency. • It is the optical contribution to the contrast sensitivity function (CSF).
  • 13. MTF: Cutoff FrequencyMTF: Cutoff Frequency 0 0.5 1 0 50 100 150 200 250 300 1 mm 2 mm 4 mm 6 mm 8 mm modulationtransfer spatial frequency (c/deg) cut-off frequency 57.3 cutoff a f λ = ⋅ Rule of thumb: cutoff frequency increases by ~30 c/d for each mm increase in pupil size
  • 14.  One adjacent pair of light and dark bars makes up one cycle.  The thickness of the grating is described by their spatial frequency in cycles per degree of the visual angle at the eye..  Large number of grating can fit with in a degree of visual angle
  • 15.  Gratings are broader and are of low spatial frequency.  Spatial phase defines its position.  Change in spatial phase by 180 degrees indicates that the grating is displaced by half a cycle.
  • 16.  These gratings are lacking in sharp borders.  Sinusoidal gratings are used because they are not subject to defocus, aberration,diffraction, light scatter.  Only the contrast and spatial position are affected.
  • 17.  square-wave gratings have characteristics like a square such as sharp edges.
  • 18.
  • 19.  1. Spatial contrast sensitivity  2. temporal contrast sensitivity
  • 20.  Detection of striped pattern at various levels of contrast and spatial frequency.  Sine wave gratings of parallel light and dark bands.  Measured with stationary gratings  width of the bar is defined as spatial frequency  High spatial frequency- narrow bars.  low spatial frequency- wide bars.
  • 21.  The spatial frequency increases exponentially from left to right. The contrast also varies logarithmically from 100% at the bottom to about 0.5% at the top
  • 22.  Temporal contrast sensitivity is measured with gratings that reverse contrast at various rates over time.  here contrast sensitivity function is generated for the time related processing in the visual system by presenting a uniform target field modulated sinusoidal in time.  Both the system provides more complete and systemic data on the status of visual performance.
  • 23. The shape of the contrast sensitivity function varies with factors:  Luminance  Target size  Grating motion  Grating shape
  • 24.  Have problems with night driving, including inability to see traffic lights  May require extra light to read  Their eyes may become tired when they read or watch television  Not being able to see spots on clothes, counters, or dishes  Missing facial gestures
  • 25.  There are three variables in measurement of contrast sensitivity: 1. Average amount of light reflected depends on illumination of paper and darkness of ink. 2.Degree of blackness in relation to white background that is contrast. 3. The distance between the grating periods of cycles per degree of visual angle.
  • 26.  The various methods available to measure CS include  Pelli Robson test  Bailey Lovie chart  Vision contrast test system (VCTS) by Vistech  Cambridge low contrast grating  Regan charts  FACT charts
  • 27.  letters of the same size but with reducing contrast  two charts and two scoring pads.  Each chart has 6 letters in each row organized into two triplets of varying contrast.  illumination of the chart is 85 cd/mm2  1 meter distance
  • 28.  The score of the test is recorded by the faintest triplet out of which at least 2 letters are correctly identified.  The log CS value for this triplet is given by the number on the scoring pad.
  • 29.  It is a rapid and simple screening test for contrast sensitivity.  Performed at a distance of 6m.  It comprises of 12 pair of plates consisting of stripes of varying contrast.  First one is for demonstration and rest are for the proper testing and are numbered from 1-10.
  • 30.  The plates are changed sequentially starting from plate 1 till the patient fails to respond.  Then a new series is begun starting 4 plates prior to where the patient failed to respond.  Four such series are completed and the score of each series is noted (numbered as per the number of plate read) and added.  The final total value is converted into contrast sensitivity from the provided table.
  • 31.
  • 32.  Low contrast acuity testing & acuity testing in presence of glare.  Each row has same no. of symbols & constant spacing is used between rows & letters.  Chart is logarithmic based & visual acuity is based on log of minimum angle of resolution or logMAR.  Berkely Glare Test provides 10% of contrast & is provided with glare source
  • 33.
  • 34.  FACT charts were developed by Dr. Arthur Ginsburg.  FACT comprises of a chart with sine-wave gratings of varying frequencies.  The chart tests five spatial frequencies (sizes) and nine levels of contrast  The Contrast varies in a row, decrease from left to right
  • 35.  And the spatial frequencies increase as one move down the various columns from top to bottom.  This test is performed at a distance of 10 feet.  The patient determines the last grating seen for each row (A, B, C, D and E) and reports the orientation of the grating: right, up or left.  The last correct grating seen for each spatial frequency is plotted on a contrast sensitivity curve.
