Tetanus is a serious bacterial infection caused by Clostridium tetani that causes painful muscle spasms and stiffness. It enters the body through breaks in the skin, especially wounds contaminated with dirt or manure. Symptoms include jaw cramping, sudden involuntary muscle tightening, headache, and fever. Complications can include breathing problems, pneumonia, and death. Tetanus is prevented through vaccination and proper wound care. Treatment involves antibiotics, tetanus immune globulin, muscle relaxers, wound cleaning, and vaccination.
An acute and infectious disease caused by the toxin produced by a kind of bacteria that enters the body through the cuts or wounds also called lockjaw.
Tetanus is an infection caused by bacteria called Clostridium tetani, is often associated with puncture wounds that do not appear to be infected.
When these bacteria enter the body, they produce a toxin that causes painful muscle contractions.
Another name for tetanus is “lockjaw”.
It often causes a person’s neck and jaw muscles to lock, making it hard to open the mouth or swallow
An acute and infectious disease caused by the toxin produced by a kind of bacteria that enters the body through the cuts or wounds also called lockjaw.
Tetanus is an infection caused by bacteria called Clostridium tetani, is often associated with puncture wounds that do not appear to be infected.
When these bacteria enter the body, they produce a toxin that causes painful muscle contractions.
Another name for tetanus is “lockjaw”.
It often causes a person’s neck and jaw muscles to lock, making it hard to open the mouth or swallow
The information about Tetanus is a basic content intended to share Students of Graduate and postgraduate in Life Sciences.
The up loader has no Commercial interests
Tetanus is a serious illness caused by Clostridium bacteria. The bacteria live in soil, saliva, dust, and manure. The bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. It can lead to "locking" of the jaw. This makes it impossible to open your mouth or swallow.
Tetanus |Causes | Signs and symptoms| All aspects - medical discussion martinshaji
this is a brief study regarding almost all aspects of tetanus .Tetanus is a condition caused by a nerve toxin produced by the bacteria Clostridium tetani, which may also cause fatal condition too.
please comment
thank you
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The information about Tetanus is a basic content intended to share Students of Graduate and postgraduate in Life Sciences.
The up loader has no Commercial interests
Tetanus is a serious illness caused by Clostridium bacteria. The bacteria live in soil, saliva, dust, and manure. The bacteria can enter the body through a deep cut, like those you might get from stepping on a nail, or through a burn. It can lead to "locking" of the jaw. This makes it impossible to open your mouth or swallow.
Tetanus |Causes | Signs and symptoms| All aspects - medical discussion martinshaji
this is a brief study regarding almost all aspects of tetanus .Tetanus is a condition caused by a nerve toxin produced by the bacteria Clostridium tetani, which may also cause fatal condition too.
please comment
thank you
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. What is tetanus?
Tetanus is a serious bacterial infection that affects the nervous system and
causes muscles throughout the body to tighten. It’s also called lockjaw
because the infection often causes muscle contractions in the jaw and neck.
However, it can eventually spread to other parts of the body.
Tetanus is an infection caused by a bacterium called Clostridium tetani.
Spores of tetanus bacteria are everywhere in the environment, including soil,
dust, and manure. The spores develop into bacteria when they enter the
body.
3. Causes
Tetanus infection has been associated with:
Wounds contaminated with dirt, poop (feces),
Wounds caused by an object puncturing the skin (puncture wounds), like a nail or needle
Burns
Crush injuries
Injuries with dead tissue
Less commonly, it’s been associated with:
animal bites
dental infections
insect bites
chronic sores and infections
4. Other Ways Tetanus Gets Into Your Body
Tetanus bacteria can also infect the body through breaks in the skin caused by:
• Clean superficial wounds (when only the topmost layer of skin is scraped off)
• Surgical procedures
• Insect bites
• Dental infections
• Compound fractures (a break in the bone where it is exposed)
• Chronic sores and infections
• Intravenous (IV) drug use
• Intramuscular injections (shots given in a muscle)
5. Tetanus affects the nerves that control your muscles, You may also
experience spasms and stiffness in various muscles, especially those in your
jaw, abdomen, chest, back, and neck.
