2. Contents
SOEPEL
Anatomy
Introduction of Cholelithiasis
Characteristics and composition
Clinical features
Pathophysiology
Diagnosis and investigations
Treatment
References
3. SOEPEL
Subject :
Mr. B is a middle age. He has abdominal pain in right upper quadrant after a
fatty meal. Also the pain radiating to the R scapula and causes nausea.
additionally, it come suddenly.
6. INTRODUCTION
Definition.
CHOLELITHIASIS refers to presence or formation of gallstones in the gallbladder
or bile ducts.
Gallstones are the most common biliary stones.
Overall prevalence of gallstones of 7.9% in men and 16.6% in women
In Acute Cholecystitis gallstones are present in about 95% of cases -calculous cholecystitis.
The exact incidence of acute Cholecystitis among patients who harbor gallstones is not known
but in about 20% of patients who enter a hospital for biliary tract disease have acute
cholecystitis.
7. Characteristics and composition
1. CHOLESTEROL STONES –
- . Cholesterol gallstones usually contain >50% cholesterol monohydrate plus an
admixture of calcium salts, bile pigments, and proteins
2. PIGMENT STONES
Composed almost entirely of calcium bilirubinate. They are mostly small,
black and multiple. Some are hard and coral like, others are soft and really
concretions of sludge rather than stones.Two types
Hemolysis and liver disease are associated with the black stones;
the brown, earthy stones more frequently are formed outside the gallbladder and
often are associated with bacterial infections of the biliary tract
8. Cont….
3. MIXED STONES
Cholesterol is the major component. Other components includes
calcium bilirubinate, calcium palmitate, calcium carbonate, calcium
phosphate and proteins. They are usually multiple and often they are
faceted.
.
9. Clinical features
Gallstones may cause no signs or symptoms. If a gallstone lodges in a duct and
causes a blockage, signs and symptoms may result, such as:
Sudden and rapidly intensifying pain in the upper right portion of your abdomen
Sudden and rapidly intensifying pain in the center of your abdomen, just below your
breastbone
Back pain between your shoulder blades
Pain in your right shoulder
10. Pathophysiology
• Cholesterol gallstones develop when bile contains too much cholesterol and
not enough bile salts.
• ncomplete and infrequent emptying of the gallbladder may cause the bile to
become overconcentrated and contribute to gallstone formation.
• the presence of proteins in the liver and bile that either promote or inhibit
cholesterol crystallization into gallstones.
• increased levels of the hormone estrogen.
11. Diagnosis and investigations
Ultrasound
Most sensitive and specific test for gallstones
Computerized tomography (CT) scan
May show gallstones or complications, such as infection and rupture of GB or bile ducts
Cholescintigraphy (HIDA scan)
Used to diagnose abnormal contraction of gallbladder or obstruction of bile ducts
Endoscopic retrograde cholangiopancreatography (ERCP)
Used to locate and remove stones in bile ducts
Blood tests
Performed to look for signs of infection, obstruction, pancreatitis, or jaundice
12. Treatment
• Nonsurgical treatment:
• Only in special situations
• When a patient has a serious medical condition preventing surgery
• Only for cholesterol stones
• Oral dissolution therapy
• Ursodeoxycholic acid - to dissolve cholesterol gallstones
• Months or years of treatment may be necessary before all stones dissolve
• Contact dissolution therapy
• Experimental procedure
• Involves injecting a drug directly into the gallbladder to dissolve cholesterol stones
13. Cont….
• Surgery: Cholecystectomy (gallbladder removal)
laparoscopic cholecystectomy has become the "gold standard" for treating symptomatic
cholelithiasis
16. Conclusion
The bile play a major role in the excretion of cholesterol & absorption
of fat sol Vit.
Alteration of bile composition lead to the formation of GS .
Finally GB hypomotility & bile stasis promote GS formation .
