ICREA Research Professor David Block argues that a Marxist framing of issues related to language in society can lead to understandings of how the use of language and other semiotic modes is embedded in ongoing political, economic, social and cultural processes, showing how class struggle and class warfare are both materially and discursively constructed.
71st ICREA Colloquium "Intrinsically disordered proteins (id ps) the challeng...ICREA
The unbearable lightness of being (a protein)
Proteins adopt beautiful shapes that enable them to perform an incredible array of tasks. But these wiggly little creatures cannot stay still. Is this a nuisance or a blessing?
After a basic introduction to proteins, Xavier Barril focuses on the implications of protein flexibility for drug discovery. Showing that a rigid representation has been, and continues to be, extremely useful. He will present some of the failures and challenges in introducing a more realistic view, but also how the dynamic perspective is gaining ground thanks to the advances in structural biology and computational chemistry.
Xavier Salvatella discusses where the limit is: can proteins be completely disorganised? Can we study and understand intrinsically disordered proteins from a structural point of view? How can this class proteins perform functions if they have no structure? Why have they evolved? Is it ever going to be possible to modify the function of this class of proteins with small molecules, as we have learned to do with proteins that fold?
72nd ICREA Colloquium "Laws, Chance and Quantum Randomness" by Carl HoeferICREA
The laws of nature could be indeterministic, in the sense that they simply fail to be deterministic. There are numerous examples of determinism-failure even in classical physics. A different idea entirely is that of irreducibly probabilistic laws of nature: laws whose contents are, or entail, putative objective probabilities or chances for events.
In my work I raise concerns about how well we understand the notion of an irreducible probabilistic law in general. I will explain some of these philosophical concerns, and how they motivate interest in the Bohmian approach to quantum physics. I will also discuss the relation between Bohmian quantum mechanics and the theoretical and experimental results of physicists such as Acín, Gisin, Colbeck and Renner.
71st ICREA Colloquium "Intrinsically disordered proteins (id ps) the challeng...ICREA
The unbearable lightness of being (a protein)
Proteins adopt beautiful shapes that enable them to perform an incredible array of tasks. But these wiggly little creatures cannot stay still. Is this a nuisance or a blessing?
After a basic introduction to proteins, Xavier Barril focuses on the implications of protein flexibility for drug discovery. Showing that a rigid representation has been, and continues to be, extremely useful. He will present some of the failures and challenges in introducing a more realistic view, but also how the dynamic perspective is gaining ground thanks to the advances in structural biology and computational chemistry.
Xavier Salvatella discusses where the limit is: can proteins be completely disorganised? Can we study and understand intrinsically disordered proteins from a structural point of view? How can this class proteins perform functions if they have no structure? Why have they evolved? Is it ever going to be possible to modify the function of this class of proteins with small molecules, as we have learned to do with proteins that fold?
72nd ICREA Colloquium "Laws, Chance and Quantum Randomness" by Carl HoeferICREA
The laws of nature could be indeterministic, in the sense that they simply fail to be deterministic. There are numerous examples of determinism-failure even in classical physics. A different idea entirely is that of irreducibly probabilistic laws of nature: laws whose contents are, or entail, putative objective probabilities or chances for events.
In my work I raise concerns about how well we understand the notion of an irreducible probabilistic law in general. I will explain some of these philosophical concerns, and how they motivate interest in the Bohmian approach to quantum physics. I will also discuss the relation between Bohmian quantum mechanics and the theoretical and experimental results of physicists such as Acín, Gisin, Colbeck and Renner.
69th ICREA Colloquium "Everything you always wanted to know about creating a ...ICREA
Why would you, decent and exemplary ICREA researchers, ever want to get involved in the creation of a spin-off company? In this colloquium we will take a stroll on the ‘dark side of science’: its commercial exploitation. The talk aims at covering both the practical and the institutional points of view. To that end, Joan Seoane, who started his own company ‘Mosaic Biomedicals’ in 2012, will share his experience with all of us. And Emilià Pola will present the vision and the position of ICREA as an institution, or in other words, why an institution like ICREA gets involved in such mundane activities.
