Current concepts of pemphigus with a deep insight into its molecular aspectishita1994
Pemphigus vulgaris is an autoimmune bullous disease involving both the skin and mucosal areas, which
is characterized by intraepithelial flaccid blisters and erosions. The pathogenesis of this disease is not
yet completely established, but novel intuitions into its pathogenesis have recently been published. An
unanswered question in its pathophysiology is the mechanism of acantholysis or loss of keratinocyte
cell adhesion. Acantholysis seems to result from a communal action of autoantibodies against numerous
keratinocyte self‑antigens, of which desmogleins 1 and 3, desmocollins and nondesmosome components,
such as the mitochondrion, might take part in the disease initiation. Lately, apoptosis was described as
a possible underlying mechanism of acantholysis. Likewise, apoptolysis is assumed to be the association
between suprabasal acantholytic and cell death pathways. Hence, the present review focuses on the current
concepts in the pathogenesis of the pemphigus in a nutshell.
1. Cutaneous T-cell pseudolymphomas
A) Primarily with stripe-like infiltration (the majority of cases)
Lymphomatoid drug eruption (most cases);
Lymphomatoid contact dermatitis;
Actinic reticuloid;
Nodular scabies (individual cases);
Idiopathic forms;
Clonal cutaneous T-cell pseudolymphomas.
B) Primarily with nodular infiltration (a small percentage
of the cases)
Drug-induced – mainly by anti-convulsive drugs
Persistent nodules after insect bites;
Nodular scabies (the majority of cases).
2. Cutaneous B-cell pseudolymphomas (with nodular infiltration)
Cutaneous lymphocytoma from Borrelia burgdorferi;
Cutaneous lymphocytoma after antigens injection;
Cutaneous lymphocytoma resulting from tattoo;
Cutaneous lymphocytoma after Herpes zoster;
Idiopathic forms;
Clonal cutaneous B-cell pseudolymphomas
Current concepts of pemphigus with a deep insight into its molecular aspectishita1994
Pemphigus vulgaris is an autoimmune bullous disease involving both the skin and mucosal areas, which
is characterized by intraepithelial flaccid blisters and erosions. The pathogenesis of this disease is not
yet completely established, but novel intuitions into its pathogenesis have recently been published. An
unanswered question in its pathophysiology is the mechanism of acantholysis or loss of keratinocyte
cell adhesion. Acantholysis seems to result from a communal action of autoantibodies against numerous
keratinocyte self‑antigens, of which desmogleins 1 and 3, desmocollins and nondesmosome components,
such as the mitochondrion, might take part in the disease initiation. Lately, apoptosis was described as
a possible underlying mechanism of acantholysis. Likewise, apoptolysis is assumed to be the association
between suprabasal acantholytic and cell death pathways. Hence, the present review focuses on the current
concepts in the pathogenesis of the pemphigus in a nutshell.
1. Cutaneous T-cell pseudolymphomas
A) Primarily with stripe-like infiltration (the majority of cases)
Lymphomatoid drug eruption (most cases);
Lymphomatoid contact dermatitis;
Actinic reticuloid;
Nodular scabies (individual cases);
Idiopathic forms;
Clonal cutaneous T-cell pseudolymphomas.
B) Primarily with nodular infiltration (a small percentage
of the cases)
Drug-induced – mainly by anti-convulsive drugs
Persistent nodules after insect bites;
Nodular scabies (the majority of cases).
