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COMPOSITION

Alpha-Cypermethrin

Flufenoxuron

3%

3%
ALPHA-CIPERMETHRIN

MAIN
FEATURES
 94% to 97% active
Isomer CIS
 Not irritating
 WHO standard
World Helth Organization
GROWTH REGULATORS
Compounds which have a different action
from the conventional insecticides

They
a

INSE re also known
as “ I
CT G
R O W GR ”
REG
TH
U

LATO
R
“IGRs” CHARACTERISTICS

 Interfere with the
metamorphosis and ecdysis
control mechanism.
 Act on specific Arthropods
enzymes.
 Give a long residual protection.
 Act on juvenile forms of insects.
 Can cause the adult females to
lay unviable eggs.
 They don’t offer the knock
down effect.
ACTION MODE - CLASSIFICATION
CHITIN
SYNTHESIS
INHIBITORS
Synthetase enzyme =
responsible for the
chitin formation
process. IGRs
prevent its
polymerization.
Ex.: Flufenoxuron.

AGONISTS OF
ECDYSTEROIDS

JUVENILE
HORMONE AGONISTS

Imitate the insects natural
hormone ("ecdisônio"),
prematurely triggering the
process of change.

"Juvenoid" = Imitate the action
of the insects juvenile
hormone by interfering with
the skin changes.

Ex.: Tefubenoside,
Metoxifenoside.

Ex.: Piriproxifen,
Fenoxicarb, Metoprene.
POLYSACCHARIDES

Carbohydrates formed by the union of more
than ten monosaccharide molecules, forming
a polymer of monosaccharides

MONOSACCHARIDES
FRUCTOSE

BETA- GLUCOSE

Energy
Ex.: Starch, Glycogen

Structural
Ex.: Chitin, Cellulose

Unlike the mono-and disaccharides (glucose, galactose, fructose),
polysaccharides are insoluble in water and are well suited to the role of
nutritional reserves or storage.
CHITIN

Polysaccharide which contains
nitrogen in its acetylglucosamine
units.
Main constituent of the
arthropods exoskeletons.
Also found in the fungi cell walls.
FUNGUS - CELL WALL

mannoproteins

FUNCTIONS
ß (1,3)

Protection adverse
factors

ß (1,6) glucan

Permeability
barrier
ß (1,3) glucan
Plasma membrane

chitin

synthase

Cell shape

ergosterol

Interaction with the
external environment

Atlas of fungal Infections, Richard Diamond Ed. 1999 - Introduction to Medical Mycology. Merck and Co. 2001
FLUFENOXURON

Chemical group:
Benzoyl phenyl urea

Solubility in water: 0,0043 mg/l
(25º)

Acute oral DL50(rat):
> 3000 mg/kg (téc.)
85% eliminated in feces within
72 hours (rats)
Not irritanting
Classe III – OMS
LABORATORY RESULTS- FLUFENOXURON
Blattella germanica

Until 98 days:

5 mg/m²
M
O
R
T
A
L
I
T

Start with 8 adults (3 males/ 5
females, and 3 with ooteca), and
10 nymphs in 1º ínstar and 5 the
last ínstar.

10 mg/m²
Control

After 100 days:

Y%

New population with 7 adults (3
males/4 females, and 2 with
ooteca), and 7 nymphs in 1º ínstar
and 5 the last ínstar.
Area treated: 10% of the total area disponível.Obs.: Total area
with availability of food, shelter and water.

Food And Environment Protection Act 1985, Part III
ESTIMATED POPULATION IN 98 DAYS
Blattella germanica

Biological Characteristics

Domestic Species
Blattella germanica

Size

12 a 16 mm

Color

yellowish brown

Ootheca Deposition

not release

Number of eggs / ootheca

30-40

Number of ootheca

4-5

Number of Ecdysis

5-7

young period

2-3 months

longevity

1 year

eggs incubation

15-30 days

posture interval

45 days

Succession number

20 000

days to produce the first ootheca

17

98 days estimate

5369X 5 – 26.845
FIELD RESULTS - FLUFENOXURON
Blattella germanica
%
P
O
P
U
L
A
T
I
O
N
R
E
D
U
C
T
I
O
N

