This document contains the curriculum vitae of Kun Yang. It summarizes his education, research experience, publications, conference presentations, honors and awards. Yang received a B.S. in Biotechnology from Beijing Normal University in 2006, and is currently pursuing a Ph.D. in Pathobiology at Brown University, with a focus on epigenetic regulation of bone development and osteoarthritis. His research has identified miR-365 and the Ihh signaling pathway as critical regulators of bone mineral density and osteoarthritis.

1. Kun Yang
395 Angell Street, Apt 108
Providence RI 02912
H +1 (401) 580 3182
B kun_yang@brown.edu
Education
September
2009–present
Ph.D. in Pathobiology, Brown University, Department of Orthopaedics, Providence, RI, .
September
2006–June
2009
Sc.M. in Molecular Cell Biology, Beijing Normal University, Department of Cell Biology,
Beijing, China, .
September
2002–June
2006
B.S. in Biotechnology, Beijing Normal University, Department of Biochemistry and
Biotechnology, Beijing, China, .
Research Experience
September
2010–
Present
Graduate Student Research Assistant, Brown University , Providence, RI.
{ Created miR-365 dual-fluorescence switch transgenic mice, discovered the differentiation promotion
function of one epigenetic regulator, miR-365, during development which results in higher bone
mineral density during development but early onset of osteoarthritis during aging
{ Identified Ihh signaling pathway as the most critical pathway regulated by miR-365 which in turn
affecting bone development and osteoarthritis by microarray screening and OMIC data analysis
{ Discovered potential rescue method for osteoarthritis in mice model by oral gavage treatment with
Ihh pathway inhibitor PF-04449913 from Pfizer, Inc
September
2006–June
2009
Graduate Student Research Assistant, Key Laboratory for Cell proliferation and Reg-ulation
Biology of Ministry of Education , Beijing, China.
{ Discovered that Lysophosphatidic Acid is a key regulator to induce expression of hTERT and
telomerase activity in ovarian cancer cell lines through HIF-1? pathway
{ Investigated potential diagnosis markers for breast cancer with patient serum
{ Identified PP2A scaffolding subunit PR65 alpha isoform as a telomerase binding protein using
yeast-two-hybrid method
September
2005–June
2006
Student intern for Undergraduate Thesis, Beijing Normal University, Beijing, China.
{ Screened effective small molecule telomerase inhibitors from efficient components of Chinese Drugs
with telomere repeat amplification method
September
2004–June
2005
Project leader of Undergraduate Research Project, Beijing Normal University, Bei-jing,
China.
{ Extracted and analyzed the efficient compounds, phenylethanoidg lycosides, in Chinese drugs with
cultured Herba Cistanch tissues after optimizing the culture condition for Herba Cistanch tissues
Publications
Kun Yang, Yingjie Guan, Yupeng Chen, et al. "Endochondral Regulation of Bone Mass by
a Mechanically Sensitive MicroRNA Inducing Hedgehog Signaling", Submitting to Gene and
Development. 2014.
Kun Yang, Yun Gao, Qian Chen. "MiR-365 promotes the onset of osteoarthritis in vivo by
up-regulating cellular senescence through repressing Wnt2 signaling", Manuscript in prepara-tion.
2014.
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2. Kun Yang, Jason T Machan, Qian Chen. "Droplet Digital PCR facilitates accurate estima-tion
of transgene copy numbers which is essential for creating FloxP mice", Manuscript in
preparation. 2014.
"Orthopaedic Internal Medicine (In Chinese)". People’s Public Health Publisher, Co-author
2013
Yupeng Chen, Kun Yang. "Intra-Articular Drug Delivery Systems for Arthritis Treatment",
Rheumatology. 2012; 2:2.
Kun Yang, Danhua Zheng, Xiaoli Deng, Lin Bai, Yan Xu, and Yu-Sheng Cong. "Lysophos-phatidic
Acid Activates Telomerase in Ovarian Cancer Cells Through Hypoxia-Inducible
Factor-1a and the PI3K Pathway", J Cell Biochem. 2008;105(5):1194-1201.
Kun Yang. "Evolutional Genomics", Bulletin of Biology. 2006; 41(12): 60-61
Xuanhe Li, Kun Yang. "Inducer affects Paclitaxel production in Taxus cells", Bulletin of
Biology. 2006; 41(6): 55-57
Kun Yang, Zhihao Jiao, Genfa Zhang. " Research progress and application prospect on
tissue culture of Herba Cistanch", Chinese Traditional and Herbal Drugs. 2006; 37(1): 140-
143
Conference Abstracts
Kun Yang, Yun Gao, Wentian Yang, Qian Chen. ORS Podium Presentation. 2015.
Control # 2015–ORS.
Yun Gao, Kun Yang, Qian Chen. ORS Poster Presentation. 2015. Control # 2015–
ORS.
Rajiv Iyengar, Kun Yang, Yun Gao, Zehong Yang, Wentian Yang, Qian Chen. ORS Poster
Presentation. 2015. Control # 2015–ORS.
Kun Yang, Wentian Yang, Qian Chen. ORS NIRA Winner. 2014. Control # 2014-A-
2913-ORS.
Mariana Miranda, Nan Shen, Kun Yang, Liangjun Li, Dongye Zhang, Minyi Hu, Qian Chen,
Yi-Xian Qin. ORS Poster Presentation. 2014. Control # 2014-A-11071-ORS.
Kun Yang, Alex Han, Qian Chen. ORS Podium Presentation. 2013. Control ID:
1482486.
Kun Yang, Qian Chen. ORS Podium Presentation. 2012. Control ID: 1214072.
Qian Chen, Kun Yang. ASBMR Poster Presentation. 2012. ID: A12009611.
Kun Yang, Qian Chen. ORS Poster Presentation. 2011. ID: 934545.
Honors & Awards
{ 19th Annual Hospital Research Celebration 1st Place Winner in translational research
(RIH) 2014
{ Annually Program Retreat Poster Competition 2nd Place Winner (Brown University) 2014
{ New Investigator Recognition Awards Grand Prize Winner for Orthopaedic Research Soci-ety
(ORS) 2014
{ Chinese Scholarship Council fellowship 2011
{ Orthopaedic Pre-doctoral fellowship 2011
{ University Scholarship for Outstanding Students 2004 & 2005
{ University Excellent Leadership Award 2003
{ Department Excellent League Member 2003
{ The Best Advocator in Campus Debate 2003
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3. Qualifications
Laboratory Creating transgenic mice, microCT, FACS, Real time PCR, Omics data analysis for RNA
and epigenetics, IPA analysis, Western blot, In situ hybridization, Immunohistochemistry,
Cell culture, mice and rat breading, handling and oral gavage, Surgical mice/rat model for
osteoarthritis, Imaging photograph, Histology staining, X-ray scanning, gene promoter or 3’
UTR reporter construction, and yeast two hybrid protein protein binding analysis
Computer
Skills
Proficiency with R and Bioconductor, Microsoft Office (Word, Excel, Access, PowerPoint),
Photoshop.
Language English, Chinese Mandarin
Certification SAS Certified Base Programmer Credential for SAS 9
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