A variety of perfluorocycloalkenyl (PFCA) aryl ether monomers and polymers with enchained triarylamine units were successfully synthesized, characterized and reported here. These polymers are highly thermally stable and show variable thermal properties. Successful conver- sion of the newly synthesized TAA enchained perfluoro- cyclopentenyl (PFCP) aryl ether polymers via formylation and EAS demonstrates the synthetic versatility of TAA moiety and provides an excellent option for application specific post polymerization reactions. The cross-linking behavior of PFCP aryl ether polymers was studied under different reaction conditions. The combination of pro- cessability, thermal stabilities, and tailorability makes these polymers suitable for a wide variety of applications including electro-optics, proton exchange membranes and super-hydrophobic applications.
A variety of perfluorocycloalkenyl (PFCA) arylether monomers and polymers with enchained triarylamineunits were successfully synthesized, characterized andreported here. These polymers are highly thermally stableand show variable thermal properties. Successful conver-sion of the newly synthesized TAA enchained perfluoro-cyclopentenyl (PFCP) aryl ether polymers via formylationand EAS demonstrates the synthetic versatility of TAAmoiety and provides an excellent option for applicationspecific post polymerization reactions. The cross-linkingbehavior of PFCP aryl ether polymers was studied underdifferent reaction conditions. The combination of pro-cessability, thermal stabilities, and tailorability makes thesepolymers suitable for a wide variety of applicationsincluding electro-optics, proton exchange membranes andsuper-hydrophobic applications.
Rheological and optical characterization of Polyvinylpyrrolidone (PVP) - Poly...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Perfluorocyclopentenyl (PFCP) Aryl Ether Polymers via Polycondensation of Oct...Babloo Sharma, Ph.D.
A unique class of aromatic ether polymers
containing perfluorocyclopentenyl (PFCP) enchainment was
prepared from the simple step growth polycondensation of
commercial bisphenols and octafluorocyclopentene (OFCP)
in the presence of triethylamine. Model studies indicate that
the second addition/elimination on OFCP is fast and poly-
condensation results in linear homopolymers and copolymers
without side products. The synthesis of bis(heptafluoro-
cyclopentenyl) aryl ether monomers and their condensation
with bisphenols further led to PFCP copolymers with alternating structures. This new class of semifluorinated polymers exhibit surprisingly high crystallinity in some cases and excellent thermal stability.
This document summarizes a study on developing supertough poly(lactic acid) (PLA) blends through reactive melt blending of PLA, ethylene-methyl acrylate-glycidyl methacrylate (EMA-GMA) terpolymer, and a series of renewable poly(ether-b-amide) elastomeric copolymer (PEBA). Ternary blends of PLA/EMA-GMA/PEBA were fabricated and their phase morphology, thermal behavior, and mechanical properties were investigated. An optimized blending ratio of 70 wt% PLA, 20 wt% EMA-GMA, and 10 wt% PEBA achieved an impact strength of ~500 J/m
This study aimed to investigate the polymerisation process of Merbau extractives (ME) and the characteristics of the phenolic resin polymers made from ME. These polymerised ME (PME) can potentially be utilised as an impregnating material to enhance the wood properties of young plantation timber. Selected PME were characterised via Fourier transform
infrared (FTIR) spectroscopy, differential scanning calorimetry, thermogravimetric analysis, Xray diffraction analysis, and ultraviolet-visible analysis. The prediction of the enhancement to
the wood properties when treated with the obtained PME was discussed in relation to the physico-chemical and thermal characteristics of the polymeric materials. The results showed that the ME can be polymerised in its base condition with formaldehyde and resorcinol as the copolymer to produce the PME. The resin was classified as a resole and polymerisation can be done at room temperature. The physico-chemical tests and analyses, via boiling tests and FTIR spectra confirmed that the polymeric compound is a promising impregnating material that can enhance wood properties. This polymeric material is also eco-friendly as the low level of free formaldehyde.
This article discusses electroluminescence of MEH-PPV and poly(styrene-co-acrylic acid-co-1-pyrenylmethyl methacrylate) (SAA) blends. The SAA copolymer contains 3 mol% acrylic acid units and a small amount of pyrenyl groups. Blend films with various MEH-PPV/SAA ratios were prepared and their morphology was studied using microscopy. Devices using MEH-PPV alone had a turn-on voltage of 3.5 V and luminance of 500 cd/m2 at 5 V, while a 50/50 blend showed a turn-on of 2.5 V and luminance of 2300 cd
This document describes a fluorous synthesis method for producing mono-dispersed poly(ethylene glycols) (PEGs) in multi-gram quantities. A fluorous tag is developed and used to modify PEGs, allowing purification using fluorous solid-phase extraction. Repeated cycles of deprotection and coupling of tetra(ethylene glycol) building blocks results in mono-dispersed PEGs of increasing length, up to 20 ethylene glycol units. The fluorous tags and solid-phase extractions simplify purification compared to conventional methods. This synthesis provides improved access to valuable mono-dispersed PEGs for biomedical applications.
synthesis and spectral studies on cardanol based polyurethanesINFOGAIN PUBLICATION
Cardanol is a renewable organic resource obtained as a byproduct from the cashew industry. The present study has been carried out with an aim to manufacture rigid polyurethanes from natural and eco – friendly sources due to the rising prices of petrochemicals and also as an environmental concern. Vegetable oil based polyurethanes promising a new generation polymers which are low cost materials in the family of polyurethanes. Cardanol based phenolic resin has been synthesized by condensing cardanol with furfural in a particular mole ratio using phthalic acid as catalyst. The progress of the reaction was monitored by determining the free furfural and free phenol content. The resin was cured by using the curing agent 4, 41 - methylene bis(cyclohexyl isocyanate) and the catalyst dibutyltin dilaurate to produce polyurethane. Polyurethanes are an important class of polymers that have found place in many applications. The physico chemical and spectral properties of resin and polyurethane have also been studied.
A variety of perfluorocycloalkenyl (PFCA) arylether monomers and polymers with enchained triarylamineunits were successfully synthesized, characterized andreported here. These polymers are highly thermally stableand show variable thermal properties. Successful conver-sion of the newly synthesized TAA enchained perfluoro-cyclopentenyl (PFCP) aryl ether polymers via formylationand EAS demonstrates the synthetic versatility of TAAmoiety and provides an excellent option for applicationspecific post polymerization reactions. The cross-linkingbehavior of PFCP aryl ether polymers was studied underdifferent reaction conditions. The combination of pro-cessability, thermal stabilities, and tailorability makes thesepolymers suitable for a wide variety of applicationsincluding electro-optics, proton exchange membranes andsuper-hydrophobic applications.
Rheological and optical characterization of Polyvinylpyrrolidone (PVP) - Poly...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Perfluorocyclopentenyl (PFCP) Aryl Ether Polymers via Polycondensation of Oct...Babloo Sharma, Ph.D.
A unique class of aromatic ether polymers
containing perfluorocyclopentenyl (PFCP) enchainment was
prepared from the simple step growth polycondensation of
commercial bisphenols and octafluorocyclopentene (OFCP)
in the presence of triethylamine. Model studies indicate that
the second addition/elimination on OFCP is fast and poly-
condensation results in linear homopolymers and copolymers
without side products. The synthesis of bis(heptafluoro-
cyclopentenyl) aryl ether monomers and their condensation
with bisphenols further led to PFCP copolymers with alternating structures. This new class of semifluorinated polymers exhibit surprisingly high crystallinity in some cases and excellent thermal stability.
This document summarizes a study on developing supertough poly(lactic acid) (PLA) blends through reactive melt blending of PLA, ethylene-methyl acrylate-glycidyl methacrylate (EMA-GMA) terpolymer, and a series of renewable poly(ether-b-amide) elastomeric copolymer (PEBA). Ternary blends of PLA/EMA-GMA/PEBA were fabricated and their phase morphology, thermal behavior, and mechanical properties were investigated. An optimized blending ratio of 70 wt% PLA, 20 wt% EMA-GMA, and 10 wt% PEBA achieved an impact strength of ~500 J/m
This study aimed to investigate the polymerisation process of Merbau extractives (ME) and the characteristics of the phenolic resin polymers made from ME. These polymerised ME (PME) can potentially be utilised as an impregnating material to enhance the wood properties of young plantation timber. Selected PME were characterised via Fourier transform
infrared (FTIR) spectroscopy, differential scanning calorimetry, thermogravimetric analysis, Xray diffraction analysis, and ultraviolet-visible analysis. The prediction of the enhancement to
the wood properties when treated with the obtained PME was discussed in relation to the physico-chemical and thermal characteristics of the polymeric materials. The results showed that the ME can be polymerised in its base condition with formaldehyde and resorcinol as the copolymer to produce the PME. The resin was classified as a resole and polymerisation can be done at room temperature. The physico-chemical tests and analyses, via boiling tests and FTIR spectra confirmed that the polymeric compound is a promising impregnating material that can enhance wood properties. This polymeric material is also eco-friendly as the low level of free formaldehyde.