2. Cutaneous B-cell pseudolymphomas (with nodular infiltration)
Cutaneous lymphocytoma from Borrelia burgdorferi;
Cutaneous lymphocytoma after antigens injection;
Cutaneous lymphocytoma resulting from tattoo;
Cutaneous lymphocytoma after Herpes zoster;
Idiopathic forms;
Clonal cutaneous B-cell pseudolymphomas
cute haemorrhagic oedema of infancy is a rare type of cutaneous vasculitis with a characteristic presentation.It consists of a clinical triad of:
Large bruise-like lesions (purpura)
Swelling (oedema)
Fever
A comprehensive review of Cutaneous Lymphomas - both B-Cell and T-Cell with latest treatment strategies. Target audience are oncologists, dermatologists, oncology physicians, dermatology and oncology fellows
cute haemorrhagic oedema of infancy is a rare type of cutaneous vasculitis with a characteristic presentation.It consists of a clinical triad of:
Large bruise-like lesions (purpura)
Swelling (oedema)
Fever
A comprehensive review of Cutaneous Lymphomas - both B-Cell and T-Cell with latest treatment strategies. Target audience are oncologists, dermatologists, oncology physicians, dermatology and oncology fellows
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Affiliate marketing is a dynamic and performance-based online marketing strategy. It involves individuals or businesses (affiliates) partnering with companies (merchants) to promote their products or services. Affiliates earn commissions for driving traffic, leads, or sales through their marketing efforts. It's a win-win model, where affiliates benefit from monetizing their online presence, and merchants expand their reach through a network of marketers. Affiliate marketing thrives on trust, value-driven content, and the power of recommendation to drive sales and income.
Marketing is an organizational function and a set of processes for creating, communicating and delivering value to customers and for managing customers’ relationships in ways that benefit the organization and its stakeholder.
Exploring the Dynamics of In-House Marketers vs. Marketing Agencies: Which Serves Your Business Better?
Delve into the intricate debate surrounding the employment of in-house marketers versus the engagement of marketing agencies for business advancement. This comprehensive analysis dissects the advantages and limitations of both approaches, shedding light on the evolving landscape of contemporary marketing strategies.
Uncover the shifting preferences observed in recent years, where businesses increasingly favor in-house marketing teams over external service providers. A nuanced examination reveals the intricacies of crafting effective marketing strategies tailored to meet diverse business challenges.
Navigate through the multifaceted realm of in-house marketers, individuals dedicated to sculpting bespoke marketing plans aligned with the core ethos of your enterprise. Discover the unparalleled insights these insiders offer, from brand understanding to rapid adaptation to market trends, fostering seamless collaboration across internal departments while maintaining cost control and nurturing marketing expertise within the organization.
Contrast the strengths and weaknesses inherent in the in-house model, ranging from limited exposure to industry practices to the risk of echo chamber thinking, prompting the necessity for periodic external audits to ensure strategic relevance and innovation.
Conversely, explore the realm of digital marketing agencies, equipped with specialized expertise to amplify your online presence and navigate the ever-changing digital landscape. Unveil the advantages of tapping into external resources, from accessing specialized skills to embracing scalability and flexibility in marketing endeavors.
Grapple with the intricacies of choosing between an in-house marketer and a digital agency, considering factors such as company culture alignment, control over marketing activities, and cost-effectiveness. Embrace the tailored solutions offered by IM4U Digital Marketing Agency, bridging the best of both worlds to elevate your brand in the dynamic arena of digital marketing.
Embark on a journey of strategic decision-making, guided by insights into brand alignment, consistent messaging, and the pursuit of marketing ROI. Join the discourse on navigating the evolving terrain of digital marketing, where success hinges on strategic partnerships and adaptive strategies in a landscape ripe with possibilities and challenges alike.
Marketing First Steps: Planning, Budgeting & Hiring (Series: Digital Marketin...Financial Poise
One of the most critical components to an entrepreneur’s success is well planned and strategic marketing implementation. But, what should a business owner know if they wish to be successful with their marketing? Three fundamental elements of marketing include planning, budgeting and hiring. With a well defined plan, the business owner will be able to set realistic goals and measurements for success. With proper budgeting, the owner will be able to know how much they should spend, and plan their marketing tactics accordingly. And hiring skilled marketing staff can be incredibly beneficial, but there are considerations to be made when hiring. In this webinar, we provide details designed to give business owners expert marketing advice pertaining to marketing planning, budgeting and hiring.