69th ICREA Colloquium "Everything you always wanted to know about creating a ...ICREA
Everything you always wanted to know about creating a company (but were afraid to ask) - Joan Seoane (ICREA at VHIO)
Why would you, decent and exemplary ICREA researchers, ever want to get involved in the creation of a spin-off company? In this colloquium we will take a stroll on the ‘dark side of science’: its commercial exploitation. The talk aims at covering both the practical and the institutional points of view. To that end, Joan Seoane, who started his own company ‘Mosaic Biomedicals’ in 2012, will share his experience with all of us. And Emilià Pola will present the vision and the position of ICREA as an institution, or in other words, why an institution like ICREA gets involved in such mundane activities.
What can and cannot be said about randomness using quantum physics acínMayi Suárez
It is usually said that quantum physics is, contrary to classical physics, intrinsically random. The intrinsic randomness of quantum physics follows from the fact that it is possible to observe correlations among quantum particles for which there exists no classical and deterministic model. The observation of these correlations, however, requires some assumptions about the setup. In particular, it requires some initial randomness, which makes the whole argument apparently circular.
We discuss how it is possible to relax this circularity and conclude that an intrinsic form of randomness with no classical analogue does exist in the quantum world.
68th ICREA Colloquium "The Worldwide LHC Computing Grid: Riding the computing...ICREA
The World Wide Web was invented at CERN in 1991. Construction of CERN's LHC was approved in 1994. Building the data processing system required by LHC's detectors in 1994 would have costed more than the accelerator itself. CERN and data centres from around the world started collaborating in 1999 to prototype and deploy the LHC Computing Grid, the first planetary scale high performance data processing system, which enabled the discovery of the Higgs boson in 2012. A review will be made of these developments, and their relationship to current areas of interest in data processing, such as "Big Data" and digitally supported collaborative science.
70th ICREA Colloquium "What would Karl say? Two ICREA professors engage with ...ICREA
Although Marxist scholarship in the social sciences and humanities has never entirely disappeared, certainly since the current economic crisis began in 2007/2008 there has been a renewed interest in it. In this colloquium, a sociolinguist (David Block) and a philosopher (Santiago Zabala) discuss what Marxist thought provides in their respective academic activity.
David Block will argue that a Marxist framing of issues related to language in society can lead to understandings of how the use of language and other semiotic modes is embedded in ongoing political, economic, social and cultural processes, showing how class struggle and class warfare are both materially and discursively constructed.
Santiago Zabala will discuss the return to communism as a route to political emancipation, proposing a "hermeneutic communism" which embraces the ecological cause of degrowth and the decentralization of the state bureaucratic system in order to permit independent counsels to increase community involvement.
72nd ICREA Colloquium "What can and cannot be said about randomness using qua...ICREA
What can and cannot be said about randomness using quantum physics
It is usually said that quantum physics is, contrary to classical physics, intrinsically random. The intrinsic randomness of quantum physics follows from the fact that it is possible to observe correlations among quantum particles for which there exists no classical and deterministic model. The observation of these correlations, however, requires some assumptions about the setup. In particular, it requires some initial randomness, which makes the whole argument apparently circular.
We discuss how it is possible to relax this circularity and conclude that an intrinsic form of randomness with no classical analogue does exist in the quantum world.
71st ICREA Colloquium "The unbearable lightness of being (a protein)" by Xavi...ICREA
Proteins adopt beautiful shapes that enable them to perform an incredible array of tasks. But these wiggly little creatures cannot stay still. Is this a nuisance or a blessing?
Proteins are the gooey stuff that makes life possible. They live in a state that is neither solid nor liquid, and their biological functions depend crucially on keeping a balance between order and disorder. However, solid entities are far simpler to understand and we tend to use (and abuse) the rigid body approximation until it breaks. In this colloquium Xavier Barril and Xavier Salvatella will present the issue of protein flexibility from different perspectives, discussing structure and dynamics, and exploring how far we must/can go into the order-disorder spectrum.
After a basic introduction to proteins, Xavier Barril will focus on the implications of protein flexibility for drug discovery. Showing that a rigid representation has been, and continues to be, extremely useful. He will present some of the failures and challenges in introducing a more realistic view, but also how the dynamic perspective is gaining ground thanks to the advances in structural biology and computational chemistry.
