Time reveals the truth.pdf

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More than two years ago, we warned about the dangers of treatment methods that are based on the use of antivirals, but it took a long time for the issue of selective pressure caused by antivirals to be widely discussed in scientific societies. Now the Science report published on June 29, 2022 clearly points to this issue.

Health & Medicine

Time reveals the
truth!
Antivirals Vs. LDRT
Low-Dose Radiation Therapy for COVID-19

SMJ Mortazavi, Ph.D
5
29 June 2022
“Taken together, the studies show that
“when you put pressure on the virus it
escapes,” says David Ho, a virologist at
Columbia University”
“That rise creates selective pressure on
the virus, favoring mutations that help it
survive in the presence of the drug. And
because each infected person makes
trillions of copies of SARS-CoV-2, the virus
has plenty of opportunities to test out
different mutations as it replicates”.
https://www.science.org/content/article/bad-news-paxlovid-
coronavirus-can-find-multiple-ways-evade-covid-19-drug

SMJ Mortazavi, Ph.D
6
“In less than a month, the report by Ghadimi-Moghadam et
al.4 received attention not only for introducing LDRT as a
treatment method for pneumonia in COVID-19 patients but
also for noting the key disadvantages of other treatment
methods such as using antiviral drugs. Rödel et al.5 in their
paper published recently state SARS-COV-2 is an RNA virus
with an expected moderate to high mutation rate …..6 In
addition, as discussed in a recent manuscript,4 any antiviral
drug treatment against SARS-CoV-2 would probably result in
a more intense selective pressure on the virus. Moreover
Dilucca et al.7 in their paper published recently in the
Viruses Journal highlight the importance of LDRT and
address the potential problems associated with the
widespread use of different antiviral drugs as discussed in a
recent paper,4 any antiviral drug against SARS-CoV-2 would
exert an intense selective pressure on the virus.This may
result in highly adaptive and treatment-resistant virus types
with enhanced pathogenicity”.
Rebuttal:
SMJ Mortazavi, Ph.D
Point/Counterpoint
Low-dose radiation as a treatment for
COVID-19 pneumonia: A threat or real
opportunity?
Seyed Mohammad Javad Mortazavi
Ph.D.,Amirhosein Kefayat M.D.,Jing Cai
Ph.D.
First published: 03 July 2020
https://doi.org/10.1002/mp.14367
2 years ago (July 2020)

SMJ Mortazavi, Ph.D
7
Low-Dose Radiation Therapy for COVID-19
Time reveals the truth!

Part 2
Which treatment is
buried, Antivirals or
LDRT?

SMJ Mortazavi, Ph.D
9
“It is somehow apparent that
using antiviral drugs and
vaccines for COVID-19
treatment would be more
acceptable for patients in
comparison with ionizing
radiations even in low-dose
form.Therefore, further
achievements in these fields
like approving Remdesivir for
COVID-19 treatment25 may
bury the subject of
employing LDRT for COVID-19
treatment“.
Rebuttal:
Amirhosein Kefayat, M.D
Point/Counterpoint
Low-dose radiation as a treatment for COVID-
19 pneumonia: A threat or real opportunity?
Seyed Mohammad Javad Mortazavi
Ph.D.,Amirhosein Kefayat M.D.,Jing Cai Ph.D.
First published: 03 July 2020
https://doi.org/10.1002/mp.14367
2 years ago (July 2020)

SMJ Mortazavi, Ph.D
10
“. ……any antiviral drug
against SARS-CoV-2 would
exert an intense selective
pressure on the virus.This
may result in highly
adaptive and treatment-
resistant virus types with
enhanced pathogenicity.”.
Rebuttal:
SMJ Mortazavi, Ph.D
Point/Counterpoint
Low-dose radiation as a treatment for COVID-
19 pneumonia: A threat or real opportunity?
Seyed Mohammad Javad Mortazavi
Ph.D.,Amirhosein Kefayat M.D.,Jing Cai Ph.D.
First published: 03 July 2020
https://doi.org/10.1002/mp.14367
2 years ago (July 2020)

