Applying Photonics to User Needs: The Application ChallengeLarry Smarr
05.02.28
Invited Talk to the 4th Annual On*VECTOR International Photonics Workshop
Sponsored by NTT Network Innovation Laboratories
Title: Applying Photonics to User Needs: The Application Challenge
University of California, San Diego
Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analys...Larry Smarr
06.07.31
Invited Talk
CONNECT Investment Community Meeting
Calit2@UCSD
Title: Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis (CAMERA)
La Jolla, CA
Sustainable Computing and Telecom Can Contribute to Limiting Global Climatic ...Larry Smarr
10.07.28
Invited Seminar
AT&T Shannon Labs
Title: Sustainable Computing and Telecom Can Contribute to Limiting Global Climatic Disruption
Florham Park, NJ
Can a Greener Internet Help Us Moderate Climate Change?Larry Smarr
09.05.13
High Definition Remote Presentation to the
Monash Undergraduate Research Projects Abroad (MURPA) Program, located at Monash University, Australia
Title: Can a Greener Internet Help Us Moderate Climate Change?
La Jolla, CA
Applying Photonics to User Needs: The Application ChallengeLarry Smarr
05.02.28
Invited Talk to the 4th Annual On*VECTOR International Photonics Workshop
Sponsored by NTT Network Innovation Laboratories
Title: Applying Photonics to User Needs: The Application Challenge
University of California, San Diego
Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analys...Larry Smarr
06.07.31
Invited Talk
CONNECT Investment Community Meeting
Calit2@UCSD
Title: Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis (CAMERA)
La Jolla, CA
Sustainable Computing and Telecom Can Contribute to Limiting Global Climatic ...Larry Smarr
10.07.28
Invited Seminar
AT&T Shannon Labs
Title: Sustainable Computing and Telecom Can Contribute to Limiting Global Climatic Disruption
Florham Park, NJ
Can a Greener Internet Help Us Moderate Climate Change?Larry Smarr
09.05.13
High Definition Remote Presentation to the
Monash Undergraduate Research Projects Abroad (MURPA) Program, located at Monash University, Australia
Title: Can a Greener Internet Help Us Moderate Climate Change?
La Jolla, CA
Global Climatic Disruption and its Impact on Victoria and CaliforniaLarry Smarr
10.05.20
High Definition Remote Presentation to the
Monash Undergraduate Research Projects Abroad (MURPA) Program, Located at Monash University, Australia
Title: Global Climatic Disruption and its Impact on Victoria and California
Irvine, CA
Global LambdaGrid Applications Driving InnovationLarry Smarr
06.03.14
Acceptance Speech for Maxine Brown and Tom DeFanti
Innovation Award for Experimental / Developmental Applications – iGrid2005
CENIC 2006
Title: Global LambdaGrid Applications Driving Innovation
Oakland, CA
Supercomputers and Supernetworks are Transforming ResearchLarry Smarr
09.03.25
Invited Talk
Computing Research that Changed the World: Reflections and Perspectives
Title: Supercomputers and Supernetworks are Transforming Research
Washington, DC
High Performance Cyberinfrastructure Enables Data-Driven Science in the Globa...Larry Smarr
10.10.28
Invited Speaker
Grand Challenges in Data-Intensive Discovery Conference
San Diego Supercomputer Center, UC San Diego
Title: High Performance Cyberinfrastructure Enables Data-Driven Science in the Globally Networked World
La Jolla, CA
The Digital Transformation of HealthcareLarry Smarr
12.05.18
Guest Lecture
Professor Kevin Zhu’s MBA Class
“Disruptive Technologies in Healthcare”
Title: The Digital Transformation of Healthcare
UCSD’s Rady School
People don't resist change. They struggle with change for a variety of reasons, let's bridge the gap between Agile and what change management folks have known for decades.
