This document provides an agenda and overview for the HSG 2016 conference. It summarizes the conference attendance numbers, recognizes sponsors and award recipients, and thanks outgoing and welcomes new board members. It highlights the HSG's strategic plan and 2016 accomplishments including clinical trials. Speakers discuss the future of HD care including education, coordinated care models, and improving access. The future of HD clinical trials is outlined including new recruitment strategies, quantitative disease models, virtual visits, objective measures, digital biomarkers from smartphones, and the need for new measurement classes.
NIHR CLAHRC East Midlands Annual Meeting 2015 presentations - Day 2CLAHRC-NDL
This document summarizes the proceedings of the NIHR CLAHRC East Midlands annual meeting on March 25, 2015. The meeting brought together partners from Nottinghamshire Healthcare NHS Foundation Trust and the Universities of Nottingham and Leicester to share progress and learning over the past year. Key highlights included 18 research projects making progress, over £500,000 in matched funding received, and the establishment of a 90-member faculty. The East Midlands AHSN discussed supporting implementation of CLAHRC projects through knowledge brokers and £525,000 in funding. Presentations also covered priority areas like individual placement and support for employment, bipolar disorder research, and building effective partnerships across the region.
Professor Richard Morriss - Enhancing Mental HealthCLAHRC-NDL
Presentation on Enhancing Mental Health theme research, by Professor Richard Morriss at the NIHR CLAHRC East Midlands launch event, 14 February 2014, Loughborough.
Colorectal screening evidence & colonoscopy screening guidelines Health Evidence™
Health Evidence hosted a 90 minute webinar examining colorectal cancer screening: benefits and harms, effective screening methods, and screening guidelines.Click here for access to the audio recording for this webinar: https://www.youtube.com/watch?v=JqOV-KHCBq8
Donna Fitzpatrick-Lewis, MSW, Senior Research Coordinator at the McMaster Evidence Review and Synthesis Centre and Dr. Maria Bacchus, Associate Professor of Medicine, Faculty of Medicine University of Calgary, and member of the Canadian Task Force on Preventive Health Care led the session. Donna presented the findings of the Synthesis Centre’s latest review and Dr. Bacchus presented findings from the Task Force’s latest guidelines:
Fitzpatrick-Lewis, D., Usman, A., Warren, R., Kenny, M., Rice, M., Bayer, A., Ciliska, D., Sherifali, D., Raina, P. Screening for colorectal cancer. Ottawa: Canadian Task Force on Preventive Health Care; 2015. Available: http://canadiantaskforce.ca/files/crc-screeningfinal2.pdf
Bacchus, C. M., Dunfield, L., Gorber, S. C., Holmes, N. M., Birtwhistle, R., Dickinson, J. A., Lewin, G., Singh, H., Klarenbach, S., Mai, V., Tonelli, M. (2016). Recommendations on screening for colorectal cancer in primary care. Canadian Medical Association Journal, cmaj-151125.
Among men and women, colorectal cancer is the second and third most common cause of cancer related death, respectively. Colorectal cancer screening guidelines, developed by the Canadian Task Force on Preventive Health Care, are based on a systematic review synthesizing evidence on the benefits and harms of screening, and the characteristics of effective screening tests. The guidelines, developed from the review, outline screening recommendations for adults aged 50 and older who are asymptomatic and not at high risk for colorectal cancer. This webinar provided a high level overview of the systematic review that informed these recommendations, followed by an overview of the recent Canadian screening guidelines.
Member experiences in an Australian Translational Cancer Research Centre and ...Cancer Institute NSW
The experience of membership of multidisciplinary collaborative cancer research networks is largely unreported. Sydney Catalyst Translational Cancer Research Centre (TCRC) is a multi-disciplinary and multi-institutional virtual consortium of researchers and clinicians from institutions in metropolitan Sydney and regional New South Wales. Following the Westfall model of translational research, we support multi-disciplinary collaborative cancer research focused on T1112 bench to bedside research and T2/3 translation of evidence into practice.
Sir Muir Gray - CLAHRC East Midlands launch eventCLAHRC-NDL
The document discusses several issues facing healthcare systems and proposes a new paradigm is needed. It outlines problems with the current system including harm from overuse, inequity from underuse, waste, and failure to prevent disease. Additional future challenges mentioned are rising expectations, increasing need, financial constraints, and climate change. The document argues that more of the same approach is not the solution and that a new system needs to be designed instead of just improving the current one. It emphasizes the importance of population health, systems of care, culture change, and personalized medicine.
Operational research to increase the efficiency of ART initiation in AfricaSydney Rosen
RapIT tested a single-visit ART initiation approach that significantly increased the proportion of patients starting ART within 90 days compared to standard of care. However, it relied on expensive point-of-care tests. SLATE aims to evaluate a simplified algorithm without these tests to determine immediate ART eligibility and initiate treatment in a single visit, with the goals of increasing prompt ART uptake and evaluating its costs and patient outcomes compared to standard care. If successful, SLATE could help standardize a fast, effective, and low-cost ART initiation model to strengthen the testing to treatment cascade.
This document provides an agenda and overview for the HSG 2016 conference. It summarizes the conference attendance numbers, recognizes sponsors and award recipients, and thanks outgoing and welcomes new board members. It highlights the HSG's strategic plan and 2016 accomplishments including clinical trials. Speakers discuss the future of HD care including education, coordinated care models, and improving access. The future of HD clinical trials is outlined including new recruitment strategies, quantitative disease models, virtual visits, objective measures, digital biomarkers from smartphones, and the need for new measurement classes.