Inicial
on
populati

Index Infestation measured
with glue trap.
(captures per night)

Dose found in the treated surfaces
(chromatographic analysis - mg / m²):
Apart 01:

-

Apart 02: 6,33
Apart 03:

-

Apart 04: 4,53

Rate: 7,5 mg/m²
Food And Environment Protection Act 1985, Part III

Apart 05: 5,24
Apart 06: 3,65
FIELD RESULTS - FLUFENOXURON
Blattella germanica
Apart. 02

Nº
I
N
S
E
C
T
S
C
A
P
T
U
R
E
D

Food And Environment Protection Act 1985, Part III

ADULTS

NYMPHS
LABORATORY RESULTS – FLUFENOXUROM
Ctenocephalides felis

PUPAE

DEAD LARVAE

TREATMENT

RESULTS WITH
ADULTS - SECOND
STAGE (%)

Control

72,5

62

4

0,8 mg/m²

0,98

38

23

4,0 mg/m²

0

5

68

NUMBER

5 repetitions of 15 to 20 larvae of second ínstar

Flufenoxuron - control in
the development of the
second stage
LIFE CYCLE - FLEAS
Ctenocephalides felis
Adults

Pupa

Adult Flea

Eggs

Pupa

Animals

Larvae

Larvae
3º stage

Larvae
1º stage

Environment

Environment

Environment

Larvae
2º stage

LIFE CYCLE
Eggs

Cycle Time - 17 to 25 days
Approximately 3000 eggs
FIELD RESULTS - FLUFENOXURON
Ctenocephalides felis

Rate:
Eggs collected
Dead Larvae

15 mg/m²
METHODOLOGY
1)

Cat’s Cloth (40 cm²) jerky
and collected;

Alive Adults

2)

Count number of eggs;

Adults Control (%)

3)

Incubated eggs;

4)

Note the development of
eggs.

Alive Larvae

W

ks
ee

Control with 77 weeks

Food And Environment Protection Act 1985, Part III
FLUFENOXURON RECOMMENDATIONS - OMS

Cockroaches: Rate 0,3 g/L
“Due to its slow-acting insecticides are usually combined with faster
acting insectcides. This combination eliminates adults and prevents the
development of young forms”

Bed Bugs: Rate 0,3 g/L
“Studies have shown the bed bugs resistance to conventional
insecticides.The mixtures of Growth Regulators + Pyrethroids have
proven to be an effective control compared to infestations tolerant to
pyrethroids when it is used alone. "

Food And Environment Protection Act 1985, Part III
TENOPA® - ESPECIFICATIONS

Physical State:

opaque and
viscous liquid
Color: white

Oxidant:

considered
non oxidizing
Density: 1,028

Smell: Odeurless

Shelf stability

Good stability in:
20 a 28º C - 104 weeks / 728 days

Acid/Base: PH

7.2

29 a 37º C - 52 weeks / 364 days
INSTRUCTIONS FOR USE

PESTS

COMERCIAL
PRODUCT
(ml/ 10 L of water)

I.A.
CONCENTRATION
ALPHA-CIPERMETRIN
(%P/P)

I.A.
CONCENTRATION
FLUFENOXURON
(%P/P)