This article discusses electroluminescence of MEH-PPV and poly(styrene-co-acrylic acid-co-1-pyrenylmethyl methacrylate) (SAA) blends. The SAA copolymer contains 3 mol% acrylic acid units and a small amount of pyrenyl groups. Blend films with various MEH-PPV/SAA ratios were prepared and their morphology was studied using microscopy. Devices using MEH-PPV alone had a turn-on voltage of 3.5 V and luminance of 500 cd/m2 at 5 V, while a 50/50 blend showed a turn-on of 2.5 V and luminance of 2300 cd
This document describes a fluorous synthesis method for producing mono-dispersed poly(ethylene glycols) (PEGs) in multi-gram quantities. A fluorous tag is developed and used to modify PEGs, allowing purification using fluorous solid-phase extraction. Repeated cycles of deprotection and coupling of tetra(ethylene glycol) building blocks results in mono-dispersed PEGs of increasing length, up to 20 ethylene glycol units. The fluorous tags and solid-phase extractions simplify purification compared to conventional methods. This synthesis provides improved access to valuable mono-dispersed PEGs for biomedical applications.
synthesis and spectral studies on cardanol based polyurethanesINFOGAIN PUBLICATION
Cardanol is a renewable organic resource obtained as a byproduct from the cashew industry. The present study has been carried out with an aim to manufacture rigid polyurethanes from natural and eco – friendly sources due to the rising prices of petrochemicals and also as an environmental concern. Vegetable oil based polyurethanes promising a new generation polymers which are low cost materials in the family of polyurethanes. Cardanol based phenolic resin has been synthesized by condensing cardanol with furfural in a particular mole ratio using phthalic acid as catalyst. The progress of the reaction was monitored by determining the free furfural and free phenol content. The resin was cured by using the curing agent 4, 41 - methylene bis(cyclohexyl isocyanate) and the catalyst dibutyltin dilaurate to produce polyurethane. Polyurethanes are an important class of polymers that have found place in many applications. The physico chemical and spectral properties of resin and polyurethane have also been studied.
This document summarizes research on synthesizing polylactide/clay nanocomposites by in situ polymerization of D,L-lactide monomer in supercritical carbon dioxide. Polylactide chains were grafted onto clay surfaces, leading to exfoliated nanocomposite morphologies. High clay content "masterbatches" of 30-50% clay were produced and used to create commercial polylactide nanocomposites with 3% clay by melt blending. The resulting nanocomposites showed improved stiffness, toughness, and impact resistance compared to pure polylactide.
Solution And Solid Phase Synthesis Publicationadotse
This document describes the solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential ligands for peroxisome proliferator-activated receptors (PPARs). Initial studies focused on the low-yielding solution-phase synthesis of two target compounds. Improved yields were obtained using solid-phase synthesis and protecting the thiazolidinedione nitrogen. A small library of nine resin-bound peptide-substituted thiazolidinediones was then synthesized to examine structural features that facilitate PPAR binding and identify new PPAR activators/inhibitors.
solid phase synthesis Presentation by komalKomal Rajgire
The document summarizes solid phase synthesis. It begins with an introduction describing how solid phase synthesis involves coupling reagents to a solid support to perform multi-step reactions leading to a target molecule. It then discusses various aspects of planning solid phase synthesis such as suitable resin supports, linkers, protective groups, and monitoring reactions. Examples of resin types, linkers, and protective groups are provided. The document concludes by outlining advantages such as simplified purification and green chemistry principles, as well as disadvantages such as potential low reaction rates. Applications mentioned include combinatorial synthesis, peptide synthesis, and DNA synthesis.
PLGA is a biodegradable and FDA-approved copolymer of poly lactic acid and poly glycolic acid. It is commonly used as a carrier for drug delivery due to its biodegradability and ability to tune degradation kinetics by adjusting the lactic acid to glycolic acid ratio. The document discusses the types of biodegradable polymers including synthetic polymers like PLGA and natural polymers. It explains that PLGA degradation is dependent on hydrolysis and factors like crystallinity and molecular weight that influence properties. The pharmacokinetics of PLGA is non-linear and dose-dependent, and PLGA has been shown to accumulate in organs like the liver and spleen. Surface modification with polymers like PEG can
In this work a new prodrug polymer was
prepared with two attachment groups (amid-ester), using di
functional spacer such as ethanol amine, which could react with
polyacrylic acid producing amide group, with remain ethanol
terminal group which could react with captopril acyl chloride,
producing ester group with extended the arm substituted drug to
improve the hydrolysis and to prevent the steric effect of polymer
chains. Many advantages enhanced the prodrug of polymer. The
prepared polymers were characterized by FTIR, 1H –NMR
spectroscopies. Controlled drug release was studied in different
pH values at 37℃, using UV. Spectra with comparing with
calibration curve. The modification percentage test was studied,and swelling percentage was calculated and all physical properties were observed.
Gelatin-grafted N- proflavine acryl amide was synthesized through two steps; firstly the Gelatin was grafted with
acrylic acid free radically using Ammonium per-sulfate at 60℃, Then it was modified to its corresponding acyl
chloride derivation, second step included the substitution with amino group of proflavine, in this research Gelatin
was used as a natural nontoxic, water soluble polymer as a drug carrier.
The prepared pro drug polymer was characterized by FTIR and 1H-NMR spectroscopies, Controlled drug release
was studied in different pH values at 37℃. Many advantages were obtained comparing with other known
methods.
The document discusses using the solvent N-methylmorpholine-N-oxide (NMMO) to dissolve cellulose for enzymatic hydrolysis. Key findings include:
1) Enzymatic hydrolysis rates were higher for cellulose dissolved in NMMO compared to regenerated cellulose. This supports conducting pretreatment and hydrolysis in a single step.
2) Among ionic liquids tested, enzymatic activity was highest in NMMO and gradually decreased in two other ionic liquids.
3) Preliminary experiments in a twin screw reactor demonstrated the potential to process high cellulose loads and achieve higher sugar yields in a continuous process.
PLGA is a biodegradable and biocompatible copolymer of PLA and PGA that is widely used for controlled drug delivery. It can be synthesized via melt polycondensation or ring opening polymerization to produce copolymers of varying molecular weight and properties. PLGA nanoparticles are effectively used to encapsulate drugs and provide sustained release over time. The drug release kinetics from PLGA nanoparticles are dependent on factors like polymer composition, drug loading, particle size and shape. PLGA degrades via hydrolysis of its ester linkages into biocompatible monomers. Alpha-1 antitrypsin encapsulated in PLGA nanoparticles is a promising approach for pulmonary delivery to treat lung diseases.
Kevlar is a synthetic fiber known for its high tensile strength and heat resistance. It is 5 times stronger than steel yet only one-quarter of the density. Kevlar is synthesized from the monomers para-phenylenediamine and terephthaloyl chloride. It has many applications where light weight and high strength are important, including in aerospace, body armor, helmets, vehicle armor, and cables.
This document discusses peptide synthesis methods, including solution phase peptide synthesis and solid phase peptide synthesis (SPPS). SPPS involves attaching the starting peptide to an inert resin bead and performing sequential amino acid couplings and deprotections while the growing peptide remains attached to the resin. This allows for easy purification after each step. Once the full peptide is synthesized, it is cleaved off the resin bead. SPPS allows for faster synthesis of longer peptides up to 70-100 amino acids in length compared to solution phase synthesis. Applications of synthetic peptides include vaccines, hormones, antibiotics, toxins, and enzyme inhibitors.
12 th biotechnology and Chemistry ,By Kalpana Wagh kalpanawagh
This document summarizes key biomolecules including carbohydrates, proteins, and nucleic acids. It provides details on the classification, structure, and properties of carbohydrates and proteins. Carbohydrates are classified based on their chain length as monosaccharides, disaccharides, oligosaccharides, and polysaccharides. Proteins are classified based on their solubility, shape, function, and chemical composition. The four levels of protein structure - primary, secondary, tertiary, and quaternary - are also described.
plain 4 SYNTHESIS, PURIFICATION AND STABILITY STUDY OF ISLETAndrew Apals
This document outlines Andrew Apals' thesis defense presentation on the synthesis, purification, and stability study of the islet neogenesis-associated protein peptide (INGAP-P) and analogs. The presentation covers solid phase peptide synthesis of INGAP-P, linear and cyclic analogs. It also discusses reverse-phase HPLC method development for the separation and quantification of peptides in synthetic mixtures, including degradation studies of INGAP-P standards. The goal of the research is to develop purification methods to resolve INGAP-P from crude synthesis mixtures using analytical HPLC instrumentation.
combinatorial chemist Piyush lodhi b. pharma 6th sem Drx Piyush Lodhi
Combinatorial chemistry allows for the rapid synthesis of large collections of compounds through various techniques. It has applications in drug discovery by enabling the efficient synthesis and screening of thousands of compounds. Solid phase synthesis is a common method, using resin beads as a solid support onto which compounds are built up through sequential addition of reagents. Merrifield solid phase peptide synthesis pioneered this approach, using insoluble polymer beads and filtration to remove excess reagents at each step. Parallel synthesis is also used, involving the simultaneous synthesis of many compounds in an array of individual reaction vessels to efficiently generate compound libraries for screening.
A Novel Statistical Method for Thermostable Proteins Discrimination IJORCS
This document summarizes a novel statistical method for discriminating between thermostable proteins. The method uses amino acid frequency, dipeptide frequency, and physical-chemical features extracted from protein sequences to classify proteins as mesophilic, thermophilic, or hyper-thermophilic. The researchers tested the effect of each set of features individually and combined on classification accuracy. Their results show the proposed method using all feature types together achieved the best performance, correctly classifying over 90% of proteins on average.
Efficient and Re-usable SAPO Catalyst for the Selective Production of Furans ...pbpbms6
Selective production of furufral from hemicellulose and HMF from various C6 sugars (fructose, glucose, maltose, cellobiose, starch) are shown using solid acid catalyst, SAPO's.
This document summarizes a study on the influence of pH on the structure and properties of poly(o-phenylenediamine) (PoPD) synthesized from o-phenylenediamine. PoPD was synthesized using ammonium persulfate as the oxidizing agent in reaction mediums of varying pH. The polymers were characterized through various techniques. The results showed that the polymer synthesized in lower pH medium was insoluble due to its ladder structure, while the polymer synthesized at higher pH had some open ring and dimer structure and was soluble. Conductivity measurements found the open ring polymer had higher conductivity than the ladder polymer.
CHEMISTRY OF PEPTIDES [M.PHARM, M.SC, BSC, B.PHARM]Shikha Popali
THE CHEMISTRY OF PEPTIDES THE DIFFICULT TO COLLECT DATA FOR READERS , THREFORE HERE WE HAVE COLLECTED ALL THE DATA AT A PLACE AND PROVIDED EASIER TO CHEMISTRIANS.