NIHR CLAHRC East Midlands Annual Meeting 2015 presentations - Day 2CLAHRC-NDL
This document summarizes the proceedings of the NIHR CLAHRC East Midlands annual meeting on March 25, 2015. The meeting brought together partners from Nottinghamshire Healthcare NHS Foundation Trust and the Universities of Nottingham and Leicester to share progress and learning over the past year. Key highlights included 18 research projects making progress, over £500,000 in matched funding received, and the establishment of a 90-member faculty. The East Midlands AHSN discussed supporting implementation of CLAHRC projects through knowledge brokers and £525,000 in funding. Presentations also covered priority areas like individual placement and support for employment, bipolar disorder research, and building effective partnerships across the region.
Professor Richard Morriss - Enhancing Mental HealthCLAHRC-NDL
Presentation on Enhancing Mental Health theme research, by Professor Richard Morriss at the NIHR CLAHRC East Midlands launch event, 14 February 2014, Loughborough.
Colorectal screening evidence & colonoscopy screening guidelines Health Evidence™
Health Evidence hosted a 90 minute webinar examining colorectal cancer screening: benefits and harms, effective screening methods, and screening guidelines.Click here for access to the audio recording for this webinar: https://www.youtube.com/watch?v=JqOV-KHCBq8
Donna Fitzpatrick-Lewis, MSW, Senior Research Coordinator at the McMaster Evidence Review and Synthesis Centre and Dr. Maria Bacchus, Associate Professor of Medicine, Faculty of Medicine University of Calgary, and member of the Canadian Task Force on Preventive Health Care led the session. Donna presented the findings of the Synthesis Centre’s latest review and Dr. Bacchus presented findings from the Task Force’s latest guidelines:
Fitzpatrick-Lewis, D., Usman, A., Warren, R., Kenny, M., Rice, M., Bayer, A., Ciliska, D., Sherifali, D., Raina, P. Screening for colorectal cancer. Ottawa: Canadian Task Force on Preventive Health Care; 2015. Available: http://canadiantaskforce.ca/files/crc-screeningfinal2.pdf
Bacchus, C. M., Dunfield, L., Gorber, S. C., Holmes, N. M., Birtwhistle, R., Dickinson, J. A., Lewin, G., Singh, H., Klarenbach, S., Mai, V., Tonelli, M. (2016). Recommendations on screening for colorectal cancer in primary care. Canadian Medical Association Journal, cmaj-151125.
Among men and women, colorectal cancer is the second and third most common cause of cancer related death, respectively. Colorectal cancer screening guidelines, developed by the Canadian Task Force on Preventive Health Care, are based on a systematic review synthesizing evidence on the benefits and harms of screening, and the characteristics of effective screening tests. The guidelines, developed from the review, outline screening recommendations for adults aged 50 and older who are asymptomatic and not at high risk for colorectal cancer. This webinar provided a high level overview of the systematic review that informed these recommendations, followed by an overview of the recent Canadian screening guidelines.
Member experiences in an Australian Translational Cancer Research Centre and ...Cancer Institute NSW
The experience of membership of multidisciplinary collaborative cancer research networks is largely unreported. Sydney Catalyst Translational Cancer Research Centre (TCRC) is a multi-disciplinary and multi-institutional virtual consortium of researchers and clinicians from institutions in metropolitan Sydney and regional New South Wales. Following the Westfall model of translational research, we support multi-disciplinary collaborative cancer research focused on T1112 bench to bedside research and T2/3 translation of evidence into practice.
Sir Muir Gray - CLAHRC East Midlands launch eventCLAHRC-NDL
The document discusses several issues facing healthcare systems and proposes a new paradigm is needed. It outlines problems with the current system including harm from overuse, inequity from underuse, waste, and failure to prevent disease. Additional future challenges mentioned are rising expectations, increasing need, financial constraints, and climate change. The document argues that more of the same approach is not the solution and that a new system needs to be designed instead of just improving the current one. It emphasizes the importance of population health, systems of care, culture change, and personalized medicine.
Operational research to increase the efficiency of ART initiation in AfricaSydney Rosen
RapIT tested a single-visit ART initiation approach that significantly increased the proportion of patients starting ART within 90 days compared to standard of care. However, it relied on expensive point-of-care tests. SLATE aims to evaluate a simplified algorithm without these tests to determine immediate ART eligibility and initiate treatment in a single visit, with the goals of increasing prompt ART uptake and evaluating its costs and patient outcomes compared to standard care. If successful, SLATE could help standardize a fast, effective, and low-cost ART initiation model to strengthen the testing to treatment cascade.
School and community social influence programming for preventing tobacco and ...Health Evidence™
Health Evidence hosted a 90 minute webinar on substance use prevention and treatment interventions in children and adolescents, funded by the Canadian Centre on Substance Abuse. This webinar presented key messages and implications for practice.
This webinar focussed on interpreting the evidence in the following review, which synthesizes evidence related to social influence programming:
Skara, S. & Sussman, S. (2003). A review of 25 long-term adolescent tobacco and other drug use prevention program evaluations. Preventive Medicine (37) 451-474.
Decision aids for people facing health treatment or screening decisions: What...Health Evidence™
This webinar discussed a Cochrane review on the effectiveness of patient decision aids. It found that compared to usual care, decision aids improve patient knowledge by 13%, accuracy of risk perceptions by 82%, and the match between patient values and the health choices made by 51%. Decision aids may also reduce the use of discretionary treatments or screening by up to 20% and 14% respectively. While decision aids are effective, they are not being widely used in practice. The webinar provided an overview of the evidence on decision aids and highlighted their potential for improving shared decision making.