Cockroaches

50

0,015%

0,015%

Mosquitoes

67

0,020%

0,020%

Flies

67

0,020%

0,020%

Fleas

33

0,010%

0,010%

Ants

50

0,015%

0,015%

Triatomines

133

0,040%

0,040%

Ticks

80

0,024%

0,024%

Scorpions

170

0,050%

0,050%

Mealworm

150

0,045%

0,045%

Bed bug

170

0,050%

0,050%

Brown spider

170

0,050%

0,050%
LIFE CYCLE - COKROACHES
Periplaneta Americana

Males

Females
LABORATORY RESULTS
Tile surface - Blatella germanica
9
8
7

Minutes

6
5

Upper limit
KT50

4

Lower limit

K
IC N
QU TIO
AC

3
2
1
0

Check

Alfa-Cipermetrina 3%+
Flufenoxueom 3%

(TENOPA )
®

Source : Non Crop Laboratory = EEA BASF- Brazil, 2010

Alpha-Cypermethrin

Lambdacyalothrin

Deltamethrin

5%

2,5%

2,5%
LABORATORY RESULTS
Wood surface - Blatella germanica

100
90

K
IC N
QU TIO
AC

80
70

Minutes

60

Upper limit

50

KT50

40

Lower limit

30
20
10
0

Check

Alpha-Cypermethrin 3%+ Alpha-Cypermethrin
5%
Flufenoxueon 3%

(TENOPA )
®

Source : Non Crop Laboratory = EEA BASF- Brazil, 2010

Lambdacyalothrin

Deltamethrin

2,5%

2,5%
LABORATORY RESULTS
Blatella germanica
TILE SURFACE - tile surface
PRELIMINARY PROFILE
ACTIVE
INGREDIENT

CONC. Appl.
(g a.i./l) (Nº)

RATE
(10l of water)

Alphacypermethrin+
Flufenoxuron

30/30

1

50

1

25

1

25

1

EFFICACY
30 DAYS

EFFICACY
60 DAYS

EFFICACY
90 DAYS

10%

20%

EFFICACY
60 DAYS

EFFICACY
90 DAYS

100ml/200m²

Deltamethrin

EFFICACY
72 HOURS

50ml/200m²

Lambdacyalothrin

EFFICACY
48 HOURS

50ml/200m²

Alphacypermethrin

EFFICACY
24 HOURS

100ml/200m²
Subtitles

WOOD SURFACE
PRELIMINARY PROFILE - wooden surface
ACTIVE
INGREDIENT

CONC. Appl.
(g a.i./l) (Nº)

RATE
(10l of water)

Alphacypermethrin+
Flufenoxuron

30/30

1

50ml/200m²

Alphacypermethrin

50

1

50ml/200m²

Lambdacyalothrin

25

1

100ml/200m²

Deltamethrin

25

1

100ml/200m²

P&D Brasil

Source : Non Crop Laboratory = EEA BASF- Brazil, 2010

EFFICACY
24 HOURS

EFFICACY
48 HOURS

EFFICACY
72 HOURS

0
EFFICACY
30 DAYS
RESULTS – RESIDUAL EFFECT
Periplaneta / Blatella

Rate:
50 mL - 10 L of
water

Days

Ecolyzer
ANVISA Standard
RESULTS – KNOCK DOWN
Periplaneta / Blatella

Rate:
TIME

50 mL - 10 L of
water

Days

Ecolyzer
ANVISA Standard

KT 50 with confidence interval of 95%
Ex.: Periplaneta - time 24h - result 6,13 min – confidence interval = 4,49/8,35 min
RESULTS
Ctenocephalides felis

Rate:
33 mL - 10 L of
water

Days

lity %
Morta

Ecolyzer
ANVISA Standard
RESULTS
Culex quinquefasciatus

Rate:
67 mL - 10 L of
water

Days

lity %
Morta

Ecolyzer
ANVISA Standard
RESULTS
Musca domestica

Rate:
67 mL - 10 L of
water

Days

lity %
Morta

Ecolyzer
ANVISA Standard
RESULTS
Monomorium floricola

Rate:
50 mL - 10 L of
water

Days

lity %
Morta

Ecolyzer
ANVISA Standard
RESULTS
Triatoma infestans

Rate:
133 mL - 10 L of
water

Days

lity %
Morta

Ecolyzer
ANVISA Standard
RESULTS
Alphitobius diaperinus

Rate:
33 mL - 10 L of
water

Days

lity %
Morta

Ecolyzer
ANVISA Standard
RESULTS
Tityus serrulatus

Rate:
170 mL - 10 L of
water

Days

lity %
Morta

Ecolyzer
ANVISA Standard
3 1

Single Insecticide = The first
in
on the market:
KNOCK DOWN + RESIDUAL + ACTION
in all the insects phases.