To listen to this webinar on-demand, go to: https://www.financialpoise.com/financial-poise-webinars/marketing-first-steps-2020/
Market Research: Understanding your target audience is essential. Conduct market research to gather information about your customers, competitors, and industry trends. This will help you tailor your products or services to meet the needs and preferences of your target market.
Product Development: Develop products or services that fulfill the needs and desires of your target audience. Consider factors such as features, quality, pricing, and branding to create offerings that differentiate your business from competitors.
Branding: Develop a strong brand identity that resonates with your target audience. Your brand should communicate your unique value proposition and differentiate your business from competitors. This includes elements such as your brand name, logo, colors, and messaging.
Promotion: Use various promotional tactics to communicate the value of your products or services to your target audience. This may include advertising, public relations, social media marketing, content marketing, and other forms of communication.
Distribution: Determine the most effective distribution channels to reach your target audience and deliver your products or services to them. This may involve selling directly to consumers, distributing through retailers or wholesalers, or using e-commerce platforms.
Pricing: Set prices for your products or services that reflect their value and are competitive within the market. Consider factors such as production costs, competitor pricing, perceived value, and pricing strategies.
Customer Relationship Management: Build and maintain strong relationships with your customers to foster loyalty and repeat business. This may involve providing excellent customer service, engaging with customers on social media, offering loyalty programs, and soliciting feedback to continuously improve your offerings.
Evaluation and Adjustment: Continuously monitor and evaluate the effectiveness of your marketing efforts. Use metrics such as sales, customer feedback, and brand awareness to assess performance and make adjustments as needed to achieve your marketing goals.
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Choosing the right marketing agency is a critical step for business growth. In this blog, we’ll explore key considerations and tips to guide you in making an informed decision for your unique business needs. Whether you’re new to digital marketing or looking to enhance existing strategies, these insights aim to empower your decision-making process. When opting to engage a marketing agency, numerous factors warrant consideration. Continue reading to discover our tips for selecting the ideal marketing company for your business. Supercharge your brand’s success with Khushi Ambient Media Solutions, India’s top-tier Marketing Company. Ignite growth and visibility choose excellence, choose Khushi.
How to build a culture that supports growth june 27 2012Chris R. Keller
Having a good culture within your company is critical for success, employee productivity and creativity. Read this presentation now to learn how to create a culture within your small business or company that foster success and lead to higher profits.
A great presentation from John Marovino on how small businesses can get more out of their branding. The presentation provides a model and frame work for small businesses to build a brand essence and brand equity. Presentation originally given to the Waterloo Region Small Business Owner Association on Wednesday April 25th, 2012.
Enterprise Excellence is Inclusive Excellence.pdfKaiNexus
Enterprise excellence and inclusive excellence are closely linked, and real-world challenges have shown that both are essential to the success of any organization. To achieve enterprise excellence, organizations must focus on improving their operations and processes while creating an inclusive environment that engages everyone. In this interactive session, the facilitator will highlight commonly established business practices and how they limit our ability to engage everyone every day. More importantly, though, participants will likely gain increased awareness of what we can do differently to maximize enterprise excellence through deliberate inclusion.
What is Enterprise Excellence?
Enterprise Excellence is a holistic approach that's aimed at achieving world-class performance across all aspects of the organization.
What might I learn?
A way to engage all in creating Inclusive Excellence. Lessons from the US military and their parallels to the story of Harry Potter. How belt systems and CI teams can destroy inclusive practices. How leadership language invites people to the party. There are three things leaders can do to engage everyone every day: maximizing psychological safety to create environments where folks learn, contribute, and challenge the status quo.
Who might benefit? Anyone and everyone leading folks from the shop floor to top floor.
Dr. William Harvey is a seasoned Operations Leader with extensive experience in chemical processing, manufacturing, and operations management. At Michelman, he currently oversees multiple sites, leading teams in strategic planning and coaching/practicing continuous improvement. William is set to start his eighth year of teaching at the University of Cincinnati where he teaches marketing, finance, and management. William holds various certifications in change management, quality, leadership, operational excellence, team building, and DiSC, among others.