The Digital Transformation to Predictive & Preventive Personalized MedicineLarry Smarr
12.09.28
Invited Talk
Center for Digital Transformation Advisory Board Meeting
Title: The Digital Transformation to Predictive & Preventive Personalized Medicine
UC Irvine
The Role of the Intangibles Information Gap in the Financialization of the A...Smarter-Companies
Short-term thinking and financialization of the American corporation has be fueled and enabled by the intangibles information gap. Closing this gap is imperative to enable longer-term thinking about the future capacity of our corporations.
Exit Planners Guide to Building Corporate Value through Intangible CapitalSmarter-Companies
80% of the value of the average company is intangible. So if you want to build value in a company, this is the place to focus. Presentation made to Exit Planning Exchange in Boston in September, 2010.
This presentation was delivered as an introduction to social enterprise and business model generation at the University of Sheffield.
Information in the presentation was gathered from organisations across the social enterprise sector, including UnLtd, Regen School, The Social Investment Business, The Young Foundation and Venturesome.
The Business Model Canvas is based on the work of Alexander Osterwalder. See http://alexosterwalder.com/ for more information.
Global Climatic Disruption and its Impact on Victoria and CaliforniaLarry Smarr
10.05.20
High Definition Remote Presentation to the
Monash Undergraduate Research Projects Abroad (MURPA) Program, Located at Monash University, Australia
Title: Global Climatic Disruption and its Impact on Victoria and California
Irvine, CA
Global LambdaGrid Applications Driving InnovationLarry Smarr
06.03.14
Acceptance Speech for Maxine Brown and Tom DeFanti
Innovation Award for Experimental / Developmental Applications – iGrid2005
CENIC 2006
Title: Global LambdaGrid Applications Driving Innovation
Oakland, CA
Supercomputers and Supernetworks are Transforming ResearchLarry Smarr
09.03.25
Invited Talk
Computing Research that Changed the World: Reflections and Perspectives
Title: Supercomputers and Supernetworks are Transforming Research
Washington, DC
High Performance Cyberinfrastructure Enables Data-Driven Science in the Globa...Larry Smarr
10.10.28
Invited Speaker
Grand Challenges in Data-Intensive Discovery Conference
San Diego Supercomputer Center, UC San Diego
Title: High Performance Cyberinfrastructure Enables Data-Driven Science in the Globally Networked World
La Jolla, CA
The Digital Transformation of HealthcareLarry Smarr
12.05.18
Guest Lecture
Professor Kevin Zhu’s MBA Class
“Disruptive Technologies in Healthcare”
Title: The Digital Transformation of Healthcare
UCSD’s Rady School
People don't resist change. They struggle with change for a variety of reasons, let's bridge the gap between Agile and what change management folks have known for decades.
The Digital Transformation to Predictive & Preventive Personalized MedicineLarry Smarr
12.09.28
Invited Talk
Center for Digital Transformation Advisory Board Meeting
Title: The Digital Transformation to Predictive & Preventive Personalized Medicine
UC Irvine
The Role of the Intangibles Information Gap in the Financialization of the A...Smarter-Companies
Short-term thinking and financialization of the American corporation has be fueled and enabled by the intangibles information gap. Closing this gap is imperative to enable longer-term thinking about the future capacity of our corporations.
Exit Planners Guide to Building Corporate Value through Intangible CapitalSmarter-Companies
80% of the value of the average company is intangible. So if you want to build value in a company, this is the place to focus. Presentation made to Exit Planning Exchange in Boston in September, 2010.
This presentation was delivered as an introduction to social enterprise and business model generation at the University of Sheffield.
Information in the presentation was gathered from organisations across the social enterprise sector, including UnLtd, Regen School, The Social Investment Business, The Young Foundation and Venturesome.