Versatility of the product = Broad spectrum of action
Pyrethroid + IGR = Residual Effecty longer
Active Formulation = For use in the Resistance Management.
Technical Advantage Formulation = To control
cockroaches and Bed Bugs

Differentiated Formulation "SC" = Odorless, water
based, solvent-free organic.

Low toxicity
BASF PRODUCT = DIFFERENTIATED PRODUCT
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Tenopa slideshare

  • 1.
  • 3. ALPHA-CIPERMETHRIN MAIN FEATURES  94% to 97% active Isomer CIS  Not irritating  WHO standard World Helth Organization
  • 4. GROWTH REGULATORS Compounds which have a different action from the conventional insecticides They a INSE re also known as “ I CT G R O W GR ” REG TH U LATO R
  • 5. “IGRs” CHARACTERISTICS  Interfere with the metamorphosis and ecdysis control mechanism.  Act on specific Arthropods enzymes.  Give a long residual protection.  Act on juvenile forms of insects.  Can cause the adult females to lay unviable eggs.  They don’t offer the knock down effect.
  • 6. ACTION MODE - CLASSIFICATION CHITIN SYNTHESIS INHIBITORS Synthetase enzyme = responsible for the chitin formation process. IGRs prevent its polymerization. Ex.: Flufenoxuron. AGONISTS OF ECDYSTEROIDS JUVENILE HORMONE AGONISTS Imitate the insects natural hormone ("ecdisônio"), prematurely triggering the process of change. "Juvenoid" = Imitate the action of the insects juvenile hormone by interfering with the skin changes. Ex.: Tefubenoside, Metoxifenoside. Ex.: Piriproxifen, Fenoxicarb, Metoprene.
  • 7. POLYSACCHARIDES Carbohydrates formed by the union of more than ten monosaccharide molecules, forming a polymer of monosaccharides MONOSACCHARIDES FRUCTOSE BETA- GLUCOSE Energy Ex.: Starch, Glycogen Structural Ex.: Chitin, Cellulose Unlike the mono-and disaccharides (glucose, galactose, fructose), polysaccharides are insoluble in water and are well suited to the role of nutritional reserves or storage.
  • 8. CHITIN Polysaccharide which contains nitrogen in its acetylglucosamine units. Main constituent of the arthropods exoskeletons. Also found in the fungi cell walls.
  • 9. FUNGUS - CELL WALL mannoproteins FUNCTIONS ß (1,3) Protection adverse factors ß (1,6) glucan Permeability barrier ß (1,3) glucan Plasma membrane chitin synthase Cell shape ergosterol Interaction with the external environment Atlas of fungal Infections, Richard Diamond Ed. 1999 - Introduction to Medical Mycology. Merck and Co. 2001
  • 10. FLUFENOXURON Chemical group: Benzoyl phenyl urea Solubility in water: 0,0043 mg/l (25º) Acute oral DL50(rat): > 3000 mg/kg (téc.) 85% eliminated in feces within 72 hours (rats) Not irritanting Classe III – OMS
  • 11. LABORATORY RESULTS- FLUFENOXURON Blattella germanica Until 98 days: 5 mg/m² M O R T A L I T Start with 8 adults (3 males/ 5 females, and 3 with ooteca), and 10 nymphs in 1º ínstar and 5 the last ínstar. 10 mg/m² Control After 100 days: Y% New population with 7 adults (3 males/4 females, and 2 with ooteca), and 7 nymphs in 1º ínstar and 5 the last ínstar. Area treated: 10% of the total area disponível.Obs.: Total area with availability of food, shelter and water. Food And Environment Protection Act 1985, Part III