Personal Brand Statement:
As an Army veteran dedicated to lifelong learning, I bring a disciplined, strategic mindset to my pursuits. I am constantly expanding my knowledge to innovate and lead effectively. My journey is driven by a commitment to excellence, and to make a meaningful impact in the world.
Remote sensing and monitoring are changing the mining industry for the better. These are providing innovative solutions to long-standing challenges. Those related to exploration, extraction, and overall environmental management by mining technology companies Odisha. These technologies make use of satellite imaging, aerial photography and sensors to collect data that might be inaccessible or from hazardous locations. With the use of this technology, mining operations are becoming increasingly efficient. Let us gain more insight into the key aspects associated with remote sensing and monitoring when it comes to mining.
Taurus Zodiac Sign_ Personality Traits and Sign Dates.pptxmy Pandit
Explore the world of the Taurus zodiac sign. Learn about their stability, determination, and appreciation for beauty. Discover how Taureans' grounded nature and hardworking mindset define their unique personality.
"𝑩𝑬𝑮𝑼𝑵 𝑾𝑰𝑻𝑯 𝑻𝑱 𝑰𝑺 𝑯𝑨𝑳𝑭 𝑫𝑶𝑵𝑬"
𝐓𝐉 𝐂𝐨𝐦𝐬 (𝐓𝐉 𝐂𝐨𝐦𝐦𝐮𝐧𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬) is a professional event agency that includes experts in the event-organizing market in Vietnam, Korea, and ASEAN countries. We provide unlimited types of events from Music concerts, Fan meetings, and Culture festivals to Corporate events, Internal company events, Golf tournaments, MICE events, and Exhibitions.
𝐓𝐉 𝐂𝐨𝐦𝐬 provides unlimited package services including such as Event organizing, Event planning, Event production, Manpower, PR marketing, Design 2D/3D, VIP protocols, Interpreter agency, etc.
Sports events - Golf competitions/billiards competitions/company sports events: dynamic and challenging
⭐ 𝐅𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐬:
➢ 2024 BAEKHYUN [Lonsdaleite] IN HO CHI MINH
➢ SUPER JUNIOR-L.S.S. THE SHOW : Th3ee Guys in HO CHI MINH
➢FreenBecky 1st Fan Meeting in Vietnam
➢CHILDREN ART EXHIBITION 2024: BEYOND BARRIERS
➢ WOW K-Music Festival 2023
➢ Winner [CROSS] Tour in HCM
➢ Super Show 9 in HCM with Super Junior
➢ HCMC - Gyeongsangbuk-do Culture and Tourism Festival
➢ Korean Vietnam Partnership - Fair with LG
➢ Korean President visits Samsung Electronics R&D Center
➢ Vietnam Food Expo with Lotte Wellfood
"𝐄𝐯𝐞𝐫𝐲 𝐞𝐯𝐞𝐧𝐭 𝐢𝐬 𝐚 𝐬𝐭𝐨𝐫𝐲, 𝐚 𝐬𝐩𝐞𝐜𝐢𝐚𝐥 𝐣𝐨𝐮𝐫𝐧𝐞𝐲. 𝐖𝐞 𝐚𝐥𝐰𝐚𝐲𝐬 𝐛𝐞𝐥𝐢𝐞𝐯𝐞 𝐭𝐡𝐚𝐭 𝐬𝐡𝐨𝐫𝐭𝐥𝐲 𝐲𝐨𝐮 𝐰𝐢𝐥𝐥 𝐛𝐞 𝐚 𝐩𝐚𝐫𝐭 𝐨𝐟 𝐨𝐮𝐫 𝐬𝐭𝐨𝐫𝐢𝐞𝐬."
RMD24 | Debunking the non-endemic revenue myth Marvin Vacquier Droop | First ...BBPMedia1
Marvin neemt je in deze presentatie mee in de voordelen van non-endemic advertising op retail media netwerken. Hij brengt ook de uitdagingen in beeld die de markt op dit moment heeft op het gebied van retail media voor niet-leveranciers.
