In this article we want to provethat inhibition of telomerasethat is reactivated when thetelomeres become tooshort, the scientists plan to usethis, for cancer treatment, as itwas shown to be more effectivefor combat malignanttumors, avoiding damage toharmless cells.
During each cycle of cell division, small portions of the ends of chromosomes are lost in DNA replications. When the telomere gets too short, continuous replication of DNA could completely remove the telomeres, giving rise to genomic instability resulting in a deterioration of the cell even lead to death.
Scientists have thought that telomere length is a key indicator of cancer risk, we have identified links between telomere length and cancer mortality.They found a doubling of cancer death with each decrease of telomere length.
This news was thought as a possible cure for patients with heart disease •The researchers successfully modified stem cells in the laboratory with PIM-1, a Protein That Promotes cell growth and survival growth, rejuvenation Allowing modified by the activity of cells mother, by the enzyme telomerase Achieved Which extends the length of telomeres.
• Stem cells can be used tocounteract the aging processof cardiac cells caused bydegradation of the telomere.•Studies in mice and pigs intheir cells with lengtheningof telomeres leads to newgrowth of heart tissue cangrow in four weeks
It is considered as a viable treatment, make a modification heart cells to regenerate heart muscle has been damaged by causes such as ischemia and that also is overgrown. Currently, this patient may be offered stem cell therapies with regenerative potential PIM-1 modification is a significant advance for clinical treatment. "
MEDICAL UTILITY These advances in genetic research have brought the opportunity to detect early disease and can also be complemented by prevention.
MEDICAL UTILITY FIGHTING CANCER BY INHIBITINGTo discover that over time and that our body is constantly regenerating causes shortening of telomeres size, becoming more susceptible to suffer from cancer. This encourages us some peace when we get older.
MEDICAL UTILITY AGING HEART CELLS REJUVENATED BY MODIFIED STEM CELLS With the discovery of this new protein PIM-1 and utility of heart cells modify these cells affected mothers, provide a broad spectrum of life, provided a new alternative for the treatment of cardiovascular diseases.
BIBLIOGRAPHY MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7. ed. Medellín: UPB. Fac. de Medicina, 2012.68-73 p. -Pal. E. Fighting Cancer by InhibitingTelomerase.ThetripleHelixonline [Internet journal] 2012 Jul [access 12 of July of 2012]. Available: http://triplehelixblog.com/2012/07/fighting-cancer-by- inhibiting-telomerase/ - Khan M. Wallach K. Aging heart cells rejuvenated by modified stem cells. ScienceDaily[Internet journal] 2012 Jul [access 23 of July of 2012].Available: http://www.sciencedaily.com/releases/2012/07/120723 171843.htm
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