  • 12. ESTIMATED POPULATION IN 98 DAYS Blattella germanica Biological Characteristics Domestic Species Blattella germanica Size 12 a 16 mm Color yellowish brown Ootheca Deposition not release Number of eggs / ootheca 30-40 Number of ootheca 4-5 Number of Ecdysis 5-7 young period 2-3 months longevity 1 year eggs incubation 15-30 days posture interval 45 days Succession number 20 000 days to produce the first ootheca 17 98 days estimate 5369X 5 – 26.845
  • 13. FIELD RESULTS - FLUFENOXURON Blattella germanica % P O P U L A T I O N R E D U C T I O N Inicial on populati Index Infestation measured with glue trap. (captures per night) Dose found in the treated surfaces (chromatographic analysis - mg / m²): Apart 01: - Apart 02: 6,33 Apart 03: - Apart 04: 4,53 Rate: 7,5 mg/m² Food And Environment Protection Act 1985, Part III Apart 05: 5,24 Apart 06: 3,65
  • 14. FIELD RESULTS - FLUFENOXURON Blattella germanica Apart. 02 Nº I N S E C T S C A P T U R E D Food And Environment Protection Act 1985, Part III ADULTS NYMPHS
  • 15. LABORATORY RESULTS – FLUFENOXUROM Ctenocephalides felis PUPAE DEAD LARVAE TREATMENT RESULTS WITH ADULTS - SECOND STAGE (%) Control 72,5 62 4 0,8 mg/m² 0,98 38 23 4,0 mg/m² 0 5 68 NUMBER 5 repetitions of 15 to 20 larvae of second ínstar Flufenoxuron - control in the development of the second stage
  • 16. LIFE CYCLE - FLEAS Ctenocephalides felis Adults Pupa Adult Flea Eggs Pupa Animals Larvae Larvae 3º stage Larvae 1º stage Environment Environment Environment Larvae 2º stage LIFE CYCLE Eggs Cycle Time - 17 to 25 days Approximately 3000 eggs
  • 17. FIELD RESULTS - FLUFENOXURON Ctenocephalides felis Rate: Eggs collected Dead Larvae 15 mg/m² METHODOLOGY 1) Cat’s Cloth (40 cm²) jerky and collected; Alive Adults 2) Count number of eggs; Adults Control (%) 3) Incubated eggs; 4) Note the development of eggs. Alive Larvae W ks ee Control with 77 weeks Food And Environment Protection Act 1985, Part III
  • 18. FLUFENOXURON RECOMMENDATIONS - OMS Cockroaches: Rate 0,3 g/L “Due to its slow-acting insecticides are usually combined with faster acting insectcides. This combination eliminates adults and prevents the development of young forms” Bed Bugs: Rate 0,3 g/L “Studies have shown the bed bugs resistance to conventional insecticides.The mixtures of Growth Regulators + Pyrethroids have proven to be an effective control compared to infestations tolerant to pyrethroids when it is used alone. " Food And Environment Protection Act 1985, Part III
  • 19. TENOPA® - ESPECIFICATIONS Physical State: opaque and viscous liquid Color: white Oxidant: considered non oxidizing Density: 1,028 Smell: Odeurless Shelf stability Good stability in: 20 a 28º C - 104 weeks / 728 days Acid/Base: PH 7.2 29 a 37º C - 52 weeks / 364 days
  • 20. INSTRUCTIONS FOR USE PESTS COMERCIAL PRODUCT (ml/ 10 L of water) I.A. CONCENTRATION ALPHA-CIPERMETRIN (%P/P) I.A. CONCENTRATION FLUFENOXURON (%P/P) Cockroaches 50 0,015% 0,015% Mosquitoes 67 0,020% 0,020% Flies 67 0,020% 0,020% Fleas 33 0,010% 0,010% Ants 50 0,015% 0,015% Triatomines 133 0,040% 0,040% Ticks 80 0,024% 0,024% Scorpions 170 0,050% 0,050% Mealworm 150 0,045% 0,045% Bed bug 170 0,050% 0,050% Brown spider 170 0,050% 0,050%