This document provides an overview of peptidomimetics. It begins with the evolution of peptidomimetics and how they were developed to overcome limitations of peptides as drugs. It then covers classification of peptidomimetics, design strategies like modifying amino acids and imposing structural constraints, and examples of peptidomimetic drugs that inhibit enzymes like ACE, thrombin, and HIV protease. The document concludes by stating peptidomimetics are an important area of drug design for developing small molecule mimics of peptide functions.
Segment and Sequential Stratergies for Solution Phase Peptide SynthesisRUTUJAPAWAR32
This document discusses strategies for solution phase peptide synthesis, including linear and convergent approaches. Linear strategies involve stepwise coupling of amino acids from the C to N terminus, while convergent strategies condense pre-made peptide segments. Both approaches can be used, considering factors like the target peptide complexity, protection schemes, and economics. Convergent synthesis has advantages like dividing labor and being closer to starting materials, but linear strategies may be better for smaller peptides due to issues with segment coupling like low concentration and solubility. Common techniques discussed include manual synthesis using syringes or the tea bag method, and automated synthesis systems.
This document appears to be a collection of phrases related to activities at Mickey Park. It includes welcoming phrases, encouragement to play and work together, references to characters like Mickey Mouse and Goofy, and calls to participate in silly activities like slides. The document promotes teamwork, learning, and having fun through interactive games and adventures at Mickey Park.
Perfluorocyclohexenyl Aryl Ether Polymers via Polycondensation of Decafluoroc...aaaa zzzz
ABSTRACT: A novel class of semifluorinated perfluorocyclohex- enyl (PFCH) aryl ether homo/copolymers was successfully synthesized with high yield through the step-growth polymer- ization of commercially available bisphenols and decafluorocy- clohexene in the presence of a triethylamine base. The synthesized polymers exhibit variable thermal properties depending on the functional spacer group (R). PFCH aryl ether copolymers with random and alternating architectures were also prepared from versatile bis-perfluorocyclohexenyl aryl ether monomers. The PFCH polymers show high thermal
stabilities with a 5% decomposition temperature ranging from 359 to 444 ﰀC in air and nitrogen atmosphere. These semifluori- nated PFCH aromatic ether polymers contain intact enchained PFCH olefin moieties, making further reactions such as cross- linking and application specific functionalization possible. VC 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 232–238
This document summarizes research on synthesizing polylactide/clay nanocomposites by in situ polymerization of D,L-lactide monomer in supercritical carbon dioxide. Polylactide chains were grafted onto clay surfaces, leading to exfoliated nanocomposite morphologies. High clay content "masterbatches" of 30-50% clay were produced and used to create commercial polylactide nanocomposites with 3% clay by melt blending. The resulting nanocomposites showed improved stiffness, toughness, and impact resistance compared to pure polylactide.
Solution And Solid Phase Synthesis Publicationadotse
This document describes the solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential ligands for peroxisome proliferator-activated receptors (PPARs). Initial studies focused on the low-yielding solution-phase synthesis of two target compounds. Improved yields were obtained using solid-phase synthesis and protecting the thiazolidinedione nitrogen. A small library of nine resin-bound peptide-substituted thiazolidinediones was then synthesized to examine structural features that facilitate PPAR binding and identify new PPAR activators/inhibitors.
solid phase synthesis Presentation by komalKomal Rajgire
The document summarizes solid phase synthesis. It begins with an introduction describing how solid phase synthesis involves coupling reagents to a solid support to perform multi-step reactions leading to a target molecule. It then discusses various aspects of planning solid phase synthesis such as suitable resin supports, linkers, protective groups, and monitoring reactions. Examples of resin types, linkers, and protective groups are provided. The document concludes by outlining advantages such as simplified purification and green chemistry principles, as well as disadvantages such as potential low reaction rates. Applications mentioned include combinatorial synthesis, peptide synthesis, and DNA synthesis.
PLGA is a biodegradable and FDA-approved copolymer of poly lactic acid and poly glycolic acid. It is commonly used as a carrier for drug delivery due to its biodegradability and ability to tune degradation kinetics by adjusting the lactic acid to glycolic acid ratio. The document discusses the types of biodegradable polymers including synthetic polymers like PLGA and natural polymers. It explains that PLGA degradation is dependent on hydrolysis and factors like crystallinity and molecular weight that influence properties. The pharmacokinetics of PLGA is non-linear and dose-dependent, and PLGA has been shown to accumulate in organs like the liver and spleen. Surface modification with polymers like PEG can
In this work a new prodrug polymer was
prepared with two attachment groups (amid-ester), using di
functional spacer such as ethanol amine, which could react with
polyacrylic acid producing amide group, with remain ethanol
terminal group which could react with captopril acyl chloride,
producing ester group with extended the arm substituted drug to
improve the hydrolysis and to prevent the steric effect of polymer
chains. Many advantages enhanced the prodrug of polymer. The
prepared polymers were characterized by FTIR, 1H –NMR
spectroscopies. Controlled drug release was studied in different
pH values at 37℃, using UV. Spectra with comparing with
calibration curve. The modification percentage test was studied,and swelling percentage was calculated and all physical properties were observed.
Gelatin-grafted N- proflavine acryl amide was synthesized through two steps; firstly the Gelatin was grafted with
acrylic acid free radically using Ammonium per-sulfate at 60℃, Then it was modified to its corresponding acyl
chloride derivation, second step included the substitution with amino group of proflavine, in this research Gelatin
was used as a natural nontoxic, water soluble polymer as a drug carrier.
The prepared pro drug polymer was characterized by FTIR and 1H-NMR spectroscopies, Controlled drug release
was studied in different pH values at 37℃. Many advantages were obtained comparing with other known
methods.
The document discusses using the solvent N-methylmorpholine-N-oxide (NMMO) to dissolve cellulose for enzymatic hydrolysis. Key findings include:
1) Enzymatic hydrolysis rates were higher for cellulose dissolved in NMMO compared to regenerated cellulose. This supports conducting pretreatment and hydrolysis in a single step.
2) Among ionic liquids tested, enzymatic activity was highest in NMMO and gradually decreased in two other ionic liquids.
3) Preliminary experiments in a twin screw reactor demonstrated the potential to process high cellulose loads and achieve higher sugar yields in a continuous process.
PLGA is a biodegradable and biocompatible copolymer of PLA and PGA that is widely used for controlled drug delivery. It can be synthesized via melt polycondensation or ring opening polymerization to produce copolymers of varying molecular weight and properties. PLGA nanoparticles are effectively used to encapsulate drugs and provide sustained release over time. The drug release kinetics from PLGA nanoparticles are dependent on factors like polymer composition, drug loading, particle size and shape. PLGA degrades via hydrolysis of its ester linkages into biocompatible monomers. Alpha-1 antitrypsin encapsulated in PLGA nanoparticles is a promising approach for pulmonary delivery to treat lung diseases.
Kevlar is a synthetic fiber known for its high tensile strength and heat resistance. It is 5 times stronger than steel yet only one-quarter of the density. Kevlar is synthesized from the monomers para-phenylenediamine and terephthaloyl chloride. It has many applications where light weight and high strength are important, including in aerospace, body armor, helmets, vehicle armor, and cables.
This document discusses peptide synthesis methods, including solution phase peptide synthesis and solid phase peptide synthesis (SPPS). SPPS involves attaching the starting peptide to an inert resin bead and performing sequential amino acid couplings and deprotections while the growing peptide remains attached to the resin. This allows for easy purification after each step. Once the full peptide is synthesized, it is cleaved off the resin bead. SPPS allows for faster synthesis of longer peptides up to 70-100 amino acids in length compared to solution phase synthesis. Applications of synthetic peptides include vaccines, hormones, antibiotics, toxins, and enzyme inhibitors.
12 th biotechnology and Chemistry ,By Kalpana Wagh kalpanawagh
This document summarizes key biomolecules including carbohydrates, proteins, and nucleic acids. It provides details on the classification, structure, and properties of carbohydrates and proteins. Carbohydrates are classified based on their chain length as monosaccharides, disaccharides, oligosaccharides, and polysaccharides. Proteins are classified based on their solubility, shape, function, and chemical composition. The four levels of protein structure - primary, secondary, tertiary, and quaternary - are also described.
plain 4 SYNTHESIS, PURIFICATION AND STABILITY STUDY OF ISLETAndrew Apals
This document outlines Andrew Apals' thesis defense presentation on the synthesis, purification, and stability study of the islet neogenesis-associated protein peptide (INGAP-P) and analogs. The presentation covers solid phase peptide synthesis of INGAP-P, linear and cyclic analogs. It also discusses reverse-phase HPLC method development for the separation and quantification of peptides in synthetic mixtures, including degradation studies of INGAP-P standards. The goal of the research is to develop purification methods to resolve INGAP-P from crude synthesis mixtures using analytical HPLC instrumentation.
combinatorial chemist Piyush lodhi b. pharma 6th sem Drx Piyush Lodhi
Combinatorial chemistry allows for the rapid synthesis of large collections of compounds through various techniques. It has applications in drug discovery by enabling the efficient synthesis and screening of thousands of compounds. Solid phase synthesis is a common method, using resin beads as a solid support onto which compounds are built up through sequential addition of reagents. Merrifield solid phase peptide synthesis pioneered this approach, using insoluble polymer beads and filtration to remove excess reagents at each step. Parallel synthesis is also used, involving the simultaneous synthesis of many compounds in an array of individual reaction vessels to efficiently generate compound libraries for screening.
A Novel Statistical Method for Thermostable Proteins Discrimination IJORCS
This document summarizes a novel statistical method for discriminating between thermostable proteins. The method uses amino acid frequency, dipeptide frequency, and physical-chemical features extracted from protein sequences to classify proteins as mesophilic, thermophilic, or hyper-thermophilic. The researchers tested the effect of each set of features individually and combined on classification accuracy. Their results show the proposed method using all feature types together achieved the best performance, correctly classifying over 90% of proteins on average.
