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THE INFECTION PROCESS
By: Rommel Luis C. Israel III
CAUSATIVE AGENTS
TYPES
• Bacterium
• Virus
• Fungus
• Parasite
• Rickettssia
• Chlamydia
• etc
CAUSATIVE AGENTS
CHARACTERISTICS DESCRIPTION
Pathogenecity Ability to cause disease
Virulence Disease severity
Disease invasiveness
(ability to enter and
move through tissue)
Infective Dose Number of organisms to
initiate infection
CAUSATIVE AGENTS
CHARACTERISTICS DESCRIPTION
Organism Specificity (Host Preference)
Antigenic Variations
RESERVOIR
• the environment in which the agent is
found
Human a reservoir that is more
dangerous to humans than to
other species
Animal responsible for infestation with
tropozoites, worms, etc
Non-animal street dust, garden soil, lint
from beddings
MODE OF ESCAPE FROM THE
RESERVOIR
• Respiratory Tract (Most common)
• GIT
• GUT
• Open Lesions
• Mechanical Escape (includes Insect Bites)
• Blood
MODE OF TRANSMISSION
CONTACT TRANSMISSION
Direct Contact Person-to-person
Indirect Contact
Usually an inanimate
object
Droplet Contact
Coughing, Sneezing,
talking by an infected
person
MODE OF TRANSMISSION
VEHICLE ROUTE (through contaminated items)
FOOD Salmonellosis
WATER Shigellosis
Legionellosis
DRUGS Bacteremia resulting from infusion
of a contaminated infusion product
BLOOD Hepatitis B, Non-A Hepatitis,
Non-B Hepatitis
MODE OF TRANSMISSION
AIRBORNE
Droplet Nuclei
Residue of evaporated droplets
that remain suspended in air
Dust Particles
In the air containing the
infectious agent
Organism shed
into the
environment
From skin, hair, wounds or
perineal area
MODE OF TRANSMISSION
VECTORBORNE TRANSMISSION
Via
contaminated
or infected
arthropods
Flies, mosquitoes, ticks, and
others
MODE OF ENTRY OF ORGANISMS
INTO HUMAN BODY
• Respiratory Tract
• GIT
• GUT
• Direct Infection of mucous
membrane/skin
HOST FACTORS
• Age, Sex, Genetic, Constitution of
host
• Nutritional Status, Fitness,
Environmental Factors
• General Physical, Mental, and
emotional health
• Absent or abnormal
immunoglobulins
HOST FACTORS
• Status of hematopoietic systems,
efficacy of reticulo-endothelial system
• Presence of underlying disease
(diabetes mellitus, lymphoma,
leukemia, neoplasia,
granulocytopenia, or uremia)
• Patient treated with certain
antimicrobials, corticosteroids,
irradiation, immunosuppressive agents
EMERGING PROBLEMS IN
INFECTIOUS DISEASE
• Increasing number of different
organisms that are developing
resistance to increasing number
of available antimicrobials.
• Increasing number of person in
state of immuno-suppression
(cancer, leukemia, etc)
EMERGING PROBLEMS IN
INFECTIOUS DISEASE
• Person with serious disease
and are exposed to more
aggressive surgical
procedures
• Use of indwelling lines and
implanted foreign bodies

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THE INFECTION PROCESS

  • 1. THE INFECTION PROCESS By: Rommel Luis C. Israel III
  • 2. CAUSATIVE AGENTS TYPES • Bacterium • Virus • Fungus • Parasite • Rickettssia • Chlamydia • etc
  • 3. CAUSATIVE AGENTS CHARACTERISTICS DESCRIPTION Pathogenecity Ability to cause disease Virulence Disease severity Disease invasiveness (ability to enter and move through tissue) Infective Dose Number of organisms to initiate infection
  • 4. CAUSATIVE AGENTS CHARACTERISTICS DESCRIPTION Organism Specificity (Host Preference) Antigenic Variations
  • 5. RESERVOIR • the environment in which the agent is found Human a reservoir that is more dangerous to humans than to other species Animal responsible for infestation with tropozoites, worms, etc Non-animal street dust, garden soil, lint from beddings
  • 6. MODE OF ESCAPE FROM THE RESERVOIR • Respiratory Tract (Most common) • GIT • GUT • Open Lesions • Mechanical Escape (includes Insect Bites) • Blood
  • 7. MODE OF TRANSMISSION CONTACT TRANSMISSION Direct Contact Person-to-person Indirect Contact Usually an inanimate object Droplet Contact Coughing, Sneezing, talking by an infected person
  • 8. MODE OF TRANSMISSION VEHICLE ROUTE (through contaminated items) FOOD Salmonellosis WATER Shigellosis Legionellosis DRUGS Bacteremia resulting from infusion of a contaminated infusion product BLOOD Hepatitis B, Non-A Hepatitis, Non-B Hepatitis
  • 9. MODE OF TRANSMISSION AIRBORNE Droplet Nuclei Residue of evaporated droplets that remain suspended in air Dust Particles In the air containing the infectious agent Organism shed into the environment From skin, hair, wounds or perineal area
  • 10. MODE OF TRANSMISSION VECTORBORNE TRANSMISSION Via contaminated or infected arthropods Flies, mosquitoes, ticks, and others
  • 11. MODE OF ENTRY OF ORGANISMS INTO HUMAN BODY • Respiratory Tract • GIT • GUT • Direct Infection of mucous membrane/skin
  • 12. HOST FACTORS • Age, Sex, Genetic, Constitution of host • Nutritional Status, Fitness, Environmental Factors • General Physical, Mental, and emotional health • Absent or abnormal immunoglobulins
  • 13. HOST FACTORS • Status of hematopoietic systems, efficacy of reticulo-endothelial system • Presence of underlying disease (diabetes mellitus, lymphoma, leukemia, neoplasia, granulocytopenia, or uremia) • Patient treated with certain antimicrobials, corticosteroids, irradiation, immunosuppressive agents
  • 14. EMERGING PROBLEMS IN INFECTIOUS DISEASE • Increasing number of different organisms that are developing resistance to increasing number of available antimicrobials. • Increasing number of person in state of immuno-suppression (cancer, leukemia, etc)
  • 15. EMERGING PROBLEMS IN INFECTIOUS DISEASE • Person with serious disease and are exposed to more aggressive surgical procedures • Use of indwelling lines and implanted foreign bodies