NIHR CLAHRC East Midlands Annual Meeting 2015 presentations - Day 1CLAHRC-NDL
The document provides an overview of the NIHR infrastructure for supporting applied health research in the UK. It discusses how the NIHR was established to improve health outcomes through advancing research, improving NHS care through research participation, strengthening the UK's international research position, and driving economic growth. The NIHR aims to overcome past problems like a lack of research incentives in the NHS, low applied evidence bases, and difficulties developing sustainable research capacity. It created a national health research system to integrate patients, the NHS, universities, investigators and other stakeholders.
Health Evidence hosted a 60 minute webinar examining the effectiveness of school-based interventions for preventing HIV, sexually transmitted infections and pregnancy in adolescents. Click here for access to the audio recording for this webinar: https://youtu.be/yCeIEQ4OTCc
Amanda Mason-Jones, Senior Lecturer in Global Public Health, Faculty of Science, University of York led the session and presented findings from her recent Cochrane review:
Mason-Jones A, Sinclair D, Mathews C, Kagee A, Hillman A, & Lombard C. (2016). School-based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents.Cochrane Database of Systematic Reviews, 2016(11), CD006417
http://healthevidence.org/view-article.aspx?a=school-based-interventions-preventing-hiv-sexually-transmitted-infections-29881
Sexually active adolescents are at risk of contracting HIV and STIs. Unintended pregnancy can have detrimental impact on young people’s lives. This review examines the impact of school sexual education programs on number of young people that contract STIs and number of adolescent pregnancies. Eight cluster randomized control trials, including 55,157 participants are included in this review. Findings suggest there is little evidence that school programs alone are effective in improving sexual and reproductive health outcomes for adolescents. This webinar examined the effectiveness and components of interventions that prevent HIV, STIs and adolescent pregnancy.
Professor Kamlesh Khunti - Introduction to CLAHRC East MidlandsCLAHRC-NDL
Professor Kamlesh Khunti, Director of NIHR CLAHRC East Midlands - Introductory presentation given at CLAHRC East Midlands launch event, 14 February 2014, Loughborough.
Interventions for preventing elder abuse: What's the evidence?Health Evidence™
Health Evidence hosted a 90 minute webinar examining the effectiveness of interventions for preventing elder abuse.
Philip Baker, Australia Regional Director APACPH, School of Public Health and Social Work Queensland University of Technology led the session and presented findings from their review:
Baker PRA, Francis DP, Hairi NN, Othman S, Choo WY. (2016). Interventions for preventing abuse in the elderly. Cochrane Database of Systematic Reviews, 2016, CD010321
http://www.healthevidence.org/view-article.aspx?a=interventions-preventing-abuse-elderly-29428
Many older adults experience some form of abuse (psychological, physical, and sexual) that often goes unreported. Elder abuse is associated with morbidity and premature mortality. This review examines the effectiveness of interventions for preventing elder abuse in the home, institutions and community settings. Findings of the review suggest there is uncertainty in the effectiveness of educational interventions to improve knowledge of caregivers about elder abuse and uncertainty on its effect of reducing abuse. This webinar will examine the effectiveness and components of interventions that prevent elder abuse.
The slide presentation from the combined meeting of PCORI'S Advisory Panels on Patient Engagement and Addressing Disparities April 28, 2014 meeting in Alexandria, VA.
Does family therapy for adolescent behavior problems work in the real worldCenter on Addiction
This document summarizes a study that compared the effectiveness of routine family therapy (RFT) to treatment as usual (TAU) for adolescent behavior problems. 205 adolescents were randomly assigned to RFT or TAU. Both treatments showed improvements in externalizing and internalizing symptoms, delinquency, and substance use, with some outcomes showing greater improvements for RFT. The study provides preliminary evidence that RFT can be effective when delivered with fidelity in usual care settings, though more research is still needed.
This document summarizes 5 research studies that will impact clinical practice for academic family physicians. It discusses studies on appropriate use of antithrombotic medication in atrial fibrillation patients, the association between neighborhood walkability and rates of overweight/obesity/diabetes, predictors of frequent primary care visits among older patients, differences in patient experience survey responses based on survey delivery method, and a randomized trial on oral/topical antibiotics for infected eczema in children. The document analyzes the research questions, methods, findings and implications of each study.
Community engagement in public health interventions for disadvantaged groups:...Health Evidence™
Health Evidence hosted a 60 minute webinar examining the effectiveness of community engagement in public health interventions for disadvantaged groups. Click here for access to the audio recording for this webinar: https://youtu.be/tUZ-u7QbMCY.
Alison O'Mara-Eves, Senior Researcher, University College London, EPPI-Centre and Ginny Brunton, Senior Health Researcher, University College London, EPPI-Centre presented findings from their review:
O'Mara-Eves A., Brunton G., Oliver S., Kavanagh J., Jamal F., & Thomas J. (2015). The effectiveness of community engagement in public health interventions for disadvantaged groups: A meta-analysis . BMC Public Health, 15, 129.
Community engagement is becoming an increasingly popular component included in the development and implementation of public health interventions. Involved community members take on roles that range from merely being informed, to being consulted, to collaborating or leading on the design, delivery and evaluation of public health strategies. This review examines the use of public health interventions with a community engagement component, particularly for its use in reducing health inequities among disadvantaged populations. Findings of the review suggest community engagement in public health interventions has an effect on several health outcomes, including health behaviours and self-efficacy. This webinar will examine the effectiveness and components of public health interventions that include community engagement and the impact on health outcomes.
This document discusses evaluations of the Alzheimer's Association's TrialMatch clinical research matching program in Massachusetts and New Hampshire. Survey results found that while TrialMatch was helpful for learning about research opportunities, follow-up could be improved to increase enrollment. Suggestions included promoting TrialMatch at more community events, educating physicians and volunteers, and using various media. Ongoing evaluation is needed to expand outreach and better serve minority populations.