The incubation period — the time between exposure to the bacteria and the
onset of illness — is between 3 and 21 days. Symptoms typically appear
within 14 days
Symptoms
6. Symptoms of tetanus include:
The first sign is most commonly spasms of the muscles of the jaw, or “lockjaw.”
•Jaw cramping
•Sudden, involuntary muscle tightening (muscle spasms) — often in the stomach
•Painful muscle stiffness all over the body
•Trouble swallowing
•Jerking or staring (seizures)
•Headache
•Fever and sweating
•Changes in blood pressure and heart rate
7. Complications
Severe muscle spasms as a result of tetanus can also cause serious
health complications, such as:
breathing problems
pneumonia (an infection of the lungs)
brain damage due to lack of oxygen
abnormal heart rhythm
8. • Uncontrolled/involuntary tightening of the vocal cords (laryngospasm)
• Broken bones (fractures)
• Infections gotten by a patient during a hospital visit (hospital-acquired infections)
• Blockage of the main artery of the lung or one of its branches by a blood clot that has travelled from
elsewhere in the body through the bloodstream (pulmonary embolism)
• Pneumonia, a lung infection, that develops by breathing in foreign materials (aspiration pneumonia)
• Breathing difficulty, possibly leading to death (1 to 2 in 10 cases are fatal)
9. Diagnosis
Doctors diagnose tetanus based on a physical exam, medical
and vaccination history, and the signs and symptoms of
muscle spasms, muscle rigidity and pain. A laboratory test
would
10. Prevention
Vaccination and good wound care are important to help prevent tetanus
infection. Doctors can also use a medicine to help prevent tetanus
Several vaccines protect against tetanus
• DTaP protects against diphtheria, tetanus, and pertussis
(whooping cough)
• DT protects against diphtheria and tetanus
• Tdap protects against tetanus, diphtheria, and pertussis
• Td protects against tetanus and diphtheria
11. Good Wound Care
Immediate and good wound care can also help prevent infection.
• Don’t delay first aid of even minor, non-infected wounds like blisters, scrapes, or
any break in the skin.
• Wash hands often with soap and water or use an alcohol-based hand rub if
washing is not possible.
• Consult your doctor if you have concerns and need further advice.
12. Treatment
Treatment depends on the severity of your symptoms. Tetanus is typically treated with
a variety of therapies and medications, such as:
antibiotics such as penicillin to kill the bacteria in your system
tetanus immune globulin (TIG) to neutralize the toxins that the bacteria have
created in your body
muscle relaxers to control muscle spasms
a tetanus vaccine given along with the treatment
cleaning the wound to get rid of the source of the bacteria
13. •Epidemiology and prevention of vaccine-preventable diseases: Tetanus. (2016).
cdc.gov/vaccines/pubs/pinkbook/tetanus.html
•Mayo Clinic Staff. (2016). Tetanus: Overview.
mayoclinic.org/diseases-conditions/tetanus/home/ovc-20200456
•Tetanus. (2016).
kidshealth.org/en/parents/tetanus.html
•Tetanus and the vaccine (shot) to prevent it. (2014).
cdc.gov/vaccines/parents/diseases/child/tetanus.html
•Tetanus: Causes and transmission. (2017).
cdc.gov/tetanus/about/causes-transmission.html
•Tetanus (lockjaw). (2014).
health.ny.gov/diseases/communicable/tetanus/fact_sheet.htm
•Tetanus: Symptoms and complications. (2017).
cdc.gov/tetanus/about/symptoms-complications.html
•Tetanus vaccination. (2016).
cdc.gov/vaccines/vpd/tetanus/index.html
•Stevens, D. L., Bisno, A. L., Chambers, H. F., Dellinger, E. P., Goldstein, E. J. C., Gorbach,
S. L., … Wade, J. C. (2014, June 18). Practice guidelines for the diagnosis and
management of skin and soft tissue infections: 2014 update by the Infectious Diseases
Society of America. Clinical Infectious Diseases
cid.oxfordjournals.org/content/early/2014/06/14/cid.ciu296.full
References