6. Betaβ cellsCentral
Pe
in Thymus, many autologous protein antigens
are processed and presented by thymic APCs.
Any immature T cell that encounters such a
self antigen undergoes apoptosis
elf
Some
nto
7. Betaβ cellsCentral
Pe
Not all immature T cells that see self
antigens in the thymus are deleted. Some
CD4+ T cells survive and develop into
regulatory T cells
cells to
ergo
8. Betaβ cellsCentral
Pe
in Bone Marrow, reactive Immature B cells to
self antigens with high affinity undergo
Apoptosis or Receptor Editing.
sent in
nce
such
hery.
9. Betaβ cellsCentral
Pe
However, Not all self antigens are present in
the Thymus or Bone Marrow, & hence
lymphocytes bearing receptors for such
autoantigens escape into the periphery.
11. Betaβ cellsAnergy
functional inactivation rather than Apoptosis
of lymphocytes that is induced by encounter
with antigens under certain conditions
Suppression
Deletion
12. Betaβ cellsSuppression
By Treg cells, their inhibitory activity mediated
by immunosuppressive cytokines which inhibit
lymphocyte activation & effector functions.
Deletion
Deletion
13. Betaβ cells
T cells that recognize self antigens may receive
signals that promote their death by apoptosis.
Deletion
Deletion