The top five causes of premature death in England are cancer, heart disease, stroke, lung disease, and liver disease. These five illnesses account for over 150,000 deaths per year among people under 75 years old, and about two-thirds of those deaths are considered preventable. The document discusses lifestyle risk factors that contribute to these illnesses, such as smoking, lack of exercise, poor diet, obesity, and excessive drinking. It emphasizes that preventing these illnesses through healthy lifestyle choices could significantly reduce premature deaths in England each year.