▪WHO Guideline
Development Group
advises against use
of remdesivir for
covid-19.
Rodríguez-Tomàs et al. Antioxidants 2022,
11(6), 1184;
https://doi.org/10.3390/antiox11061184,
Published: 16 June 2022
11
Time reveals the truth!
Now, after 2 years, we know that:
 Several groups, including our own,
have shown that whole-lung
radiation at doses of 0.5–1.5 Gy can
accelerate the recovery in clinical
and radiographic status without
acute toxicity
[12,13,14,15,16,17,18,19,20,21].".
LDRT for COVID-19

And viruses can evolve faster when there is
selection pressure, he says, because mutations
are more likely to stick around if they give the
virus an increased ability to propagate under
certain environmental conditions.

Any attempt to inactivate a virus exerts strong selective pressure on the virus. Given this consideration, antiviral drugs can exert strong selective pressure on SARS-COV-2. In March 2020, we proposed the concept of Low Dose Radiation Therapy (LDRT) for COVID-19 associated pneumonia. This treatment was a 100% "selective pressure-free" therapeutic approach. After our paper, tens of papers published on this issue, and now LDRT for COVID-19 is receiving rapidly increasing global attention.

Confirmation of Safety of COVID 19 mRNA Vaccination for Cancer Patients

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Patients in the active phase of treatment for cancer are a population at risk of coronavirus disease 19 COVID 19 with poor prognosis. While a majority of patients treated for cancer expressed their will to be vaccinated as early as December 2020 in a French survey, no data were available in terms of vaccine efficacy and tolerance, because they were excluded from initial registration trials. Several clinical facilities aimed to assess the safety and immunogenicity of the BNT162b2 Pfizer–BioNTech vaccine in patients with cancer. In patients with cancer, one dose of the BNT162b2 vaccine yields poor efficacy. Immunogenicity increased significantly in patients with solid cancer within 2 weeks of a vaccine boost at day 21 after the first dose. However, the anti SARS CoV 2 immune response was lower in patients with solid tumors who were vaccinated a second dose of BNT162b2 vaccine than in healthy individuals. These data support prioritization of patients with cancer for an early day 21 second dose of the BNT162b2 vaccine. Takuma Hayashi | Nobuo Yaegashi | Ikuo Konishi "Confirmation of Safety of COVID-19 mRNA Vaccination for Cancer Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42563.pdf Paper URL: https://www.ijtsrd.commedicine/other/42563/confirmation-of-safety-of-covid19-mrna-vaccination-for-cancer-patients/takuma-hayashi

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The efficiency of low dose radiation therapy as a potential treatment of pneumonia in COVID-19 patients has been addressed by many scientists from different parts of the world. For further reading please see the first report of Ghadimi-Moghadam et al. (COVID-19 Tragic Pandemic: Concerns over Unintentional “Directed Accelerated Evolution” of Novel Coronavirus (SARS-CoV-2) and Introducing a Modified Treatment Method for ARDS https://lnkd.in/dzXtqkc) and later reports by Canadian (Is low dose radiation therapy a potential treatment for COVID-19 pneumonia? https://lnkd.in/d7TQKcS), Spanish (Low Dose Lung Radiotherapy for COVID-19 Pneumonia. The Rationale for a Cost-Effective Anti-Inflammatory Treatment https://lnkd.in/dStMJKr), American (Low dose radiation therapy as a potential life saving treatment for COVID-19-induced acute respiratory distress syndrome (ARDS) https://lnkd.in/dnR8kyJ), German (Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence? https://lnkd.in/dWGCQBb) and French (Irradiation pulmonaire à faible dose pour l’orage de cytokines du COVID-19 : pourquoi pas ? https://lnkd.in/dsW65ew) scientists.

