This document discusses using cloud computing infrastructure for automated parameter estimation. It outlines some limitations of traditional computing like limited processors, computing power, and availability. Cloud computing allows leveraging third-party computing capabilities over the internet as a service. Examples are provided of using cloud infrastructure for serial and parallel parameter estimation modeling runs. The conclusions state that parameter estimation using PEST can be performed on cloud infrastructure, eliminating limitations of small to mid-size businesses and providing scalable and low-cost computational resources.