Simon Denegri - Public involvement in CLAHRCsCLAHRC-NDL
Simon Denegri (INVOLVE chair and NIHR National Director for Public Participation and Engagement in Research) keynote presentation at NIHR CLAHRC East Midlands launch event on 14 February 2014, Loughborough.
This document summarizes six research studies that will impact family medicine practice. The studies include: 1) decreased STI screening rates in young women after changes to cervical cancer guidelines, 2) reduced cervical dysplasia in adolescent girls receiving the HPV vaccine, 3) potential cost savings of a universal public drug plan in Canada, 4) using an online smoking cessation program to increase medication use, 5) unintended effects of wait time policies on medical education, and 6) increasing potentially inappropriate bupropion prescriptions suggesting misuse. The document provides an overview of each study's question, methods, findings, and implications for academic and clinical practice.
The document discusses lessons learned from the Southwark and Lambeth Integrated Care (SLIC) program in London. Key points:
- SLIC aimed to reduce hospital admissions and care home placements for older adults through risk stratification, holistic assessments, and care management.
- Success required agreement on the problem, dedicated teams, funding shifts to support community care, and leadership development.
- Future programs need a strong business case, co-design with citizens, and a dedicated "engine room" team to drive local transformation.
Health Evidence hosted a 90 minute webinar examining different types of screening tool administration methods used for the detection of intimate partner violence.
Nasir Hussain, MD Candidate, Central Michigan University College of Medicine will present findings from his latest Trauma, Violence & Abuse review:
Hussain N., Sprague S., Madden K., Hussain F., Pindiprolu B., & Bhandari M. (2015). A comparison of the types of screening tool administration methods used for the detection of intimate partner violence: A systematic review and meta-analysis. Trauma, Violence & Abuse, 16(1), 60-69.
Intimate partner violence (IPV) is associated with significant health consequences for victims, including acute/chronic pain, depression, trauma, suicide, death, as well as physical, emotional, and mental harms for families and children. This review discusses the rate of IPV disclosure in adult women (over 18 years of age) with the use of three different screening tool administration methods: computer-assisted self-administered screen, self-administered written screen, and face-to-face interview screen. This webinar highlighted factors that contribute to the effectiveness of screening tool administration methods used for the detection of intimate partner violence.
This document summarizes results from the PRIDE-HD clinical trial of the drug pridopidine for Huntington's disease. The trial involved 437 patients across multiple countries and clinical sites. Key results included:
- Pridopidine did not show a significant effect on total motor score at 26 weeks, though some improvement was seen.
- Pridopidine showed a significant slowing of functional decline as measured by Total Functional Capacity (TFC) at 52 weeks, particularly in early stage patients.
- Responder analysis found more early stage patients on pridopidine maintained or improved TFC scores compared to placebo.
- Safety analysis found no new safety issues, though some psychiatric events were
HD Insights recognized three papers from 2016 with awards.
Flavia Niccolini of King's College London won for "Altered PDE10A Expression Detectable Early Before Symptomatic Onset in Huntington's Disease."
Jong-Min Lee of the GeM-HD Consortium, won for "Genetic Modifiers of HD"
School and community social influence programming for preventing tobacco and ...Health Evidence™
Health Evidence hosted a 90 minute webinar on substance use prevention and treatment interventions in children and adolescents, funded by the Canadian Centre on Substance Abuse. This webinar presented key messages and implications for practice.
This webinar focussed on interpreting the evidence in the following review, which synthesizes evidence related to social influence programming:
Skara, S. & Sussman, S. (2003). A review of 25 long-term adolescent tobacco and other drug use prevention program evaluations. Preventive Medicine (37) 451-474.
Decision aids for people facing health treatment or screening decisions: What...Health Evidence™
This webinar discussed a Cochrane review on the effectiveness of patient decision aids. It found that compared to usual care, decision aids improve patient knowledge by 13%, accuracy of risk perceptions by 82%, and the match between patient values and the health choices made by 51%. Decision aids may also reduce the use of discretionary treatments or screening by up to 20% and 14% respectively. While decision aids are effective, they are not being widely used in practice. The webinar provided an overview of the evidence on decision aids and highlighted their potential for improving shared decision making.
NIHR CLAHRC East Midlands Annual Meeting 2015 presentations - Day 1CLAHRC-NDL
The document provides an overview of the NIHR infrastructure for supporting applied health research in the UK. It discusses how the NIHR was established to improve health outcomes through advancing research, improving NHS care through research participation, strengthening the UK's international research position, and driving economic growth. The NIHR aims to overcome past problems like a lack of research incentives in the NHS, low applied evidence bases, and difficulties developing sustainable research capacity. It created a national health research system to integrate patients, the NHS, universities, investigators and other stakeholders.
Health Evidence hosted a 60 minute webinar examining the effectiveness of school-based interventions for preventing HIV, sexually transmitted infections and pregnancy in adolescents. Click here for access to the audio recording for this webinar: https://youtu.be/yCeIEQ4OTCc
Amanda Mason-Jones, Senior Lecturer in Global Public Health, Faculty of Science, University of York led the session and presented findings from her recent Cochrane review:
Mason-Jones A, Sinclair D, Mathews C, Kagee A, Hillman A, & Lombard C. (2016). School-based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents.Cochrane Database of Systematic Reviews, 2016(11), CD006417
http://healthevidence.org/view-article.aspx?a=school-based-interventions-preventing-hiv-sexually-transmitted-infections-29881
Sexually active adolescents are at risk of contracting HIV and STIs. Unintended pregnancy can have detrimental impact on young people’s lives. This review examines the impact of school sexual education programs on number of young people that contract STIs and number of adolescent pregnancies. Eight cluster randomized control trials, including 55,157 participants are included in this review. Findings suggest there is little evidence that school programs alone are effective in improving sexual and reproductive health outcomes for adolescents. This webinar examined the effectiveness and components of interventions that prevent HIV, STIs and adolescent pregnancy.