Efficient and Re-usable SAPO Catalyst for the Selective Production of Furans ...pbpbms6
Selective production of furufral from hemicellulose and HMF from various C6 sugars (fructose, glucose, maltose, cellobiose, starch) are shown using solid acid catalyst, SAPO's.
This document summarizes a study on the influence of pH on the structure and properties of poly(o-phenylenediamine) (PoPD) synthesized from o-phenylenediamine. PoPD was synthesized using ammonium persulfate as the oxidizing agent in reaction mediums of varying pH. The polymers were characterized through various techniques. The results showed that the polymer synthesized in lower pH medium was insoluble due to its ladder structure, while the polymer synthesized at higher pH had some open ring and dimer structure and was soluble. Conductivity measurements found the open ring polymer had higher conductivity than the ladder polymer.
CHEMISTRY OF PEPTIDES [M.PHARM, M.SC, BSC, B.PHARM]Shikha Popali
THE CHEMISTRY OF PEPTIDES THE DIFFICULT TO COLLECT DATA FOR READERS , THREFORE HERE WE HAVE COLLECTED ALL THE DATA AT A PLACE AND PROVIDED EASIER TO CHEMISTRIANS.
This document provides an overview of peptidomimetics. It begins with the evolution of peptidomimetics and how they were developed to overcome limitations of peptides as drugs. It then covers classification of peptidomimetics, design strategies like modifying amino acids and imposing structural constraints, and examples of peptidomimetic drugs that inhibit enzymes like ACE, thrombin, and HIV protease. The document concludes by stating peptidomimetics are an important area of drug design for developing small molecule mimics of peptide functions.
Segment and Sequential Stratergies for Solution Phase Peptide SynthesisRUTUJAPAWAR32
This document discusses strategies for solution phase peptide synthesis, including linear and convergent approaches. Linear strategies involve stepwise coupling of amino acids from the C to N terminus, while convergent strategies condense pre-made peptide segments. Both approaches can be used, considering factors like the target peptide complexity, protection schemes, and economics. Convergent synthesis has advantages like dividing labor and being closer to starting materials, but linear strategies may be better for smaller peptides due to issues with segment coupling like low concentration and solubility. Common techniques discussed include manual synthesis using syringes or the tea bag method, and automated synthesis systems.
This document appears to be a collection of phrases related to activities at Mickey Park. It includes welcoming phrases, encouragement to play and work together, references to characters like Mickey Mouse and Goofy, and calls to participate in silly activities like slides. The document promotes teamwork, learning, and having fun through interactive games and adventures at Mickey Park.
Perfluorocyclohexenyl Aryl Ether Polymers via Polycondensation of Decafluoroc...aaaa zzzz
ABSTRACT: A novel class of semifluorinated perfluorocyclohex- enyl (PFCH) aryl ether homo/copolymers was successfully synthesized with high yield through the step-growth polymer- ization of commercially available bisphenols and decafluorocy- clohexene in the presence of a triethylamine base. The synthesized polymers exhibit variable thermal properties depending on the functional spacer group (R). PFCH aryl ether copolymers with random and alternating architectures were also prepared from versatile bis-perfluorocyclohexenyl aryl ether monomers. The PFCH polymers show high thermal
stabilities with a 5% decomposition temperature ranging from 359 to 444 ﰀC in air and nitrogen atmosphere. These semifluori- nated PFCH aromatic ether polymers contain intact enchained PFCH olefin moieties, making further reactions such as cross- linking and application specific functionalization possible. VC 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 232–238
Ultra low dielectric constant (k 1⁄4 1.53) materials with self-cleansing properties were synthesized via incorporation of fluorodecyl-polyhedral oligomeric silsesquioxane (FD-POSS) into recently synthesized perfluorocyclopentenyl (PFCP) aryl ether polymers. Incorporation of fluorine rich, high free volume, and low surface energy POSS into a semifluorinated PFCP polymer matrix at various weight percentages resulted in a dramatic drop in dielectric constant, as well as a significant increase in hydrophobicity and oleophobicity of the system. These ultra-low dielectric self-cleansing materials (qtilt 1⁄4 38) were fabricated into electrospun mats from a solvent blend of fluorinated FD-POSS with PFCP polymers.
This document defines insurance and outlines key terminology used in the insurance industry such as policy, premium, insured, and indemnity. It discusses various principles of insurance contracts including utmost good faith, indemnity, insurable interest, and proximate cause. The document also categorizes different types of insurance like life, fire, marine, and general insurance. It provides examples of life and general insurance policies. Additionally, it defines roles of insurance intermediaries like agents, brokers, surveyors, and TPAs. Finally, the document outlines different types of risks covered by insurance like systematic, unsystematic, credit, country, and foreign exchange risk.
Bab V membahas alat-alat optik seperti mata, kacamata, lup, kamera, mikroskop, dan teropong. Mata merupakan alat optik tercanggih yang dapat mendeteksi cahaya dan membentuk bayangan pada retina untuk melihat. Ada beberapa cacat mata seperti miopi dan hipermetropi yang dapat ditangani dengan kacamata berlensa cekung atau cembung."
This document discusses key concepts related to leadership and strategic quality management. It defines leadership as a process of influencing others to accomplish objectives through applying attributes like vision, values and skills. It also discusses strategic quality management as a structured process for establishing long-term quality goals through strategic planning, development and deployment led by top management. Finally, it covers additional topics like corporate social responsibility, quality culture, and change management.
A marketing channel is a set of activities needed to transfer ownership of goods from production to consumption, consisting of institutions and activities in the marketing process. Key factors in determining a marketing channel include the product, customers, competition, distribution systems, and target markets. The structure of a channel refers to the number of intermediary levels between producer and consumer, which can be zero, one, two, or three levels deep. Common channel strategies are intensive, exclusive, and selective distribution. Typical channel members are manufacturers' representatives, sales forces, and industrial distributors.
The document discusses investigative science learning environments (ISLE). It summarizes that learning is a physical process that occurs through neural network activation and extension, and also a social process when learners work together. The goal of ISLE is to engineer learning environments where students can actively construct their own ideas through representation, data analysis, pattern finding, testing explanations, and revising understandings based on new evidence, similar to how physicists work. An example ISLE model involves students conducting observational experiments to form explanations, then testing experiments to revise understandings, representing the process scientists use to make new knowledge.
Dokumen tersebut membahas tentang gelombang elektromagnetik, yang merupakan gelombang yang terdiri atas medan listrik dan magnet yang saling tegak lurus dan dapat merambat di ruang hampa tanpa memerlukan medium. Gelombang elektromagnetik memiliki berbagai panjang gelombang dan frekuensi yang membentuk spektrum gelombang elektromagnetik, mulai dari sinar gamma hingga gelombang radio. Teori gelombang elektromagnetik dikembangkan oleh James Clerk
This document discusses human resource forecasting, recruitment, placement, and induction processes. It begins by outlining factors that affect human resource demand forecasting such as employment trends, replacement needs, productivity, and organizational growth. It then describes various forecasting techniques including ratio-trend analysis, nominal group technique, and Delphi technique. The document also outlines the recruitment process including purposes, advantages, disadvantages, and outlines the selection procedure. It defines placement and induction, and describes their objectives and advantages for integrating new employees.
El documento presenta un modelo relacional para una base de datos de una empresa. El modelo contiene tablas para clientes, empleados, productos, ventas, materia prima, y proveedores, así como sus atributos respectivos. También incluye una sección de álgebra relacional con ejemplos de consultas sobre las tablas.
Introducción a la corrosión johalbert almarzaSukano Yekh
El documento proporciona información sobre la clasificación de materiales, el proceso siderúrgico para obtener metales y aleaciones, las propiedades mecánicas de los materiales y cómo se determinan, y los factores ambientales que afectan el comportamiento de los materiales. Explica que los materiales se clasifican en metales, cerámicos, polímeros y semiconductores, y describe el proceso para obtener acero a partir de minerales en un alto horno. También cubre conceptos como la dureza, ductilidad, resistencia y cómo p
This document summarizes a study on the multifunctionalization of octafluorocyclopentene (OFCP) under mild conditions. OFCP undergoes multiple substitutions with nucleophiles derived from phenols in a stepwise manner. Initially, the vinylic fluorine atoms at the 1 and 5 positions undergo displacement exclusively, followed by displacement of two fluorine atoms, one each at the 2 and 4 positions, with no further substitution beyond tetrasubstitution. Two types of semi-fluorinated linear polymers bearing various pendant groups were synthesized - one with the polymer chain formed by substitution at the 1 and 5 positions with bisphenols and pendant groups at the 2 and 4 positions, and the other with pendant groups
Crystallization behaviour of a polymeric membraneSHALU KATARIA
The document describes a study of the crystallization behavior of the polymer PVdF–HFP (poly(vinylidenefluoride)–hexafluoropropylene) in the presence and absence of the ionic liquid BMIMBF4 (1-butyl-3-methylimidazolium tetrafluoroborate). Isothermal and non-isothermal crystallization processes were analyzed using differential scanning calorimetry. The addition of BMIMBF4 was found to suppress the crystallization of PVdF–HFP, resulting in lower crystal growth rates. Three kinetic methods were used to analyze the non-isothermal crystallization, with Mo's method providing the best explanation of
Bis-perfluorocycloalkenyl (PFCA) aryl ether monomers towards a versatile clas...Babloo Sharma, Ph.D.
A unique class of perfluorocycloalkenyl (PFCA) aryl ether monomers was synthesized from commercially available perfluorocycloalkenes (PFCAs) and bisphenols in good yields. This facile one pot reaction of perfluorocycloalkenes, namely, octafluorocyclopentene (OFCP), and decafluorocyclohexene (DFCH), with bisphenols occurs at room temperature via an addition–elimination reaction in the presence of a base. The synthesis of PFCA monomers and their condensation with bisphenols lead to perfluorocycloalkenyl (PFCA) aryl ether homopolymers and copolymers with random and/or alternating polymer architectures.
