This document discusses semantic interoperability for electronic health records (EHRs). It provides an overview of semantic interoperability and health information, including challenges with historic systems. Current issues include rising healthcare costs and quality/safety concerns due to errors. The document outlines workflows in a care organization using proprietary interfaces and standards like HL7. It discusses personal health information and information systems. Finally, it proposes innovative solutions like standardizing identifiers and information, educating all actors, identifying authoritative sources, and using proven technologies to improve interoperability.