This document discusses the history and current state of medical marijuana in the United States. It provides background on marijuana's medical use in the early 20th century and subsequent criminalization. Today, over half of Americans support legalization and 21 states have legalized medical marijuana, though it remains illegal at the federal level. The document outlines administration methods, potential medical benefits seen with certain conditions, and the need for more robust research studies. It also discusses the conflict between state and federal law on marijuana and analyzes trends in marijuana use and perceived risk among the public.
Dr. Tom Frieden, Director of the Centers for Disease Control and Prevention, keynote presentation at the National Rx Drug Abuse & Heroin Summit on March 30, 2016.
Dr. Tom Frieden, Director of the Centers for Disease Control and Prevention, keynote presentation at the National Rx Drug Abuse & Heroin Summit on March 30, 2016.
Marijuana is a banned drug in many countries over the world. Although it is effective in treating nausea associated with chemotherapy as well as in increasing appetite in HIV patients. inspite of being useful in giving palliative care to terminal patients, marijuana is a banned drug in india and many other countries. This slide deals with the ethical issues in the medical use of marijuana.
Global Medical Cures™ | Prescription Painkiller Overdoses (Growing Epidemic A...Global Medical Cures™
Global Medical Cures™ | Prescription Painkiller Overdoses (Growing Epidemic Among Women)
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
Kana Enomoto, Acting Administrator, Substance Abuse and Mental Health Services Administration, keynote presentation at the National Rx Drug Abuse & Heroin Summit March 29, 2016
Drug Treatment Courts: How America’s Most Trusted Alternative to Incarceration is Providing Hope in the Midst of the Rx Drug Abuse and Opiate Epidemic - Vision Session Presented by National Association of Drug Court Professionals
Tuesday Vision Session: Substance Abuse and Mental Health Services Administration (SAMHSA): Examining Prescription Drug Misuse and Abuse from Federal and National Perspectives
Marijuana is a banned drug in many countries over the world. Although it is effective in treating nausea associated with chemotherapy as well as in increasing appetite in HIV patients. inspite of being useful in giving palliative care to terminal patients, marijuana is a banned drug in india and many other countries. This slide deals with the ethical issues in the medical use of marijuana.
Global Medical Cures™ | Prescription Painkiller Overdoses (Growing Epidemic A...Global Medical Cures™
Global Medical Cures™ | Prescription Painkiller Overdoses (Growing Epidemic Among Women)
DISCLAIMER-
Global Medical Cures™ does not offer any medical advice, diagnosis, treatment or recommendations. Only your healthcare provider/physician can offer you information and recommendations for you to decide about your healthcare choices.
Kana Enomoto, Acting Administrator, Substance Abuse and Mental Health Services Administration, keynote presentation at the National Rx Drug Abuse & Heroin Summit March 29, 2016
Drug Treatment Courts: How America’s Most Trusted Alternative to Incarceration is Providing Hope in the Midst of the Rx Drug Abuse and Opiate Epidemic - Vision Session Presented by National Association of Drug Court Professionals
Tuesday Vision Session: Substance Abuse and Mental Health Services Administration (SAMHSA): Examining Prescription Drug Misuse and Abuse from Federal and National Perspectives
National Rx Drug Abuse Summit, April 2-4, 2013. General Session presentation, "Prevention and Prosecution," Frances M. Harding, Director, Center for Substance Abuse Prevention, SAMHSA
College Student Perceptions of Marijuana 2015SarahMartin33
This marketing research project was created to better understand college students perceptions on marijuana. In this paper we cover background research concerning legalization of marijuana and behavior. After identifying questions that were not answered during our research, we administered a survey via Qualtrics and received over 700 responses from college students in different colleges in the nation. We took their responses and analyzed our data over SPSS. We discovered that most of our hypotheses held true.
Cannabis as Medicine: Redefining the Paradigm of the Doctor-Patient Relations...Canna Holdings, LLC
Dr. D'Angelo will cover the need and best practices for maintaining a standard of care in a changing medical environment, and establish the responsibilities of the patient and provider during cannabis therapy treatments.
BRP Pharmaceuticals Physician dispensing services enables doctors and clinics to offer their patients timely, convenient, and hassle-free alternatives for receiving their medication. Visit: http://www.brppharma.com/
Legalization of marijuanaMarijuana i.docxsmile790243
Legalization of marijuana
Marijuana is a controversial and prominent issue in the society today.
The use and possession of marijuana have been criminalized in many
nations though some countries that have legalized it.
These countries impose penalties on the possession and the use of the pot.