Covid 19 vaccine_rohimah mohamud

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On January 13, 2020, a paper was published online touting the creation of a possible therapy that could be used against all known strains of the flu. A week later, the first laboratory-confirmed case of SARS-CoV-2 sparked the two-and-a-half-year COVID-19 pandemic in the United States. Interestingly, before the virus temporarily halted their work, the international team of researchers for this flu paper also investigated treatments for the coronavirus.

Coronavirus disease 2019

LORENZONEITA

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ijtsrd

From late fall to winter of 2020, the further challenge of medical care for thetwindemic of coronavirus infectious disease 2019 COVID 19 and seasonal influenza is imminent. The key to that is the ability of family doctors to protect the front lines of community medicine. It is difficult not only for patients but also for doctors to distinguish COVID 19 from seasonal flu only based on initial symptoms such as fever and malaise. Every year, patients with suspected seasonal flu are tested and, if positive, are treated with influenza drugs. However, due to the expansion of COVID 19, tests using a nasopharyngeal swab have a high risk of droplet infection. In this review, we would like to discuss the clinical similarities and differences between COVID 19 and seasonal influenza, including new findings.The coronavirus infectious disease 2019 COVID 19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of COVID 19, caused by severe acute respiratory syndrome coronavirus 2 SARS CoV 2 1 .The outbreak was first identified in December 2019 in Wuhan, China 2,3 .The World Health Organization WHO declared the outbreak a Public Health Emergency of International Concern on 30January 2020 and a pandemic on 11March 2020 4,5 .As of 30 August 2020,more than 25million cases of COVID 19 have been reported in more than 188 countries and territories, resulting in more than 843,000 deaths more than 16.4million people have recovered 6 .The WHO has published a report summarizing the differences between the COVID 19 and influenza 7 . Takuma Hayashi | Ikuo Konishi "Similarities and Differences between the New Coronavirus Infectious 2019 (COVID-19) and Seasonal Influenza" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33370.pdf Paper Url: https://www.ijtsrd.com/medicine/other/33370/similarities-and-differences-between-the-new-coronavirus-infectious-2019-covid19-and-seasonal-influenza/takuma-hayashi

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The severity and mortality of COVID 19 cases has been associated with the Three category such as vaccination status, severity of disease and outcome. Objective presently study was aimed to assess the severity and mortality among covid 19 patients. Methods Using simple lottery random method 100 samples were selected. From these 100 patients, 50 patients were randomly assigned to case group and 50 patients in control group after informed consents of relative obtained. Patients in the case group who being died after got COVID 19 whereas 50 patients in the control group participated who were survive after got infected from COVID 19 patients. Result It has three categories such as a Vaccination status For the vaccination status we have seen 59 patients were not vaccinated and 41 patients was vaccinated out of 100. b Incidence There were 41 patients were vaccinated whereas 59 patients were not vaccinated. c Severity In the case of mortality we selected 50 patients who were died from the Corona and I got to know that out of 50 patients there were 12 24 patients were vaccinated whereas 38 76 patients were non vaccinated. Although for the 50 control survival group total 29 58 patients were vaccinated and 21 42 patients was not vaccinated all graph start. Conclusion we have find out that those people who got vaccinated were less infected and mortality rate very low. Prof. (Dr) Binod Kumar Singh | Dr. Saroj Kumar | Ms. Anuradha Sharma "To Assess the Severity and Mortality among Covid-19 Patients after Having Vaccinated: A Retrospective Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd45065.pdf Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/45065/to-assess-the-severity-and-mortality-among-covid19-patients-after-having-vaccinated-a-retrospective-study/prof-dr-binod-kumar-singh

