This document provides guidelines for tissue submission and fixation to ensure high quality histology processing. Key points include: 1. Tissue must be accurately described and labeled to avoid questions. Fixation preserves morphology and antigenicity. 2. Fixation factors like temperature, tissue size, fixative type and duration influence results. Over or under fixation can reduce quality. 3. Tissue should be processed promptly after removal, washed, dehydrated and stored properly before submission. 4. Samples must be accurately labeled and described on the submission form including genotype, age, tissue, orientation, areas of interest and number of sections/slides requested. The form provides instructions for standardization.