Perfluorocyclopentenyl (PFCP) Aryl Ether Polymers via Polycondensation of Oct...aaaa zzzz
ABSTRACT: A unique class of aromatic ether polymers
containing perfluorocyclopentenyl (PFCP) enchainment was
prepared from the simple step growth polycondensation of
commercial bisphenols and octafluorocyclopentene (OFCP)
in the presence of triethylamine. Model studies indicate that
the second addition/elimination on OFCP is fast and poly-
condensation results in linear homopolymers and copolymers
without side products. The synthesis of bis(heptafluoro-
cyclopentenyl) aryl ether monomers and their condensation
with bisphenols further led to PFCP copolymers with alternating structures. This new class of semifluorinated polymers exhibit surprisingly high crystallinity in some cases and excellent thermal stability.
This document summarizes the development of efficient protocols for the synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones. Specifically, it describes:
1) A concise 5-step synthesis of a key phenol intermediate from 4-benzyloxybenzaldehyde.
2) Three parallel arrays utilizing the phenol intermediate to explore structure-activity relationships, including a Mitsunobu reaction, copper-catalyzed arylation, and nucleophilic aromatic substitution.
3) The need to further optimize the key 5-step synthesis to enable more diverse SAR exploration of the chemical series.
This document provides an introduction to fluoropolymers, including their classification and important examples. It describes the major commercial fluoropolymers based on tetrafluoroethylene, vinylidene fluoride, and chlorotrifluoroethylene monomers. The document also summarizes the synthesis processes for these important monomers as well as other fluoromonomers such as hexafluoropropylene and perfluoroalkylvinylethers.
Electrical, Mechanical, Structural, and Thermal Behaviors of PolymericSHALU KATARIA
This document summarizes research on polymeric gel electrolyte membranes made of poly(vinylidene fluoride-co-hexafluoropropylene) [P(VdF–HFP)] polymer with an ionic liquid (IL) and lithium salt added. The IL and salt used were 1-butyl-3-methylimidazolium tetrafluoroborate and lithium tetrafluoroborate. Various properties of the membranes were characterized, including thermal behavior, structure, ionic conductivity, and mechanical properties. The addition of the IL-salt solution was found to increase ionic conductivity but decrease the glass transition temperature, melting temperature, crystallinity, thermal stability, elastic modulus, and hardness of the membranes
Studies on some economic and effective Ion exchange Resin used as catalyst in...IOSR Journals
Terrenes are the abundant group of natural compounds that can be transformed into products of higher commercial value by organic reaction under the influence of suitable catalyst. Isolongifoline ketone was synthesized by Isolongifoline with the application of ion exchange catalyst viz. Tulsion T-421, Tulsion T-521, Indion 225, Indion 770.It is evident that Tulsion T-421 & T-521 shows higher yield of Isolongifoline ketone due to its characteristics. Characterization of resin was done by determine the elemental analysis, ion exchange capacity, FTIR analysis, TGA and SEM analysis. The significance of the ion exchange resin is revealed by the conversion of Isolongifoline to Isolongifoline ketone.Thermax T-421was finding to possess the higher selectivity for isolongifoline ketone and high thermal stability.
The document describes using reversible addition-fragmentation chain transfer (RAFT) polymerization to synthesize novel block copolymers containing both a polyolefin block and a poly(styrene-co-maleic anhydride) block. Specifically, it details:
1) Using a commercially available polyolefin (Kraton L-1203) modified with a dithioester group to serve as a macroinitiator for RAFT polymerization and form the polyolefin block.
2) Conducting RAFT polymerizations of styrene and styrene-co-maleic anhydride using this macroinitiator and a small molecule RAFT agent to form the second block and yield polyolefin
This document summarizes the development of ion conducting polymer gel electrolyte membranes based on poly(vinylidene fluoride-co-hexafluoropropylene) (PVdF-HFP), the ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMIMTFSI), and lithium salt LiTFSI. The membranes were characterized using various techniques and were found to have ionic conductivities up to 2.1x10-3 S/cm at 30°C, good thermal stability up to 300-400°C, and flexibility. The addition of the ionic liquid was found to increase the ionic conductivity
This document summarizes research on developing a phosphoric acid doped poly(2,5-benzimidazole) membrane for use in high temperature fuel cells. Key points:
- Undoped and phosphoric acid doped poly(2,5-benzimidazole) membranes were prepared using a solvent casting method. Phosphoric acid concentration was varied from 0-60% by volume to improve proton conductivity at high temperatures.
- The 60% phosphoric acid doped membrane with a doping level of 1.65 showed the highest proton conductivity of 2.2 x 10-2 S/cm. It exhibited a decrease in crystallinity and mechanical properties compared to the undoped membrane.
This document summarizes research into the effects of methoxy-substituted metalloporphyrins as catalysts in the epoxidation of alkenes. Five different manganese tetraphenylporphyrin acetates were synthesized with varying numbers and positions of methoxy substituents on the phenyl rings. These porphyrins were then used as catalysts for the epoxidation of various alkenes using tetra-n-butylammonium hydrogen monopersulfate as the oxidant and imidazole as the axial ligand. The catalytic activity of the porphyrins followed the order: unmodified TPPMnOAc ≥ di-methoxy substituted T(2,3-
Thermal stability, complexing behavior, and ionic transport ofSHALU KATARIA
This document describes a study on polymeric gel membranes composed of poly(vinylidenefluoride-co-hexafluoropropylene) (PVdF-HFP) polymer and an ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]). The membranes were synthesized by solution casting and characterized using various techniques. It was found that the ionic liquid partly complexes with the PVdF-HFP polymer chains and partly remains dispersed. The ionic conductivity of the membranes increases with increasing ionic liquid content, reaching a maximum of 1.6 × 10−2 S·cm−1 for a membrane with 90% ionic liquid
This document summarizes the chemical synthesis of 2-amino-4-heteroarylpyrimidines and related compounds for use as JNK1 inhibitors. Key steps include:
1) Microwave-induced SNAr reactions of primary amines with 2-methylsulfonylpyrimidines or 2-chloropyrimidines to access initial targets.
2) Elaboration of pendant piperidine functionality using silica-bound reagents in microwave reductive amination and amide bond formation.
3) Exploration of variations to the core pyrimidine scaffold and piperidine substitutions using efficient parallel synthesis methods.
This document summarizes a study on how geometric confinement of building blocks controls the mechanical properties of poly(urethane−urea) copolymer films. The researchers prepared copolymer films using poly(ethylene oxide) soft segments of different molecular weights and dried the films at different temperatures. They found that films dried at higher temperatures exhibited a hierarchical structure with tightly packed helical and sheet-like secondary structures. These films demonstrated an unusual combination of stiffness, strength, extensibility, and toughness due to confinement of soft segment crystallization within hard segment channels. The confinement is driven by interactions not previously observed in polyurethane copolymers and results in a structural hierarchy that mimics protein structures.
This document summarizes a study on how geometric confinement of building blocks controls the mechanical properties of poly(urethane−urea) copolymer films. The researchers prepared copolymer films using poly(ethylene oxide) soft segments of different molecular weights and dried the films at different temperatures. They found that films dried at higher temperatures exhibited a hierarchical structure with tightly packed helical and sheet-like secondary structures. These films demonstrated an unusual combination of stiffness, strength, extensibility, and toughness due to confinement of soft segment crystallization within hard segment channels. The severity of confinement could be tuned through soft segment molecular weight and drying temperature, offering a way to control material properties.
This document describes a one-pot, three-component reaction to synthesize densely substituted benzofurans from methyl ketones, phenols, and nucleophiles. Specifically, it details:
1) The reaction of phenylglyoxal monohydrate, phenols like sesamol, and indoles produces benzofurans in good to excellent yields with acid catalysis.
2) Replacing phenylglyoxal with methyl ketones and using I2/DMSO allows an in situ generation of arylglyoxal from the methyl ketone for the reaction.
3) Various substituted benzofurans can be synthesized from different methyl ketones, phenols
This is ppt presentation of Dr. P.T. Perumal on the topic of preparation and reactions various Vilsmeir reagent and their applications in Heterocyclic chemistry.
This is very useful presentation and will be useful as a good reference for work on Heterocyclic chemistry.
Bis-perfluorocycloalkenyl (PFCA) aryl ether monomers towards a versatile clas...aaaa zzzz
A unique class of perfluorocycloalkenyl (PFCA) aryl ether monomers was synthesized from commercially available perfluorocycloalkenes (PFCAs) and bisphenols in good yields. This facile one pot reaction of per- fluorocycloalkenes, namely, octafluorocyclopentene (OFCP), and decafluorocyclohexene (DFCH), with bisphenols occurs at room temperature via an addition–elimination reaction in the presence of a base. The synthesis of PFCA monomers and their condensation with bisphenols lead to perfluorocycloalkenyl (PFCA) aryl ether homopolymers and copolymers with random and/or alternating polymer architectures.
Published by Elsevier Ltd.
Similar to Triarylamine-enchained semifluorinated perfluorocycloalkenyl (PFCA) aryl ether polymers (20)
Crosslinked Microgels as Platform for Hydrolytic Catalysts Article pubs.acs.o...aaaa zzzz
This document describes the development of a new protocol for synthesizing crosslinked microgels via UV-initiated free radical polymerization of miniemulsions at ambient temperature or below. The microgels are formed from butyl acrylate, ethylene glycol dimethacrylate, and a catalyst-precursor ligand. The catalytic activity of the microgels is demonstrated through the hydrolysis of 4-methylumbelliferyl β-D-galactopyranoside. A correlation is observed between the crosslinking content of the microgels and their catalytic proficiency, with peak performance at 40 mol% crosslinking.