Professor Kamlesh Khunti - Introduction to CLAHRC East MidlandsCLAHRC-NDL
Professor Kamlesh Khunti, Director of NIHR CLAHRC East Midlands - Introductory presentation given at CLAHRC East Midlands launch event, 14 February 2014, Loughborough.
Interventions for preventing elder abuse: What's the evidence?Health Evidence™
Health Evidence hosted a 90 minute webinar examining the effectiveness of interventions for preventing elder abuse.
Philip Baker, Australia Regional Director APACPH, School of Public Health and Social Work Queensland University of Technology led the session and presented findings from their review:
Baker PRA, Francis DP, Hairi NN, Othman S, Choo WY. (2016). Interventions for preventing abuse in the elderly. Cochrane Database of Systematic Reviews, 2016, CD010321
http://www.healthevidence.org/view-article.aspx?a=interventions-preventing-abuse-elderly-29428
Many older adults experience some form of abuse (psychological, physical, and sexual) that often goes unreported. Elder abuse is associated with morbidity and premature mortality. This review examines the effectiveness of interventions for preventing elder abuse in the home, institutions and community settings. Findings of the review suggest there is uncertainty in the effectiveness of educational interventions to improve knowledge of caregivers about elder abuse and uncertainty on its effect of reducing abuse. This webinar will examine the effectiveness and components of interventions that prevent elder abuse.
The slide presentation from the combined meeting of PCORI'S Advisory Panels on Patient Engagement and Addressing Disparities April 28, 2014 meeting in Alexandria, VA.
Does family therapy for adolescent behavior problems work in the real worldCenter on Addiction
This document summarizes a study that compared the effectiveness of routine family therapy (RFT) to treatment as usual (TAU) for adolescent behavior problems. 205 adolescents were randomly assigned to RFT or TAU. Both treatments showed improvements in externalizing and internalizing symptoms, delinquency, and substance use, with some outcomes showing greater improvements for RFT. The study provides preliminary evidence that RFT can be effective when delivered with fidelity in usual care settings, though more research is still needed.
This document summarizes 5 research studies that will impact clinical practice for academic family physicians. It discusses studies on appropriate use of antithrombotic medication in atrial fibrillation patients, the association between neighborhood walkability and rates of overweight/obesity/diabetes, predictors of frequent primary care visits among older patients, differences in patient experience survey responses based on survey delivery method, and a randomized trial on oral/topical antibiotics for infected eczema in children. The document analyzes the research questions, methods, findings and implications of each study.
Community engagement in public health interventions for disadvantaged groups:...Health Evidence™
Health Evidence hosted a 60 minute webinar examining the effectiveness of community engagement in public health interventions for disadvantaged groups. Click here for access to the audio recording for this webinar: https://youtu.be/tUZ-u7QbMCY.
Alison O'Mara-Eves, Senior Researcher, University College London, EPPI-Centre and Ginny Brunton, Senior Health Researcher, University College London, EPPI-Centre presented findings from their review:
O'Mara-Eves A., Brunton G., Oliver S., Kavanagh J., Jamal F., & Thomas J. (2015). The effectiveness of community engagement in public health interventions for disadvantaged groups: A meta-analysis . BMC Public Health, 15, 129.
Community engagement is becoming an increasingly popular component included in the development and implementation of public health interventions. Involved community members take on roles that range from merely being informed, to being consulted, to collaborating or leading on the design, delivery and evaluation of public health strategies. This review examines the use of public health interventions with a community engagement component, particularly for its use in reducing health inequities among disadvantaged populations. Findings of the review suggest community engagement in public health interventions has an effect on several health outcomes, including health behaviours and self-efficacy. This webinar will examine the effectiveness and components of public health interventions that include community engagement and the impact on health outcomes.
This document discusses evaluations of the Alzheimer's Association's TrialMatch clinical research matching program in Massachusetts and New Hampshire. Survey results found that while TrialMatch was helpful for learning about research opportunities, follow-up could be improved to increase enrollment. Suggestions included promoting TrialMatch at more community events, educating physicians and volunteers, and using various media. Ongoing evaluation is needed to expand outreach and better serve minority populations.
Simon Denegri - Public involvement in CLAHRCsCLAHRC-NDL
Simon Denegri (INVOLVE chair and NIHR National Director for Public Participation and Engagement in Research) keynote presentation at NIHR CLAHRC East Midlands launch event on 14 February 2014, Loughborough.
This document summarizes six research studies that will impact family medicine practice. The studies include: 1) decreased STI screening rates in young women after changes to cervical cancer guidelines, 2) reduced cervical dysplasia in adolescent girls receiving the HPV vaccine, 3) potential cost savings of a universal public drug plan in Canada, 4) using an online smoking cessation program to increase medication use, 5) unintended effects of wait time policies on medical education, and 6) increasing potentially inappropriate bupropion prescriptions suggesting misuse. The document provides an overview of each study's question, methods, findings, and implications for academic and clinical practice.
The document discusses lessons learned from the Southwark and Lambeth Integrated Care (SLIC) program in London. Key points:
- SLIC aimed to reduce hospital admissions and care home placements for older adults through risk stratification, holistic assessments, and care management.
- Success required agreement on the problem, dedicated teams, funding shifts to support community care, and leadership development.
- Future programs need a strong business case, co-design with citizens, and a dedicated "engine room" team to drive local transformation.
Health Evidence hosted a 90 minute webinar examining different types of screening tool administration methods used for the detection of intimate partner violence.
