3. Surface Anatomy of Gall Bladder
Right hypochondrium
Transpyloric plane :
horizontal plane
at level of lower
border of L1
vertebral body
Mid-clavicular line
Angle between right
costal margin &
lateral border of
rectus abdominis
muscle
Normally not palpable
4. Calot’s Triangle
Boundaries :
Lateral : cystic duct, gall
bladder
Medial : common hepatic
duct
Above : inferior surface of
right lobe of liver
Contents :
Right hepatic artery
Cystic artery
Cystic lymph node of
Lund
5. Anatomy of Cystic Duct
About 3 cm long (variable),
1 to 3 mm diameter
Joins common hepatic duct
(80%) to form common bile
duct(CBD)
6. Anatomy of CBD
About 7.5 cm long, about 6 mm in
diameter
4 parts :
1.Supraduodenal : 2.5 cm long, on free
edge of lesser omentum
2.Retroduodenal : behind first part of
duodenum
3.Infraduodenal : on posterior surface or
through part of the pancreas
4.Intraduodenal : opens in second part
of
duodenum, surrounded by sphincter of
Oddi
Ends on summit of the ampulla of
Vater
7. Sphincter of Oddi
Muscular valve that
controls the flow of
digestive juices (bile and
pancreatic juice)
through the ampulla of
Vater into the
second part of the
duodenum.
8. Blood Supply of GB
Cystic artery, a branch of right hepatic artery
Rarely, cystic artery arise from common hepatic
artery
Gall bladder may also get accessory artery from
gastro-duodenal artery
9.
10. Lymphatic Drainage &
Nerve Innervation
Lymph drains into cystic lymph node of Lund
in Calot’s triangle, from there it drains into
liver hilar lymph nodes & coeliac lymph nodes
Parasympathetic from Vagus nerve (CN X)
- maintain tone & contractility
Afferent sympathetic fibres mediate pain of
biliary colic
12. At Liver :
Bile production : 97% water, 1 to 2% bile salts,
1% bile pigments, cholesterol, calcium & fatty acids
Excretion : about 40 mls/ hour (about 1 L/ 24 hours)
At Gall Bladder : 3 main functions
Reservoir for bile : during fasting
Concentration of bile : 5 to 10 times, by active
absorption of water
Mucin secretion : about 20 ml/hr
Vagus & Cholecystokinin (CCK) cause GB contraction,
sphincter of Oddi relaxation - bile excreted
16. Plain Xray Abdomen :
Only 10% of gall stones are radio-opaque
Some gall bladders may be calcified (porcelain)
Gas in bile ducts (aerobilia) – ERCP/infection
17. Ultrasonography (USG)
Most important initial imaging
Safe, painless, accurate, convenient,cost-effective & readily available
Gallstones, gall bladder,thickness of gall bladder wall & surrounding
inflammation
Biliary stones,size of ducts & sometimes
stones in common bile duct & growth in pancreas
18. CT & MRI Scans
Computed Tomography (CT) :
Useful for detecting liver & pancreas lesion
Staging of liver, bile duct, pancreatic cancers;
check for enlarged lymph nodes
Only 75% gallstones seen on CT, not for screening
Magnetic Resonance Cholangio-Pancreaticogram
(MRCP) :
Imaging of gall-bladder & bile ducts
Can show bile duct obstruction, stricture &
other intraductal abnormalities
21. Gallstones (Cholelithiasis)
About 10 to 15% of adults have gallstones but
80% are asymptomatic; females 4 : 1 male
Every year about 1 to 2% of asymptomatic cases
will develop symptoms requiring surgery
Classical teaching :
Fat
Fertile
Flatulent
Female of
Forty
22. Stone Formation
Bile salts & Lecithin
Keep cholesterol in solution
When stability is lost
due to excess cholesterol
& reduced bile salts &
lecithin gallstones form
(lithogenic bile)
24. Cholesterol stones
Contain up to 99%
pure cholesterol
Supersaturation with
cholesterol
Usually large, yellowish
Single or a few
25. Pigment stones
Stones having less than 30% cholesterol
Two types : black & brown
Black pigment stones (20 to 30% of stones) :
Associated with haemolysis, usually hereditary
spherocytosis or sickle cell disease & liver cirrhosis
26. Brown pigment stones
Rare in gall bladder; form in bile ducts &
related to bile stasis & infected bile
Also associated with foreign bodies within bile
ducts, eg. endoprosthesis (stents)
27.
