This document discusses treatments for rare diseases developed by Genzyme, including treatments for Pompe disease, Gaucher disease, and multiple sclerosis. It provides an overview of Genzyme's focus on rare diseases, marketed products, employees, and history of pioneering treatments for rare diseases. It also summarizes the challenges of developing treatments for rare diseases and orphan drugs, the regulatory pathways and incentives for such treatments, and Genzyme's manufacturing network and approach to working with patients.