The Business Model Canvas is based on the work of Alexander Osterwalder. See http://alexosterwalder.com/ for more information.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
"Impact of front-end architecture on development cost", Viktor TurskyiFwdays
I have heard many times that architecture is not important for the front-end. Also, many times I have seen how developers implement features on the front-end just following the standard rules for a framework and think that this is enough to successfully launch the project, and then the project fails. How to prevent this and what approach to choose? I have launched dozens of complex projects and during the talk we will analyze which approaches have worked for me and which have not.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
Search and Society: Reimagining Information Access for Radical FuturesBhaskar Mitra
The field of Information retrieval (IR) is currently undergoing a transformative shift, at least partly due to the emerging applications of generative AI to information access. In this talk, we will deliberate on the sociotechnical implications of generative AI for information access. We will argue that there is both a critical necessity and an exciting opportunity for the IR community to re-center our research agendas on societal needs while dismantling the artificial separation between the work on fairness, accountability, transparency, and ethics in IR and the rest of IR research. Instead of adopting a reactionary strategy of trying to mitigate potential social harms from emerging technologies, the community should aim to proactively set the research agenda for the kinds of systems we should build inspired by diverse explicitly stated sociotechnical imaginaries. The sociotechnical imaginaries that underpin the design and development of information access technologies needs to be explicitly articulated, and we need to develop theories of change in context of these diverse perspectives. Our guiding future imaginaries must be informed by other academic fields, such as democratic theory and critical theory, and should be co-developed with social science scholars, legal scholars, civil rights and social justice activists, and artists, among others.
PHP Frameworks: I want to break free (IPC Berlin 2024)Ralf Eggert
In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
Leading Change strategies and insights for effective change management pdf 1.pdf
The Ten Year Calit2 Path Forward
1. The Ten Year
Calit2 Path Forward
• A Ten-Year Vision of Digital Transformation
– Affiliated Academic Units
– Calit2 News and Videos
• This Talk Focuses in on:
– The Digital Transformation of Health
www.calit2.net/research/index.php
2. Where I Believe We are Headed: Predictive,
Personalized, Preventive, & Participatory Medicine
I am Leroy Hood’s Lab Rat!
Using a “LifeChip”
Quantify ~2500 Blood Proteins,
50 Each from 50 Organs or Cell Types
from a Single Drop of Blood
To Create a Time Series
www.newsweek.com/2009/06/26/a-doctor-s-vision-of-the-future-of-medicine.html
3. Calit2 Has Been Had a Vision of
“the Digital Transformation of Health” for a Decade
www.bodymedia.com
• Next Step—Putting You On-Line!
– Wireless Internet Transmission
– Key Metabolic and Physical Variables
– Model -- Dozens of Processors and 60 Sensors /
Actuators Inside of our Cars
• Post-Genomic Individualized Medicine
– Combine
– Genetic Code
– Body Data Flow
– Use Powerful AI Data Mining Techniques
The Content of This Slide from 2001 Larry Smarr
Calit2 Talk on Digitally Enabled Genomic Medicine
4. The Calit2 Vision of Digitally Enabled Genomic Medicine
is an Emerging Reality
4
July/August 2011 February 2012
5. Lifechips--Merging Two Major Industries:
Microelectronic Chips & Life Sciences
LifeChips: the merging of two major industries, the
microelectronic chip industry with the life science
industry
65 UCI Faculty
LifeChips medical devices
6. SMART:
Social Mobile Approach to Reduce Weight
• Leveraging social networks, social media, mobile phones, and
the web for weight loss among 18-35 year old young adults
– Funded with a 5-year grant from NHLBI/NIH
Source: Kevin Patrick, UCSD SOM & Calit2
7. CitiSense –UCSD NSF Grant for Fine-Grained
Environmental Sensing Using Cell Phones
Seacoast Sci.
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discover PI: Bill Griswold
Ingolf Krueger
Tajana Simunic Rosing
Sanjoy Dasgupta
Hovav Shacham
Kevin Patrick
Integrate
Into a
“LifeChip”
8. By Measuring the State of My Body and “Tuning” It
Using Nutrition and Exercise, I Became Healthier
1999 2010
2000
Age Age
51 61
I Arrived in La Jolla in 2000 After 20 Years in the Midwest
and Discovered I was Pre-Diabetic
10. Quantifying My Sleep Pattern Using a Zeo “LifeChip” -
Surprisingly About Half My Sleep is REM!
