Distribution of Drugs- A pharmacokinetic process

1. Presenter-
Akash Agnihotri
M.Sc. Medical Pharmacology

3. Drug + Excipients
Drug in dosage form
Drug release and dissolution
Drug in systemic circulation
Extravascular Tissues
(Tissue at the site of action)
Pharmacological Response
Therapeutic/Toxic effects
PHARMACEUTICS FORMULATION
Oral administration
ABSORPTION
Disposition
DISTRIBUTION
Metabolism
&
Excretion
ELIMINATIONPHARMACOKINETICS
PHARMACODYNAMICS
THERAPEUTICS
ParenteralAdministration

11. Permeation of unionized and ionized drugs across the capillary and the cell membrane

26. Relative volume of different organs, blood flow and perfusion rate under
basal conditions assuming the total body volume to be 70 liters:

31. Four major drug binding sites of human plasma albumin

38. Vd =

39. NXY-059 is the Disufenton sodium, A 2005 phase-3 clinical
trial called "SAINT-1" reported some efficacy in the acute treatment
of ischemia injury due to stroke

40. Vd =
Vd =
Vd is low When plasma
concentration
Is hgh
Vd is high When plasma
concentration Is
low
So, volume of distribution(Vd) is inversely proportional to plasma concentration

42. T1/2 = 0.7 X Vd
CL