Nasir Hussain, MD Candidate, Central Michigan University College of Medicine will present findings from his latest Trauma, Violence & Abuse review:
Hussain N., Sprague S., Madden K., Hussain F., Pindiprolu B., & Bhandari M. (2015). A comparison of the types of screening tool administration methods used for the detection of intimate partner violence: A systematic review and meta-analysis. Trauma, Violence & Abuse, 16(1), 60-69.
Intimate partner violence (IPV) is associated with significant health consequences for victims, including acute/chronic pain, depression, trauma, suicide, death, as well as physical, emotional, and mental harms for families and children. This review discusses the rate of IPV disclosure in adult women (over 18 years of age) with the use of three different screening tool administration methods: computer-assisted self-administered screen, self-administered written screen, and face-to-face interview screen. This webinar highlighted factors that contribute to the effectiveness of screening tool administration methods used for the detection of intimate partner violence.
This document summarizes results from the PRIDE-HD clinical trial of the drug pridopidine for Huntington's disease. The trial involved 437 patients across multiple countries and clinical sites. Key results included:
- Pridopidine did not show a significant effect on total motor score at 26 weeks, though some improvement was seen.
- Pridopidine showed a significant slowing of functional decline as measured by Total Functional Capacity (TFC) at 52 weeks, particularly in early stage patients.
- Responder analysis found more early stage patients on pridopidine maintained or improved TFC scores compared to placebo.
- Safety analysis found no new safety issues, though some psychiatric events were
HD Insights recognized three papers from 2016 with awards.
Flavia Niccolini of King's College London won for "Altered PDE10A Expression Detectable Early Before Symptomatic Onset in Huntington's Disease."
Jong-Min Lee of the GeM-HD Consortium, won for "Genetic Modifiers of HD"
Neuroimaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have provided important advances in our understanding of Huntington's disease and may be a suitable biomarker for monitoring disease progression in HD and for assessing the efficacy of future disease modifying therapies.
Healthcare is undergoing a technological transformation, and it is imperative for the industry to leverage new technologies to generate, collect, and track novel data. Panel chaired by Ralf Reilmann of the George Huntington Institut, Muenster.
This document provides information on diagnosing Huntington's disease (HD). It discusses the clinical features of HD including motor dysfunction such as chorea, cognitive impairment, and psychiatric features. The diagnostic evaluation for patients with a family history of HD or symptoms is described, including use of the Unified Huntington's Disease Rating Scale. Differential diagnoses for chorea are also reviewed, including other genetic, metabolic, autoimmune, and drug-induced causes. Workup of patients with chorea may include blood tests, imaging, and genetic testing.
Understanding patient-reported outcome measures in Huntington disease: at wha...Huntington Study Group
Understanding patient-reported outcome measures in Huntington disease: at what point is cognitive impairment related to poor measurement reliability, presented by Nicole Carlozo, PhD, University of Michigan, HSG 2016
The Cystic Fibrosis Foundation (CFF) and Cystic Fibrosis Foundation Therapeutics (CFFT) are non-profit organizations that fund research to cure cystic fibrosis. They invest $73.2 million annually in research. CFFT operates a drug development program that has brought 9 therapies to market and has 13 drugs in clinical trials. Funding comes primarily from donations and the sale of intellectual property rights, and is used to support research grants, fellowships, and drug discovery efforts through matching awards to researchers and a network of clinical centers. This model has yielded successful treatments for cystic fibrosis and billions in returns through drug approvals that are reinvested into further research.
The strategic plan outlines the Huntington Study Group's (HSG) vision, mission, and values, as well as strategic initiatives from 2015-2019 to investigate new HD therapies, expand the therapy pipeline, educate about HD research and care, develop sensitive outcome measures, expand the HSG research network, improve clinical trial efficiency, identify and develop new investigators, build human capital within HSG, and foster community. Key actions include completing clinical trials, launching new trials annually, developing online training and tools, adding new sites, and recognizing members' contributions.
This document discusses cystic fibrosis, including its causes, symptoms, diagnosis, and treatment. It is a genetic disorder that causes thick mucus buildup in the lungs and digestive tract. The primary symptom is severe lung infections. It is caused by mutations in the CFTR gene and is usually diagnosed via sweat test. Treatments include antibiotics, mucus-thinning drugs, and lung therapies to help clear mucus and treat infections. Ongoing research is working to develop new diagnostic tests and find a cure.
Joan Walton, an RN, has three research goals: to increase her understanding of cystic fibrosis (CF) complexity and progression; to enhance her ability to care for respiratory patients; and to gain knowledge on how the Cystic Fibrosis Foundation (CFF) supports those with CF. CF is a genetic disease causing thick mucus buildup due to a faulty CFTR gene. It affects many organs and leads to complications like lung infections. The CFF funds research to find a cure and ensures access to specialized care through a network of accredited centers. Treatment involves therapies to clear mucus and manage symptoms.
The meeting discussed increasing rates of early-age onset colorectal cancer (EAO CRC) and summarized efforts to address this trend. Major topics included identifying priority risk factors for EAO CRC like diet, antibiotics and obesity during childhood for further study. Participants agreed to explore relationships between these factors and the microbiome, and develop prospective cohort studies to examine incidence and adenoma outcomes. Next steps involve continued collaboration to seek funding and publish findings to inform further research.
Lung cancer is the leading cause of cancer deaths worldwide, with over 1.6 million deaths per year. While screening and treatment have improved, five-year survival rates have remained low at around 16.8%. A social media movement called Lung Cancer Social Media (#LCSM) was started to raise awareness, educate the public, and advocate for increased research funding. Through #LCSM's efforts on Twitter and other platforms, Medicare agreed to cover lung cancer screening for high-risk patients, which is estimated to save thousands of lives annually. Continued advocacy is needed to implement screening recommendations in other areas.