C-SAP teaching resources: Teaching race and ethnicity mapping theoriesCSAPSubjectCentre
This resource was produced as part of C-SAP's project "Teaching Race and Ethnicity" http://www.teachingrace.bham.ac.uk/ by Dr Stephen Spencer from Sheffield Hallam University.
How To Kill A Mockingbird Essay. To Kill A Mockingbird Essay TelegraphBeth Retzlaff
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This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
3. An interesting life
Died broke, stateless and relatively unknown.
9-11 people present at his funeral
On the 14th of March [1883], at a quarter to
three in the afternoon, the greatest living
thinker ceased to think. …His name will
endure through the ages, and so also will his
work!“ (Engel’s eulogy at Marx’s funeral, 22
March 1883)
BUT, would he have made a good ICREA?
(see:
http://scholar.google.es/citations?user=I6dIhH
QAAAAJ&hl=eses)
4. Lasting words
All fixed, fast-frozen relations, with their train of ancient and
venerable prejudices and opinions, are swept away, all new-formed
ones become antiquated before they can ossify. All that is solid melts
into air, all that is holy is profaned, and man is at last compelled to
face with sober senses his real conditions of life, and his relations
with his kind. (Marx & Engels, 1948 [1848]: 12)
Hegel remarks somewhere that all great historical facts and
personages occur, as it were, twice. He has forgotten to add: the
first time as tragedy, the second as farce. (Marx, 1972 [1852]: 436)
The ideas of the ruling class are in every epoch the ruling ideas, i.e.,
the class which is the ruling material force of society, is at the same
time the ruling intellectual force. (Marx & Engels, 1998 [1846]: 67)
5. The camera obscura – the world upside
down
If in all ideology men and their circumstances appear upside
down as in a camera obscura, this phenomenon arises just as
much from their historical life-process as the inversion of objects
on the retina does from their physical life-process."
Marx & Engels, 1998 [1845]: 42)
7. Sociolinguistics
What is a sociolinguist?
Sociolinguists study the relationship between language
and society. They are interested in explaining why we
speak differently in different social contexts, and they are
concerned with identifying the social functions of
language and the ways it is used to convey social meaning.
(Holmes, 2008: 1)
Disciplinarity:
Linguistics dominant?
Sociology, Anthropology, Geography, Social Theory …
Political Economy
Semiotics/Multimodality → communicative resources
8. Critical Discourse Analysis (CDA)
The focus is thus not exclusively on discourse as language,
but on semiosis, the processes through which multiple
semiotic modes are deployed or simply emerge in ‘the
inter-subjective making of meaning’ (Fairclough et al, 2010:
220).
A radical view of CDA … emphasises the power behind
discourse rather than just the power in discourse (how
people with power shape the ‘order of discourse’ as well as
the social order in general, versus how people with power
control what happens in specific interactions such as
interviews). (Fairclough, 2015: 3)
9. Class struggle and class warfare
Class struggle as ‘conflicts between the practices of
individuals and collectives in pursuit of opposing class
interests … from the strategies of individual workers
within the labour process to reduce their level of toil, to
conflicts between highly organized collectives of workers
and capitalists over the distribution of rights and powers
within production’ (Wright, 2005: 20–21).
Class warfare: … neoliberal policies from late 1970s
onwards have constituted not only a point of conflict and
struggle but an actual attack on the well-being and
survival of the popular classes’ (Block, 2017).
10. Warren Buffet’s famous line (in
an interview with journalist Lou
Dobbs, CNN, 25/05/16)
BUFFETT: Yeah. The rich people are doing so well in this
country. I mean, we never had it so good.
DOBBS: What a radical idea.