REM is Normally 20% of Sleep An Infant Typically
Mine is Between 45-65% of Sleep Has 50% REM
11. Combining the Wireless Internet, Body Sensors, Smart Phones,
and Social Networks to Drive Healthier Lifestyles
12. From One to a Billion Data Points Defining Me:
The Exponential Rise in Body Data in Just One Decade!
Billion:Microbial Genome
My Full DNA,
MRI/CT Images
Improving Body
SNPs
Million: My DNA SNPs,
Zeo, FitBit
Discovering Disease
Blood
Variables
One: Hundred: My Blood Variables
Weight Weight
My
15. I Have Greatly Lowered My Body’s Inflammation
From Food By Increasing Omega-3s
“Silent Inflammation”
Chronically Ill I take 6 Fish Oil
American
Pills Per Day
Average “Healthy”
American
Blood Ratio of
Omega 6 to Omega 3 Ideal Range
My Range
Range Source: Barry Sears
My Tests by www.yourfuturehealth.com
16. I Track 100 Variables in Blood Tests
Done Quarterly to Annually
• Electrolytes • Liver
– Sodium, Potassium, Calcium, – GGTP, SGOT, SGPT, LDH, Total
Magnesium, Phosphorus, Boron, Direct Bilirubin,
Chlorine, CO2 Alkaline Phosphatase
• Micronutrients • Thyroid
– Arsenic, Chromium, Cobalt, – T3 Uptake, T4, Free Thyroxine
Copper, Iron, Manganese, Index, FT4, 2nd Gen TSH
Molybdenum, Selenium, Zinc • Blood Cells
• Blood Sugar Cycle – Complete Blood Cell Count
– Glucose, Insulin, A1C Hemoglobin – Red Blood Cell Subtypes
• Cardio Risk – White Blood Cell Subtypes
– Complex Reactive Protein • Cancer Screen
– Homocysteine – CEA, Total PSA, % Free PSA
• Kidneys – CA-19-9
– Bun, Creatinine, Uric Acid • Vitamins & Antioxidant Screen
• Protein – Vit D, E; Selenium, ALA, coQ10,
– Total Protein, Albumin, Globulin Glutathione, Total Antioxidant Fn.
Only One of These Was
Far Out of Normal Range
17. But, In Spite of My High Levels of Omega-3s,
My Blood Measurements Revealed Chronic Inflammation
Episodic Peaks in Inflammation 27x
Followed by Spontaneous Drop
15x
Antibiotics
5x
Antibiotics
Normal Range CRP < 1
Complex Reactive Protein (CRP) is a Blood Biomarker
for Detecting Presence of Inflammation
18. By Quantifying Stool Measurements Over Time
I Discovered Source of Inflammation Was Likely in Colon
124x Upper Limit Typical
Lactoferrin
Value for
Stool Samples Analyzed Active
by www.yourfuturehealth.com IBD
Normal Range
<7.3 µg/mL
Lactoferrin is a Sensitive and Specific Biomarker for
Detecting Presence of Inflammatory Bowel Disease (IBD)
19. Putting Multiple Biomarker Time Series Together,
Gives an Quantitative Readout of Health or Disease
Green : Inside Range
Orange: 1-10x Over
Red: 10-100x Over
Purple: >100x Over
Source: Calit2 Future Health Expedition Team
20. Confirming the IBD (Crohn’s) Hypothesis:
Finding the “Smoking Gun” with MRI Imaging
Liver I Obtained the MRI Slices
Transverse Colon
From UCSD Medical Services
and Converted to Interactive 3D
Working With
Small Intestine Calit2 Staff & DeskVOX Software
Descending Colon
MRI Jan 2012
Cross Section
Diseased Sigmoid Colon
Major Kink
Sigmoid Colon
Threading Iliac Arteries
21. Putting Your Organs On-line
• Videos of Me Giving Tours of My Insides:
– http://www.youtube.com/watch?v=9c4DtJ_L_Ps
– www.theatlantic.com/magazine/archive/2012/07/the-measured-man/309018/
Photo & DeskVOX Software Courtesy of Jurgen Schulze, Calit2
22. Why Did I Have an Autoimmune Disease like IBD?
Despite decades of research,
the etiology of Crohn's disease
remains unknown.