Virgil H. Simons presented on developing a global platform for prostate cancer advocacy. He discussed the disparities in prostate cancer incidence and outcomes around the world. While spending on prostate cancer treatment is increasing, barriers remain to implementing precision medicine and equitable research. There are also deficits in communication between patients and providers. Simons proposes engaging communities to conduct appropriate research and creating advocacy networks to influence policies that result in comprehensive cancer control programs. The goal is to achieve sustainable and equitable access to healthcare.
The Intersection of Medical Research and Public Healthkmbrown08
The purpose of this project is to show the necessity of collaboration between medical research and public health to improve the outlook of our nation’s future. Case studies focusing on influenza, childhood obesity and HIV/AIDS show how the fields have intersected to address health problems in the past, and how they can continue to intersect in the present and the future. Finally, this study identifies key public health advocacy messages that need to be heard on a national level in order to bolster the intersection of medical research and public health.
UTI collaborative 28th June 2018 presentations NHS Improvement
This document provides an agenda for an NHS Improvement Urinary Tract Infection Collaborative event on June 28th, 2018. The agenda includes sessions on storyboard feedback, presentations on reducing UTIs through hydration, measurement for improvement, and Plan-Do-Study-Act cycles. There will also be opportunities for panel Q&A and evaluation of the event. The goal is to support collaborative members in using quality improvement tools to reduce healthcare-associated UTIs within their trusts.
FLASCO: WHY YOU SHOULD BELONG & LEGISLATIVE UPDATEflasco_org
The document discusses the benefits of membership in the Florida Society of Clinical Oncology (FLASCO). Key benefits include educational opportunities through newsletters and events, advocacy for oncology issues, and networking opportunities. FLASCO also supports patients through various advocacy events, fellow/resident outreach programs, and partnerships with corporate organizations on initiatives like improving access to care.
CER 2016 Nguyen ctsi collaborative researchCTSI at UCSF
This document describes the Health Within Reach project, a collaborative effort between UCSF, SFGH, and SF Hep B Free to improve hepatitis B and C screening for Asian Americans. The team was formed due to their shared focus on Asian American health disparities and complementary expertise in clinical research, community engagement, and multi-lingual interventions. Challenges in collaborating across organizations were addressed through regular communication, consensus decision-making, and flexibility. The project aims to develop and evaluate a video and provider alert intervention to increase screening rates.
The document outlines the development of CAMH's Lower-Risk Nicotine Use Guidelines, which were created to educate the public on lower-risk options for nicotine use given the changing landscape of tobacco and nicotine products. The Guidelines development process included a literature review and formulation of recommendations by a guideline development group. The Guidelines contain 6 recommendations on nicotine products and aim to empower lower-risk choices while acknowledging that complete abstinence from nicotine is the safest option.
The document describes an exploratory study examining changes in functional recovery levels and associated factors over the first six months following right hemisphere stroke. The study assessed 93 right hemisphere stroke patients at four time points - within 7 days of admission, at discharge, 6 weeks post-discharge, and 6 months post-stroke - using a battery of validated tests. Functional ability was the primary outcome measured, while factors like age, stroke severity, cognition, inattention, self-efficacy, therapy received, and discharge location were examined. A multi-level model was used to analyze the hierarchical longitudinal data and determine the variability in functional ability attributed to each factor over time.
In this global pandemic, IBD patients and their healthcare providers from around the world share similar fears and concerns. SECURE-IBD is an international database to monitor and report on COVID-19 in IBD patients. By working across borders, we are learning how factors like age, other conditions, and IBD treatments impact COVID-19 outcomes. This slide deck also shares information about other research efforts that are ongoing to better understand the impact of COVID-19 on IBD patients.
The Foundation would like to thank AbbVie Inc., Genentech, Inc., Gilead Sciences, Inc., Janssen Biotech, Inc., Shire, and Takeda Pharmaceuticals U.S.A., Inc., sponsors of our COVID-19 materials. Additional support is provided through the Foundation’s annual giving program and individual donors.
The Cystic Fibrosis Foundation is committed to finding new therapies and ultimately a cure for cystic fibrosis. Cystic fibrosis is a life-threatening genetic disease that affects the respiratory and digestive systems. The Foundation has helped increase the median predicted age of survival from 5 years old in 1950 to 37 years old today through research, care centers, and new therapies. The Foundation is efficient, with 89.6% of revenue funding vital programs to support research, care, and education.
This document discusses Dr. Wafik El-Deiry's research interests in colorectal cancer treatment and other cancers. It outlines the value of social media platforms like Twitter and LinkedIn for scientists and physicians to share information, enhance collaborations, and raise their professional visibility. Specific examples are provided of how Dr. El-Deiry uses Twitter to tweet about research findings, curate relevant news, and live tweet conferences and documentaries. LinkedIn is used to connect with other professionals, engage in discussions, and highlight his credentials and publications.
A presentation delivered by IPPOSI CEO, Derick Mitchell at the University College Dublin PharmTox Society event on Clinical Trials in Ireland on March 6th, 2017
On July 7, 2014, the Green Park Collaborative (GPC) of the Center for Medical Technology Policy (CMTP) and the Institute for Clinical and Economic Review (ICER) co-hosted a web conference to explore the evidence needed to demonstrate the effectiveness and value of new drugs to treat chronic hepatitis C (HCV) infection. Representatives from various stakeholder groups, including payers, patients, pharmaceutical industry, health technology assessment organizations, and regulatory bodies, presented and discussed this issue with a particular focus on:
1. The evidence generated for regulatory approval;
2. The evidence preferences of post-approval decision makers; and
3. Strategies to efficiently generate the additional evidence.
Each of the invited speakers gave a brief presentation followed by a question and answer session at the end of the presentations. Audience members had an opportunity to submit questions through a chat feature. The conference was moderated by Dr. Sean Tunis, Founder
and CEO of CMTP. More than 200 participants, including a variety of subject matter experts and stakeholder representatives, attended the web conference.
