There are 5 key options for implementing REST APIs in ColdFusion: 1) Natively in CF10+, 2) Natively in Railo 4+, 3) Using the Taffy framework, 4) Using the ColdBox framework with the RELAX module, 5) Using the lightweight FW1 framework. Each option has different configurations, routing conventions, and considerations around simplicity, extensibility, and documentation. The document recommends choosing based on application architecture needs and that every option can work - the most important things are taking security seriously, making the API robust, and getting creative.