Retail media wordt gezien als het nieuwe advertising-medium en ook mediabureaus richten massaal retail media-afdelingen op. Merken die niet in de betreffende winkel liggen staan ook nog niet in de rij om op de retail media netwerken te adverteren. Marvin belicht de uitdagingen die er zijn om echt aansluiting te vinden op die markt van non-endemic advertising.
Explore our most comprehensive guide on lookback analysis at SafePaaS, covering access governance and how it can transform modern ERP audits. Browse now!
Cracking the Workplace Discipline Code Main.pptxWorkforce Group
Cultivating and maintaining discipline within teams is a critical differentiator for successful organisations.
Forward-thinking leaders and business managers understand the impact that discipline has on organisational success. A disciplined workforce operates with clarity, focus, and a shared understanding of expectations, ultimately driving better results, optimising productivity, and facilitating seamless collaboration.
Although discipline is not a one-size-fits-all approach, it can help create a work environment that encourages personal growth and accountability rather than solely relying on punitive measures.
In this deck, you will learn the significance of workplace discipline for organisational success. You’ll also learn
• Four (4) workplace discipline methods you should consider
• The best and most practical approach to implementing workplace discipline.
• Three (3) key tips to maintain a disciplined workplace.
What are the main advantages of using HR recruiter services.pdfHumanResourceDimensi1
HR recruiter services offer top talents to companies according to their specific needs. They handle all recruitment tasks from job posting to onboarding and help companies concentrate on their business growth. With their expertise and years of experience, they streamline the hiring process and save time and resources for the company.
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[Note: This is a partial preview. To download this presentation, visit:
https://www.oeconsulting.com.sg/training-presentations]
Sustainability has become an increasingly critical topic as the world recognizes the need to protect our planet and its resources for future generations. Sustainability means meeting our current needs without compromising the ability of future generations to meet theirs. It involves long-term planning and consideration of the consequences of our actions. The goal is to create strategies that ensure the long-term viability of People, Planet, and Profit.
Leading companies such as Nike, Toyota, and Siemens are prioritizing sustainable innovation in their business models, setting an example for others to follow. In this Sustainability training presentation, you will learn key concepts, principles, and practices of sustainability applicable across industries. This training aims to create awareness and educate employees, senior executives, consultants, and other key stakeholders, including investors, policymakers, and supply chain partners, on the importance and implementation of sustainability.
LEARNING OBJECTIVES
1. Develop a comprehensive understanding of the fundamental principles and concepts that form the foundation of sustainability within corporate environments.
2. Explore the sustainability implementation model, focusing on effective measures and reporting strategies to track and communicate sustainability efforts.
3. Identify and define best practices and critical success factors essential for achieving sustainability goals within organizations.
CONTENTS
1. Introduction and Key Concepts of Sustainability
2. Principles and Practices of Sustainability
3. Measures and Reporting in Sustainability
4. Sustainability Implementation & Best Practices
To download the complete presentation, visit: https://www.oeconsulting.com.sg/training-presentations
2. 1.
A negative return on
investment.
Good marketing ALWAYS returns a positive return
on investment.
3. 2.
Only advertising
Good marketing includes strategies and tactics for public
relations, generating referrals, entering new segments,
developing new products, pricing strategies and adding
new distribution networks for your products or services.
4. 3.
Gambling
Good marketing is not a gamble it is either a
calculated experiment or pretested proven initiative
with a positive return on investment.
6. 5.
Inconsistent
Good marketing is consistent, because consistency
increases marketing effectiveness. This means using the
same wording, colour, messages, images and logo.
7. 6.
A one time event
Good marketing includes excessive repetition. For the
average person to remember a message then need to see it
seven times. Repetition in marketing increases return on
investment.
8. 7.
A guessing game
Good marketing is calculated and strategic actions that have
the ability to accomplish the desired goal with a high
likelihood of success, where the approximate outcome can
be predicted ahead of time
9. Guaranteed Return On Investment Or
Your Money Back.
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Sales & Marketing
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