Its pathogenesis may involve
a complex interplay between
host genetics,
immune dysfunction,
and microbial or environmental factors.
--The Role of Microbes in Crohn's Disease
So I Set Out to Quantify All Three!
Paul B. Eckburg & David A. Relman
Clin Infect Dis. 44:256-262 (2007)
23. I Wondered if Crohn’s is an Autoimmune Disease,
Did I Have a Personal Genomic Polymorphism?
From www.23andme.com Polymorphism in
Interleukin-23 Receptor Gene
— 80% Higher Risk
ATG16L1
of Pro-inflammatory
Immune Response
IRGM
NOD2 SNPs Associated with CD
24. I Tracked My Innate Immune System
By Measuring Lysozyme From Stool Samples Over Time
My Immune System Seems to Be Fighting Bacteria Episodically
2x Upper Limit
Normal
Values from www.yourfuturehealth.com stool test
Lysozyme is an Enzyme of the Innate Immune System
that Attacks Bacterial Cell Walls
25. Your Human Cells are Only 10% of Your Superorganism:
How Can We Track the 90% which are Microbes?
16 = All 4 at Full Strength
Antibiotics Antibiotics
Stool
But Cultured Bacteria Are a Small Fraction of Total
Values From www.yourfuturehealth.com stool test
26. Determining My Gut Microbes
and Their Time Variation
Shipped Stool Sample
December 28, 2011
I Received
a Disk Drive April 3, 2012
With 35 GB FASTQ Files
Weizhong Li, UCSD
NGS Pipeline:
230M Reads
Only 0.2% Human
Required 1/2 cpu-yr
Per Person Analyzed!
27. Almost All Abundant Species (≥1%) in Healthy Subjects
Are Severely Depleted in LS Gut
1/35 Numbers Over Bars Represent
Ratio of LS to Healthy Abundance
1/15
1/8
1/18 1/3 1/3 1/7 1/25 1.1 1/12
1/9 1/6 1/62 1/15 1/22 1/65 1/39
28. LS Abundant Microbe Species (≥1%) Are
Dominated by Rare Species in Healthy Subjects
Numbers Over Bars Represent
214x Ratio of LS to Healthy Abundance
58x
1/8x
254x 1/3x 1/3x
43x 17x 2x 2x
1x
30. Next Step: Use Microarray to
Measure Time Series of Microbial Diversity
www.secondgenome.com
“Second Genome has developed
a sensitive, flexible and robust platform
for the identification of
microbiome-based signatures
for the rapid identification
of microbial gut health biomarkers.”
DNA microarray that can identify,
within hours,
over 50,000 different microbes
LBL’s Gary Andersen
and his PhyloChip
31. Metabolomics Can Differentiate
Ileum vs. Colon Inflammation in Crohn’s Disease
blue N= Ileum (ICD)
red N= Colon (CCD)
green N= Healthy
Jansson, et al. PLOS ONE, July 2009 | Volume 4 | Issue 7 | e6386
32. Integrative Personal Omics Profiling
Reveals Details of Clinical Onset of Viruses and Diabetes
Cell 148, 1293–1307, March 16, 2012
• Michael Snyder,
Chair of Genomics
Stanford Univ.
• Genome 140x
Coverage
• Blood Tests 20
Times in 14 Months
– tracked nearly
20,000 distinct
transcripts coding
for 12,000 genes
– measured the
relative levels of
more than 6,000
proteins and 1,000
metabolites in
Snyder's blood
33. Publically Sharing Your Genome and Medical Records:
Is it Crazy or the Future?
I Have Been Accepted by PGP and Spoke at GET 2012