BUFFETT: It's class warfare, my class is winning, but
they shouldn't be.
http://www.cnn.com/2005/US/05/10/buffett/index.html
11. Inequality (private property as
original sin)
The first man who after enclosing a piece of ground,
took it into his head to say, "This is mine," and found
people simple enough to believe him, was the true
founder of civil society. How many crimes, how many
wars, how many murders, how many misfortunes and
horrors, would that man have saved the human species,
who pulling up the stakes or filling up the ditch should
have cried to his fellows: Be sure not to listen to this
impostor; you are lost, if you forget that that the fruits
of the earth belong equally to us all, and the earth itself
to nobody! (Rousseau, 1754 [2004]: 27)
12. Göran Therborn’s (2006) three
types of inequality
vital inequality - basic life and death chances and
individuals and collectives’ relative exposure to life-
threatening natural phenomena, self-inflicted human
conditions and larger human-made disasters.
existential inequality - systems of oppression denying
individuals and collectives their basic human rights, e.g.
patriarchy, slavery, caste systems, racism, religious
persecution, homophobia …
resource inequality - the variable access that individuals
and collectives have to material and symbolic resources
13. Accumulations
Primitive accumulation: ‘historical process of divorcing
the producer from the means of production’ (Marx 1990
[1867]: 875)
Accumulation by dispossession: Activity by governments
and financial institutions which transfers wealth from the
less well-off to the wealthy. Examples:
• the privatisation of state owned and operated
industries and services
• the sale of state-owned assets to private investors
• financial activities such as Ponzi schemes
• massive defaults on mortgages and subsequent home
evictions executed by banks (Harvey, 2010, 2014)
15. La PAH (La Plataforma de Afectados por la
Hipoteca)
Los motivos que sustentan la campaña son sencillos:
nos roban las viviendas y nos condenan a seguir
pagándolas. Nos dejan en la calle y sin alternativa
habitacional. Los bancos, incluso los rescatados, siguen
con su actitud antisocial desahuciando y acumulando
un gigantesco parque de viviendas vacías, vulnerando la
función social de la vivienda. El Gobierno lo ampara: ni
lo detiene ni ofrece soluciones como, por ejemplo, el
alquiler social, paralización de los desahucios, dación en
pago.
http://afectadosporlahipoteca.com/wp-
content/uploads/2013/07/MANUAL-OBRA-SOCIAL-WEB-ALTA.pdf
18. María Dolores de Cospedal (13/04/13)
los acosos/la violencia física y verbal/los ataques a las personas/a
sus viviendas/a sus familias (3) eso no refleja más que un espíritu
totalitario y sectario/ y eso es lo más contrario que hay a la
democracia/ [applause] … tenemos en el recuerdo/y se ha ilustrado
mucho afortunadamente/ como en los años 30 se iba a señalar a las
casas de ciertas personas/por su pertenencia a ciertos grupos
políticos/ étnicos/ culturales/ o religiosos/y decían/están ahí/ y por
tanto tenéis que ir a atacar/pero qué es esto de tratar de violentar
el voto? (1) esto es nazismo puro (1.5) ya sé que esto me lo van a
criticar (1.5) [sonriendo] pero esto es nazismo puro … y este partido
sostiene un gobierno/el gobierno del partido popular de Mariano
Rajoy/que está tramitando una reforma en los cortes
generales/para ayudar de verdad a los que no pueden pagar su
vivienda hoy/porque tienen una situación/que es hoy mala/ o que
lleva siendo mala hace más de cinco años/cuando empezaron los
desahucios.
https://www.youtube.com/watch?v=HfWN6QPvEso
19. Esperanza Aguirre (14/04/13)
La sociedad española, sus legítimos representantes políticos y, por
supuesto, la Justicia y las Fuerzas de Seguridad del Estado tienen
que reaccionar y plantar cara a la desfachatez, a la chulería y a la
impunidad con que unos émulos de los peores totalitarismos de la
Historia han decidido acosar, insultar y amedrentar a los políticos
del Partido Popular, que han sido elegidos por sus conciudadanos.
