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Gustakhi Kis-Cheez-Ka-Naam-Hay

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As personalized cancer care evolves, the patient’s nucleic acid becomes ever so important to provide valuable information regarding their genetic makeup and disease state. Common sample types for these analyses include biopsies, which can be very limited in material making the downstream measurement of more than one analyte rather difficult. Obtaining another biopsy, using a different section or splitting the sample can be problematic because of tumor heterogeneity. Even adjacent areas of the same tumor tissue can result in different RNA/DNA profiles so the ability to isolate multiple analytes from the same sample offer a number of benefits, which include preserving samples and data consistency eliminating any sample to sample variation. As more tests are developed to simultaneously monitor genetic alterations, there is a strong need to efficiently isolate both DNA and RNA from the same starting sample in a format compatible with high-throughput processing.

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Presented at ISBER 2015, Dr. Alex Esmon, Senior Product Manager at Thermo Fisher Scientific explains how to manage the cold chain to minimize pre-analytical variability. In his presentation, he discusses three scenarios: the importance of maintaining sample conditions, concerns during inventorying, and sample transport (including unit transfer and content transfer). To read more about biobanking best practices, check out our Inside Biobanking blog here: http://acceleratingscience.com/biobanking/

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Mycoplasma are generally small (0.3 to 0.8 micrometers), gram negative, mostly facultative anaerobic, pleomorphic bacteria that lack cell walls, rendering them resistant to common antibiotics. Mycoplasma bovis is one of the most pathogenic species to affect cattle and the most frequent cause of bovine mastitis. Other conditions caused by M. bovis include arthritis, pneumonia, meningitis, otitis media, kerato-conjunctivitis, decubital abscesses, vaginitis, synovitis, and genital conditions. to learn more about Mycoplasma, follow this link: http://acceleratingscience.com/food/fact-sheet-on-mycoplasma-mastitis/

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Vibrio is a genus of Gram-negative, facultative anaerobic comma-shaped bacteria. Many species of Vibrio are halophilic (salt-loving) and therefore can be found in seawater and seafood. Large numbers of Vibrio are found in the summer months as the temperature of water rises, causing them to multiply. This genus contains several pathogenic species, including Vibrio cholerae, Vibrio parahaemolyticus and Vibrio vulnificus. Learn more about Vibrio here: http://acceleratingscience.com/food/fact-sheet-on-vibrio/

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Salmonella are Gram-negative, facultative anaerobic, rod-shaped bacteria; most with peritrichous flagella. Salmonella spp. belong to the family Enterobacteriaceae. Salmonellae are chemoorganotropic, with an ability to metabolize nutrients by both respiratory and fermentative pathways. The bacteria are oxidase and catalase negative, grow optimally at 37°C, and catabolize D-glucose and other carbohydrates with the production of acid and gas (hydrogen sulfide). However, they readily adapt to extreme environmental conditions and can grow at both elevated and refrigerator temperatures. To see the whole fact sheet, click here: http://acceleratingscience.com/food/fact-sheet-on-salmonella/

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www.seribangash.com The Mariana Trench is one of the most remarkable geological features on Earth. Here are some details about it: Location: The Mariana Trench is located in the western Pacific Ocean, east of the Mariana Islands. It stretches for about 2,550 kilometers (1,580 miles) and is known as the deepest part of the world's oceans. Depth: The trench reaches incredible depths, with its deepest point known as the Challenger Deep, which plunges down to approximately 10,984 meters (36,037 feet) below sea level. To put this into perspective, if Mount Everest, the tallest mountain on Earth, were placed at the bottom of the Challenger Deep, its peak would still be over 2 kilometers (1.25 miles) underwater. Formation: The Mariana Trench was formed by the subduction of the Pacific Plate beneath the Mariana Plate. This process creates a deep trench as the heavier Pacific Plate is forced beneath the lighter Mariana Plate. Geological Features: The trench is characterized by steep, V-shaped valleys, and its walls are composed of highly compressed sedimentary rock. At the bottom of the trench, there are also large amounts of marine sediment. Pressure: The pressure at the bottom of the Mariana Trench is immense, reaching over 1,000 times the pressure at the surface. This extreme pressure creates a challenging environment for exploration and makes it difficult for organisms to survive. Exploration: Despite its extreme conditions, the Mariana Trench has been the subject of numerous scientific expeditions and explorations. One of the most famous explorations was the dive to the Challenger Deep by Swiss scientist Jacques Piccard and U.S. Navy Lieutenant Don Walsh in 1960. More recently, in 2012, filmmaker James Cameron made a solo dive to the bottom of the Challenger Deep in the Deepsea Challenger submersible. Biological Discoveries: Despite the harsh conditions, the Mariana Trench is home to a surprising variety of life forms, including unique species of deep-sea fish, crustaceans, and microbial life. Some organisms have adapted to survive in the extreme pressure and darkness of the trench. Environmental Importance: Studying the Mariana Trench provides valuable insights into the geology, biology, and oceanography of the deep sea. It also helps scientists better understand the processes that shape the Earth's crust and the distribution of life in the oceans. Conservation: Due to its remote location and extreme depths, the Mariana Trench has remained relatively untouched by human activity. However, there is growing concern about the potential impacts of deep-sea mining and pollution on this fragile ecosystem, highlighting the need for conservation efforts to protect this unique environment. https://seribangash.com/barber-shop-business-complete-guide-for-beginners/ https://seribangash.com/legend-virat-kohli-in-cricket-history/

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