Video and webinar summary available here: http://www.cmtpnet.org/featured-projects/green-park-collaborative/gpc-usa-meetings/webinars/hepatitis-c-drugs-evidence-to-demonstrate-effectiveness-value
This document discusses patient engagement and outlines strategies that health systems have used to increase engagement. It begins with an overview of a framework for patient and family engagement in health and healthcare. It then provides examples from various health systems of strategies they have implemented to increase engagement and discusses the results, such as improved outcomes and cost savings. Some of the key strategies discussed include shared decision making, care coordination, chronic disease management, and targeting interventions based on patient needs and activation levels. The document emphasizes that patient engagement is associated with better health outcomes, care experiences, and lower costs. It concludes that building a truly patient-centered healthcare system can improve quality in a way that benefits both patients and costs.
This document provides summaries from several presentations about driving progress in health care through research supported by the National Institute for Health Research (NIHR) in the UK. The first presentation introduces the NIHR and its role in supporting different types of health care research. The second presentation describes a clinical academic fellowship funded by the NIHR and the research and career development it enabled. The third presentation summarizes a large clinical trial called DRAFFT that compared wire fixation and plate fixation for distal radius fractures and found wires to be as effective and cost less, leading to a change in practice. The last presentation discusses the experience of patients who participate in research and how it can benefit the NHS.
This document discusses biobanking from the patient perspective. It provides information about IPPOSI, a partnership between patient groups, industry, and science that aims to expedite development and patient access to innovative therapies. IPPOSI receives funding from the Irish Department of Health and industry membership fees. It also discusses the role of "patient experts" who are trained by IPPOSI and EUPATI on clinical research, health technology assessment, and other topics to disseminate information. The document outlines IPPOSI's involvement with BBMRI to include the patient perspective in biobanking initiatives and form research partnerships. It notes challenges with patient consent, data management, and costs for patient registries and the potential for legislation to mandate
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Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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The CFF Story: Innovating for a Cure
1. The CFF Story:
Innovating for a Cure
Huntington Study Group
November 4, 2016
Robert J. Beall, Ph.D.
Former President and CEO, Cystic Fibrosis Foundation
2. The CFF Story:
Innovating for a Cure
Community
Clinical Care
Research
Discovery & Development
Treatment
3. Median Predicted Survival Age of US Patients
with Cystic Fibrosis
Source: Cystic Fibrosis Foundation, National Patient Registry
41
0
5
10
15
20
25
30
35
40
45
1940 1950 1960 1970 1980 1990 2000 2010 2015
4. As of 2015 There Are More Adults With CF
Than Children With CF in the U.S.
Cystic Fibrosis Foundation. Patient Registry Annual Report. Bethesda, MD: Cystic Fibrosis Foundation.
2015
%ofCFindividualsovertheageof18
1965 1970 1975 1980 1985 1990 1995 2000 2005 2010 2015
0
10%
20%
30%
40%
50%
8. Academics
• Research
• Care
• Training
Biopharmaceutical
• Translation
• Commercialization
CF Foundation
• Care
• Research
• Education
Ecosystem for Cystic Fibrosis Foundation Success
FDA
NIH
23. Therapeutics Development Program (TDP)
Started in 1998
• Created to encourage industry and academia to
focus on CF and CFTR as drug target
• Components of TDP
– Financial assistance
– Research tools and scientific advice
– Well organized clinical trial network
Venture Philanthropy
24. TDP Process
Available
to
CF Patients
DISTRIBUTION
FDA
P
P
R
O
V
A
L
DEVELOPMENT
TDN
Bring Existing Drugs for
CF Indication
NDA
Clinical
Dosage
and
Efficacy
IND
Preclinical
Safety
Testing
Therapeutics
Development
Awards
DISCOVERY
Basic Research
• CFTR Corrector
Consortium
• CFTR Structural
Consortium
• Mucociliary
Clearance
Consortium
High-throughput
Screening
The CF Foundation has “really paved the way for other
small disease nonprofits to take drug discovery into their
own hands.”
-Harvard Business School Professor Robert Higgins
26. Highlights of CF TDN Studies (1998-2016)
• Network supports 25-35 studies annually:
– 75% industry-based therapeutic trials
– 25% PI-initiated
• Initial studies were early Phase (1 and 2)
• Transition to larger Phase 3 trials
– First CFFT Phase 3 study in 2001
– Industry moved to predominantly Phase 3 by
2009
• PI initiated studies have focused on outcome
measure development
• In total, over 150 studies involving thousands of
individuals with CF have been successfully
completed.
32. Venture Philanthropy: It is not just the
money! It also involves access to:
• Expertise
• Patients
• Clinical Trial Network
• Data
• Specialized Resources
• Committed Community
Venture Philanthropy is not for the faint of heart…
The model-adjusted absolute mean difference between ivacaftor and placebo was 10.68 percentage points (95% CI 7.26, 14.10).
Significant ivacaftor treatment effects were also observed at Weeks 2 and 4 (p<0.0001 at both time points) when compared to placebo.
Table 14.2.1.2.1
Table 14.2.1.2.2
Table 14.2.1.2.2
Just a list of some of the partners to take us to the next level—some small molecules approaches--- but generally limited to one day approaches,,, but Shire and ProQR are moving toward newer approaches,,, multiple day novel therapies