Biomimetic Glycoside Hydrolysis by a Microgel Templated with a Competitive Gl...aaaa zzzz
This document summarizes the synthesis and characterization of biomimetic microgel catalysts templated with a competitive glycosidase inhibitor (galactonoamidine). The microgels were synthesized via free radical polymerization in the presence of a binuclear copper complex and the inhibitor. Computational modeling was used to determine the inhibitor binds to the copper complex through its amidine and hydroxyl groups. The resulting microgels were characterized and found to have a narrow size distribution and near-quantitative incorporation of the copper complex. The microgels show potential as biomimetic catalysts for glycoside hydrolysis.
This document summarizes research on the synthesis of semi-fluorinated polymers via polycondensation of perfluoroalkenes (PFCAs) such as perfluorocyclopentene (PFCP) and perfluorocyclohexene (PFCH) with various bisphenols. Key findings include:
- PFCA monomers such as PFCP and PFCH were synthesized and reacted with bisphenols including biphenol, bisphenol A, and bisphenol-6F via polycondensation to obtain semi-fluorinated polymers.
- The polymers were characterized using NMR (1H, 19F, 13C), IR, TGA, DSC to determine structure, purity
- Babloo Sharma earned a Doctor of Philosophy degree in Chemistry in 2013 from [University name omitted] with a GPA of 4.0.
- He completed his PhD coursework and research under Professor Dennis W Smith, earning straight A's in several chemistry courses.
- Sharma maintained a GPA of 4.0 throughout his graduate studies from 2010 to 2013, and received his degrees in good academic standing.
1. The document discusses similarities between subatomic and astronomical levels, noting electrons orbiting nuclei like planets orbiting stars and spherical shapes at many scales.
2. It then notes Avogadro's constant of 6.022140857(74) ×1023 mol-1, which relates the number of entities at the macro and microscopic levels.
3. Based on the similarities observed and Avogadro's constant, the author postulates that there are exactly 6.022140857(74) ×1023 stars in the universe, equivalent to 1 mole of stars.
This book focuses on novel perflurocycloalkenyl (PFCA) aryl ether polymers, derived via polycondensation of perfluorocycloalkenes with bisphenols. Chapter 1 describes the detailed background of fluorine, its reactivity and effect in organic chemistry. This chapter also discusses the application of fluoropolymers with a detailed study of two fluoropolymers: perfluorocyclobutyl aryl ether polymers and fluorinated arylene vinylene ether polymers. Chapter 2, 3 and 4 describe the detailed synthesis, characterization and different properties of bis-PFCA aryl ether monomers, perfluorocyclopentenyl (PFCP) aryl ether polymers and perfluorocyclohexenyl (PFCH) aryl ether polymers, respectively. Chapter 3 also includes the potential crosslinking and post-functionalization studies of PFCA aryl ether polymers. Chapter 5 discusses the application section of these newly synthesized PFCA aryl ether polymers. Ultra low dielectric constant (k = 1.53) materials with self-cleansing properties were synthesized via incorporation of fluorodecyl-polyhedral oligomeric silsesquioxane (FD-POSS) into PFCP aryl ether polymers.
Sulfonated perfluorocyclopentenyl polymers and uses thereofaaaa zzzz
An aspect of the invention is directed to a polymer comprising a Sulfonated PerfluorocycIopentyl compound. Another aspect of the invention is directed to a sulfonated copolymer comprising one or more sulfonated polymers.A further aspect of the invention is directed to membranes prepared from the polymers of the claimed invention.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptxMAGOTI ERNEST
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
ESPP presentation to EU Waste Water Network, 4th June 2024 “EU policies driving nutrient removal and recycling
and the revised UWWTD (Urban Waste Water Treatment Directive)”
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
Nucleophilic Addition of carbonyl compounds.pptxSSR02
Nucleophilic addition is the most important reaction of carbonyls. Not just aldehydes and ketones, but also carboxylic acid derivatives in general.
Carbonyls undergo addition reactions with a large range of nucleophiles.
Comparing the relative basicity of the nucleophile and the product is extremely helpful in determining how reversible the addition reaction is. Reactions with Grignards and hydrides are irreversible. Reactions with weak bases like halides and carboxylates generally don’t happen.
Electronic effects (inductive effects, electron donation) have a large impact on reactivity.
Large groups adjacent to the carbonyl will slow the rate of reaction.
Neutral nucleophiles can also add to carbonyls, although their additions are generally slower and more reversible. Acid catalysis is sometimes employed to increase the rate of addition.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...Travis Hills MN
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
Phenomics assisted breeding in crop improvementIshaGoswami9
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
The binding of cosmological structures by massless topological defectsSérgio Sacani
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field
equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational
field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin
spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling
concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect
light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is
mitigated, at least in part.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
1. ORIGINAL ARTICLE
Triarylamine-enchained semifluorinated perfluorocycloalkenyl
(PFCA) aryl ether polymers
Babloo Sharma • Mohammad Faisal •
Shawna M. Liff • Dennis W. Smith Jr.
Received: 6 May 2014 / Accepted: 12 May 2014 / Published online: 20 September 2014
Ó The Author(s) 2014. This article is published with open access at Springerlink.com
Abstract A variety of perfluorocycloalkenyl (PFCA) aryl
ether monomers and polymers with enchained triarylamine
units were successfully synthesized, characterized and
reported here. These polymers are highly thermally stable
and show variable thermal properties. Successful conver-
sion of the newly synthesized TAA enchained perfluoro-
cyclopentenyl (PFCP) aryl ether polymers via formylation
and EAS demonstrates the synthetic versatility of TAA
moiety and provides an excellent option for application
specific post polymerization reactions. The cross-linking
behavior of PFCP aryl ether polymers was studied under
different reaction conditions. The combination of pro-
cessability, thermal stabilities, and tailorability makes these
polymers suitable for a wide variety of applications
including electro-optics, proton exchange membranes and
super-hydrophobic applications.
Keywords Semi-fluorinated polymers Á Step-growth
polycondensation Á Addition–elimination reaction Á
Perfluorocycloalkenes
Introduction
The serendipitous discovery of poly(tetrafluoroethylene)
by Roy Plunkett caught the global attention and led to
tremendous improvement in fluoropolymer field [1, 2].
Due to their high thermal and chemical stabilities, fluo-
ropolymers are regarded for adverse applications. Fluo-
ropolymers also exhibit low refractive index and fraction
coefficient, low optical loss at telecom wavelength, good
hydrophobicity and oleophobicity, low intermolecular
and intramolecular interactions, which result in low
surface energy and low relative permittivity [3, 4].
Crediting to these properties, fluoropolymers have shown
their use in a variety of applications including paints
and coatings, optical fibers, antifouling coatings, materi-
als for photoresist and micro-lithography, conducting
polymers, aerospace, and wire and cable industry mate-
rials [5–19].
Due to their high crystalline nature, high melting point
and the low solubility problem, the processability of these
fluoropolymers is difficult. The modification of these
fluoropolymers to high performance materials without melt
and solution processing limitations demands high cost.
There is always a constant demand for fluoropolymers with
cheaper feed stocks, variable thermal properties and
excellent properties. Although, majority volume of fluo-
ropolymers is derived via chain growth polymerization of
fluorinated olefin monomers, step growth polymerization
methodology also has been used. Perfluorocyclobutyl
(PFCB) aryl ether polymers and fluorinated arylene
vinylene ether (FAVE) polymers are two such classes,
synthesized via step growth polymerization of aromatic
trifluorovinyl ether (TFVE) monomers (Scheme 1). [20–
24] The aromatic backbones in these semifluorinated
polymers not only address the performance issue, but also
Electronic supplementary material The online version of this
article (doi:10.1007/s13203-014-0063-0) contains supplementary
material, which is available to authorized users.
B. Sharma Á M. Faisal Á D. W. Smith Jr. (&)
Department of Chemistry, The Alan G. MacDiarmid NanoTech
Institute, The University of Texas at Dallas, Richardson,
TX 75080, USA
e-mail: dwsmith@utdallas.edu
S. M. Liff
Intel Corporation, Chandler, Arizona 85226, USA
123
Appl Petrochem Res (2015) 5:35–45
DOI 10.1007/s13203-014-0063-0
2. provide a means for facile modification to achieve modular
utility.
PFCB aryl ether polymers are first synthesized and
investigated by The Dow Chemical Company in the early
1990s as potential dielectric materials for integrated cir-
cuits applications [20]. PFCB aryl ether polymers are
prepared via [2 ? 2] thermo-cyclodimerization reaction
of TFVE monomers at reaction temperature of
150–200 °C (Scheme 1a). The cycloaddition results in
stereo-random PFCB rings in primarily 1,2 fashion (i.e.,
head-to-head). These uniquely amorphous polymers
demonstrate excellent solution processability, modular
utility, comparable properties with the highly-market
fluoropolymers and high performance in a variety of
applications including electro-optics, fuel cell mem-
branes, etc. [21, 25].
In 2006, our research group extended TFVE monomer
chemistry and introduced a new class of fluoropolymers,
namely, fluorinated arylene vinylene ether (FAVE) poly-
mers, derived from the step-growth polycondensation of
TFVE monomers with bisphenols (Scheme 1b) [22, 23].
FAVE polymers are telechelic in nature and possess dual
functionalities, which facilitate chain extension (via ther-
mal [2 ? 2] cyclodimerization of end groups) and tandem
cross-linking (due to internal olefins) to polymeric network
without the use of any cross-linker additives [23]. The
content of internal fluoro-olefin moieties depends on the
reaction conditions and can be manipulated on the
requirement [22, 26].
More recently, we have extended our high performance
fluoropolymer materials research and developed perflu-
orocyclopentenyl (PFCP) aryl ether polymers and perflu-
orocyclohexenyl (PFCH) aryl ether polymers, collectively
categorized as perfluorocycloalkenyl (PFCA) aryl ether
polymers via polycondensation of commercially available
perfluorocycloalkenes (PFCAs) and bisphenols (Scheme 2)
[27, 28]. In this manuscript, we are presenting new per-
Scheme 1 a Synthesis of PFCB
aryl ether polymers via thermal
mediated [2 ? 2]
cyclodimerization reaction.
b Synthesis of FAVE polymers
via step-growth polymerization
Scheme 2 Synthesis of perfluorocycloalkenyl (PFCA) aryl ether
polymers [28]
36 Appl Petrochem Res (2015) 5:35–45
123
3. fluorocycloalkenyl (PFCA) aryl ether polymers with tria-
rylamine moieties, and cross-linking behavior of PFCA
aryl ether polymers. TAA moieties provide an excellent
reaction site for post polymerization modification to make
these fluoropolymers application specific [26, 29].