Nadie, con un mínimo de sentido democrático, puede ni debe
mostrar la menor complacencia ante el espectáculo, que se está
convirtiendo en habitual, de unos energúmenos que, con total
impunidad, irrumpen en la intimidad familiar o doméstica de
algunos políticos del Partido Popular. Estos violentos acosadores se
creen el paradigma de los buenos sentimientos pero sólo son
simples epígonos de las tácticas de los peores totalitarismos del
siglo pasado: el acoso con que las juventudes hitlerianas o las
patrullas castristas en Cuba trataban y tratan de amedrentar a los
que no se someten a sus designios. Y también son imitadores del
matonismo de los seguidores de ETA en el País Vasco, ese
matonismo que no ha dejado vivir en libertad a los ciudadanos de
esa parte de España. …
http://esperanza.ppmadrid.es/el-acoso-a-politicos-del-partido-popular/
20. CDA elements at work
• Semiosis, or the making of meaning via the use of semiotic resources
(speech, written script, visuals, body movement, gaze and so on) as
a way of understanding how power relationship are symbolically
established and reproduced in society (Fairclough, 2006)
• Thematic shifts (flipping the script): e.g. home evictions → rights of
PP politicians
• Emotive keywords:
behaviour: desfachatez, chulería, impunidad
actions: acosar, insultar y amedrentar
people: energúmenos, violentos acosadores, epígonos de las
tácticas de los peores totalitarismos, imitadores del matonismo
de los seguidores de ETA
21. • Intertextuality: bringing forward into the present genres, voices
and other elements from texts produced in the past.
• Topos of history as teacher (Wodak et al, 1999): Nazi Germany
invoked.
• Anything goes: ‘discursive and rhetorical strategies which combine
incompatible phenomena [home evictees victimising the
powerful], make false claims sound innocent [that PAH members
‘are merely followers of the worst totalitarian tactics of the last
century’] … [and] ‘say the ‘unsayable’ and transcend the limits of
the permissible’ [likening PP members to the persecuted Jews of
Nazi Germany]’ (Wodak, 2013: 32-33).
22. Escrache of Javier Barbero (Ahora Madrid),
Madrid’s Concejal de Seguridad, by municipal
police officers, 16/02/16.
23. Talking about escraches 2:
Jorge Fernandez Diaz,
17/02/16
La gente tiene el suficiente sentido común como para darse cuenta
de que probar el sabor de la propia medicina te hace dar cuenta
hasta qué punto lo que estabas haciendo tú no era precisamente
algo susceptible de ser considerado como libertad de expresión.
Hasta no hace mucho tiempo esos hechos calificados como
escraches los padecíamos otras personas fundamentalmente y en
su mayor proporción sin ningún género de dudas cargos públicos
del Partido Popular. Y quienes los protagonizaban decían que era
libertad de expresión. Lo que no podemos aceptar es que cuando tú
los haces lo son y que cuando tú los padeces son conductas
odiosas o delictivas.
http://www.lavanguardia.com/vida/20160217/302231727480/f-diaz-dice-que-el-edil-de-madrid-
increpado-ha-probado-su-propia-medicina.html
24. So what? What would Karl say?
‘The ideas of the ruling class are in every epoch
the ruling ideas. …’
The material and the discursive
CDA= Corrupt(ed) Discourse Analysis?
Discourses of the corrupt/the corruption of
discourses
25. Relevant publications
Block, D. (2017). Political economy and sociolinguistics:
Redistribution and recognition. London: Bloomsbury.
Block, D. (2017). The materiality and semiosis of inequality and class
struggle and warfare: the case of home evictions in Spain. In R.
Wodak & B. Forchtner (eds) Routledge handbook of language and
politics. London: Routledge.
Block, D. (2016). Political economy in applied linguistics research.
Language Teaching, 49.
Block, D. (2016). Critical discourse analysis and class. In J.
Flowerdew & J. Richardson (eds) Routledge handbook of critical
discourse analysis. London: Routledge.
Block, D. (2014). Social class and applied linguistics. London:
Routledge.
Block, D. , Gray, & Holborow, M. (2012). Neoliberalism and applied
linguistics. London: Routledge.
26. Gràcies/Thank you.
David Block
ICREA Research Professor in Sociolinguistics
Universitat de Lleida
dblock@dal.udl.cat
http://www.icrea.cat/Web/ScientificForm.aspx?key=549
http://www.cla.udl.cat/fitxa.php?id=64
https://independent.academia.edu/DBlock