  • 21. LIFE CYCLE - COKROACHES Periplaneta Americana Males Females
  • 22. LABORATORY RESULTS Tile surface - Blatella germanica 9 8 7 Minutes 6 5 Upper limit KT50 4 Lower limit K IC N QU TIO AC 3 2 1 0 Check Alfa-Cipermetrina 3%+ Flufenoxueom 3% (TENOPA ) ® Source : Non Crop Laboratory = EEA BASF- Brazil, 2010 Alpha-Cypermethrin Lambdacyalothrin Deltamethrin 5% 2,5% 2,5%
  • 23. LABORATORY RESULTS Wood surface - Blatella germanica 100 90 K IC N QU TIO AC 80 70 Minutes 60 Upper limit 50 KT50 40 Lower limit 30 20 10 0 Check Alpha-Cypermethrin 3%+ Alpha-Cypermethrin 5% Flufenoxueon 3% (TENOPA ) ® Source : Non Crop Laboratory = EEA BASF- Brazil, 2010 Lambdacyalothrin Deltamethrin 2,5% 2,5%
  • 24. LABORATORY RESULTS Blatella germanica TILE SURFACE - tile surface PRELIMINARY PROFILE ACTIVE INGREDIENT CONC. Appl. (g a.i./l) (Nº) RATE (10l of water) Alphacypermethrin+ Flufenoxuron 30/30 1 50 1 25 1 25 1 EFFICACY 30 DAYS EFFICACY 60 DAYS EFFICACY 90 DAYS 10% 20% EFFICACY 60 DAYS EFFICACY 90 DAYS 100ml/200m² Deltamethrin EFFICACY 72 HOURS 50ml/200m² Lambdacyalothrin EFFICACY 48 HOURS 50ml/200m² Alphacypermethrin EFFICACY 24 HOURS 100ml/200m² Subtitles WOOD SURFACE PRELIMINARY PROFILE - wooden surface ACTIVE INGREDIENT CONC. Appl. (g a.i./l) (Nº) RATE (10l of water) Alphacypermethrin+ Flufenoxuron 30/30 1 50ml/200m² Alphacypermethrin 50 1 50ml/200m² Lambdacyalothrin 25 1 100ml/200m² Deltamethrin 25 1 100ml/200m² P&D Brasil Source : Non Crop Laboratory = EEA BASF- Brazil, 2010 EFFICACY 24 HOURS EFFICACY 48 HOURS EFFICACY 72 HOURS 0 EFFICACY 30 DAYS
  • 25. RESULTS – RESIDUAL EFFECT Periplaneta / Blatella Rate: 50 mL - 10 L of water Days Ecolyzer ANVISA Standard
  • 26. RESULTS – KNOCK DOWN Periplaneta / Blatella Rate: TIME 50 mL - 10 L of water Days Ecolyzer ANVISA Standard KT 50 with confidence interval of 95% Ex.: Periplaneta - time 24h - result 6,13 min – confidence interval = 4,49/8,35 min
  • 27. RESULTS Ctenocephalides felis Rate: 33 mL - 10 L of water Days lity % Morta Ecolyzer ANVISA Standard
  • 28. RESULTS Culex quinquefasciatus Rate: 67 mL - 10 L of water Days lity % Morta Ecolyzer ANVISA Standard
  • 29. RESULTS Musca domestica Rate: 67 mL - 10 L of water Days lity % Morta Ecolyzer ANVISA Standard
  • 30. RESULTS Monomorium floricola Rate: 50 mL - 10 L of water Days lity % Morta Ecolyzer ANVISA Standard
  • 31. RESULTS Triatoma infestans Rate: 133 mL - 10 L of water Days lity % Morta Ecolyzer ANVISA Standard
  • 32. RESULTS Alphitobius diaperinus Rate: 33 mL - 10 L of water Days lity % Morta Ecolyzer ANVISA Standard
  • 33. RESULTS Tityus serrulatus Rate: 170 mL - 10 L of water Days lity % Morta Ecolyzer ANVISA Standard
  • 34. 3 1 Single Insecticide = The first in on the market: KNOCK DOWN + RESIDUAL + ACTION in all the insects phases. Versatility of the product = Broad spectrum of action Pyrethroid + IGR = Residual Effecty longer Active Formulation = For use in the Resistance Management. Technical Advantage Formulation = To control cockroaches and Bed Bugs Differentiated Formulation "SC" = Odorless, water based, solvent-free organic. Low toxicity BASF PRODUCT = DIFFERENTIATED PRODUCT