  • 36.
  • 37.  Introduced in 1978.  Consists of a booklet containing several sine wave gratings patterns  Each grating is oriented vertically  The contrast varies from the top to the bottom of the grating, lowest at the top and highest at the bottom.
  • 38.  These charts consist of sine wave gratings. Each chart contains five rows and nine columns of circular photographic plates (disc) on gray background.  Each row has different spatial frequency (1.5 to 18 c.p.d. at three meters) and contrast within the row reduces from left to right.  The gratings are presented in three orientations: vertical 90 degrees, 15 degrees clockwise or anticlockwise.
  • 39.
  • 40.  Two separate Vistech charts are available: the VCTS-6500 for distance testing and the VCTS- 6000 for near testing.  A projector slide the VCTS-500S is also available.  A luminance of between 103 and 240cd/m2 is recommended.  It can be used to document the performance of low vision patients.
  • 41.  Consists of three letter charts, printed on white cardboard having contrast of 97%, 7% and 4%  3 meter with eight letters in each line  Patients are instructed to start at the top and to continue reading until they can correctly identify no letters on a line.  For one chart letter size goes on reducing and contrast remains constant  Regan in 1988 suggested there chief role in detecting early visual loss in diabetes and glaucoma.
  • 42.
  • 43. 1. refractive errors. 2. age 3.cataract 4.contact lenses 5.refractive surgery. 6.glaucoma. 7.diabetic retinopathy. 8.optic neruopathies 9.pituitary adenoma. 10.drugs. 11.toxic chemicals
  • 44. Refractive errors:  Uncorrected refractive disorders manifest themselves as a decline in contrast sensitivity first at smaller grating sizes or higher spatial frequencies for mild refractive disorders.  As the degree of refractive disorder increases, contrast sensitivity declines at the middle and then larger grating sizes (middle to lower spatial frequencies).
  • 45.  Measurements were made at distance (with Vistech charts), at near (with Arden gratings), and with a pinhole to control pupil size.  Under all conditions, when visual acuity was reduced by spherical lenses, there was a loss of contrast sensitivity over a broad range of spatial frequencies. Ophthalmology 1988 Jan;95(1):139-43. Eeffectof visual blur on contrast sensitivity. Clinical implication Marmor MF, Gawande A
  • 46. Age:  There occurs a definite decrease in contrast sensitivity with increasing age.  The pathogenesis of this decline in vision is likely involves changes in the spherical aberration of the crystalline lens
  • 47.  As the aperture of lens increases the average focal point move towards the lens so that a larger pupil produces greater spherical aberration  Spherical aberration of cornea changes little with the age of the people.
  • 48.  Total wavefront aberration of the eye increases more than threefold, between 20 to 70 years of age.  the aging lens loses its balance with the cornea, because both the magnitude and sign of its spherical aberration change significantly.  A loss of balance between corneal and lenticular spherical aberration causes the degradation of optical quality in the aging eye.
  • 49.  Monocular and binocular contrast sensitivity function for a range of spatial frequencies was measured in two groups of subjects with normal vision.  In the age range 50-87 years there was a linear decline in contrast sensitivity with age for medium and high spatial frequencies, but sensitivity for low spatial frequencies was independent of age. Effect of age on contrast sensitivity function: uniocular and binocular findings  J E Ross D D Clarke and A J Bron. 
  • 50. Cataract:  Early cataracts generally cause contrast sensitivity losses similar to refractive disorders at higher spatial frequencies.  The addition of glare source will exacerbate the results for patients with cataract, producing lower contrast sensitivity at some or all grating sizes
  • 51.  significant loss of contrast sensitivity at all spatial frequencies with increasing cataract severity. Contrast sensitivity was significantly reduced at high spatial frequency (18 cpd) in cortical cataracts in the presence of glare in day light and at low spatial frequency (3 cpd) in night light.  Contrast sensitivity scores may offer additional information over standard VA tests in patients with early age-related cataracts.   Ophthalmic Vis Res. 2011 January; 6(1): 26–31.  Effect of Cataract Type and Severity on Visual Acuity and Contrast Sensitivity Javad Heravian Shandiz MSc, PhD,1 Akbar Derakhshan MD,2
  • 52. Contact lenses:  to ensure proper contact lens fit as well as determining when replacement is necessary.  Uncorrected residual astigmatism from soft contact lens can result in decrease contrast sensitivity at the middle and higher spatial frequencies when compared to hard contact lenses.