The information in the American public about marijuana has been relatively inaccurate because of years of misinformation and propaganda that private interests have often tabled for personal gains.
.
Introduction
In most nations, the use and possession of marijuana have been prohibited. However, there are some countries that have legalized it while there are some that have not. These countries impose various penalties on the possession and the use of the pot. Some of these penalties are either simple or severe regarding punishment. Besides, there are regions such as North America, Europe, and South America have allowed small quantities of the substance. Moreover, states such as Colorado and Washington have not only legalized the use of cannabis but also the possession of the drug majorly on medical grounds.
Marijuana is a controversial and prominent issue in the contemporary society. Recent history has been characterized by slanderous claims concerning the substance. In fact, truths and facts have surfaced, and they have been heavily criticized because of stereotypical views and perception of individuals including the smokers.The information in the American public about marijuana has been relatively skewed because of years of misinformation and propaganda that private interests for personal gains. This paper, therefore, seeks to provide insights concerning the background of marijuana, the paradoxes on the topic, the opposing and affirmative positions concerning its legalization, and the stakeholder involved.
2
Cannabis is a scientific name used in referring to the hemp plant.
Its consumption is in several forms such as in the form of dried buds or flowers (marijuana), pressed resin from leaves and flowers (hash or hashish), loose resin (kief), and hash oil which is focus of removed resin using a solvent.
The users either smoke or consume the drug in food products.
Individuals react differently when they consumed the drugs
Background of marijuana
Brief overview background of marijuana
Cannabis is a scientific name used in referring to the hemp plant. The plant has seeds, leaves, flowers, roots, and a stalk with the three species being Cannabis ruderalis, Cannabis Sativa, and Cannabis Indica. Its consumption is in several forms such as in the form of dried buds or flowers (marijuana), pressed resin from leaves and flowers (hash or hashish), loose resin (kief), and hash oil which is a concentration of an extracted resin using a solvent. In these forms, the users may smoke them through either a pipe or in a joint. On another occasion, it is often mixed with other herbs before being smoked (Boffey, 2015). Moreover, it can ...
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Tue vs ameritox -yasko-brasika_de_george
1. Mixing Medicine and Marijuana
Scott E Yasko – PRIUM
Rachel Brozina, esq. – Lester, Norton & Brozina
Michael DeGeorge Jr., PharmD – Ameritox
Rx Drug Abuse Summit – April 22, 2014 – Atlanta, GA
2. Quick History of Marijuana in the U.S.
• Cannabis was used legitimately at the turn of
the century
– Primarily used for pain
– Use declined with negative public perception and
the development of aspirin and morphine
• 1925, League of Nations sign a treaty
restricting use to scientific and medical
• Became illegal in 1937 via the Marijuana Tax
Act
3. The Administration of Marijuana
• Smoke
• Oil extract & Butter
– Added to and used to make foods
• Tinctures & Tonics
– Transdermal, sublingual and ingested
• Vaporized
– Heating the plant to inhale the mist
– Alternative to smoking
4. Marijuana in the U.S. Today
• According to CBS News, 51% of Americans
support full legalization
• Indicated for diagnoses such as chronic and
cancer pain, seizure disorders, etc.
– Varies by state
– Physicians do not prescribe; they recommend
• Medical Marijuana has potential
– Charlotte Figi – Dravet Syndrome
– Chaz Moore – myoclonus diaphragmatic flutter
5. What’s Next?
• Reassess drug scheduling
– Schedule I indicates no medicinal use
– 1988, DEA ALJ ruled in favor of reclassification
• More robust studies are needed
– Red tape surrounding U.S. studies
– Leading research coming out of Israel and Spain
6. Federal versus State Law
U.S. Constitution
•Supremacy Clause: generally, federal law
supersedes state law in areas in which Congress
has appropriately exercised its power to legislate
•Commerce Clause: generally, Congress has
express power to regulate commerce among
the states
7. Federal versus State Law
Controlled Substances Act
•Purpose: regulate the manufacture,
importation, possession, use, and
distribution of certain substances
•Execution: five schedules outline the
qualifications for a substance to be
classified
• Schedule 1 substances:
1. High potential for abuse,
2. No currently accepted medical
use in treatment in US, and
3. No accepted safety for use of the
substance under medical
supervision.
• Prescription cannot be written for
substance
U.S. Supreme Court decision:
Gonzales v. Raich
•Situation: a caregiver and a patient
possessing and using marijuana per
California’s Compassionate Use Act
sought an injunction to stop government
from interfering with their activities
•Plaintiffs’ argument: CSA is
unconstitutional as applied to their
conduct
•Government’s argument: CSA preempts
state law; Congress may regulate and
prohibit use and possession of marijuana
under Commerce Clause
•Decision: Congress has authority to
prohibit possession and use of
marijuana, even for medical purposes,
under commerce clause.