Results and discussion
Step-growth polymers: methodology
PFCP aryl ether polymers and PFCH aryl ether polymers
are synthesized via step-growth polymerization of com-
mercially available bisphenols with octafluorocyclopentene
(OFCP) and decafluorocyclohexene (DFCH), respectively
(Scheme 2) [27, 28]. In optimized reaction condition, the
bisphenols are mixed with perfluorocycloalkene (PFCA)
monomers in a stoichiometric ratio of 1:1 and heated at
80 °C in the presence of a base, triethylamine. This method
produces PFCA aryl ether polymers with enchained per-
fluoro-olefin moieties intact, in good yield.
Nucleophilic attack on a perfluoro-olefin is a well
studied and documented organofluorine transformation and
continues to attract attention periodically [30]. Here, attack
on PFCA ring by phenoxide ion, resulted in situ due to
action of base on bisphenol, generates a carbanion on
perfluorocycloalkene ring which, theoretically, can elimi-
nate fluoride ion resulting in allyl and vinyl substituted
products (Scheme 3). However, as the literature demon-
strates, the ratio of vinyl to allyl substituted products varies
and depends on the PFCA ring size, nucleophilicity of
attacking anion, and reaction conditions. [28, 31, 32].
Synthesis and characterization
PFCP aryl ether polymers derived from the OFCP gave
exclusively vinyl fluoro-olefin enchainments, no trace of
allyl product was noticed [27]. However, the PFCH aryl
ether polymers prepared from DFCH gave both, vinyl fluoro-
olefins as major and allyl fluoro-olefins as minor enchain-
ments via a double addition–elimination mechanism [28].
Gel permeation chromatography (GPC) showed num-
ber-average molecular weights (Mn) from 9,100 to 15,400
for PFCP aryl ether polymers derived from different bi-
sphenols [27]. In case of PFCH aryl ether polymers, Mn
ranged from 9,400 to 15,600 [28]. Thermogravimetric
analysis (TGA) showed excellent thermal stability of these
polymers. The degradation temperature at 5 % weight loss
(Td 5 %) varied from 432 to 483 °C and 383 to 444 °C for
PFCP aryl ether polymers and PFCH aryl ether polymers,
respectively. Thermal analysis via differential scanning
calorimetry (DSC) showed variable glass transition tem-
perature (Tg) ranging from 432 to 483 °C and 90 to 132 °C
for PFCP aryl ether polymers and PFCH aryl ether poly-
mers, respectively. Interestingly, both PFCA aryl ether
polymers synthesized from Bisphenol-AF also showed
melting peaks in their respective DSC thermogram. This
anomalous crystalline nature was attributed to a higher
fluorine content, as found with -C(CF3)2 moiety of the
bisphenol-AF group [33].
In this manuscript, PFCP aryl ether monomer and
polymers with enchained triarylamine (TAA) units were
synthesized and studied (Scheme 4, 5). The latent reac-
tivity of TAA unit provides the post polymerization mod-
ification opportunities to achieve application specific
properties Scheme 6.
Bis(4-methoxyphenyl)phenylamine (A) and its depro-
tected analogous (B) were prepared by following the
standard literature procedure via Ullman coupling (i) and
BBr3 methoxy deprotection (ii), respectively [26, 34, 35].
The bis(perfluorocyclopentenyloxy)triarylamine monomer
(M) was synthesized by treating B with OFCP in a stoi-
chiometric ratio of 1:3 in the presence of a base, triethyl-
amine at room temperature (Scheme 4). 19
F NMR shows
only three distinct resonances (8:4:2) corresponding to
three different fluorine atoms (Fig. 1). As expected, PFCA
Scheme 3 Nucleophilic attack
on PFCA rings leads to vinyl
and allyl products [28]
Appl Petrochem Res (2015) 5:35–45 37
123
4. aryl ether monomers derived from OFCP, there was no
product with allyl substituted enchainments [31].
The polymerization of M with different bisphenols, in the
presence of base, triethylamine, and reaction temperature of
80 °C, yields a variety of copolymers with alternating
architectures (Scheme 5). Polymers P1–P3 were obtained in
good yield ([70 %) and characterized via, 1
H NMR, 19
F
NMR, GPC, TGA and DSC techniques (Table 1). 19
F NMR
spectra show the uniform vinyl linkage along the polymer
chain and supports the concept of double addition–elimina-
tion reaction on OFCP rings which leave the double bond
intact. A small 19
F NMR signal around -150 ppm was
observed for polymer P3 indicating the presence of a trace
amount of allyl substitution along the polymer chain (Figs. 2,
3s, 5s). Thermal stabilities for these polymers studied via
TGA analysis. The decomposition temperature (Td at 5 %
weight loss, in nitrogen atmosphere) ranges from 370 to
456 °C (Fig. 3). The impressive degradation temperatures
(Td 5 %) up to 450 °C are typicalforPFCP aryl ether polymer
systems [27]. Thermal analysis via differential scanning
calorimetry (DSC) shows the polymers show variable glass
transition temperature (Tg) depending on the bisphenol used.
The Tg for these polymers ranges from 87 to 106 °C (Fig. 4).
There was no sign of melting peak, as expected.
Post-polymerization functionalization [e.g. chromoph-
orization- synthesizing an electro-optic (EO) chromophore
NH2
+
I
O
N
O
2
N
OHO HO
i ii
N
OO
FF
F
F
F
F F
F
F
F
F
F
F
F
F
F
F
F F
F
F
F
Monomer (M)
(A) (B)
Scheme 4 Synthesis of
monomer/precursor (M)
Scheme 5 Synthesis of PFCP-
TAA ether polymers
38 Appl Petrochem Res (2015) 5:35–45
123
5. on an inert polymer backbone] is an excellent tool to make
a polymer system application specific. Here, we have post-
functionalized PFCP aryl ether polymer with enchained
TAA moieties via formylation and electrophilic aromatic
substitution (EAS) (Scheme 6). Successful conversion of
the TAA enchained PFCP polymers via formylation and
EAS demonstrated the synthetic versatility of TAA moiety.
All these reported reactions resulted in high yields. The
Scheme 6 Post polymerization
modification (i.e.
chromophorization) of PFCP-
TAA ether polymer
Fig. 1 19
F NMR for monomer
M
Appl Petrochem Res (2015) 5:35–45 39
123
6. incorporated aldehyde (P4) can be further modified into a
range of application-specific molecules, including exten-
sion into an EO chromophore, hole-transport and photo-
voltaic materials [29, 34, 36, 37]. EAS reaction on these
PFCP aryl ether polymers demonstrates the accessibility of
these TAA moieties for further post polymerization mod-
ifications, which extends the overall versatility of this
polymeric system.
Network polymers: cross-linking behavior of PFCA
polymers
(a) Thermal mediated cross-linking
FAVE polymers with enchained fluoro-olefins show
induced thermal cross-linking of internal fluoro-olefins on
heating to [325 °C [23]. Being similar in backbone
structure, PFCP polymers were also tested for thermal
cross-linking. The heating of PFCP aryl ether polymer with
biphenyl enchainments to temperature [240 °C gives
cross-linked product. Possible cross-linking mechanisms
might involve [2 ? 2] cyclodimerization between two
PFCP-olefin moieties, [2 ? 2] cyclodimerization between
PFCP-olefin and the benzene ring, or [4 ? 2] cycloaddition
reaction between PFCP-olefin (dienophile) and the biphe-
nyl (diene). As experimental results show, the successful
thermal cross-linking was obtained only with PFCP aryl
ether polymer with biphenyl enchainment, whereas with
PFCP polymers with bisphenol A and Bisphenol-6F
enchainments do not show any gel formation (Fig. 5).
This observation suggests the cross-linking might follow
[4 ? 2] cycloaddition reaction between diene of biphenyl
moiety and dienophile of PFCP ring, and thus the presence
of biphenyl (diene) moiety is necessary for network
formation. Further studies on the cross-linking mechanism,
Fig. 2 19
F NMR of polymer P1
Fig. 3 TGA thermograms for polymers P1–P5
Table 1 PFCP aryl ether polymers with enchained triarylamine
unites
Entry Mn Mw PDI Td 5 % (°C) Tg (°C)
Polymer P1 23,600 36,800 1.4 456 99
Polymer P2 11,100 18,500 1.6 420 87
Polymer P3 22,100 36,000 1.6 370 106
Polymer P4 14,100 26,500 1.8 337 101
Polymer P5 17,200 32,100 1.8 416 100
40 Appl Petrochem Res (2015) 5:35–45
123
7. extent of cross-linking and reaction conditions are
warranted.
(b) Free radical cross-linking
Cross-linking efforts using free radical initiators including
AIBN and lauroyl peroxide did not work. As the literature
suggests, perfluorocyclic-olefins do not homopolymerize
under radical conditions [38]. Therefore, electron deficiency
factor combined with steric hindrance factor inhibits the cross-
linking of these PFCP polymers via free radical mechanism.
(c) Ionic cross-linking
The PFCP polymers keep the cyclic olefin intact. The lit-
erature suggests, in suitable conditions, multiple nucleophilic
substitutions on PFCP ring are possible [39]. Model reactions
also support the multiple substitutions on PFCP rings
(Scheme 7). Model compound 1,2-diphenyl
perfluorocyclopentenyl ether (1) shows two clean signals,
corresponding to two kinds of fluorine atoms in a symmetric
environment, as expected (Fig. 6a). When the sodium phen-
oxide reacts with (1), 19
F NMR shows vinyl fluorine signal at
158.6 ppm confirming the third substitution (Fig. 6b). This
vinyl fluorine signal goes away with further reaction of (2)
with the phenoxide ion.
