This document summarizes transporter superfamilies in the human genome. It discusses the two main superfamilies - solute carrier (SLC) and ATP-binding cassette (ABC) transporters. The SLC superfamily includes 52 families and around 395 genes encoding mostly facilitative transporters. The ABC superfamily includes 7 families with 49 genes encoding active transporters that use ATP hydrolysis to transport substrates against gradients. Key transporters from these families play important roles in drug absorption, distribution, and elimination. Polymorphisms in various transporters have been associated with human diseases and drug interactions.