C R I T I C A L PAT H W AY I N C E L L
C YC L E M AY L E A D TO
C A N C E R D E V E L O P M E N T
A N D
C E L L S M A K E C O S T U M E
C H A N G E S F O R C A R D I AC
R E G E N E R AT I O N
Lina Acevedo Forero
Now days the genetic engineering in human is not approved by
ethical commite; most of the studies are in others animals but not
in our spicie.
Thats why sometimes is difficult to use techniques that help the
human health because they are only demostrate in other
The techniques that transfer genetic material have a vital
importance for the study of certains pathologies. These
techniques are helping the medicine world, finding cures for some
These news are giving us hopes about the future of patients with
cancer or heart attack.
CRITICAL PATHWAY IN CELL CYCLE MAY
LEAD TO CANCER DEVELOPMENT
The investigators already gave us a hard
concepts about the process that explain the
defense mechanism against uncontrolled
growing of cells.
The main objective conduce to discover the
mechanisms implicated in the failure of celular
g1 step (p53) and telomeres, and develop
strategies for avoid this modifications that is an
importnt part of the cancer development.
Karlseder identified an specific
part of cell cycle called G1 phase
which is altered when a person
develop a tumor. It’s the causative
phenomenon of the uncotrolled
growing of cells and their
subsequently lost – shortening of
telomeres, an important defense
entity that ends in cancer
The investigators also discovered that one and important
guilty of a tumors development is the natural caracteristic
of aging. When the cells get older constantly lost the
telomeres weight and the lost or reduction of this specific
zone is directly involved with cancer.
In conclusion, in this article we
have the most important
explanation of cancer
development (others are
enviroment factors and
“luck”), and now there’s a necesity
of continue studying and creating
solutions to avoid the specific
biological modications showed by
Actually, we are getting the
results of futuristic investigator
visions through molecular biology.
The genome modifications are
possible nowadays, and with
this, all problems in genes have
the risk of be repared.
This is the key of this article, what
explain the route to a new
generation of modifications in
altered proteins, enzimes, or like
this case, in the cell cycle.
This study is showing us how after a
heart attack, the heart is permanently
damaged because of the long-term
interrupted oxygen supply and it tissue
The objective was try to stimulate the
regeneration of damaged heart tissue
and find a way that the results that
they obteined can be also used in
Cells Make Costume Changes for
After a heart attack the heart is damage because coronary
arteries didn´t give it the blood necesary for the normal
In this study the scientist found that muscle cells from a
zebrafish migrate from the undamaged atrium into the
ventricle, trying to regenerate the died tissue.
They didn´t only find the migration of the cells they also
found a clear evidence of transdifferentiation of cells.
The cells that migrates from the atria lost their
characteristic properties and transformed into
“With the progression of heart regeneration, these cells
were permanently installed in the muscle tissue and
made their contribution to the restoration of cardiac
After a long study the scientist found that the
zebrafish heart was in good conditions after a
heart attack, thanks to the migration and
transdifferentiation of atrium cells to ventricle
Im very impressed with the results
of this article, because it can be the
future of the cardiology process.
The findings of this studie will help
to persons who had a heart attack
to continue their lives with a
normal heart activity.
This projects show us that
everyday we can know sometime
new about medicine; and that this
science has still thousands of
Firstable, if researchers get a way for stop or repair
mutations directly implicated in altered p53 function –
telomere lenght, it would be analogued with the
cancer cure because its an intervention in a specific
Cancer is a compliated disease with treatment
alternatives based in radiation, chemical drugs
or ablation surgery, all this affects and
destroys tumoral cells but also beat directly
benign body cells too, becoming a heavy
therapy for patients. The new medicaments
based in article theory, would work before
cancer development and would avoid the
growing in big masses, more complicated for
treat, and without the comorbilities caused for
treatment used for destroyd tumors when are
This study is talking about problems with the heart , that in the
present are becoming a pandemic.
If the migration of atrium cells is demostrate in human
heart, the medicine will have a change in cardiology area.
This can be the solution for those who have diseases after a
heart attack because of the unusual activity of the heart.
The findings obtained in this study
give us hopes; if the atrium cells
can can have the properties of
ventricular cells in humans, those
changes will help the damaged
heart tissue after a herat attack to
behave normal. And this can
completely change the life of
these kind of patients.
· MARTINEZ SANCHEZ, Lina Maria . Bilogia Molecular. 7. ed.Medellin:
UPB. Fac. de Medicina, 2012.
· Critical Pathway in Cell Cycle May Lead to Cancer
Development, Molecullar cell. July 11,2013.
· Cells make costume changes for cardiac regeneration, Maxn-Planck-
Gesellschaft. July 11, 2013.