Initial studies show PFCP aryl ether polymers react with
dinucleophiles, undergo cross-linking in different reaction
conditions and give insoluble products (Scheme 8). Vari-
ous parameters, including different reaction conditions and
different dinucleophiles are under study.
Experimental details
Materials and instrumentation
Octafluorocyclopentene and decafluorocyclohexene were
purchased from SynQuest Laboratories, while all other
chemicals were purchased from Alfa Aesar. Commercially
purchased chemicals were used as purchased unless otherwise
stated. All synthesized polymers P1–P5 were characterized by
1
H and 19
F NMR Spectroscopy, Gel permeation chromatog-
raphy (GPC), Thermogravimetric analysis (TGA) and Dif-
ferential scanning calorimetry (DSC) techniques. NMR
Spectroscopy was performed on Bruker advanced IIITM
500 MHz spectrometer. Chemical shifts were reported in ppm
(d) with reference to deuterated acetone (2.09 ppm) and tri-
chlorofluoromethane (0 ppm) for 1
H and 19
F NMR, respec-
tively. GC–MS was obtained on Shimadzu GCMS solution.
Analytical thin layer chromatography was performed on EM
reagents 0.25 mm silica gel 60-F plates. Molecular weight
Fig. 5 Thermal cross-linking
behavior for PFCA aryl ether
polymers
Fig. 4 DSC thermograms for polymers P1–P5
Appl Petrochem Res (2015) 5:35–45 41
123
8. measurements were performed on gel permeation chroma-
tography (Viscotek GPCmax, VE2001) system equipped with
a ViscotekTDA 302Triple ArrayDetector andtwo ViscoGEL
I-Series (I-MBHMW 3078, Viscotek) columns in series. THF
was used as eluent and polystyrene standards were used for
calibration. Attenuated total reflectance—Fourier transform
infrared (ATR-FTIR) spectroscopy was done on a Thermo-
Nicolet Magna 550 FIR spectrophotometer with a high
endurance diamond ATR attachment. DSC analysis was per-
formed on a Mettler Toledo DSC 1 system in the nitrogen
atmosphere with heating and cooling rate of 10 C/min. The Tg
of polymers were measured from the third heating cycle using
Star-E version 10.0 software suite. The thermal stability
measurementswere performedon a Mettler Toledo TGA/DSC
1 LF instrument, in the nitrogen atmosphere with a heatingrate
of 10 C/min.
Synthesis of monomer (M)
In a flame dried 50 ml single necked round bottom flask,
equipped with a magnetic stirrer, 3.84 mmol of bis(4-
hydroxyphenyl)phenylamine (B), 9.60 mmol of triethyl-
amine and 6 ml of anhydrous DMF were introduced. The
solution was purged with nitrogen for 10 min. The solution
was heated at 65 °C for 2 h. Let the reaction mixture cooled
down to room temperature. This reaction mixture was added
to a 6 ml DMF solution containing 9.60 mmol of octaflu-
orocyclopentene, in a 100 ml single necked flask equipped
with stirrer, dropwise with a syringe. The solution was stirred
at room temperature for next 12 h. Further, the reaction was
heated at 65 °C for the next 2 h to ensure the completion of
the reaction. The solution was then cooled down, and the pure
product was isolated by column chromatography with pure
hexane, as eluent, to give white product (yield = 71 %). 1
H
NMR (500 MHz, acetone-d6, d): 7.18–7.08 (m, 2H),
6.94–6.86 (m, 4H), 6.74–6.65 (m, 7H), 3.37 (brs, 2H). 19
F
NMR (470 MHz, acetone-d6, d): -115.64 (m, 8F), -129.72
(brs, 4F), -150.95 (brs, 2F). FTIR (m, cm-1
): 825, 973, 1003,
1,128, 1,195, 1,291, 1,335, 1,364, 1,487, 1,601, 1,727.
Synthesis of polymer P1
To a heat dried 100 ml single necked round bottom flask,
equipped with a magnetic stirrer, 0.980 g (1.48 mmol) of
monomer(M),0.276 g (1.48 mmol) ofbiphenol,and0.679 g
(6.67 mmol) of triethylamine was added and then dissolved
in 1 ml of anhydrous DMF. The solution was degassed with
nitrogen for 10 min and the flask was heated slowly to 80 °C
for 36 h under stirring. The dissolved polymer was then
precipitated in 100 ml of methanol and washed again with the
same, giving a white powder after drying (yield = 81 %). 1
H
NMR (500 MHz, acetone-d6, d): 6.61–7.70 (m). 19
F NMR
(470 MHz, acetone-d6, d): -113.59 (4F), -114.38 (4F),
-129.74 (4F). FTIR (d m, cm-1
): 823 (aromatic C–H),
1,080–1,285 (C–F and C–O–C), 1,497 and 1,599 (aromatic
C=C), and 1,686 (C=C).
Synthesis of polymer P2
Polymer P2 was synthesized using the same method as P1,
giving a white powder after drying (yield = 85 %). 1
H
NMR (500 MHz, acetone-d6, d): 1.58 (brs, 6H), 6.63–7.39
(m). 19
F NMR (470 MHz, acetone-d6, d): -114.20 (8F),
-129.73 (4F). FTIR (m, cm-1
): 831 (aromatic C–H),
Scheme 7 Model study for
multiple substitutions on PFCA
ring
42 Appl Petrochem Res (2015) 5:35–45
123
9. 1,080–1,285 (C–F and C–O–C), 1,497 and 1,595 (aromatic
C=C), and 1,686 (C=C).
Synthesis of polymer P3
Polymer P3 was synthesized using the same method as P1,
giving a white powder after drying (yield = 80 %). 1
H
NMR (500 MHz, acetone-d6, d): 6.70–7.40 (m). 19
F NMR
(470 MHz, acetone-d6, d): -63.35 (6F), -113.88 (4F),
-114.74 (4F), -129.69 (4F). FTIR (m, cm-1
): 827 (aromatic
C–H), 1,080–1,285 (C–F and C–O–C), 1,498 and 1,603
(aromatic C=C), and 1,688 (C=C).
Synthesis of polymer P4
A mixture of phosphorous oxychloride (0.3 ml) and 0.45
gram of polymer P1 were dissolved in 15 ml anhydrous
DMF under the nitrogen atmosphere. The reaction mixture
was heated for next 5 h at 90 °C. The reaction mixture was
cooled down and poured in H2O to complete the reaction
and precipitate the polymer. Polymer was filtered after 1 h
of stirring and dried under vacuum (yield = 75 %). 1
H
NMR (500 MHz, acetone-d6, d): 6.59–7.59 (m), 9.78 (s).
19
F NMR (470 MHz, acetone-d6, d): -113.61 (4F),
-114.40 (4F), -129.76 (4F). FTIR (m, cm-1
): 825 (aromatic
C–H), 1,080–1,285 (C–F and C–O–C), 1,498 and 1,596
(aromatic C=C), 1,691 (C=C) and 1,706 (C=O).
Synthesis of polymer P5
Polymer P1 (0.49 gram) and tetracyanoethylene (0.23
gram) were dissolved in 15 ml anhydrous DMF under
nitrogen atmosphere. The reaction mixture was stirred for
next 12 h. The product was then precipitated in H2O and
washed with methanol. The purple colored polymer was
filtered and dried under vacuum (yield = 79 %). 1
H NMR
(500 MHz, acetone-d6, d): 6.52–7.59 (m). 19
F NMR
(470 MHz, acetone-d6, d): -113.66 (4F), -114.36 (4F),
-129.80 (4F). FTIR (m, cm-1
): 825 (aromatic C–H),
1,080–1,285 (C–F and C–O–C), 1,496 and 1,597 (aromatic
C=C), and 1,689 (C=C).
Conclusion
We have developed a step-growth polymerization of bi-
sphenols with PFCA towards synthesis of a new class of
PFCA aryl ether polymers from commercial feedstock.
PFCA aryl ether polymers can be easily modified and
functionalized using bisphenols with different spacer
functional groups. PFCA aryl ether polymers exhibited
very interesting thermal properties with variable Tg
depending upon the chosen bisphenol. These polymers
were obtained in good yields and show high thermal sta-
bilities under nitrogen atmosphere. Successful conversion
of the newly synthesized TAA enchained PFCP aryl ether
polymers via formylation and EAS demonstrated the syn-
thetic versatility of TAA moiety and provides an excellent
option for application specific post polymerization
reactions.
PFCP aryl ether polymers with biphenyl units also
demonstrate cross-linking behavior upon thermal activa-
tion. Exact mechanistic details for this thermal cross-link-
ing are still unknown and further investigations are
warranted. Also, PFCP aryl ether polymers undergo ionic
cross-linking upon treatment with strong dinucleophiles.
Future studies include the mechanistic studies on the
cross-linking behavior of PFCA aryl ether polymers, full
chromophorization on TAA units of these successfully
Fig. 6 a 19
F NMR for 1,2-diphenyl perfluoropentenyl ether (1); and
b 19
F NMR of the crude reaction mixture showing third substitution
Appl Petrochem Res (2015) 5:35–45 43
123
10. synthesized PFCP aryl ether polymers, and their incorpo-
ration in electro-optics and photonic devices.
Acknowledgments The authors want to express their gratitude
towards Intel Corporation (Grant # 4606175) CHEMS (Grant# IIP-
1035024), Welch Foundation (Grant # AT-0041) and University of
Texas at Dallas for providing the financial supports. The authors
also acknowledge the NSF-MRI grant (CHE-1126177) used to pur-
chase the Bruker Advance III 500 NMR spectrometer.
Open Access This article is distributed under the terms of the
Creative Commons Attribution License which permits any use, dis-
tribution, and reproduction in any medium, provided the original
author(s) and the source are credited.
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