28. Complications of gallstones
Biliary colic
Acute cholecystitis
Chronic cholecystitis
Acute pancreatitis
Mucocoele of GB
Empyema of GB
Perforation of GB
Obstructive jaundice
Acute cholangitis, liver abscess
Mirizzi’s syndrome
Intestinal obstruction (gallstone ileus)
Carcinoma of gallbladder
33. 1.Acute Cholecystitis & biliary colic
Mostly associated with cholelithiasis
95% gall stone found impacted in
Hartmann’s pouch or cystic duct
Types of gall stones :
mixed stones – commonest,
multifaceted
pure cholesterol stones – round, single, large
pigment stones – black/ brown, irregular,
hard
Bacteria : Usually Gram-negative aerobes,
eg. Escherichia coli, Klebsiella, Streptococcus
faecalis
Rarely : Bacteroides & Clostridia (gas in
biliary tree)
35. Pathophysiology
Stone obstruct bile outflow
Distension & ischaemia of gall
bladder
Mucosa damaged by lysolecithin
or trauma by stone
(chemical cholecystitis)
Secondary bacterial infection
(septic Cholecystitis)
Sequelae :
Stone slip back into gall bladder with
relief of obstruction & inflammation
subsides (Biliary colic)
Empyema of gall bladder
Gangrene & perforation of gall bladder
with localised abscess/ diffuse peritonitis
(mortality rate of 50%)
36. Clinical Features
Sudden onset of right hypochondrial pain
Fever, nausea, vomiting
Tenderness & guarding over right hypochondrium
Boas’s sign : area of hyperaesthesia between right
9th & 11th ribs posteriorly
Murphy’s sign : sudden holding of breath on deep
palpation of right hypochondrium
44. Treatment
Initially : conservative followed by
cholecystectomy
Nil by mouth,Naso-gastric
aspiration,
Analgesics, antibiotics,
intravenous fluids to replace &
correct electrolytes & fluids losses
Cholecystectomy
preferably laparoscopic done 2 to
3 days after initial treatment
(within 5 to 7 days of onset of
infection; otherwise delay 6
weeks)
45. 2.Chronic Cholecystitis
Shrunken, scarred, fibrotic with
thickened wall
Adhesions to surrounding
structures
Due to repeated inflammation &
mechanical irritations
Clinical features :
Chronic recurrent right
hypochondrial pain;
Nausea & vomiting, abdominal
fullness especially
precipitated by fatty foods
Flatulent dyspepsia, belching &
heartburn
Murphy’s sign may be positive
46. Management
Conservative
Chemical dissolution of stones
using Chenodeoxycholic acid or
Ursodeoxycholic acid
can be tried in elderly patients
Lithotripsy usually not done due
to poor success rate or
recurrence
Surgery - cholecystectomy
Laparoscopic cholecystectomy
treatment of choice
Open cholecystectomy through
Kocher’s (right hypochondrial)
incision
47. 3.Bile Duct Stones (Choledocholithiasis)
Charcot’s triad :
pain, jaundice (obstructive) & fever
Obstruction to outflow of bile leads
to stasis & infection
Jaundice
Ascending cholangitis
50. 5.GB Polyps
A gallbladder polyp is a small,
abnormal growth of tissue with a
stalk protruding from the lining of
the inside of the gallbladder. They
are relatively common.
95% benign, rarely cancerous
Gallbladder polyp size is often an
indication of the presence of cancer:
less than <10mm in diameter —
are typically benign don’t need
to be treated.
larger than >10mm inch in
diameter have a greater
likelihood of being or becoming
malignant.
52. Gall bladder polyp treatment
Asymtomatic
RHC pain & tenderness
Nausea
Vomiting
No treatment
Regular follow up
Cholecystectomy
Symptoms Treatment
53. 6.Gallbladder cancer ●● Very rare
Elderly women above 60 years
old
●● Similar presentation to
gallstones
●● Diagnosis by ultrasound, CT,
●● Most patients present with
advanced disease
●● Surgical resection in less than
10% palliative treatment
●● Prognosis is poor – median
survival approximately 6 months
Cholecystectomy for any gall-
bladder polyp more
than 1 cm diam.
54. 7.Cholangiocarcinoma
Uncommon malignancy
Elderly, more than 65 years old
Adenocarcinoma from extrahepatic
bile ducts
Higher risk with primary sclerosing
cholangitis, hepatolithiasis, hepatitis C,
ascending cholangitis,
choledochal cyst, Caroli’s disease
Locations :
Intrahepatic : 10 to 20%
Hilar cholangiocarcinoma or Klatskin tumours : 60%
Distal bile duct : 20 to 30%
Klatskin 60%
10-25%
20-30%
55. Cholangiocarcinoma
Clinical features :
Jaundice, abdominal pain, early satiety, cachexia
Slow-growing, local invasion & lymphadenopathy
Treatment
Mostly inoperable, 10 to 15% can have radical
resection & reconstruction of bile ducts
Whipple’s operation for distal bile duct tumours
Liver transplant
Limited role of chemotherapy/ radiotherapy
56. “ Courvoisier’s Law”
“ In the presence of obstructive jaundice, a palpable
gall bladder is usually NOT due to gall stone
obstruction of common bile duct ”
Most probably it is due to
Ca head of pancreas
Periampullary tumour
Cholangiocarcinoma
Why?
Gall bladder is usuallyfibrotic & contracted
in chronic cholecystitis with stones,
BUT there can be exceptions
62. Complications of Cholecystectomy
Bleeding
Infection, cholangitis, abscess,
septicaemia
Bile duct injury, bile leakage, duct
stricture
Retained stone
Obstructive jaundice
Acute pancreatitis
After laparoscopic
cholecystectomy :
access complications during
creation of
pneumo-peritoneum:
puncture vessel, bowel, etc.
or bile duct injury
63.
64. TOUCH creates a healing bond
in health care
The TOUCH provides the utmost needed by the sick
- Reassurance -