Central Dogma of Molecular Biology states that, Genetic Information is unidirectional, detailed and residue-by-residue. However, Prions are such an exception which contradicts the statements of Central Dogma Theory

1. A Scientific Seminar Presentation on

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• In 1958and It was re-statedin Nature journal in 1970
• The word “ ” = Something that is
“ ”
• It deals with the detailed, sequential & residue-
by-residue transfer of genetic information, i.e. –
• And, once getting into the proteins,
Or nucleic
acid.

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In 1982, He isolated
The term was first coinedas –
teinaceous fectious
Particles

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Depending on the
regions of the
brain where the 
- amyloid proteins
are accumulated –
Prion diseases are
as in folowing
figure.

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