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Title: Sense of Smell Presenter: Dr. Faiza, Assistant Professor of Physiology Qualifications: MBBS (Best Graduate, AIMC Lahore) FCPS Physiology ICMT, CHPE, DHPE (STMU) MPH (GC University, Faisalabad) MBA (Virtual University of Pakistan) Learning Objectives: Describe the primary categories of smells and the concept of odor blindness. Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction. Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain. Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential. Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes. Key Topics: Olfactory Genes: 3% of the human genome accounts for olfactory genes. 400 genes for odorant receptors. Olfactory Membrane: Located in the superior part of the nasal cavity. Medially: Folds downward along the superior septum. Laterally: Folds over the superior turbinate and upper surface of the middle turbinate. Total surface area: 5-10 square centimeters. Olfactory Mucosa: Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell. Sustentacular Cells: Produce mucus and maintain ionic and molecular environment. Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months. Bowman’s Gland: Secretes mucus. Stimulation of Olfactory Cells: Odorant dissolves in mucus and attaches to receptors on olfactory cilia. Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve. Quality of a Good Odorant: Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble. Facilitated by odorant-binding proteins in mucus. Membrane Potential and Action Potential: Resting membrane potential: -55mV. Action potential frequency in the olfactory nerve increases with odorant strength. Adaptation Towards the Sense of Smell: Rapid adaptation within the first second, with further slow adaptation. Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system. Primary Sensations of Smell: Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid. Odor Detection Threshold: Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm). Some toxic substances are odorless at lethal concentrations. Characteristics of Smell: Odor blindness for single substances due to lack of appropriate receptor protein. Behavioral and emotional influences of smell. Transmission of Olfactory Signals: From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition. Primitive, less old, and new olfactory systems with different path

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Physiology of Special Chemical Sensation of Taste

MedicoseAcademics

Title: Sense of Taste Presenter: Dr. Faiza, Assistant Professor of Physiology Qualifications: MBBS (Best Graduate, AIMC Lahore) FCPS Physiology ICMT, CHPE, DHPE (STMU) MPH (GC University, Faisalabad) MBA (Virtual University of Pakistan) Learning Objectives: Describe the structure and function of taste buds. Describe the relationship between the taste threshold and taste index of common substances. Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation. Recognize different abnormalities of taste perception and their causes. Key Topics: Significance of Taste Sensation: Differentiation between pleasant and harmful food Influence on behavior Selection of food based on metabolic needs Receptors of Taste: Taste buds on the tongue Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper) Primary and Secondary Taste Sensations: Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami Chemical basis and signal transduction mechanisms for each taste Taste Threshold and Index: Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine) Taste index relationship: Inversely proportional to taste threshold Taste Blindness: Inability to taste certain substances, particularly thiourea compounds Example: Phenylthiocarbamide Structure and Function of Taste Buds: Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers Location of Taste Buds: Found in papillae of the tongue (Fungiform, Circumvallate, Foliate) Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus Mechanism of Taste Stimulation: Interaction of taste substances with receptors on microvilli Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes Taste Sensitivity and Adaptation: Decrease in sensitivity with age Rapid adaptation of taste sensation Role of Saliva in Taste: Dissolution of tastants to reach receptors Washing away the stimulus Taste Preferences and Aversions: Mechanisms behind taste preference and aversion Influence of receptors and neural pathways Impact of Sensory Nerve Damage: Degeneration of taste buds if the sensory nerve fiber is cut Abnormalities of Taste Detection: Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia) Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels Neurotransmitters and Taste Threshold: Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity Supertasters: 25% of the population with heightened sensitivity to taste, especially bitterness Increased number of fungiform papillae

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Time reveals the truth.pdf

1. Time reveals the truth! Antivirals Vs. LDRT Low-Dose Radiation Therapy for COVID-19

2. Part 1 Dark Side of Antivirals

3. SMJ Mortazavi, Ph.D 3 Dec 22, 2021

4. SMJ Mortazavi, Ph.D 4 29 June 2022

5. SMJ Mortazavi, Ph.D 5 29 June 2022 “Taken together, the studies show that “when you put pressure on the virus it escapes,” says David Ho, a virologist at Columbia University” “That rise creates selective pressure on the virus, favoring mutations that help it survive in the presence of the drug. And because each infected person makes trillions of copies of SARS-CoV-2, the virus has plenty of opportunities to test out different mutations as it replicates”. https://www.science.org/content/article/bad-news-paxlovid- coronavirus-can-find-multiple-ways-evade-covid-19-drug