  • 53.  study concluded that those female professional and collegiate tennis players wearing no corrective lenses were significantly higher in CS at intermittent and high spatial frequencies than those who wore daily-wear soft contact lenses in competition. Kluka, D.A. and Love, P.A. “Effects of Daily – Wear Contact Lenses Upon Contrast Sensitivity in Selected Professional and Collegiate Female Tennis Players,” UBA at Birmingham
  • 54.  Glaucoma: Glaucoma can reduce contrast sensitivity for all grating sizes, a number of studies shown reduce contrast sensitivity mostly at the middle spatial frequencies.  study was carried out to explore the effects of glaucoma on low-spatial-frequency contrast sensitivity by using tests designed to assess performance of either the magnocellular (M) or parvocellular (P) visual pathways. Sensitivity was reduced foveally and in the midperiphery across the spatial frequency range. In the area of early visual field loss, the glaucoma group demonstrated further sensitivity reduction across the spatial frequency range.
  • 55.  The low-spatial-frequency-sensitive channels of both pathways, which are presumably mediated by cells with larger receptive fields, are approximately equivalently impaired in glaucoma.  Contrast sensitivity changes due to glaucoma and normal aging: low-spatial- frequency losses in both magnocellular and parvocellular pathways.  McKendrick AM Sampson GP, Walland MJ, Badcock DR  Invest Ophthalmol Vis Sci.2007 May;48(5):2115-22
  • 56.  IOLs  A study was carried out to evaluate the contrast sensitivity at near and distance after MFIOL implantation in 21 patients. A control group with monofocal iol was also studied. CS measured after 1,3,6,12,and 18 months after IOL.
  • 57.  multifocal In patients with unilateral cataract, monofocal, accommodating and partially diffractive multifocal IOL provided higher CS scores when compared with refractive IOL. Clinical and experimental ophthalmology Differences in contrast sensitivity between monofocal, multifocal and accommodatingintraocular lenses: long-term results Cem Mesci MD, Hasan H Erbil MD, Ali Olgun MD, Nihat Aydin MD, Article first published online: 3 NOV 2010 DOI: 10.1111/j.1442- 9071.2010.02357.
  • 58. Diabetic retinopathy:  In diabetic retinopathy patients, contrast sensitivity loss may occur for all grating sizes.  a study was carried out to evaluate contrast sensitivity (CS) and visual acuity (VA) in detecting functional losses in participants with type 2 diabetes.  LogMAR VA and letter CS were measured on 20 type 2 diabetic and 24 age-matched control participants. The diabetic participants were sub-grouped according to the level of retinopathy present.
  • 59. RESULTS:  Letter CS was able to distinguish those participants with and without macular oedema and those with no or minimal diabetic retinopathy from the control group, whereas VA was not. Clinical optom 2003 May;86(3):152-6 Letter contrast sensitivity changes in early diabetic retinopathy Stavrou EP, Wood JM
  • 60. Optic neuropathies:  A variety of optic neuropathies including afferent pupillary defect, optic neuritis, and multiple sclerosis will affect contrast sensitivity losses over some or all grating sizes.  Multiple sclerosis can sometimes affect only middle sizes.
  • 61. Pituitary adenoma:  Pituitary adenoma has been shown to cause contrast sensitivity loss at the middle grating sizes.
  • 62.  Cases report was made by neuroophthalmological examination in two patients with parasellar pituitary adenoma before and after surgery.  The twelve months follow-up of visual dysfunction includes standard Snellen visual acuity and low contrast number visual acuity.
  • 63.  The presented cases indicate that the low contrast acuity tests in patients with parasellar pituitary adenoma are sensitive indicators.  The loss of low contrast visual acuity improved after surgery as did other visual measures, except in cases with significant low contrast deficit at 1.5% contrast. Kruzer, A.R. (1986) “ Contrast Sensitivity Signals Pitutary Adenoma,” Rev. Of.Opt. 123(4), 119
  • 64. Toxic Chemicals:  Several occupational studies have indicated that chronic, airborne exposure adversely affects neurobehavioral functions in workers, particularly visual color discrimination and tasks dependent on rapid visual-information processing Frenette, B.,Mergler, D. And Bowler, R.(1991) “Contrast Sensitivity Loss in Group of Former Microelectronics Workers with Normal Visual Acuity,” Opt. and Sci.,68(7),.
  • 65.  Why refractive surgery can affect the quality of vision. there are other factors in the eye, which affect vision quality, that are unrelated to eye focus. These factors can cause the quality of vision to vary greatly, even when a patient has 20/20 or better acuity. Contrast sensitivity is the best method for quantifying the quality of vision