•Rationale: marijuana grown for personal
consumption is likely to create high
demand in the interstate market; this
diversion into the interstate market
interferes with federal government’s
interest in eliminating commercial
transactions.
8. USDOJ Memo to U.S. Attorneys
August 29, 2013
• Urges U.S. Attorneys to exercise their discretion in
using federal resources to prosecute individuals using
marijuana for medical purposes
• Emphasizes federal policy of enforcing CSA to prevent:
1. distribution of marijuana to minors
2. revenue falling into hands of dangerous drug cartels
3. diverting medical marijuana from legal states to other states
4. state-authorized marijuana activity from being used as a cover for trafficking other
illegal drugs
5. violence in the cultivation and distribution of marijuana
6. drugged driving and other adverse public health consequences
7. growing marijuana on public or federal lands
9. 21 Jurisdictions Have Legalized
Medical Marijuana
• Alaska
• Arizona
• California
• Colorado*
• Connecticut
• DC
• Delaware
• Hawaii
• Illinois
• Maine
• Michigan
• Montana
• Nevada
• New Hampshire
• New Jersey
• New Mexico
• Oregon
• Rhode Island
• Vermont
• Washington*
* Allows for recreational use
11. Pediatric Exposure to Marijuana in
Decriminalized States
Adapted by CESAR from Wang, G.S., Roosevelt, G., Le Lait, M-C, Martinez, E.M., Bucher-Bartelson, B., Bronstein, A.C., and
Heard, K., “Association of Unintentional Pediatric Exposures with Decriminalization of Marijuana in the United States,” Annals
of Emergency Medicine, In Press, 2014. For more information, please contact Dr. George Wang at
george.wang@childrenscolorado.org.
12. New Illicit Drug Use- 2012
Substance Abuse and Mental Health Services Administration, Results from the 2012 National
Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-46, HHS
Publication No. (SMA) 13-4795. Rockville, MD: Substance Abuse and Mental Health Services
Administration, 2013.
13. New Illicit Drug Use- 2012
13
Substance Abuse and Mental Health Services Administration, Results from the 2012 National
Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-46, HHS
Publication No. (SMA) 13-4795. Rockville, MD: Substance Abuse and Mental Health Services
Administration, 2013.
14. Marijuana use increasing
Adapted by CESAR from Substance Abuse and Mental Health Services Administration, Results from the 2012 National Survey
on Drug Use and Health: Detailed Tables, 2013. Available online at
http://www.samhsa.gov/data/NSDUH/2012SummNatFindDetTables/Index.aspx
15. Perceived risk of marijuana
•University of Michigan, 2013 Monitoring the Future Study
16. Marijuana and poly drug abuse
58% of primary marijuana admissions reported abuse
of additional substances
17. Marijuana and Nonadherence
• Retrospective review of 116,011 urine
samples
• Patients prescribed hydrocodone (excluding
prn)
• May 16, 2011 to May 15, 2012
• Broken into three categories for analysis
– THC positive as only illicit (n=15,153)
– Cocaine positive as only illicit (n=1731)
– No illicit detected (n= 99,115)
An analysis of the association between marijauana use and potential nonadherence in patients prescribed hydrocodone. DeGeorge M, Dawson E, et al.
American Academy of Pain Medicine annual meeting 2013
18. Marijuana and Nonadherence
An analysis of the association between marijauana use and potential nonadherence in patients prescribed hydrocodone. DeGeorge M, Dawson E, et al.
American Academy of Pain Medicine annual meeting 2013
19. An analysis of the association between marijauana use and potential nonadherence in patients prescribed hydrocodone. DeGeorge M, Dawson E, et al.
American Academy of Pain Medicine annual meeting 2013
Marijuana and Nonadherence
20. An analysis of the association between marijauana use and potential nonadherence in patients prescribed hydrocodone. DeGeorge M, Dawson E, et al.
American Academy of Pain Medicine annual meeting 2013
Marijuana and Nonadherence
21. Thank You
Scott E Yasko
PRIUM
National Account Executive
(678) 735-7315
syasko@prium.net
Rachel Brozina, esq.
Lester, Norton & Brozina, p.c.
rachel@lesternortonlaw.com
Michael DeGeorge, PharmD
Ameritox
Associate Director, Medical Affairs
michael.degeorge@ameritox.com