6. SMJ Mortazavi, Ph.D 6 “In less than a month, the report by Ghadimi-Moghadam et al.4 received attention not only for introducing LDRT as a treatment method for pneumonia in COVID-19 patients but also for noting the key disadvantages of other treatment methods such as using antiviral drugs. Rödel et al.5 in their paper published recently state SARS-COV-2 is an RNA virus with an expected moderate to high mutation rate …..6 In addition, as discussed in a recent manuscript,4 any antiviral drug treatment against SARS-CoV-2 would probably result in a more intense selective pressure on the virus. Moreover Dilucca et al.7 in their paper published recently in the Viruses Journal highlight the importance of LDRT and address the potential problems associated with the widespread use of different antiviral drugs as discussed in a recent paper,4 any antiviral drug against SARS-CoV-2 would exert an intense selective pressure on the virus.This may result in highly adaptive and treatment-resistant virus types with enhanced pathogenicity”. Rebuttal: SMJ Mortazavi, Ph.D Point/Counterpoint Low-dose radiation as a treatment for COVID-19 pneumonia: A threat or real opportunity? Seyed Mohammad Javad Mortazavi Ph.D.,Amirhosein Kefayat M.D.,Jing Cai Ph.D. First published: 03 July 2020 https://doi.org/10.1002/mp.14367 2 years ago (July 2020)

7. SMJ Mortazavi, Ph.D 7 Low-Dose Radiation Therapy for COVID-19 Time reveals the truth!

8. Part 2 Which treatment is buried, Antivirals or LDRT?

9. SMJ Mortazavi, Ph.D 9 “It is somehow apparent that using antiviral drugs and vaccines for COVID-19 treatment would be more acceptable for patients in comparison with ionizing radiations even in low-dose form.Therefore, further achievements in these fields like approving Remdesivir for COVID-19 treatment25 may bury the subject of employing LDRT for COVID-19 treatment“. Rebuttal: Amirhosein Kefayat, M.D Point/Counterpoint Low-dose radiation as a treatment for COVID- 19 pneumonia: A threat or real opportunity? Seyed Mohammad Javad Mortazavi Ph.D.,Amirhosein Kefayat M.D.,Jing Cai Ph.D. First published: 03 July 2020 https://doi.org/10.1002/mp.14367 2 years ago (July 2020)

10. SMJ Mortazavi, Ph.D 10 “. ……any antiviral drug against SARS-CoV-2 would exert an intense selective pressure on the virus.This may result in highly adaptive and treatment- resistant virus types with enhanced pathogenicity.”. Rebuttal: SMJ Mortazavi, Ph.D Point/Counterpoint Low-dose radiation as a treatment for COVID- 19 pneumonia: A threat or real opportunity? Seyed Mohammad Javad Mortazavi Ph.D.,Amirhosein Kefayat M.D.,Jing Cai Ph.D. First published: 03 July 2020 https://doi.org/10.1002/mp.14367 2 years ago (July 2020)

11. ▪WHO Guideline Development Group advises against use of remdesivir for covid-19. Rodríguez-Tomàs et al. Antioxidants 2022, 11(6), 1184; https://doi.org/10.3390/antiox11061184, Published: 16 June 2022 11 Time reveals the truth! Now, after 2 years, we know that:  Several groups, including our own, have shown that whole-lung radiation at doses of 0.5–1.5 Gy can accelerate the recovery in clinical and radiographic status without acute toxicity [12,13,14,15,16,17,18,19,20,21].". LDRT for COVID-19

12. And viruses can evolve faster when there is selection pressure, he says, because mutations are more likely to stick around if they give the virus an increased ability to propagate under certain environmental conditions.

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